Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7
USERS' SCORE
Good
Based on 7 Reviews
8.3
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B-6 (as Pyridoxine Hydrochloride)
10 mg
590%
Calcium (from Calcium Carbonate)
63 mg
4%
Melatonin
3 mg
*
Top Medical Research Studies
9
Melatonin reduces pediatric anxiety, pain
We focused on the effects of oral melatonin on anxiety and pain in children during the stressful process of venipuncture. In a double-blind, randomized controlled trial, we found that administering 0.5 mg/kg of melatonin 30 minutes before the procedure significantly reduced both pain and anxiety levels compared to a placebo.
The results showed that only 18.8% of the kids receiving melatonin reported pain, while 78.2% in the placebo group did. Furthermore, anxiety affected 44.6% of the melatonin group compared to 94.1% of those in the control group.
While melatonin appeared to improve experiences during venipuncture, its impact on the success rate was not statistically significant.
The results showed that only 18.8% of the kids receiving melatonin reported pain, while 78.2% in the placebo group did. Furthermore, anxiety affected 44.6% of the melatonin group compared to 94.1% of those in the control group.
While melatonin appeared to improve experiences during venipuncture, its impact on the success rate was not statistically significant.
Read More
9
Melatonin reduces anxiety from glyphosate
Our research examined the effects of melatonin on anxiety and memory problems caused by exposure to glyphosate-based herbicides (GBH). We started with pregnant Wistar rats that were subjected to GBH during gestation and lactation. After weaning, the offspring were treated with melatonin to see if it could help mitigate the negative effects they experienced due to their early exposure.
We observed that exposure to GBH led to increased anxiety and depression-like behaviors in the rats. Additionally, it appeared to impair their memory function. In looking at oxidative stress markers in the brain regions associated with emotion and cognition, we found indications of increased stress—especially pronounced in the female offspring.
However, the inclusion of melatonin significantly reduced these anxiety levels and improved cognitive deficits. Interestingly, the benefits were notably greater in female rats compared to males, suggesting a potential sex-dependent response to melatonin treatment.
We observed that exposure to GBH led to increased anxiety and depression-like behaviors in the rats. Additionally, it appeared to impair their memory function. In looking at oxidative stress markers in the brain regions associated with emotion and cognition, we found indications of increased stress—especially pronounced in the female offspring.
However, the inclusion of melatonin significantly reduced these anxiety levels and improved cognitive deficits. Interestingly, the benefits were notably greater in female rats compared to males, suggesting a potential sex-dependent response to melatonin treatment.
Read More
4
We examined the effectiveness of melatonin compared to midazolam for premedication in children, particularly focusing on anxiety levels during the preoperative process. In our systematic review of ten randomized controlled trials involving 774 participants, we found that both medications were used to help children feel more relaxed before surgery. However, when it came to their impact on sedation and anxiety, the results showed no significant differences between melatonin and midazolam.
We assessed various outcomes, including sedation and levels of anxiety in the preoperative room as well as during induction. Despite our thorough examination of the data, we noted that neither melatonin nor midazolam stood out as being more effective than the other. This indicates that when it comes to controlling anxiety, both options may work similarly for children undergoing surgery. Importantly, our findings suggest that variations in how the medications were administered and evaluated contributed to challenges in data synthesis, signaling a need for standardized approaches in future studies.
We assessed various outcomes, including sedation and levels of anxiety in the preoperative room as well as during induction. Despite our thorough examination of the data, we noted that neither melatonin nor midazolam stood out as being more effective than the other. This indicates that when it comes to controlling anxiety, both options may work similarly for children undergoing surgery. Importantly, our findings suggest that variations in how the medications were administered and evaluated contributed to challenges in data synthesis, signaling a need for standardized approaches in future studies.
Read More
Most Useful Reviews
9
Deep, restful sleep
6 people found this helpful
This drug was my salvation. I always suffered from anxiety, which would keep me awake for 2-3 hours. I often woke up in the middle of the night with a racing heartbeat. Taking one pill before bed works wonders; after about 20-25 minutes, I fall asleep peacefully. The sleep is very deep and enjoyable, with calm and colourful dreams. For the first time, I sleep 7-8 hours without disturbance and wake up feeling rested and ready to start my day. My overall condition has improved without any lethargy or weakness.
Read More
7.5
Eased anxiety issues
2 people found this helpful
I feel the effect. I’ve struggled with very bad sleep, but since I started taking it just before bed, I haven’t had trouble falling asleep. It has been particularly helpful during times of increased anxiety and worry, allowing me to sleep immediately.
Read More
9
Improved sleep quality
1 people found this helpful
My boyfriend loves it! It is probably the most affordable melatonin I can find on the market. You won't believe how much they sell at my local store—60 capsules for 23 USD, it’s ridiculous! I purchased this for my boyfriend, who suffers from crippling anxiety and struggles to sleep at night. He frequently finds it hard to fall asleep, and even when he does, he experiences nightmares that disturb his sleep. With this melatonin from Natrol, he can fall asleep quickly and sleep the whole night through with no dreams or nightmares. One tablet works best for him, and as he only takes one daily, this bottle lasts him four months! The tablets are small, making them easy to swallow. He’s on his second bottle now, and I’ll definitely repurchase more.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7
- All Researches
9
Melatonin reduces anxiety from glyphosate
Our research examined the effects of melatonin on anxiety and memory problems caused by exposure to glyphosate-based herbicides (GBH). We started with pregnant Wistar rats that were subjected to GBH during gestation and lactation. After weaning, the offspring were treated with melatonin to see if it could help mitigate the negative effects they experienced due to their early exposure.
We observed that exposure to GBH led to increased anxiety and depression-like behaviors in the rats. Additionally, it appeared to impair their memory function. In looking at oxidative stress markers in the brain regions associated with emotion and cognition, we found indications of increased stress—especially pronounced in the female offspring.
However, the inclusion of melatonin significantly reduced these anxiety levels and improved cognitive deficits. Interestingly, the benefits were notably greater in female rats compared to males, suggesting a potential sex-dependent response to melatonin treatment.
We observed that exposure to GBH led to increased anxiety and depression-like behaviors in the rats. Additionally, it appeared to impair their memory function. In looking at oxidative stress markers in the brain regions associated with emotion and cognition, we found indications of increased stress—especially pronounced in the female offspring.
However, the inclusion of melatonin significantly reduced these anxiety levels and improved cognitive deficits. Interestingly, the benefits were notably greater in female rats compared to males, suggesting a potential sex-dependent response to melatonin treatment.
Read More
9
Melatonin reduces pediatric anxiety, pain
We focused on the effects of oral melatonin on anxiety and pain in children during the stressful process of venipuncture. In a double-blind, randomized controlled trial, we found that administering 0.5 mg/kg of melatonin 30 minutes before the procedure significantly reduced both pain and anxiety levels compared to a placebo.
The results showed that only 18.8% of the kids receiving melatonin reported pain, while 78.2% in the placebo group did. Furthermore, anxiety affected 44.6% of the melatonin group compared to 94.1% of those in the control group.
While melatonin appeared to improve experiences during venipuncture, its impact on the success rate was not statistically significant.
The results showed that only 18.8% of the kids receiving melatonin reported pain, while 78.2% in the placebo group did. Furthermore, anxiety affected 44.6% of the melatonin group compared to 94.1% of those in the control group.
While melatonin appeared to improve experiences during venipuncture, its impact on the success rate was not statistically significant.
Read More
8
We examined the potential of melatonin microneedles as a novel method for treating anxiety and regulating circadian rhythms. This study utilized silk fibroin to create microneedles that deliver melatonin transdermally, offering sustainable drug release for up to 11 hours.
During our research, we found that these microneedles maintain a stable blood drug concentration for eight hours post-application. This sustained delivery method was particularly beneficial for insomnia model rats, where we saw notable improvements in both sleep patterns and reductions in anxiety levels.
The findings indicate that melatonin microneedles effectively address disrupted circadian rhythms and alleviate anxiety symptoms. Our results suggest a promising avenue for improving treatment methods, especially for those struggling with sleep-related issues.
During our research, we found that these microneedles maintain a stable blood drug concentration for eight hours post-application. This sustained delivery method was particularly beneficial for insomnia model rats, where we saw notable improvements in both sleep patterns and reductions in anxiety levels.
The findings indicate that melatonin microneedles effectively address disrupted circadian rhythms and alleviate anxiety symptoms. Our results suggest a promising avenue for improving treatment methods, especially for those struggling with sleep-related issues.
Read More
8
Melatonin reduces anxiety post-surgery
In our study, we aimed to understand how melatonin might reduce anxiety and the risk of postoperative delirium in patients undergoing elective surgeries. We focused on 162 patients aged 40 to 80, evenly split into two groups—one receiving melatonin and the other receiving standard premedication with alprazolam and ranitidine.
We administered 3 mg of melatonin the night before the surgeries and monitored various outcomes related to anxiety and cognitive function. Remarkably, we found that the incidence of anxiety was significantly lower in those who took melatonin. Furthermore, patients reported better sleep quality, and cognitive function assessments indicated less cognitive dysfunction compared to the control group.
Our investigation highlighted the positive effects of melatonin, showing it not only lessens anxiety but also contributes to a smoother recovery post-surgery. This provides valuable insight for future practices in managing preoperative anxiety effectively.
We administered 3 mg of melatonin the night before the surgeries and monitored various outcomes related to anxiety and cognitive function. Remarkably, we found that the incidence of anxiety was significantly lower in those who took melatonin. Furthermore, patients reported better sleep quality, and cognitive function assessments indicated less cognitive dysfunction compared to the control group.
Our investigation highlighted the positive effects of melatonin, showing it not only lessens anxiety but also contributes to a smoother recovery post-surgery. This provides valuable insight for future practices in managing preoperative anxiety effectively.
Read More
7
Melatonin alleviates prenatal anxiety effects
We explored the impact of prenatal constant light exposure (CLE) and melatonin treatment on anxiety-related behaviors in male and female rat offspring. In our study, six groups of rats were examined, with some experiencing a standard light/dark cycle while others were subjected to CLE. We treated these groups with either a saline solution or melatonin.
Through various anxiety assessments like the open field test and elevated plus maze, we observed that exposure to CLE led to significant behavioral deficits. Specifically, the rats showed heightened anxiety levels, alongside increased plasma cortisol levels. Surprisingly, melatonin treatment repaired these behavioral issues in a way that was different between sexes.
Even though melatonin did not change overall levels of melatonin in the bloodstream or normalize cortisol levels, it did boost the expression of specific brain receptors associated with mood regulation. This suggests that melatonin may hold therapeutic potential for addressing anxiety issues triggered by environmental factors experienced during prenatal development.
Through various anxiety assessments like the open field test and elevated plus maze, we observed that exposure to CLE led to significant behavioral deficits. Specifically, the rats showed heightened anxiety levels, alongside increased plasma cortisol levels. Surprisingly, melatonin treatment repaired these behavioral issues in a way that was different between sexes.
Even though melatonin did not change overall levels of melatonin in the bloodstream or normalize cortisol levels, it did boost the expression of specific brain receptors associated with mood regulation. This suggests that melatonin may hold therapeutic potential for addressing anxiety issues triggered by environmental factors experienced during prenatal development.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Deep, restful sleep
6 people found this helpful
This drug was my salvation. I always suffered from anxiety, which would keep me awake for 2-3 hours. I often woke up in the middle of the night with a racing heartbeat. Taking one pill before bed works wonders; after about 20-25 minutes, I fall asleep peacefully. The sleep is very deep and enjoyable, with calm and colourful dreams. For the first time, I sleep 7-8 hours without disturbance and wake up feeling rested and ready to start my day. My overall condition has improved without any lethargy or weakness.
Read More
7.5
Eased anxiety issues
2 people found this helpful
I feel the effect. I’ve struggled with very bad sleep, but since I started taking it just before bed, I haven’t had trouble falling asleep. It has been particularly helpful during times of increased anxiety and worry, allowing me to sleep immediately.
Read More
9
Improved sleep quality
1 people found this helpful
My boyfriend loves it! It is probably the most affordable melatonin I can find on the market. You won't believe how much they sell at my local store—60 capsules for 23 USD, it’s ridiculous! I purchased this for my boyfriend, who suffers from crippling anxiety and struggles to sleep at night. He frequently finds it hard to fall asleep, and even when he does, he experiences nightmares that disturb his sleep. With this melatonin from Natrol, he can fall asleep quickly and sleep the whole night through with no dreams or nightmares. One tablet works best for him, and as he only takes one daily, this bottle lasts him four months! The tablets are small, making them easy to swallow. He’s on his second bottle now, and I’ll definitely repurchase more.
Read More
9
Calming sleep aid
A wonderful product made of natural ingredients that do not affect the body negatively. It helps me achieve a comfortable and peaceful sleep when I’m feeling anxious or tense.
Read More
7.5
Reduced anxiety benefit
Very good melatonin. It helps me fall asleep without anxiety, and my sleep quality has improved significantly. I wake up feeling rested.
Read More
Frequently Asked Questions
9
Deep, restful sleep
6 people found this helpful
This drug was my salvation. I always suffered from anxiety, which would keep me awake for 2-3 hours. I often woke up in the middle of the night with a racing heartbeat. Taking one pill before bed works wonders; after about 20-25 minutes, I fall asleep peacefully. The sleep is very deep and enjoyable, with calm and colourful dreams. For the first time, I sleep 7-8 hours without disturbance and wake up feeling rested and ready to start my day. My overall condition has improved without any lethargy or weakness.
7.5
Eased anxiety issues
2 people found this helpful
I feel the effect. I’ve struggled with very bad sleep, but since I started taking it just before bed, I haven’t had trouble falling asleep. It has been particularly helpful during times of increased anxiety and worry, allowing me to sleep immediately.
7.5
Reduced anxiety benefit
Very good melatonin. It helps me fall asleep without anxiety, and my sleep quality has improved significantly. I wake up feeling rested.
9
Improved sleep quality
1 people found this helpful
My boyfriend loves it! It is probably the most affordable melatonin I can find on the market. You won't believe how much they sell at my local store—60 capsules for 23 USD, it’s ridiculous! I purchased this for my boyfriend, who suffers from crippling anxiety and struggles to sleep at night. He frequently finds it hard to fall asleep, and even when he does, he experiences nightmares that disturb his sleep. With this melatonin from Natrol, he can fall asleep quickly and sleep the whole night through with no dreams or nightmares. One tablet works best for him, and as he only takes one daily, this bottle lasts him four months! The tablets are small, making them easy to swallow. He’s on his second bottle now, and I’ll definitely repurchase more.
9
Calming sleep aid
A wonderful product made of natural ingredients that do not affect the body negatively. It helps me achieve a comfortable and peaceful sleep when I’m feeling anxious or tense.
7.5
Enhanced sleep patterns
Due to anxiety, I struggled to sleep well. The dosage of this product seems perfect, leading to improved sleep patterns. I enjoy the lack of bad taste, making it pleasant to take.
8
Melatonin reduces anxiety post-surgery
In our study, we aimed to understand how melatonin might reduce anxiety and the risk of postoperative delirium in patients undergoing elective surgeries. We focused on 162 patients aged 40 to 80, evenly split into two groups—one receiving melatonin and the other receiving standard premedication with alprazolam and ranitidine.
We administered 3 mg of melatonin the night before the surgeries and monitored various outcomes related to anxiety and cognitive function. Remarkably, we found that the incidence of anxiety was significantly lower in those who took melatonin. Furthermore, patients reported better sleep quality, and cognitive function assessments indicated less cognitive dysfunction compared to the control group.
Our investigation highlighted the positive effects of melatonin, showing it not only lessens anxiety but also contributes to a smoother recovery post-surgery. This provides valuable insight for future practices in managing preoperative anxiety effectively.
We administered 3 mg of melatonin the night before the surgeries and monitored various outcomes related to anxiety and cognitive function. Remarkably, we found that the incidence of anxiety was significantly lower in those who took melatonin. Furthermore, patients reported better sleep quality, and cognitive function assessments indicated less cognitive dysfunction compared to the control group.
Our investigation highlighted the positive effects of melatonin, showing it not only lessens anxiety but also contributes to a smoother recovery post-surgery. This provides valuable insight for future practices in managing preoperative anxiety effectively.
9
Melatonin reduces pediatric anxiety, pain
We focused on the effects of oral melatonin on anxiety and pain in children during the stressful process of venipuncture. In a double-blind, randomized controlled trial, we found that administering 0.5 mg/kg of melatonin 30 minutes before the procedure significantly reduced both pain and anxiety levels compared to a placebo.
The results showed that only 18.8% of the kids receiving melatonin reported pain, while 78.2% in the placebo group did. Furthermore, anxiety affected 44.6% of the melatonin group compared to 94.1% of those in the control group.
While melatonin appeared to improve experiences during venipuncture, its impact on the success rate was not statistically significant.
The results showed that only 18.8% of the kids receiving melatonin reported pain, while 78.2% in the placebo group did. Furthermore, anxiety affected 44.6% of the melatonin group compared to 94.1% of those in the control group.
While melatonin appeared to improve experiences during venipuncture, its impact on the success rate was not statistically significant.
9
Melatonin reduces anxiety from glyphosate
Our research examined the effects of melatonin on anxiety and memory problems caused by exposure to glyphosate-based herbicides (GBH). We started with pregnant Wistar rats that were subjected to GBH during gestation and lactation. After weaning, the offspring were treated with melatonin to see if it could help mitigate the negative effects they experienced due to their early exposure.
We observed that exposure to GBH led to increased anxiety and depression-like behaviors in the rats. Additionally, it appeared to impair their memory function. In looking at oxidative stress markers in the brain regions associated with emotion and cognition, we found indications of increased stress—especially pronounced in the female offspring.
However, the inclusion of melatonin significantly reduced these anxiety levels and improved cognitive deficits. Interestingly, the benefits were notably greater in female rats compared to males, suggesting a potential sex-dependent response to melatonin treatment.
We observed that exposure to GBH led to increased anxiety and depression-like behaviors in the rats. Additionally, it appeared to impair their memory function. In looking at oxidative stress markers in the brain regions associated with emotion and cognition, we found indications of increased stress—especially pronounced in the female offspring.
However, the inclusion of melatonin significantly reduced these anxiety levels and improved cognitive deficits. Interestingly, the benefits were notably greater in female rats compared to males, suggesting a potential sex-dependent response to melatonin treatment.
4
We examined the effectiveness of melatonin compared to midazolam for premedication in children, particularly focusing on anxiety levels during the preoperative process. In our systematic review of ten randomized controlled trials involving 774 participants, we found that both medications were used to help children feel more relaxed before surgery. However, when it came to their impact on sedation and anxiety, the results showed no significant differences between melatonin and midazolam.
We assessed various outcomes, including sedation and levels of anxiety in the preoperative room as well as during induction. Despite our thorough examination of the data, we noted that neither melatonin nor midazolam stood out as being more effective than the other. This indicates that when it comes to controlling anxiety, both options may work similarly for children undergoing surgery. Importantly, our findings suggest that variations in how the medications were administered and evaluated contributed to challenges in data synthesis, signaling a need for standardized approaches in future studies.
We assessed various outcomes, including sedation and levels of anxiety in the preoperative room as well as during induction. Despite our thorough examination of the data, we noted that neither melatonin nor midazolam stood out as being more effective than the other. This indicates that when it comes to controlling anxiety, both options may work similarly for children undergoing surgery. Importantly, our findings suggest that variations in how the medications were administered and evaluated contributed to challenges in data synthesis, signaling a need for standardized approaches in future studies.
References
- Stoyanova T, Nocheva H, Nenchovska Z, Krushovlieva D, Ivanova P, et al. Prenatal Constant Light Exposure Induces Behavioral Deficits in Male and Female Rat Offspring: Effects of Prenatal Melatonin Treatment. Int J Mol Sci. 2025;26. 10.3390/ijms26031036
- Li X, Chen Y, Shao H, Yan Z, Wang Y, et al. Silk fibroin microneedles loaded with melatonin for circadian rhythm regulation. Int J Biol Macromol. 2025;301:140500. 10.1016/j.ijbiomac.2025.140500
- Kettle J, Bolt R, Deery C, Papaioannou D, Rodd H, et al. Acceptability of midazolam and melatonin as premedications for anxious children undergoing general anaesthesia: a qualitative interview study with children, caregivers and health professionals participating in the MAGIC trial. Trials. 2024;25:813. 10.1186/s13063-024-08611-x
- Ponde VC, Singh N, Gursale A, Patil A, Chia A, et al. Efficacy of melatonin vs. midazolam for oral premedication in children: a systematic review and meta-analysis. Minerva Pediatr (Torino). 2025;77:94. 10.23736/S2724-5276.24.07519-0
- El Hamzaoui A, Lamtai M, El Brouzi MY, Azirar S, Rezqaoui A, et al. Melatonin attenuates affective disorders and cognitive deficits induced by perinatal exposure to a glyphosate-based herbicide via antioxidant pathway in adult male and female rats. Int J Dev Neurosci. 2024;84:745. 10.1002/jdn.10374
- Thakur T, Saini V, Grover S, Samra T. Role of oral melatonin in prevention of postoperative delirium in patients undergoing elective surgery under general anesthesia: A Randomized controlled trial. Indian J Psychiatry. 2024;66:457. 10.4103/indianjpsychiatry.indianjpsychiatry_965_23
- Rahafard S, Akbari Jokar Z, Hosseini SA, Alaee E. The impact of oral melatonin on pain and anxiety reduction during venipuncture in pediatric patients: a double-blind randomized clinical trial. Ann Med Surg (Lond). 2024;86:5811. 10.1097/MS9.0000000000002163
