' 
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
6.7
USERS' SCORE
Very Good
Based on 15 Reviews
8.4
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B-6 (as Pyridoxine Hydrochloride)
10 mg
588%
Calcium (as Calcium Carbonate)
60 mg
5%
Melatonin
5 mg
*
Top Medical Research Studies
9
Melatonin reduces anxiety from glyphosate
Melatonin attenuates affective disorders and cognitive deficits induced by perinatal exposure to a glyphosate-based herbicide via antioxidant pathway in adult male and female rats.
High relevance to anxiety treatment
Our research examined the effects of melatonin on anxiety and memory problems caused by exposure to glyphosate-based herbicides (GBH). We started with pregnant Wistar rats that were subjected to GBH during gestation and lactation. After weaning, the offspring were treated with melatonin to see if it could help mitigate the negative effects they experienced due to their early exposure.
We observed that exposure to GBH led to increased anxiety and depression-like behaviors in the rats. Additionally, it appeared to impair their memory function. In looking at oxidative stress markers in the brain regions associated with emotion and cognition, we found indications of increased stress—especially pronounced in the female offspring.
However, the inclusion of melatonin significantly reduced these anxiety levels and improved cognitive deficits. Interestingly, the benefits were notably greater in female rats compared to males, suggesting a potential sex-dependent response to melatonin treatment.
We observed that exposure to GBH led to increased anxiety and depression-like behaviors in the rats. Additionally, it appeared to impair their memory function. In looking at oxidative stress markers in the brain regions associated with emotion and cognition, we found indications of increased stress—especially pronounced in the female offspring.
However, the inclusion of melatonin significantly reduced these anxiety levels and improved cognitive deficits. Interestingly, the benefits were notably greater in female rats compared to males, suggesting a potential sex-dependent response to melatonin treatment.
Read More
4
No significant anxiety reduction difference
Efficacy of melatonin vs. midazolam for oral premedication in children: a systematic review and meta-analysis.
Addresses melatonin's anxiety effects
We examined the effectiveness of melatonin compared to midazolam for premedication in children, particularly focusing on anxiety levels during the preoperative process. In our systematic review of ten randomized controlled trials involving 774 participants, we found that both medications were used to help children feel more relaxed before surgery. However, when it came to their impact on sedation and anxiety, the results showed no significant differences between melatonin and midazolam.
We assessed various outcomes, including sedation and levels of anxiety in the preoperative room as well as during induction. Despite our thorough examination of the data, we noted that neither melatonin nor midazolam stood out as being more effective than the other. This indicates that when it comes to controlling anxiety, both options may work similarly for children undergoing surgery. Importantly, our findings suggest that variations in how the medications were administered and evaluated contributed to challenges in data synthesis, signaling a need for standardized approaches in future studies.
We assessed various outcomes, including sedation and levels of anxiety in the preoperative room as well as during induction. Despite our thorough examination of the data, we noted that neither melatonin nor midazolam stood out as being more effective than the other. This indicates that when it comes to controlling anxiety, both options may work similarly for children undergoing surgery. Importantly, our findings suggest that variations in how the medications were administered and evaluated contributed to challenges in data synthesis, signaling a need for standardized approaches in future studies.
Read More
8
Melatonin microneedles alleviate anxiety
Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation.
Significant effects on anxiety observed
We examined the potential of melatonin microneedles as a novel method for treating anxiety and regulating circadian rhythms. This study utilized silk fibroin to create microneedles that deliver melatonin transdermally, offering sustainable drug release for up to 11 hours.
During our research, we found that these microneedles maintain a stable blood drug concentration for eight hours post-application. This sustained delivery method was particularly beneficial for insomnia model rats, where we saw notable improvements in both sleep patterns and reductions in anxiety levels.
The findings indicate that melatonin microneedles effectively address disrupted circadian rhythms and alleviate anxiety symptoms. Our results suggest a promising avenue for improving treatment methods, especially for those struggling with sleep-related issues.
During our research, we found that these microneedles maintain a stable blood drug concentration for eight hours post-application. This sustained delivery method was particularly beneficial for insomnia model rats, where we saw notable improvements in both sleep patterns and reductions in anxiety levels.
The findings indicate that melatonin microneedles effectively address disrupted circadian rhythms and alleviate anxiety symptoms. Our results suggest a promising avenue for improving treatment methods, especially for those struggling with sleep-related issues.
Read More
Most Useful Reviews
9.5
Peaceful sleep
I enjoyed taking it an hour before bed. It helped me sleep peacefully and comfortably. Occasionally, I took two pills without experiencing anxiety or addiction.
Read More
9.5
Insomnia relief
My husband and I faced sleep issues, and this medicine has been a godsend for alleviating insomnia and anxiety. It truly makes a difference.
Read More
8.3
No harmful effects
After using two boxes, I've noticed no harmful effects. I fall asleep quickly without waking up with headaches or exhaustion. It helps manage sleep and alleviate anxiety.
Read More
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Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
6.7
9
Melatonin reduces anxiety from glyphosate
Melatonin attenuates affective disorders and cognitive deficits induced by perinatal exposure to a glyphosate-based herbicide via antioxidant pathway in adult male and female rats.
High relevance to anxiety treatment
Our research examined the effects of melatonin on anxiety and memory problems caused by exposure to glyphosate-based herbicides (GBH). We started with pregnant Wistar rats that were subjected to GBH during gestation and lactation. After weaning, the offspring were treated with melatonin to see if it could help mitigate the negative effects they experienced due to their early exposure.
We observed that exposure to GBH led to increased anxiety and depression-like behaviors in the rats. Additionally, it appeared to impair their memory function. In looking at oxidative stress markers in the brain regions associated with emotion and cognition, we found indications of increased stress—especially pronounced in the female offspring.
However, the inclusion of melatonin significantly reduced these anxiety levels and improved cognitive deficits. Interestingly, the benefits were notably greater in female rats compared to males, suggesting a potential sex-dependent response to melatonin treatment.
We observed that exposure to GBH led to increased anxiety and depression-like behaviors in the rats. Additionally, it appeared to impair their memory function. In looking at oxidative stress markers in the brain regions associated with emotion and cognition, we found indications of increased stress—especially pronounced in the female offspring.
However, the inclusion of melatonin significantly reduced these anxiety levels and improved cognitive deficits. Interestingly, the benefits were notably greater in female rats compared to males, suggesting a potential sex-dependent response to melatonin treatment.
Read More
8
Melatonin microneedles alleviate anxiety
Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation.
Significant effects on anxiety observed
We examined the potential of melatonin microneedles as a novel method for treating anxiety and regulating circadian rhythms. This study utilized silk fibroin to create microneedles that deliver melatonin transdermally, offering sustainable drug release for up to 11 hours.
During our research, we found that these microneedles maintain a stable blood drug concentration for eight hours post-application. This sustained delivery method was particularly beneficial for insomnia model rats, where we saw notable improvements in both sleep patterns and reductions in anxiety levels.
The findings indicate that melatonin microneedles effectively address disrupted circadian rhythms and alleviate anxiety symptoms. Our results suggest a promising avenue for improving treatment methods, especially for those struggling with sleep-related issues.
During our research, we found that these microneedles maintain a stable blood drug concentration for eight hours post-application. This sustained delivery method was particularly beneficial for insomnia model rats, where we saw notable improvements in both sleep patterns and reductions in anxiety levels.
The findings indicate that melatonin microneedles effectively address disrupted circadian rhythms and alleviate anxiety symptoms. Our results suggest a promising avenue for improving treatment methods, especially for those struggling with sleep-related issues.
Read More
8
Melatonin reduces anxiety post-surgery
Role of oral melatonin in prevention of postoperative delirium in patients undergoing elective surgery under general anesthesia: A Randomized controlled trial.
Moderate relevance due to confounding
In our study, we aimed to understand how melatonin might reduce anxiety and the risk of postoperative delirium in patients undergoing elective surgeries. We focused on 162 patients aged 40 to 80, evenly split into two groups—one receiving melatonin and the other receiving standard premedication with alprazolam and ranitidine.
We administered 3 mg of melatonin the night before the surgeries and monitored various outcomes related to anxiety and cognitive function. Remarkably, we found that the incidence of anxiety was significantly lower in those who took melatonin. Furthermore, patients reported better sleep quality, and cognitive function assessments indicated less cognitive dysfunction compared to the control group.
Our investigation highlighted the positive effects of melatonin, showing it not only lessens anxiety but also contributes to a smoother recovery post-surgery. This provides valuable insight for future practices in managing preoperative anxiety effectively.
We administered 3 mg of melatonin the night before the surgeries and monitored various outcomes related to anxiety and cognitive function. Remarkably, we found that the incidence of anxiety was significantly lower in those who took melatonin. Furthermore, patients reported better sleep quality, and cognitive function assessments indicated less cognitive dysfunction compared to the control group.
Our investigation highlighted the positive effects of melatonin, showing it not only lessens anxiety but also contributes to a smoother recovery post-surgery. This provides valuable insight for future practices in managing preoperative anxiety effectively.
Read More
7
Melatonin alleviates prenatal anxiety effects
Prenatal Constant Light Exposure Induces Behavioral Deficits in Male and Female Rat Offspring: Effects of Prenatal Melatonin Treatment.
Melatonin's targeted effect on anxiety
We explored the impact of prenatal constant light exposure (CLE) and melatonin treatment on anxiety-related behaviors in male and female rat offspring. In our study, six groups of rats were examined, with some experiencing a standard light/dark cycle while others were subjected to CLE. We treated these groups with either a saline solution or melatonin.
Through various anxiety assessments like the open field test and elevated plus maze, we observed that exposure to CLE led to significant behavioral deficits. Specifically, the rats showed heightened anxiety levels, alongside increased plasma cortisol levels. Surprisingly, melatonin treatment repaired these behavioral issues in a way that was different between sexes.
Even though melatonin did not change overall levels of melatonin in the bloodstream or normalize cortisol levels, it did boost the expression of specific brain receptors associated with mood regulation. This suggests that melatonin may hold therapeutic potential for addressing anxiety issues triggered by environmental factors experienced during prenatal development.
Through various anxiety assessments like the open field test and elevated plus maze, we observed that exposure to CLE led to significant behavioral deficits. Specifically, the rats showed heightened anxiety levels, alongside increased plasma cortisol levels. Surprisingly, melatonin treatment repaired these behavioral issues in a way that was different between sexes.
Even though melatonin did not change overall levels of melatonin in the bloodstream or normalize cortisol levels, it did boost the expression of specific brain receptors associated with mood regulation. This suggests that melatonin may hold therapeutic potential for addressing anxiety issues triggered by environmental factors experienced during prenatal development.
Read More
4
Melatonin's limited effectiveness on anxiety
Acceptability of midazolam and melatonin as premedications for anxious children undergoing general anaesthesia: a qualitative interview study with children, caregivers and health professionals participating in the MAGIC trial.
Comparative premedication acceptability
We focused on evaluating how melatonin may help alleviate anxiety in children about to undergo general anaesthesia. In our exploration, we included insights from children, their caregivers, and health professionals involved in the Melatonin for Anxiety prior to General Anaesthesia In Children (MAGIC) trial. Through semi-structured interviews, we gathered thoughts from 37 participants about their experiences and perspectives regarding melatonin compared to the standard premedication, midazolam.
Our findings revealed a nuanced picture. While melatonin showed promise as a potential alternative to midazolam, it was reported to be less effective in reducing pre-operative anxiety. However, there is a clear demand for a premedication with fewer side effects than midazolam, which is often considered due to its established compliance despite its drawbacks. It's important to note that acceptance of melatonin varies among different groups involved, with many remaining open to alternatives.
Overall, this study emphasizes the importance of factoring in both effectiveness and side effects when choosing premedications for anxious children.
Our findings revealed a nuanced picture. While melatonin showed promise as a potential alternative to midazolam, it was reported to be less effective in reducing pre-operative anxiety. However, there is a clear demand for a premedication with fewer side effects than midazolam, which is often considered due to its established compliance despite its drawbacks. It's important to note that acceptance of melatonin varies among different groups involved, with many remaining open to alternatives.
Overall, this study emphasizes the importance of factoring in both effectiveness and side effects when choosing premedications for anxious children.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 15 Reviews
8.4
9.5
Peaceful sleep
I enjoyed taking it an hour before bed. It helped me sleep peacefully and comfortably. Occasionally, I took two pills without experiencing anxiety or addiction.
9.5
Insomnia relief
My husband and I faced sleep issues, and this medicine has been a godsend for alleviating insomnia and anxiety. It truly makes a difference.
8.8
Calming effects
It is very calming to drink. It has allowed me to spend my days with peace of mind, particularly during nights when I needed sleep. Previously, I relied on sleeping pills due to anxiety, but this has provided a natural way to sleep without causing headaches.
8.8
Comfortable sleep
I have tried it three times and it truly makes you feel comfortable, leading to a fast, natural sleep. Upon waking, I feel relaxed and less anxious.
8.8
Deep sleep
This product provides a deep sleep. I took it as needed for anxiety and important projects when I couldn't sleep. It has greatly helped both me and my dad.
