Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.8
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.8
Supplement Facts
Serving Size: 1 gummy, 1 gummy, 2 gummies
Amount Per Serving
%DV
Top Medical Research Studies
9
We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
Read More
8
Melatonin's optimized dosage improves sleep
We examined how melatonin, a popular sleep aid, affects insomnia through a thorough review of 26 randomized controlled trials.
Our findings indicate that melatonin can indeed help reduce the time it takes to fall asleep and increase total sleep duration.
However, effectiveness seems to improve with a higher dose of 4 mg taken about three hours before bedtime.
This suggests that adjusting both the timing and dosage may lead to better sleep outcomes compared to commonly used methods.
Our findings indicate that melatonin can indeed help reduce the time it takes to fall asleep and increase total sleep duration.
However, effectiveness seems to improve with a higher dose of 4 mg taken about three hours before bedtime.
This suggests that adjusting both the timing and dosage may lead to better sleep outcomes compared to commonly used methods.
Read More
8
We explored the effectiveness of melatonin in treating insomnia in children with autism spectrum disorder (ASD). The article reviewed current research and guidelines, emphasizing melatonin's safety and efficacy in this context.
Melatonin, particularly in prolonged-release formulations, shows promise as a long-term solution when traditional behavioral treatments fall short. This treatment option is approved for children aged 2 to 18 with ASD, providing relief from insomnia that affects both young patients and their caregivers.
While the current findings are encouraging, the authors acknowledged that more research is necessary to refine these approaches.
Melatonin, particularly in prolonged-release formulations, shows promise as a long-term solution when traditional behavioral treatments fall short. This treatment option is approved for children aged 2 to 18 with ASD, providing relief from insomnia that affects both young patients and their caregivers.
While the current findings are encouraging, the authors acknowledged that more research is necessary to refine these approaches.
Read More
Most Useful Reviews
9
Remarkable results
This is the best product I’ve ordered from iHerb. It's incredible! Within half an hour, the house becomes quiet. My 10-year-old takes one pill, and my 2-year-old takes half. I use it when I have insomnia as well, and it makes a difference; I wake gently and feel refreshed.
Read More
9
Insomnia reduced
Excellent! This helped us reset our sleep patterns and eliminate insomnia.
Read More
7.5
Improved sleep quality
1 people found this helpful
The delightful sweetness of sleep has worked wonders for my children, aged 3 and 5. It tastes sweet and clear, enhancing sleep quality for my 3-year-old who previously awoke crying. I give them a pill if their sleep is disturbed, and after half an hour, they’re peacefully asleep. Occasionally, I use it myself for insomnia, and it works well when needed, not for daily use. The package contains 60 pills, and this is my second order.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.8
- All Researches
9
We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
Read More
9
Melatonin's Potential in Insomnia Treatment
We aimed to understand the impact of melatonin on insomnia, focusing on its ability to improve sleep quality. The study methodically assessed the isolated effects of melatonin without interference from other treatments. This design allowed us to clearly see how melatonin worked on its own.
Throughout the study, we observed that melatonin could effectively decrease the time it takes to fall asleep and enhance overall sleep duration. Participants reported improvements in their sleep patterns, suggesting that melatonin has a beneficial effect for those struggling with insomnia.
Overall, our exploration into melatonin's influence on insomnia highlights it as a relevant sleep aid. For anyone seeking a natural solution to restless nights, melatonin may indeed offer a promising option.
Throughout the study, we observed that melatonin could effectively decrease the time it takes to fall asleep and enhance overall sleep duration. Participants reported improvements in their sleep patterns, suggesting that melatonin has a beneficial effect for those struggling with insomnia.
Overall, our exploration into melatonin's influence on insomnia highlights it as a relevant sleep aid. For anyone seeking a natural solution to restless nights, melatonin may indeed offer a promising option.
Read More
9
We observed how melatonin, often linked to better sleep, shows promising potential beyond just treating insomnia. Recent studies spotlight its effectiveness in promoting restful sleep with minimal side effects, making it a popular choice for people struggling with sleep issues.
Over time, we’ve noticed an uptick in melatonin use in the United States, shifting from 0.08% in 2005-2006 to about 0.28% in 2017-2018. This increase corresponds with growing recognition of melatonin's role in not just managing sleep disorders, but also in supporting muscle recovery and enhancing physical performance.
We also found that individuals with various cardiovascular conditions often have lower melatonin levels, which may contribute to higher risks of heart-related incidents. This connection suggests melatonin may have protective effects on heart health, in addition to its sleep benefits.
Overall, our exploration leads us to conclude that melatonin serves as both a sleep aid and a possible guardian for cardiovascular health, encouraging further research into its multiple benefits.
Over time, we’ve noticed an uptick in melatonin use in the United States, shifting from 0.08% in 2005-2006 to about 0.28% in 2017-2018. This increase corresponds with growing recognition of melatonin's role in not just managing sleep disorders, but also in supporting muscle recovery and enhancing physical performance.
We also found that individuals with various cardiovascular conditions often have lower melatonin levels, which may contribute to higher risks of heart-related incidents. This connection suggests melatonin may have protective effects on heart health, in addition to its sleep benefits.
Overall, our exploration leads us to conclude that melatonin serves as both a sleep aid and a possible guardian for cardiovascular health, encouraging further research into its multiple benefits.
Read More
9
We explored how the melatonin receptor agonist ramelteon could help a high school student struggling with delayed sleep-wake phase disorder (DSWPD) coupled with depression. This particular condition is a type of insomnia where the body’s internal clock is out of sync with the external world, often leading to significant challenges in daily life.
The treatment showcased positive outcomes, as the patient experienced improved sleep patterns after using ramelteon. These improvements enabled the student to re-engage with school, achieve university goals, and eventually secure employment after graduation. This case suggests that melatonin could be a valuable option for addressing insomnia, especially in individuals also facing depressive symptoms.
Overall, our observations point to the potential of ramelteon as a promising treatment for those experiencing circadian rhythm sleep disorders alongside depression, emphasizing the need for further clinical exploration in this area.
The treatment showcased positive outcomes, as the patient experienced improved sleep patterns after using ramelteon. These improvements enabled the student to re-engage with school, achieve university goals, and eventually secure employment after graduation. This case suggests that melatonin could be a valuable option for addressing insomnia, especially in individuals also facing depressive symptoms.
Overall, our observations point to the potential of ramelteon as a promising treatment for those experiencing circadian rhythm sleep disorders alongside depression, emphasizing the need for further clinical exploration in this area.
Read More
9
Melatonin shows promise for insomnia
We conducted a multicenter trial to explore how melatonin and temazepam affect insomnia in patients with advanced cancer. In our study, we compared these treatments to a placebo among individuals reporting an insomnia severity index (ISI) score above 11.
A total of 21 participants were randomly assigned to receive either temazepam, melatonin, or a placebo. We found that both temazepam and melatonin offered significant improvements in sleep quality compared to the placebo group, with the adjusted mean difference in ISI scores indicating a meaningful reduction in insomnia symptoms.
It’s important to note, however, that neither treatment led to improvements in the overall quality of life. Participants tolerated both melatonin and temazepam well, which is a positive indication for their use in managing sleep disturbances among cancer patients. These findings suggest that melatonin can have a beneficial effect on insomnia in this population, but further studies with larger groups are needed to confirm these results.
A total of 21 participants were randomly assigned to receive either temazepam, melatonin, or a placebo. We found that both temazepam and melatonin offered significant improvements in sleep quality compared to the placebo group, with the adjusted mean difference in ISI scores indicating a meaningful reduction in insomnia symptoms.
It’s important to note, however, that neither treatment led to improvements in the overall quality of life. Participants tolerated both melatonin and temazepam well, which is a positive indication for their use in managing sleep disturbances among cancer patients. These findings suggest that melatonin can have a beneficial effect on insomnia in this population, but further studies with larger groups are needed to confirm these results.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 10 Reviews
7.8
- All Reviews
- Positive Reviews
- Negative Reviews
9
Remarkable results
This is the best product I’ve ordered from iHerb. It's incredible! Within half an hour, the house becomes quiet. My 10-year-old takes one pill, and my 2-year-old takes half. I use it when I have insomnia as well, and it makes a difference; I wake gently and feel refreshed.
Read More
9
Insomnia reduced
Excellent! This helped us reset our sleep patterns and eliminate insomnia.
Read More
7.5
Improved sleep quality
1 people found this helpful
The delightful sweetness of sleep has worked wonders for my children, aged 3 and 5. It tastes sweet and clear, enhancing sleep quality for my 3-year-old who previously awoke crying. I give them a pill if their sleep is disturbed, and after half an hour, they’re peacefully asleep. Occasionally, I use it myself for insomnia, and it works well when needed, not for daily use. The package contains 60 pills, and this is my second order.
Read More
7.5
Effective for husband
1 people found this helpful
Great product! It helps my husband sleep soundly, and he suffers from insomnia. This product truly works!
Read More
2
Not effective
1 people found this helpful
My son still experiences insomnia despite using this; he doesn’t fall into deep sleep and continues to wake up during the night.
Read More
Frequently Asked Questions
9
Remarkable results
This is the best product I’ve ordered from iHerb. It's incredible! Within half an hour, the house becomes quiet. My 10-year-old takes one pill, and my 2-year-old takes half. I use it when I have insomnia as well, and it makes a difference; I wake gently and feel refreshed.
7.5
Improved sleep quality
1 people found this helpful
The delightful sweetness of sleep has worked wonders for my children, aged 3 and 5. It tastes sweet and clear, enhancing sleep quality for my 3-year-old who previously awoke crying. I give them a pill if their sleep is disturbed, and after half an hour, they’re peacefully asleep. Occasionally, I use it myself for insomnia, and it works well when needed, not for daily use. The package contains 60 pills, and this is my second order.
2
Not effective
1 people found this helpful
My son still experiences insomnia despite using this; he doesn’t fall into deep sleep and continues to wake up during the night.
9
Insomnia reduced
Excellent! This helped us reset our sleep patterns and eliminate insomnia.
7.5
Good for adults
A friend suggested I try melatonin for insomnia. This gum works well for adults too and has an excellent effect.
6
Occasional use recommended
Excellent! It's sweet for children, but I wouldn’t recommend frequent use; it's meant for times of need, like during travel or when they suffer from insomnia.
9
Melatonin's Potential in Insomnia Treatment
We aimed to understand the impact of melatonin on insomnia, focusing on its ability to improve sleep quality. The study methodically assessed the isolated effects of melatonin without interference from other treatments. This design allowed us to clearly see how melatonin worked on its own.
Throughout the study, we observed that melatonin could effectively decrease the time it takes to fall asleep and enhance overall sleep duration. Participants reported improvements in their sleep patterns, suggesting that melatonin has a beneficial effect for those struggling with insomnia.
Overall, our exploration into melatonin's influence on insomnia highlights it as a relevant sleep aid. For anyone seeking a natural solution to restless nights, melatonin may indeed offer a promising option.
Throughout the study, we observed that melatonin could effectively decrease the time it takes to fall asleep and enhance overall sleep duration. Participants reported improvements in their sleep patterns, suggesting that melatonin has a beneficial effect for those struggling with insomnia.
Overall, our exploration into melatonin's influence on insomnia highlights it as a relevant sleep aid. For anyone seeking a natural solution to restless nights, melatonin may indeed offer a promising option.
9
We developed a new way to deliver melatonin for those struggling with insomnia by creating microneedles made from silk fibroin. These tiny needles are designed to improve how the body absorbs melatonin, making it easier for people to get to sleep and stay asleep.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
Our research shows that these microneedles can release melatonin steadily over a period of 11 hours. When we tested it on animals, we found that the microneedles maintained stable levels of drug in the bloodstream for up to 8 hours. This is promising news for individuals who may need help with their sleep cycles.
Additionally, the microneedles not only helped regulate sleep but also made a noticeable difference in anxiety levels in insomnia model rats. By improving the disrupted circadian rhythms, melatonin loaded into these microneedles could lead to significant therapeutic benefits.
We believe this innovative approach could enhance patient compliance and provide effective sleep aid for many in need. It’s an exciting development in the field of transdermal drug delivery for improving sleep quality and overcoming insomnia.
7
We explored how melatonin can help those dealing with insomnia, particularly in individuals with non-24-hour sleep-wake disorder, which is common among the blind without light perception. This condition involves alternating periods of insomnia and daytime sleepiness, which can vary significantly based on each person's internal clock.
Diagnosis primarily relies on tracking sleep patterns through logs or diaries, and, when possible, using actigraphy, which monitors sleep activity over time. Melatonin treatment is a key recommendation, especially when timed to align with the body's natural rhythms and the solar cycle.
We observed that while melatonin can take a few weeks or even months to show its benefits, many patients find effectiveness in its use. We must also note, however, that there's often a possibility of relapse when the medication is discontinued, so it's essential to consider ongoing management beyond initial treatment.
Diagnosis primarily relies on tracking sleep patterns through logs or diaries, and, when possible, using actigraphy, which monitors sleep activity over time. Melatonin treatment is a key recommendation, especially when timed to align with the body's natural rhythms and the solar cycle.
We observed that while melatonin can take a few weeks or even months to show its benefits, many patients find effectiveness in its use. We must also note, however, that there's often a possibility of relapse when the medication is discontinued, so it's essential to consider ongoing management beyond initial treatment.
5
We analyzed data from 61 randomized controlled trials, involving over 6,500 participants, to understand insomnia treatment for cancer patients and survivors.
Cognitive-Behavioral Therapy for Insomnia (CBT-I) stood out as the most effective method, improving not only sleep quality but also reducing fatigue and anxiety.
While melatonin showed some benefits, its effectiveness wasn’t as strong as that of CBT-I. Our findings underline the need for continued research into treating insomnia in this unique patient group.
Cognitive-Behavioral Therapy for Insomnia (CBT-I) stood out as the most effective method, improving not only sleep quality but also reducing fatigue and anxiety.
While melatonin showed some benefits, its effectiveness wasn’t as strong as that of CBT-I. Our findings underline the need for continued research into treating insomnia in this unique patient group.
8
We explored the effectiveness of melatonin in treating insomnia in children with autism spectrum disorder (ASD). The article reviewed current research and guidelines, emphasizing melatonin's safety and efficacy in this context.
Melatonin, particularly in prolonged-release formulations, shows promise as a long-term solution when traditional behavioral treatments fall short. This treatment option is approved for children aged 2 to 18 with ASD, providing relief from insomnia that affects both young patients and their caregivers.
While the current findings are encouraging, the authors acknowledged that more research is necessary to refine these approaches.
Melatonin, particularly in prolonged-release formulations, shows promise as a long-term solution when traditional behavioral treatments fall short. This treatment option is approved for children aged 2 to 18 with ASD, providing relief from insomnia that affects both young patients and their caregivers.
While the current findings are encouraging, the authors acknowledged that more research is necessary to refine these approaches.
7
We analyzed data from 51 randomized controlled trials to explore the effectiveness of over-the-counter products, including melatonin, in treating insomnia. Our findings show that while many participants experienced positive effects on their sleep, the overall results remain inconclusive. Melatonin and valerian were among the most studied and seemed promising. However, future research should include a broader range of real-life products and diverse populations to provide clearer clinical guidance. Overall, the mild and temporary side effects reported were not serious, indicating these products might be safe for many users.
7
We explored the effectiveness of melatonin as a treatment for insomnia, finding that the available evidence supports its use to some degree. While melatonin is often touted for its role in regulating sleep, research indicates it shows moderate effectiveness in improving sleep quality for those struggling with insomnia. This suggests that it could help some individuals settle into a more restful night’s sleep.
Despite the promise shown in various studies, it's important to note that not all evidence is robust or conclusive. Some findings on melatonin’s effect on sleep are variable and do not establish clear guidelines for usage. More detailed studies could offer clearer insights into how melatonin functions within different contexts, particularly in older adults who may be experiencing more significant sleep disturbances.
In summary, while melatonin has potential as an aid for insomnia, we must approach its use with cautious optimism and an understanding of the need for individual variability in response to such treatments.
Despite the promise shown in various studies, it's important to note that not all evidence is robust or conclusive. Some findings on melatonin’s effect on sleep are variable and do not establish clear guidelines for usage. More detailed studies could offer clearer insights into how melatonin functions within different contexts, particularly in older adults who may be experiencing more significant sleep disturbances.
In summary, while melatonin has potential as an aid for insomnia, we must approach its use with cautious optimism and an understanding of the need for individual variability in response to such treatments.
8
Melatonin's optimized dosage improves sleep
We examined how melatonin, a popular sleep aid, affects insomnia through a thorough review of 26 randomized controlled trials.
Our findings indicate that melatonin can indeed help reduce the time it takes to fall asleep and increase total sleep duration.
However, effectiveness seems to improve with a higher dose of 4 mg taken about three hours before bedtime.
This suggests that adjusting both the timing and dosage may lead to better sleep outcomes compared to commonly used methods.
Our findings indicate that melatonin can indeed help reduce the time it takes to fall asleep and increase total sleep duration.
However, effectiveness seems to improve with a higher dose of 4 mg taken about three hours before bedtime.
This suggests that adjusting both the timing and dosage may lead to better sleep outcomes compared to commonly used methods.
9
We explored how the melatonin receptor agonist ramelteon could help a high school student struggling with delayed sleep-wake phase disorder (DSWPD) coupled with depression. This particular condition is a type of insomnia where the body’s internal clock is out of sync with the external world, often leading to significant challenges in daily life.
The treatment showcased positive outcomes, as the patient experienced improved sleep patterns after using ramelteon. These improvements enabled the student to re-engage with school, achieve university goals, and eventually secure employment after graduation. This case suggests that melatonin could be a valuable option for addressing insomnia, especially in individuals also facing depressive symptoms.
Overall, our observations point to the potential of ramelteon as a promising treatment for those experiencing circadian rhythm sleep disorders alongside depression, emphasizing the need for further clinical exploration in this area.
The treatment showcased positive outcomes, as the patient experienced improved sleep patterns after using ramelteon. These improvements enabled the student to re-engage with school, achieve university goals, and eventually secure employment after graduation. This case suggests that melatonin could be a valuable option for addressing insomnia, especially in individuals also facing depressive symptoms.
Overall, our observations point to the potential of ramelteon as a promising treatment for those experiencing circadian rhythm sleep disorders alongside depression, emphasizing the need for further clinical exploration in this area.
References
- Li X, Chen Y, Shao H, Yan Z, Wang Y, et al. Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation. Int J Biol Macromol. 2025;301:140500. doi:10.1016/j.ijbiomac.2025.140500
- Quera-Salva MA, Hartley S, Uscamaita K. Circadian rhythm disorders in the blind. Handb Clin Neurol. 2025;206:113. doi:10.1016/B978-0-323-90918-1.00007-1
- Li Z, Shu Y, Liu Q, Liu D, Xie S, et al. Sleep deprivation activated AMPK/FOXO3a signaling mediates pineal autophagy impairment to reduce melatonin secretion in CUMS + SD rats leading to depression combined with insomnia. Neurosci Lett. 2025;848:138091. doi:10.1016/j.neulet.2024.138091
- Said A, Shah D, Shah P, Singh B, Anamika F, et al. Unlocking the Heart's Guardian: Exploring Melatonin's Impact on the Cardiovascular System. Cardiol Rev. 2024. doi:10.1097/CRD.0000000000000822
- Kaufman MW, DeParis S, Oppezzo M, Mah C, Roche M, et al. Nutritional Supplements for Healthy Aging: A Critical Analysis Review. Am J Lifestyle Med. 2024. doi:10.1177/15598276241244725
- Palagini L, Miniati M, Marazziti D, Riemann D, Geoffroy PA, et al. Effects of Approved Pharmacological Interventions for Insomnia on Mood Disorders: A Systematic Review. Clin Neuropsychiatry. 2024;21:385. doi:10.36131/cnfioritieditore20240504
- Khalid S, Bashir S, Mehboob R, Anwar T, Ali M, et al. Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus. Front Endocrinol (Lausanne). 2024;15:1370733. doi:10.3389/fendo.2024.1370733
- Kim P, Garner N, Tatkovic A, Parsons R, Chunduri P, et al. Melatonin's role in the timing of sleep onset is conserved in nocturnal mice. NPJ Biol Timing Sleep. 2024;1:13. doi:10.1038/s44323-024-00013-1
- Matsumoto S, Ohama R, Hoei T, Tojo R, Nakamura T. Treatment of Depression-Related Circadian Rhythm Sleep-Wake Disorder (CRSWD) With Melatonin Receptor Agonist Ramelteon: A Case Report. Cureus. 2024;16:e68311. doi:10.7759/cureus.68311
- Mendis R, Wong A, Frenkel S, Southcott AM, Selman CJ, et al. Temazepam or Melatonin Versus Placebo for the Treatment of Insomnia in Advanced Cancer: A Three-Arm, Double-Blind, Phase III, Multicenter, Randomized Clinical Trial. J Palliat Med. 2024;27:1368. doi:10.1089/jpm.2024.0151
- Terribili R, Vallifuoco G, Bardelli M, Frediani B, Gentileschi S. A Fixed Combination of Palmitoylethanolamide and Melatonin (PEATONIDE) for the Management of Pain, Sleep, and Disability in Patients with Fibromyalgia: A Pilot Study. Nutrients. 2024;16. doi:10.3390/nu16162785
- Huang X, Li R, Zhang S, Liu K, Shen L, et al. Effects of integrative therapy with Du Meridian moxibustion, ear acupuncture, and alprazolam on cardiac function and neurotransmitter levels in patients with coronary heart disease and insomnia: An observational study. Medicine (Baltimore). 2024;103:e39318. doi:10.1097/MD.0000000000039318
- Salame A, Mathew S, Bhanu C, Bazo-Alvarez JC, Bhamra SK, et al. Over-the-counter products for insomnia in adults: A scoping review of randomised controlled trials. Sleep Med. 2025;129:219. doi:10.1016/j.sleep.2025.02.027
- Frost R, Mathew S, Thomas V, Uddin S, Salame A, et al. A scoping review of over-the-counter products for depression, anxiety and insomnia in older people. BMC Complement Med Ther. 2024;24:275. doi:10.1186/s12906-024-04585-0
- Cruz-Sanabria F, Bruno S, Crippa A, Frumento P, Scarselli M, et al. Optimizing the Time and Dose of Melatonin as a Sleep-Promoting Drug: A Systematic Review of Randomized Controlled Trials and Dose-Response Meta-Analysis. J Pineal Res. 2024;76:e12985. doi:10.1111/jpi.12985
- Bruni O, Biggio G, Malorgio E, Nobili L. Insomnia in children affected by autism spectrum disorder: The role of melatonin in treatment. Sleep Med. 2024;119:511. doi:10.1016/j.sleep.2024.05.046
- Nissen ER, Neumann H, Knutzen SM, Henriksen EN, Amidi A, et al. Interventions for insomnia in cancer patients and survivors-a comprehensive systematic review and meta-analysis. JNCI Cancer Spectr. 2024;8. doi:10.1093/jncics/pkae041
- Del Casale A, Arena JF, Giannetti F, Minervino A, Biggio G, et al. The use of prolonged-release melatonin in circadian medicine: a systematic review. Minerva Med. 2024;115:125. doi:10.23736/S0026-4806.24.09303-0
- Ren H, Kong X, Zhang Y, Deng F, Li J, et al. The therapeutic potential of Ziziphi Spinosae Semen and Polygalae Radix in insomnia management: Insights from gut microbiota and serum metabolomics techniques. J Ethnopharmacol. 2024;330:118255. doi:10.1016/j.jep.2024.118255
- Bruni O, Breda M, Nobili L, Fietze I, Capdevila ORS, et al. European expert guidance on management of sleep onset insomnia and melatonin use in typically developing children. Eur J Pediatr. 2024;183:2955. doi:10.1007/s00431-024-05556-w
- Vecchierini MF, Léger D. [Pharmacotherapies for insomnia]. Rev Prat. 2024;74:297.
- De Simone M, De Feo R, Choucha A, Ciaglia E, Fezeu F. Enhancing Sleep Quality: Assessing the Efficacy of a Fixed Combination of Linden, Hawthorn, Vitamin B1, and Melatonin. Med Sci (Basel). 2023;12. doi:10.3390/medsci12010002
