Natrol Omega-3

EPA's role in diabetic heart health

Based on 31 Researches

Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy.

Most Relevant Research

We explored the impact of eicosapentaenoic acid (EPA), a nutrient known for its heart benefits, on diabetic cardiomyopathy (DC), a condition leading to heart failure. Our study focused on diabetic mice and revealed that EPA plays a protective role against DC, particularly by reducing harmful M1-polarized macrophages in the heart.

In our experiments, we found that EPA not only reduces cardiomyocyte injury caused by M1-polarized macrophages but also encourages a shift in macrophages' behavior from M1 to a protective Mox state—not M2. This shift is crucial because Mox macrophages help mitigate the damage inflicted by their M1 counterparts.

We identified heme oxygenase 1 (HO-1) as a key player in maintaining the Mox phenotype. EPA promotes HO-1, which helps curb macrophage M1 polarization and the resulting cardiomyocyte injury. Interestingly, our findings also showed that EPA fosters this protective Mox polarization in monocyte-derived macrophages from diabetic patients, suggesting a broader application for this treatment strategy.

Overall, our study highlights the potential of EPA as a novel approach to combat diabetic cardiomyopathy, emphasizing the importance of macrophage Mox polarization in maintaining heart health in diabetes.

9.5

Cardiovascular remedy

Most Useful Review

This "Mega" omega fish oil is superb! It helps reduce cholesterol concentrations, acts as a preventive measure against cardiovascular disease, and has shown potential in cancer prevention. Omega 3 aids in skin conditions, allergies, and arthritis, often providing relief in just days. It's crucial for brain function and normal embryo development. I take 3-4 capsules daily with meals.

Chronic Fatigue Syndrome details

Eicosapentaenoic acid benefits CFS

Based on 7 Researches

Eicosapentaenoic acid-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes.

Most Relevant Research

We explored the potential benefits of eicosapentaenoic acid (EPA), an essential fatty acid, in treating chronic fatigue syndrome (CFS). A female patient with a six-year history of persistent CFS symptoms participated in the study, receiving a daily supplement rich in EPA.

After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.

This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.

9.5

Eliminated fatigue

Most Useful Review

Works! My skin was excessively dry, and I was often fatigued and suffering from cold sores. Since taking these capsules alongside vitamin D, my issues have been resolved, and my hair appears healthier. It truly works, and I wholeheartedly recommend it for addressing chronic fatigue syndrome!

Headache details

Eicosapentaenoic acid reduces migraines

Based on 20 Researches

A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine.

Most Relevant Research

We conducted a 12-week study to explore how eicosapentaenoic acid (EPA) affects individuals suffering from episodic migraines. In our trial, 70 participants were randomly split into two groups—one received 2 grams of fish oil with 1.8 grams of pure EPA daily, while the other group got a placebo made of soybean oil.

The results were quite promising. Those taking EPA reported a significant reduction in the number of migraine days per month, averaging about 4.4 fewer days compared to just 0.6 fewer days in the placebo group. We also noticed a decline in the usage of medication to treat headache symptoms among those taking EPA.

Additionally, participants experienced less severe headaches and improved psychological wellbeing, as indicated by better scores in anxiety, depression, and overall quality of life measures. Notably, women seemed to benefit even more from EPA.

Overall, it appears that high-dose EPA can be an effective preventive treatment for episodic migraines, helping to ease frequency, severity, and even the emotional toll associated with chronic headaches. Importantly, the treatment was well tolerated, with no significant adverse effects reported.

9.5

Headache relief

Most Useful Review

I've been taking Omega for four months, and it has greatly improved my blood vessel health and eliminated my headaches. This Omega has a pleasant lemon flavour, and I find the quantity sufficient for my needs. I was sceptical about dietary supplements, but I no longer need medication for pressure issues, and I'm genuinely pleased with the results.

Hypertension details

Eicosapentaenoic acid benefits hypertension

Based on 27 Researches

5,6-diHETE lactone (EPA-L) mediates hypertensive microvascular dilation by activating the endothelial GPR-PLC-IP signaling pathway.

Most Relevant Research

We investigated the impact of eicosapentaenoic acid (EPA) on hypertension, a condition characterized by elevated blood pressure that can lead to serious health issues. The study focused on a special compound called 5,6-diHETE lactone (EPA-L), derived from EPA, which we observed to promote better blood vessel function. This compound was tested on hypertensive rats and showed a significant reduction in blood pressure.

Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.

Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.

9.5

Effective against hypertension

Most Useful Review

Omega-3 Fish Oil works brilliantly! I prescribe it to my patients with cardiovascular issues, including hypertension and arrhythmias. It's important to remember that individuals may have a specific intolerance to the components of the medication.

Leg Cramps details

Heart health improved

Most Useful Review

I occasionally experienced leg cramps in my twenties. After taking Omega 3 for years, I appreciate the lemon flavour, and it has effectively alleviated these cramps. It’s true that Omega 3 benefits the heart; stopping for just three days makes me aware of it. It works well for me.

Migraine details

Eicosapentaenoic acid helps migraines

Based on 23 Researches

A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine.

Most Relevant Research

We conducted a thorough investigation into how eicosapentaenoic acid (EPA) can impact episodic migraines. In a carefully designed study, we gathered 70 participants who experienced these migraines and divided them into two groups. One group received a high dose of EPA, while the other was given a placebo. This approach ensured that we could see the true effects of EPA without bias.

After 12 weeks, the results were compelling. We noticed that those taking EPA had significantly fewer migraine days compared to the placebo group. In fact, participants on EPA reported an average reduction of 4.4 days per month, while those on the placebo had barely any change. The EPA group also experienced less need for acute headache medication and marked improvements in headache severity, disability, anxiety, depression, and overall quality of life.

Perhaps most striking was how particularly beneficial EPA seemed to be for female participants. Overall, the study demonstrated that high-dose EPA not only helped reduce the frequency and severity of migraines but also positively influenced the psychological aspects of living with migraines.

This suggests that incorporating EPA into migraine management could be a valuable option for those suffering from episodic migraines, especially as there were no major adverse effects reported.

9.5

Migraine relief

Most Useful Review

Taking these capsules regularly has normalised my sleep and significantly improved my migraines. When I feel symptoms starting, I take my pills, add extra magnesium, and my migraine typically subsides within hours, compared to previously being incapacitated for half a day. My PMS and menstruation have also become much more manageable with regular magnesium intake, and my chronic nasopharynx pain has lessened. I've also been taking omega-3 and other supplements, which may contribute. I've experienced no side effects; the quality is excellent and natural.

Nausea details

Dysmenorrhea influences pregnancy nausea

Association of the Verbal Rating Scale-Measured Dysmenorrhea with Nausea and Vomiting in Pregnancy: A Retrospective Cohort Study.

Most Relevant Research

We conducted a retrospective cohort study to investigate the relationship between nausea and vomiting in pregnancy (NVP) and dysmenorrhea measured by a verbal rating scale. Our research included 443 pregnant women, divided into those experiencing NVP and a control group.

From our findings, we noticed a clear association between moderate to severe dysmenorrhea and a heightened risk of NVP, especially during the first trimester. This suggests that those with painful menstrual symptoms may face an increased likelihood of nausea and vomiting as part of their pregnancy experience.

Importantly, we also examined the impact of periconceptional supplementation with docosahexaenoic acid (DHA). Our results indicated that taking DHA could potentially lower the risk of NVP, offering a glimmer of hope for managing nausea during pregnancy. This suggests that combining DHA with standard prenatal care might be beneficial for those who struggle with these symptoms.

Overall, our study sheds light on the intricate connections between menstrual pain and pregnancy-related nausea, emphasizing the potential protective role of DHA in improving women's health during this time.

9.5

No nausea noted

Most Useful Review

Good budget omega. Natrol has produced quality supplements for 35 years. Their omega-3s are from fish muscles, molecularly distilled to remove impurities. The capsules have a light lemon aroma. Although not the smallest, they are easy to swallow. I take them morning and evening. I experienced no side effects, including nausea. Omega-3 helped normalise my cholesterol a few years ago. I take it in courses and have noticed benefits for my skin as well, particularly on my elbows and hands.

Osteoporosis details

DHA's role in osteoporosis treatment

Comparative study of DHA-enriched phosphatidylcholine and EPA-enriched phosphatidylcholine on ameliorating high bone turnover regulation of the osteogenesis-related Wnt/β-catenin pathway in ovariectomized mice.

Most Relevant Research

We recently looked into how docosahexaenoic acid (DHA), through its enriched phosphatidylcholine form (DHA-PC), affects osteoporosis. Using a model that simulates the condition in women after ovariectomy, we compared the impact of DHA-PC with eicosapentaenoic acid (EPA) enriched phosphatidylcholine (EPA-PC). Our findings revealed that both DHA-PC and EPA-PC significantly improved the structural quality of trabecular bone, boosted the rate of new bone formation, and elevated bone mineral density, which are crucial factors in combating osteoporosis.

We also discovered that both compounds worked to regulate bone formation by down-regulating the overactive Wnt/β-catenin signaling pathway, which is key to osteogenesis. This means that rather than allowing excessive bone growth, DHA-PC and EPA-PC help bring osteogenesis back to normal levels. Thus, our results suggest that incorporating DHA and EPA phosphatidylcholine could potentially serve as a beneficial strategy in osteoporosis management, highlighting their promising role in health and nutrition.

Overall, this study offers valuable insights into the anti-osteoporotic effects of DHA-PC and EPA-PC and supports their further exploration as functional foods in our diets.

8.8

Supports joint health

Most Useful Review

Omega-3s support joint health and help prevent osteoporosis. They reduce inflammation and fight bone loss, alleviating joint pain, and mitigate symptoms of rheumatoid arthritis while slowing cartilage degradation in arthrosis. The fish oil is of high quality with no side effects like heartburn. I take it regularly and find it excellent value for money.

Anxiety details

DHA improves milk and reduces anxiety

Based on 24 Researches

DHA Supplementation of Obese Rats throughout Pregnancy and Lactation Modifies Milk Composition and Anxiety Behavior of Offspring.

Most Relevant Research

We explored how supplementing obese mothers with docosahexaenoic acid (DHA) affects milk composition and the anxiety behavior of their offspring. In a study involving female Wistar rats, some were placed on a high-fat diet while others ate regular chow. We supplemented half of the mothers from one month before mating until they weaned their pups with DHA. The goal was to see if this supplementation could improve the quality of their milk and influence the anxiety levels of their babies.

Our findings indicated that the obese mother rats exhibited higher weight and fat levels and their milk contained less beneficial DHA but more corticosterone and leptin. Notably, their offspring showed a higher ratio of omega-6 to omega-3 fatty acids in the milk they consumed, which correlates to increased anxiety levels, especially in female pups. In contrast, those mothers who received DHA supplements had lower body weight and fat and produced milk with higher DHA content. Their offspring not only had a better balance of omega-6 to omega-3 fatty acids but also demonstrated reduced anxiety compared to those from mothers without supplementation.

Overall, this study highlights the significant positive impact of DHA supplementation during pregnancy and lactation in obese rats, as it not only improves the nutritional quality of their milk but also helps decrease anxiety levels in the offspring in a sex-dependent manner.

8.8

Reduces anxiety effectively

Most Useful Review

Excellent Omega. This is one of my favourites. Omega-3 supplementation has helped me with my anxiety and overall well-being. I find it easier to obtain essential fatty acids through supplements rather than consuming fatty fish regularly. I take 1-2 capsules daily with breakfast, and I believe Omega-3 is essential for my health. It supports blood vessel health and overall cardiovascular system functionality, making it good value for money.

Asthma details

Eicosapentaenoic acid improves asthma

Based on 29 Researches

Effects of low-dust forages on dust exposure, airway cytology, and plasma omega-3 concentrations in Thoroughbred racehorses: A randomized clinical trial.

Most Relevant Research

We compared how different types of forage affected asthma in Thoroughbred racehorses. Our focus was on assessing dust exposure, airway health, and the presence of eicosapentaenoic acid (EPA), an omega-3 fatty acid known for its anti-inflammatory properties. The horses were randomly assigned to three diets: dry hay, steamed hay, or haylage for a period of six weeks.

Throughout the study, we observed that horses fed steamed hay and haylage had significantly lower dust exposure compared to those that consumed dry hay. Interestingly, those on the haylage diet not only showed reduced levels of neutrophils in their bronchoalveolar lavage fluid, indicating better airway health, but they also had an increase in the ratio of anti-inflammatory to pro-inflammatory lipids, particularly EPA.

In fact, the horses on haylage had higher ratios of eicosapentaenoic acid compared to both their baseline measurements and horses on the other diets. This suggests that incorporating haylage could be beneficial for managing asthma symptoms in racehorses. Overall, it appears that haylage may help improve respiratory health by reducing inflammation linked to asthma through its higher anti-inflammatory lipid profile.

9.5

Asthma risk reduction

Most Useful Review

This supplement is remarkable. It can help reduce the risk of asthma in children when mothers take fish oil. It also offers numerous other benefits, including improved metabolic rate and support for various health issues, such as rheumatoid arthritis and depression.

Blurred Vision details

Boosts memory function

Most Useful Review

The best omega with lemon flavour! It is excellent for vision, brain function, and nervous system support. I highly recommend it!

Cancer details

Impact of Omega-3 on Cancer

Novel inhibitory effect of Omega-3 fatty acids regulating pancreatic cancer progression.

Most Relevant Research

We explored the effects of eicosapentaenoic acid, a type of omega-3 fatty acid, on pancreatic cancer using a specially designed mouse model that closely mimics human disease. This model allowed us to examine how adding omega-3 to the diet could impact cancer progression.

Our findings revealed that a diet enriched with eicosapentaenoic acid led to a significant reduction in tumor size and metastasis to the lungs and liver. We also observed a trend toward improved survival rates in the mice that received this dietary intervention compared to those that did not.

Interestingly, the treatment not only changed the fatty acid profile in the tumors but also influenced certain cellular processes. We noted an increase in apoptosis, or programmed cell death, without affecting how fast the cancer cells were growing. Additionally, there was a marked decrease in tumor fibrosis associated with lower levels of Sonic Hedgehog, a key player in pancreatic cancer development.

Overall, our research suggests that eicosapentaenoic acid holds promise as a dietary intervention for cancer treatment, potentially opening new doors for incorporating nutritional strategies in managing pancreatic cancer.

8.8

Cancer prevention benefits

Most Useful Review

"Mega" omega is wonderful fish oil of excellent quality! It contains a natural fish oil concentrate rich in polyunsaturated fatty acids, which dramatically lower cholesterol levels, supporting cardiovascular health. Omega 3 is noted for slowing tumour development and is effective in preventing cancer. It aids in skin disease treatment and improves healing. This supplement also normalises digestion and fat metabolism, alleviates arthritis pain, and is essential for brain activity. Recommended dosage is 3-4 capsules daily with meals.

Chest Pain details

Eicosapentaenoic acid showed mixed results

Based on 8 Researches

Improvement of coronary vasomotion with eicosapentaenoic acid does not inhibit acetylcholine-induced coronary vasospasm in patients with variant angina.

Most Relevant Research

We examined how eicosapentaenoic acid (EPA), a key ingredient found in fish oil, impacts chest pain in patients with variant angina. Our study followed 22 individuals with this condition, where we infused acetylcholine, a substance known to cause coronary vasospasm, both before and after a four-month course of EPA treatment (1.8 g/day for 12 patients).

In the group that did not receive EPA, we observed no changes in how their coronary arteries responded to acetylcholine over time. However, for those treated with EPA, the results were quite intriguing. In non-spastic areas, the response shifted from vasoconstriction (narrowing) to vasodilation (widening). This indicates a notable improvement in how these arteries are functioning.

Yet, when it came to spastic sites where vasospasm had occurred, the coronary arteries remained responsive to acetylcholine, and the vasospasm persisted despite the EPA treatment. Thus, while EPA enhanced coronary responsiveness in some areas, it did not eliminate the acetylcholine-induced coronary vasospasms associated with variant angina.

9.5

No chest pain

Most Useful Review

I take 2 capsules each morning with breakfast. After 3 weeks, I've noticed improved endurance during cardio workouts, and for the first time, I have no knee pain, which used to trouble me during lunges and squats. I experienced some mouth and stomach discomfort previously, but now, everything is excellent!

Common Cold details

DHA reduces infant cold symptoms

Prenatal docosahexaenoic acid supplementation and infant morbidity: randomized controlled trial.

Most Relevant Research

We conducted a double-blind randomized controlled trial to understand how prenatal supplementation of docosahexaenoic acid (DHA) might influence infant health, particularly concerning the common cold. Pregnant women were given either a daily dose of 400 mg of DHA or a placebo starting at 18 to 22 weeks of gestation until childbirth.

Caregivers then reported on their infants’ health at 1, 3, and 6 months, sharing details about common illness symptoms. We found that DHA supplementation appeared to reduce the number of colds at one month and also seemed to lessen the duration of various cold symptoms in infants. Specifically, infants in the DHA group experienced fewer cold symptoms and had shorter durations of cough and wheezing.

While the overall occurrence of specific illness symptoms was similar between the DHA and placebo groups, DHA did bring about noteworthy benefits. At 1 month, infants in the DHA group had a 26% shorter duration of cough and 30% shorter wheezing; however, they experienced a longer duration of rash.

Furthermore, by the time the infants reached 3 months, those whose mothers took DHA were ill for 14% less time overall. At 6 months, the DHA group showed significantly reduced durations of several illness indicators, although they did experience longer episodes of vomiting.

This study suggests that prenatal DHA not only seems to impact the occurrence of colds in children but may also play a role in the duration of symptoms over the first half-year of life.

9.5

Effective for colds

Most Useful Review

Works! My skin was extremely dry, and I suffered from frequent cold sores. However, alongside vitamin D, these capsules have alleviated my issues. My hair also appears healthier now! They work effectively, and I recommend them for health improvements!

Depression details

Eicosapentaenoic acid may reduce depression

Based on 31 Researches

The Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.

Most Relevant Research

We conducted a study to explore the effectiveness of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, in treating major depressive disorder (MDD). Over the course of 12 weeks, 60 participants suffering from MDD were divided into two groups: one received 3.2 grams of EPA daily, while the other group was given a placebo, which was soybean oil.

Throughout the study, we assessed the severity of depression using the Hamilton Rating Scale for Depression (HRSD). What we found was promising. The group taking EPA experienced significantly lower HRSD scores at various checkpoints—specifically at weeks 4, 6, 8, and 12—indicating a reduction in depressive symptoms. Although the rates of remission and response were higher in the EPA group compared to the placebo group, these findings did not achieve statistical significance.

Overall, while EPA shows potential as a treatment for depression, further research is needed to solidify its role. Our findings suggest that it may be an alternative option for MDD patients seeking additional treatment pathways.

9.5

Depression relief

Most Useful Review

This brand of fish oil has helped lift my permanent depression. There's no unpleasant fish taste or odour, and it works well compared to other Omega-3 brands I've tried.

Frozen Shoulder details

Changed my life. This product is among the best I’ve taken. It aided my digestion and joint issues. I had torn labrums in both shoulders, and it helped me recover to around 90%. I also suffered from severe acid reflux, but I can now enjoy coffee without any problems. Great stuff!

High Cholesterol details

Eicosapentaenoic acid benefits cholesterol

Based on 29 Researches

Omega-3 eicosapentaenoic polar-lipid rich extract from microalgae decreases plasma triglycerides and cholesterol in a real-world normolipidemic supplement consumer population.

Most Relevant Research

We explored the effects of eicosapentaenoic acid (EPA), a specific type of omega-3 fatty acid, on cholesterol levels in a recent study involving real-world supplement consumers. Participants took AlmegaPL capsules, which contain high amounts of EPA and are free of the other omega-3 fatty acid, DHA. This setup allowed us to gain insights from those who are already incorporating EPA into their diets.

Throughout the study, we monitored key health markers such as triglycerides, total cholesterol, and various types of cholesterol at different stages of supplementation. We observed that after six months of taking this supplement, participants showed a significant reduction in remnant cholesterol and maintained healthy triglyceride levels. Notably, this decrease in cholesterol did not come at the expense of raising low-density lipoprotein (LDL) levels, which is often a concern with other treatments.

These encouraging results reveal that EPA can be a beneficial addition for individuals looking to manage their cholesterol levels effectively. Importantly, our findings highlight AlmegaPL's unique position as a natural, over-the-counter option for those seeking to improve their lipid profiles.

8.8

Good prevention

Most Useful Review

This Omega-3 fish oil is excellent for health. It provides adequate doses of essential fatty acids and adheres to GMP standards. While it lacks the highest concentration of Omega-3s, it's cost-effective. I use it for skin and hair beauty, and my parents take it to maintain heart health. I recommend it, just follow the instructions of taking two capsules daily with meals.

Hypothyroidism details

Omega-3 aids hypothyroid cognition

Based on 14 Researches

The effect of omega-3 on cognition in hypothyroid adult male rats.

Most Relevant Research

We set out to investigate how hypothyroidism affects cognitive function and whether omega-3 could provide a helpful boost in adult male rats. The study involved thirty rats, split into three groups: one as a control, another experiencing hypothyroidism, and the last group receiving omega-3 treatment.

The findings were quite striking. Rats with induced hypothyroidism showed significant memory problems, including difficulties in spatial learning and retention in various tests. These deficits were accompanied by lower levels of important brain chemicals and noticeable structural damage in the hippocampus, a key area for memory.

However, when we provided omega-3 supplements to one group, there was a remarkable turnaround. Those rats not only saw improvements in their memory but also regained some brain health. Omega-3 helped boost antioxidant levels, lessen structural issues in the brain, and reduce the expression of a protein linked to these damages.

All in all, our research suggests that omega-3 may serve as a protective ally against the cognitive challenges posed by hypothyroidism. This offers an exciting avenue for potential treatments that could benefit not just rats but perhaps humans facing similar hormonal challenges.

9.5

Miraculous skin improvement

Most Useful Review

My first omega-3, recommended by my endocrinologist, needed for my hypothyroidism. Initially, my skin was extremely dry and sensitive, but after taking Omega for about a month, I noticed a significant improvement. My skin now remains better hydrated even after washing. I take two capsules daily after meals. I previously tried Finnish and Norwegian omega, but I prefer this one, despite the large capsule size. Highly recommend it!

Menopause details

DHA alleviates menopausal symptoms

Based on 27 Researches

Neurovegetative disorders of perimenopausal women treated with docosahexaenoic acid (DHA, 625 mg).

Most Relevant Research

We explored how docosahexaenoic acid (DHA), at a dosage of 625 mg, affects menopausal symptoms among perimenopausal women. Our study involved 42 participants who were assessed for various symptoms using the Kupperman Index, along with quality of life and sexual function measured through standardized scales.

After six months of DHA treatment, the women reported significant improvements in menopause symptoms, as reflected in their Kupperman Index scores. Specifically, psychological aspects of quality of life showed remarkable enhancement, while physical aspects did not exhibit notable changes.

Additionally, we observed improvements in sexual function, with increases in the Female Sexual Function Index scores and decreases in the Female Sexual Distress Scale, particularly in areas related to arousal and lubrication. Interestingly, the auditory brainstem response also indicated lower wave latencies after treatment, suggesting potential positive effects on neuronal conduction in the auditory system.

Overall, our findings suggest that DHA can effectively help mitigate some perimenopausal symptoms, thereby improving women's quality of life and aspects of sexual health.

8.8

Menopause relief

Most Useful Review

The condition of my skin and hair has improved. Omega-3 PUFAs, which the body cannot synthesise, are essential for various functions. They are particularly important for women during menopause, helping alleviate its symptoms, and reducing menstrual pain. I've noticed a positive effect on my digestive tract as well. After two to three weeks of taking two capsules daily, I experienced noticeable improvements. I will continue this as a preventive measure for my health and well-being.

Psoriasis details

EPA benefits psoriatic skin health

Eicosapentaenoic Acid Influences the Lipid Profile of an In Vitro Psoriatic Skin Model Produced with T Cells.

Most Relevant Research

We aimed to understand how eicosapentaenoic acid (EPA) affects psoriasis, a skin condition known for causing redness, irritation, and thickened skin. By creating skin models that reflect both healthy and psoriatic conditions, we were able to assess the impact of EPA directly on lipid profiles—a key factor in skin health.

Our research revealed that in psoriatic skin models, there was a notable increase in certain fatty acids linked to inflammation, such as arachidonic acid (AA) and linoleic acid (LA). However, when we supplemented the media with EPA, we noticed a significant shift. The levels of beneficial omega-3 fatty acids, including EPA, docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA), rose in both epidermal and dermal tissues.

More importantly, the addition of EPA helped to balance the production of lipid mediators in the skin. We observed increases in several anti-inflammatory molecules, such as prostaglandin E (PGE) and 12-hydroxyeicosapentaenoic acid (12-HEPE), indicating a move toward a more stable and healthier skin environment. These results suggest that EPA could play an important role in managing psoriasis by promoting a healthier lipid balance in the skin, potentially easing symptoms and encouraging skin healing.

9.5

Nutritional support

Most Useful Review

Omega-3 polyunsaturated fatty acids (PUFAs) are increasingly recognised for psoriasis. They not only aid in medication but also provide essential nutritional support. DHA and EPA in Omega-3 help stabilise immune functions, leading to reduced inflammation and fewer relapses in psoriasis.

Swollen Lymph Nodes details

Miraculous skin improvement

Most Useful Review

I started taking Omega-3 on the recommendation of my endocrinologist due to my AIT and hypothyroidism. My skin, particularly on my face, elbows, and knees, was extremely dry and sensitive, often feeling tight and swollen. I tried various creams, but they caused allergic reactions. However, about a month after I began taking Omega-3, I noticed a significant improvement; my skin only dried out after washing, and now I can skip cream for two days without discomfort. This has been a miracle for me! Initially, I took one capsule twice a day, but when I switched to Finnish Omega, the results worsened. I plan to reorder this Omega as the large capsules are worth it. I highly recommend it!

Yeast Infection details

Eicosapentaenoic acid combats yeast biofilms

Moderately Effective

Based on 2 Researches

Eicosapentaenoic acid as an antibiofilm agent disrupts mature biofilms of .

Most Relevant Research

We set out to explore how eicosapentaenoic acid (EPA), a type of healthy fat, can disrupt the mature biofilms formed by a significant human fungal pathogen. These biofilms are important since they enhance the pathogen's ability to cause infections. Our investigation focused on the effects of a 1 mM EPA treatment on these established biofilms.

Through various assays, we observed that EPA significantly reduced the viability of these preformed biofilms. The use of advanced microscopy techniques allowed us to see that EPA could block the transformation from yeast to a more invasive form and damaged the biofilm's structure.

We also found that EPA prompted changes at the genetic level. Specifically, it downregulated genes linked to the development of hyphae and biofilms. Additionally, EPA affected two key signaling pathways involved in biofilm formation. Notably, it reduced the production of a crucial messenger in one of these pathways.

Lastly, we noted that treatment with EPA downregulated genes related to ergosterol biosynthesis, suggesting it may lower the chances of developing resistance to existing antifungal treatments. Our findings emphasize the potential of EPA as a promising alternative or complementary option in treating yeast infections.

9.5

Promotes hair growth

Most Useful Review

Hair grows quite remarkably, almost like a yeast infection. I suggest giving it a try.

Anemia details

DHA enhances sickle cell outcomes

Based on 26 Researches

SC411 treatment can enhance survival in a mouse model of sickle cell disease.

Most Relevant Research

We explored the potential of docosahexaenoic acid (DHA) as a treatment for anemia in sickle cell disease (SCD). In this study, we utilized a special mouse model that mimics SCD, testing how SC411—a purified form of DHA—affects this condition.

After eight weeks of treatment, we observed that DHA levels, along with eicosapentaenoic acid (EPA), significantly increased in the blood of the SCD mice. Alongside these positive changes, we found that SC411 also reduced levels of arachidonic acid, minimizing the sickling of red blood cells, which is a major issue in SCD.

Notably, mice that received SC411 showcased improvements in blood flow to the brain, a decrease in neuroinflammation, and even an enhancement in working memory. These findings ultimately led to improved survival rates among the treated mice, suggesting that DHA can offer a promising therapeutic avenue for individuals suffering from SCD and its related anemia.

8.8

Helps with fatigue

Most Useful Review

This product is amazing and very helpful. I no longer feel fatigued, and it’s excellent for anaemia as it contains fish oil.

Bone Pain details

I take 2 capsules each morning with breakfast, and I've noticed greater endurance during cardio workouts. My knees, which formerly experienced bone pain during lunges and squats, feel perfectly fine now. There are no lingering issues whatsoever. I haven’t encountered any mouth or stomach discomfort, so I rate this as EXCELLENT!

Eczema details

Eicosapentaenoic Acid reduces eczema

Based on 11 Researches

Evaluating the Effect of Eicosapentaenoic Acid in Children With Atopic Dermatitis: A Randomized Triple-Blind Clinical Trial.

Most Relevant Research

We embarked on a study to find out how dietary eicosapentaenoic acid (EPA) could help children suffering from atopic dermatitis, a common form of eczema. In a randomized triple-blind clinical trial, 48 children with this condition were divided into two groups—one received 250 mg of EPA twice daily, while the other received a placebo for four weeks.

Our observations showed noticeable improvements in those who took EPA. After just two weeks, participants in the EPA group reported a reduction in their SCORAD scores, which are used to measure the severity of atopic dermatitis. The scores went down significantly compared to the placebo group. After four weeks, the number of children needing corticosteroids to manage their symptoms was also lower in the EPA group.

Despite these positive results, both groups reported few adverse effects, indicating that EPA supplementation is generally well-received. Overall, we conclude that adding EPA to the diet may be an effective and safe strategy for reducing eczema severity in children.

8.8

Improved eczema condition

Most Useful Review

I recommend this product! The capsules are large, as most omega-3s are. My husband took them alongside vitamin D, which significantly improved his dry eczema.

Insomnia details

Eicosapentaenoic acid shows limited benefits

Based on 2 Researches

Omega-3 fatty acids for a better mental state in working populations - Happy Nurse Project: A 52-week randomized controlled trial.

Most Relevant Research

We explored the effectiveness of eicosapentaenoic acid, a type of omega-3 fatty acid, on insomnia among junior hospital nurses in a well-structured trial. In this study, 80 nurses were randomly assigned to receive either 1200 mg of eicosapentaenoic acid along with 600 mg of docosahexaenoic acid daily or a placebo for 13 weeks.

Our main focus was to see how these supplements influenced insomnia and overall mental health. While we noted some improvements in various measures, including insomnia severity at the 13-week mark, the results didn't demonstrate a significant advantage when compared to the placebo group.

After analyzing data at multiple checkpoints—13, 26, and 52 weeks—we found that the effects of eicosapentaenoic acid on insomnia were not strong enough to conclude it as a beneficial treatment. Overall, while there were some positive indicators at certain times, the overall impact on insomnia was not substantial, leaving us to conclude that more research is needed to confirm any real benefits from omega-3 fatty acids for sleep disturbances.

9.5

Effective for insomnia

Most Useful Review

My husband suffers from insomnia, and the doctor recommended 1000 mg. It has helped him significantly, for which we are grateful.

Sleep Apnea details

DHA levels linked to OSA severity

Membrane level of omega-3 docosahexaenoic acid is associated with severity of obstructive sleep apnea.

Most Relevant Research

We investigated how the omega-3 fatty acid docosahexaenoic acid (DHA) impacts the severity of obstructive sleep apnea (OSA) in 350 patients undergoing sleep studies. Our study aimed to determine if there is a relationship between the levels of DHA in red blood cells (RBC) and the severity of sleep apnea, categorized as none/mild, moderate, or severe based on apnea hypopnea index (AHI) scores.

Our findings revealed that lower levels of DHA are linked to more severe cases of OSA. For each standard deviation increase in DHA, patients were about 50% less likely to be classified in the severe apnea category. Specifically, we noted decreased odds of falling into the severe OSA group when DHA levels were higher, suggesting that DHA may play an important role in the severity of this condition.

These insights imply that maintaining healthy DHA levels could potentially influence OSA severity and could aid in developing treatment strategies. We believe that future research should explore the potential benefits of DHA supplementation for those suffering from sleep apnea.

9.5

Supports sleep issues

Most Useful Review

Omega-3 fatty acids are essential for everyone. A deficiency can lead to skin issues, concentration loss, sleep disturbances, irritability, chronic fatigue, and worsened allergy reactions. This product has improved my heart function, as well as my skin and hair. They are easy to swallow. I take two capsules daily with food.

Alzheimer details

DHA shows promise in Alzheimer's

Nose-to-brain delivery of DHA-loaded nanoemulsions: A promising approach against Alzheimer's disease.

Most Relevant Research

We investigated the potential benefits of docosahexaenoic acid (DHA) in fighting Alzheimer's disease (AD) through a novel intranasal administration method. By using a specially formulated nanoemulsion that protects DHA from oxidation, we aimed to enhance its delivery to the brain. In our study, we administered this DHA-rich nanoemulsion to J20 mice, a well-known transgenic model for AD.

The results were promising. After treatment, the mice showed notable improvements in their well-being and memory performance, which we measured through their ability to navigate spatial tasks. Additionally, we observed a significant reduction in harmful amyloid deposits, oxidative stress, and neuroinflammation within their brain tissues. This positive outcome could potentially stem from DHA's ability to affect specific processes in the brain, such as the inactivation of GSK3β, a kinase associated with AD.

Overall, our findings suggest that intranasal DHA treatment not only has therapeutic effects but may also modify the progression of Alzheimer's disease. Considering that DHA has already demonstrated safety in humans, we believe there is a strong case for conducting clinical trials to explore this approach further for Alzheimer's patients.

9.5

Memory support

Most Useful Review

Omega-3 is crucial for preventing Alzheimer's and supporting heart health. I take 2 capsules daily and have also tried a higher dosage. This product is effective, with no fishy aftertaste and a pleasant lemon flavour.

Arteriosclerosis details

DHA stabilizes arterial plaques

Based on 28 Researches

Injectable liposomal docosahexaenoic acid alleviates atherosclerosis progression and enhances plaque stability.

Most Relevant Research

We embarked on a quest to understand how docosahexaenoic acid (DHA), a type of omega-3 fatty acid, can impact atherosclerosis, a condition where fatty deposits clog the arteries. Our focus was on a specially developed injectable formulation that delivers DHA directly to the site of arterial plaques.

Through our research, we discovered that this liposomal DHA formulation not only protects the compound but also enhances its effectiveness. When we administered it intravenously, DHA particles were specifically absorbed by macrophages—immune cells involved in the inflammation seen in atherosclerosis. This targeted delivery helps reduce inflammation and prevents the formation of foam cells, which are a hallmark of atherosclerotic plaques.

Furthermore, our analysis of the plaques revealed that the DHA treatment led to less macrophage infiltration and reduced lipid build-up, which improves overall plaque stability. In simpler terms, we observed that the treatment makes plaques less likely to rupture, which is critical in preventing serious cardiovascular problems. Additionally, sophisticated imaging techniques showed that DHA can help restore some of the healthy lipid profiles typical of earlier stages of plaque development.

In summary, using injectable DHA offers exciting potential for stabilizing arterial plaques and slowing down the progression of atherosclerosis. Given the importance of addressing this condition, our findings could pave the way for new therapeutic strategies to reduce the risk of heart-related issues.

8.8

Stable health checkup

Most Useful Review

For managing arteriosclerosis, it’s best to control it through diet, although taking omega can be challenging. I have my husband, who has high triglyceride levels, take it daily. The capsules are somewhat large, but one can adapt to them. I have been taking it for many years, and as my health check-up results are stable, I will continue with it.

Autoimmune Disorder details

Eicosapentaenoic acid benefits MS

Based on 31 Researches

The therapeutic effect of PEGlated nanoliposome of pistachio unsaturated oils and its efficacy to attenuate inflammation in multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial phase I.

Most Relevant Research

We conducted a randomized, double-blind, placebo-controlled clinical trial to explore the effects of PEGlated nanoliposome of pistachio unsaturated oils on inflammation in multiple sclerosis (MS). During the study, we treated MS patients with these nanoliposomes enriched with eicosapentaenoic acid, a type of omega-3 fatty acid known for its potential health benefits.

After the treatment, we observed significant improvements in various markers of inflammation. Notably, the levels of docosahexaenoic and eicosapentaenoic acids increased, while the level of matrix metallopeptidase-9, an enzyme linked to inflammation, decreased. This shift indicates a favorable response in how the patients’ bodies were managing inflammation.

Moreover, we noted a Th2-biased response in cytokine levels, which typically suggests a less inflammatory environment. The results showed a significant reduction in the frequency of relapses, lower disability scores, and fewer T2 lesions in patients treated with the nanoliposomes. Overall, our findings suggest that eicosapentaenoic acid treatment may offer promising benefits for managing inflammation associated with multiple sclerosis.

9.5

Supports overall health

Most Useful Review

I've consumed dietary supplements for 18 years and find Omega-3 beneficial for various health aspects, including memory and metabolism. Recommended by my therapist to lower cholesterol, I appreciate the quality here and take them with meals daily. This Omega-3 aids in maintaining good mood and skin, which is essential for treating my autoimmune disorder. It’s a family staple due to its effects and reasonable price.

Irritable Bowel Syndrome details

Fatty acids affect IBS metabolism

Based on 2 Researches

Bifidobacterium breve with α-linolenic acid and linoleic acid alters fatty acid metabolism in the maternal separation model of irritable bowel syndrome.

Most Relevant Research

Our study focused on understanding how eicosapentaenoic acid, alongside other fatty acids, influences irritable bowel syndrome (IBS). We designed an experiment where we treated both maternally separated and non-separated rats with Bifidobacterium breve and explored its effect on colonic sensitivity and fatty acid metabolism over a period of seven weeks.

Throughout our research, we observed significant changes in fatty acid profiles, especially in liver and serum tissues, after administering Bifidobacterium breve. Notably, in the maternally separated rats, the treatment appeared to enhance levels of palmitoleic acid, arachidonic acid, and docosahexaenoic acid in various tissues, which are fatty acids that others believe could be influential in managing symptoms related to IBS.

However, while eicosapentaenoic acid was present in the research context, it was largely studied in combination with other treatments. This made it challenging to evaluate its isolated effect on IBS directly. Thus, while we noted some positive metabolic changes with our treatment approach, the specific impact of eicosapentaenoic acid on IBS symptoms wasn’t definitively established.

Overall, our findings suggest that while Bifidobacterium breve and fatty acid supplementation may influence host fatty acid metabolism, further focused studies are necessary to clarify the role of eicosapentaenoic acid in managing irritable bowel syndrome.

8.8

Metabolism enhancement

Most Useful Review

This is an excellent quality product with well-selected ingredients. I experienced no allergies, and the large package will last a long time. I began to notice better bowel function and improved metabolism within a week. My nervous system started to perform better too, which made me feel less anxious. I have complete confidence in its effectiveness.

Back Pain details

Eicosapentaenoic acid alleviates back pain

Based on 11 Researches

Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis.

Most Relevant Research

We explored how eicosapentaenoic acid (EPA) might help in treating intervertebral disc degeneration (IDD), a major contributor to back pain. Research highlights that this condition often involves endoplasmic reticulum (ER) stress and breakdown of the extracellular matrix (ECM), key processes that worsen IDD. Our investigation demonstrated that EPA can promote autophagy, a process that helps cells clean up and maintain balance within the ECM.

Through our experiments, we treated nucleus pulposus cells—cells in the discs that often suffer from degeneration—with EPA. We observed that EPA not only boosted autophagy but also suppressed the harmful effects of ER stress, reducing cell death and limiting ECM degradation. Additionally, we utilized a rat model of IDD to see if these protective effects translated into a real-world setting. The findings indicated that EPA improved the health of the discs and effectively slowed down the progression of IDD in these rats.

In summary, this research highlights the potential of EPA as a therapeutic option for managing back pain related to disc degeneration. Our results suggest that EPA could play an important role in supporting the health of intervertebral discs and mitigating some of the common issues associated with chronic back pain.

9.5

Joint pain relief

Most Useful Review

I drank two capsules each morning with breakfast for three weeks. I've noticed increased endurance during cardio workouts and no knee pain, which was a previous issue during lunges and squats. This product has worked well for me and my husband, with no mouth or stomach discomfort experienced. I highly recommend it!

Cold Sores details

Works! My skin was very dry, and I frequently suffered from cold sores. Along with vitamin D, these capsules addressed my issues, and my hair also improved. It works 100%, I highly recommend it for health!

Dizziness details

After years of reliance on medications for sleep, I found this product excellent. After six months, I recommend taking 5mg or 3mg for sleep; it works well and suits morning people. If you drink coffee, 10mg is suitable but may cause slight dizziness and sleepiness initially. That feeling fades after some time.

Heart Disease details

Omega-3 lowers coronary risk

A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events.

Most Relevant Research

We explored the impact of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on heart disease through a significant study known as the VITAL trial. This study involved nearly 26,000 older adults in the U.S. and aimed to determine the effects of daily EPA supplementation on cardiovascular events over an average follow-up of 5.3 years.

Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.

This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.

9.5

Cardiovascular benefits

Most Useful Review

"Mega" omega!!! This quality fish oil contains essential omega-3 fatty acids, which significantly lower cholesterol levels and aid in preventing heart disease. Omega-3 has been noted by oncologists for slowing tumour growth and is effective for various skin ailments. It also reduces allergy symptoms in children, aids in wound healing, and helps with arthritis by promoting anti-inflammatory prostaglandins. Omega-3 is vital for brain function and can help pregnant women develop the embryo. I take it daily to regulate fat metabolism and support overall health.

Acne details

Based on 24 Researches

Omega-3 may improve acne

Acne and diet: a review.

Most Relevant Research

We observed that acne is a common skin condition, particularly affecting individuals under 30. Our exploration into the role of diet revealed that nutrition significantly influences acne development. Among the various dietary components, omega-3 fatty acids stood out due to their potential anti-inflammatory properties.

The research indicates that foods rich in omega-3 can help reduce the production of inflammatory substances that may contribute to acne. Additionally, specific fatty acids, such as docosapentaenoic acid and γ-linolenic acid, have shown promise in improving acne lesions.

By integrating omega-3 into the diet, we might be able to mitigate some of the troublesome symptoms associated with acne. While the evidence is still unfolding, the link between omega-3 fatty acids and reduced acne severity offers a hopeful avenue worth considering for those battling breakouts.

8.8

Skin quality improvement

Most Useful Review

I first purchased fish oil for its cost-effectiveness and lemon flavour. I was pleasantly surprised by how comfortable I felt and noticed an improvement in my skin quality, which had been prone to acne due to my meat-heavy diet. The subtle lemon aroma made it easy to consume, and the packaging is appealing. It seems to be an essential supplement for me.

Blood Clot details

Eicosapentaenoic acid influences clotting

Based on 25 Researches

Emergence of omega-3 fatty acids in biomedical research.

Most Relevant Research

We explored how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, influences blood clotting processes. The interest in EPA grew substantially after the 1970s when researchers Dyerberg and Bang noted that Greenland Eskimos had lower rates of coronary disease linked to their diet rich in marine lipids.

Their findings suggested that the higher levels of EPA led to reduced platelet aggregation, which essentially means that the blood clots less easily. This anti-clotting effect is significant since blood clots can lead to serious health issues like heart attacks and strokes.

Although studies have shown these promising effects, it’s crucial to note that much of the initial acclaim came from dietary observations rather than controlled clinical trials. This means that while we can relate high EPA intake to lower health risks in specific populations, we still need more rigorous studies to fully understand the impact of EPA on blood clotting across diverse groups.

9.5

Headache relief

Most Useful Review

I have been taking Omega for four months now, and my body feels much better. My headaches and fluctuating blood pressure have disappeared. Previously, I used omega from two other brands, but this third one with a hint of lemon is my favourite. The jar is sturdy and lasts for about 75 days. I used to be sceptical about supplements, but this has genuinely improved my vascular health and eliminated the need for pressure medication since autumn. I am very pleased!

Bloating details

Excellent! A good omega-3 supplement that is easy to take and does not cause bloating. It is essential for managing cholesterol levels.

Diarrhea details

5,6-DiHETE alleviates diarrhea

Based on 10 Researches

Efficient Attenuation of Dextran Sulfate Sodium-Induced Colitis by Oral Administration of 5,6-Dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic Acid in Mice.

Most Relevant Research

We examined how eicosapentaenoic acid, specifically a compound called 5,6-dihydroxy-8Z,11Z,14Z,17Z-eicosatetraenoic acid (5,6-DiHETE), affects diarrhea caused by inflammation in mice. In our study, the mice were given a substance that induces colitis, known as dextran sulfate sodium (DSS), and then treated with different doses of 5,6-DiHETE orally.

What we found was promising: the administration of both 150 and 600 micrograms of 5,6-DiHETE daily helped to speed up the recovery from diarrhea. After just a few days of treatment, we observed significant improvements in the mice’s condition. The daily doses led to less inflammation in the colon and a notable reduction in the symptoms of diarrhea associated with DSS-induced colitis.

We also measured how much of this compound remained in the mice's blood after taking it, finding that it peaked within half an hour of administration. This suggests that 5,6-DiHETE works relatively quickly to start affecting the inflammation. Overall, our research indicates that eicosapentaenoic acid holds potential as a beneficial treatment for inflammatory bowel diseases that cause diarrhea.

8.8

No bad breath

Most Useful Review

It tastes excellent, does not cause bad breath, and I’ve not experienced any diarrhoea.

Food Poisoning details

DHA promotes cadmium excretion

Likely Very Effective

Docosahexaenoic Acid Promotes Cd Excretion by Restoring the Abundance of in Cd-Exposed Mice.

Most Relevant Research

We explored the effects of docosahexaenoic acid (DHA) on cadmium (Cd) exposure, a common pollutant that risks human health through the food chain. Our investigation focused on how DHA might help mitigate the harmful effects of Cd, particularly by looking at changes in gut microbiota.

The study involved examining mice that had been exposed to cadmium. We observed that DHA significantly boosted the amount of cadmium expelled in feces while reducing the levels of cadmium accumulated in various organs. Our findings highlighted a particularly encouraging increase in Parabacteroides, a beneficial bacteria in the gut that appeared to play a crucial role in this process.

We noted that the representative strain of Parabacteroides not only demonstrated the ability to reduce Cd toxicity but also helped repair gut damage inflicted by cadmium exposure. Furthermore, DHA effectively reduced cadmium levels in organs such as the liver, spleen, and kidneys, leading to a noticeable increase in cadmium excretion.

Overall, our results suggest that DHA may have significant potential in promoting the excretion of cadmium in instances of exposure. This insight offers a fascinating avenue for considering DHA as a supportive treatment option for handling heavy metal toxicity.

8.8

Enhanced concentration noted

Most Useful Review

After two months of using this Omega-3, my mother has shown improved concentration and memory retention. The high DHA content is quite impressive for its price, making it worth the purchase. I researched Omega-3s extensively and found that DHA and EPA are essential for longevity and children's development. Their deficiency can lead to numerous health issues. Omega-3 sources include fish oils, zooplankton, and microalgae.

Knee Pain details

Fish oil improves knee function

Based on 15 Researches

Efficacy and Safety of Fish Oil in Treatment of Knee Osteoarthritis.

Most Relevant Research

We explored how fish oil, rich in docosahexaenoic acid (DHA), can impact knee pain, particularly for those suffering from osteoarthritis. In our study, we involved 75 participants, divided into three groups, each taking either 1,000 mg or 2,000 mg of fish oil daily for eight weeks. We carefully measured their knee pain and walking abilities before and after the supplementation.

The results were encouraging. Those who took fish oil reported notable improvements in knee performance and function compared to a control group. On a satisfaction scale, the average score was an impressive 9.06 out of 10! While most participants experienced the benefits of fish oil without complications, there was one case of hematuria that was unrelated to the treatment.

Overall, our findings suggest that taking 1,000 to 2,000 mg of fish oil daily can significantly enhance knee performance and is safe for individuals with mild to moderate knee osteoarthritis. However, it’s worth noting that increasing the dose beyond 1,000 mg didn't yield greater benefits.

9.5

No knee pain

Most Useful Review

I drink these capsules with my husband every morning alongside breakfast. After three weeks, I've noticed improved endurance during cardio workouts, and intriguingly, I experienced no knee pain during squats and lunges that previously caused discomfort. No stomach issues either! I hope my review helps others.

Constipation details

Fish oil is remarkable. Anyone suffering from constipation will quickly appreciate the benefits it offers.

Heart Attack details

Eicosapentaenoic acid aids heart recovery

Eicosapentaenoic Acid Preserves Mitochondrial Quality and Attenuates Cardiac Remodeling After Myocardial Infarction in Rats.

Most Relevant Research

We investigated how eicosapentaenoic acid (EPA) may help improve heart health after a heart attack. In our study, we induced myocardial infarction (MI) in male rats by ligating their coronary artery. Some of these rats received daily treatment with EPA, while others did not, allowing us to compare the effects.

Over 12 weeks, we observed that the rats treated with EPA showed better left ventricular function—essentially, their hearts were working more efficiently. Moreover, these rats had higher levels of EPA in their mitochondria, which are the energy factories of cells. Despite the damage caused by the heart attack, the EPA treatment helped maintain crucial energy levels and kept the mitochondrial function from declining, preserving a specific protein linked to cellular health.

Our findings suggest that including EPA in the diet can bolster mitochondrial quality and support heart function after an MI. This could mean that EPA may serve as an important dietary addition for promoting heart health following heart events.

9.5

Heart health support

Most Useful Review

Value Pack Omega-3 Fish Oil helps support heart and brain health, and maintains healthy triglyceride levels. It's molecularly distilled to remove harmful substances. Some studies suggest omega-3 may reduce heart attack risk.

Rash details

The best. I am 27 years old. I started taking Omega 3 on the advice of a beautician alongside vitamin D3 due to skin and hair issues. After just one jar, the results are evident. My hair has stopped falling out, and my skin is hydrated; the rashes on my face have disappeared. I really like this Omega 3 as it contains natural lemon oil, which is good for the stomach. The dosage of Omega is 1000 mg, which is excellent. I've ordered it twice already, and while I've tried Omega 3 from another company, I will definitely reorder from this one.

Allergies details