' 
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
6.9
USERS' SCORE
Very Good
Based on 3 Reviews
8.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
**
Polyunsaturated Fat
0.5 g
**
Monounsaturated Fat
0 g
**
Cholesterol
10 mg
3%
Omega-3 Fish Oil
1000 mg
**
EPA (Eicosapentaenoic Acid)
180 mg
**
DHA (Docosahexaenoic Acid)
120 mg
**
Top Medical Research Studies
8
Eicosapentaenoic Acid aids Alzheimer's treatment
N-3 polyunsaturated fatty acids attenuate amyloid-beta-induced toxicity in AD transgenic Caenorhabditis elegans via promotion of proteasomal activity and activation of PPAR-gamma.
Highly relevant study on Alzheimer's
We investigated how eicosapentaenoic acid (EPA), an n-3 polyunsaturated fatty acid, affects the toxicity linked to Alzheimer’s disease. Using a model of transgenic Caenorhabditis elegans, we observed that treating these worms with EPA led to a decrease in the harmful effects caused by beta-amyloid (Aβ) accumulation, a key contributor to cognitive decline in Alzheimer’s.
Notably, we found that EPA not only reduced the signs of paralysis associated with Aβ but also lowered the production of reactive oxygen species, which are harmful compounds that can damage cells. Additionally, our findings suggested that EPA restored proteasomal activity, helping clear the Aβ build-up.
We further explored the role of PPAR-gamma, a receptor that appears to be crucial for EPA's protective effects. When we used an inhibitor to block PPAR-gamma, the positive outcomes of EPA treatment were no longer evident. This suggests that EPA’s beneficial effects in fighting Aβ-induced toxicity are linked to its ability to activate PPAR-gamma.
Overall, our research underscores the potential of eicosapentaenoic acid as a promising therapeutic option for mitigating Alzheimer's symptoms by enhancing cellular functions.
Notably, we found that EPA not only reduced the signs of paralysis associated with Aβ but also lowered the production of reactive oxygen species, which are harmful compounds that can damage cells. Additionally, our findings suggested that EPA restored proteasomal activity, helping clear the Aβ build-up.
We further explored the role of PPAR-gamma, a receptor that appears to be crucial for EPA's protective effects. When we used an inhibitor to block PPAR-gamma, the positive outcomes of EPA treatment were no longer evident. This suggests that EPA’s beneficial effects in fighting Aβ-induced toxicity are linked to its ability to activate PPAR-gamma.
Overall, our research underscores the potential of eicosapentaenoic acid as a promising therapeutic option for mitigating Alzheimer's symptoms by enhancing cellular functions.
Read More
8
EPA disrupts Aβ fibrils
Destabilization of Aβ fibrils by omega-3 polyunsaturated fatty acids: a molecular dynamics study.
Direct focus on Alzheimer's treatment
We explored the potential of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, in destabilizing the toxic aggregates of the Aβ protein that form plaques in Alzheimer's disease. The study utilized advanced molecular dynamics simulations to assess how EPA interacts with these fibrils over time.
Throughout the analysis, we observed that EPA not only binds to the Aβ fibrils but also disrupts their structure. As a result, we noted increased root mean square deviation, radius of gyration, and surface area while the number of hydrogen bonds and β-sheet content decreased. This indicates that EPA interferes with the fibrils' stability, potentially paving the way for therapeutic applications in Alzheimer’s treatment.
Importantly, the interactions demonstrated that the polar head of EPA aligns with positively charged residues in the fibril, showcasing a clear mechanism behind its destabilizing effects. The hydrophobic tail of EPA competes with the natural hydrophobic interactions within the fibrils, ultimately leading to their destabilization. Overall, our findings suggest that EPA could be a promising candidate for further drug development aimed at combating Alzheimer’s disease.
Throughout the analysis, we observed that EPA not only binds to the Aβ fibrils but also disrupts their structure. As a result, we noted increased root mean square deviation, radius of gyration, and surface area while the number of hydrogen bonds and β-sheet content decreased. This indicates that EPA interferes with the fibrils' stability, potentially paving the way for therapeutic applications in Alzheimer’s treatment.
Importantly, the interactions demonstrated that the polar head of EPA aligns with positively charged residues in the fibril, showcasing a clear mechanism behind its destabilizing effects. The hydrophobic tail of EPA competes with the natural hydrophobic interactions within the fibrils, ultimately leading to their destabilization. Overall, our findings suggest that EPA could be a promising candidate for further drug development aimed at combating Alzheimer’s disease.
Read More
8
Eicosapentaenoic acid may aid Alzheimer's
Eicosapentaenoic Acid Protects against Metabolic Impairments in the APPswe/PS1dE9 Alzheimer's Disease Mouse Model.
Significant effects on Alzheimer metrics
We set out to explore the impact of eicosapentaenoic acid (EPA) on Alzheimer’s disease, especially its ability to combat the weight gain and metabolic issues that often accompany this condition. In a study involving transgenic Alzheimer’s mice and their non-transgenic counterparts, we assigned different groups to various diets: a low-fat diet, a high-fat diet, and a high-fat diet enriched with EPA.
Our findings revealed that the mice on a high-fat diet tended to gain weight more than those on a low-fat diet, particularly the male mice. However, when administered EPA, we observed a reduction in weight gain among male mice compared to those on a regular high-fat diet. While both diets affected glucose metabolism negatively, EPA improved some metabolic markers, including lowering levels of leptin and insulin and boosting adiponectin.
Most importantly, we found that EPA decreased levels of amyloid-β (Aβ), a protein linked to the progression of Alzheimer’s, in the blood of male transgenic mice. This is significant because it highlights EPA's potential role in addressing both metabolic dysfunction and Aβ accumulation, opening the door for future research into its therapeutic mechanisms against Alzheimer's disease.
Overall, our research provides fresh insights into how EPA might serve as a supportive treatment for Alzheimer’s, especially for managing obesity-related complications in patients.
Our findings revealed that the mice on a high-fat diet tended to gain weight more than those on a low-fat diet, particularly the male mice. However, when administered EPA, we observed a reduction in weight gain among male mice compared to those on a regular high-fat diet. While both diets affected glucose metabolism negatively, EPA improved some metabolic markers, including lowering levels of leptin and insulin and boosting adiponectin.
Most importantly, we found that EPA decreased levels of amyloid-β (Aβ), a protein linked to the progression of Alzheimer’s, in the blood of male transgenic mice. This is significant because it highlights EPA's potential role in addressing both metabolic dysfunction and Aβ accumulation, opening the door for future research into its therapeutic mechanisms against Alzheimer's disease.
Overall, our research provides fresh insights into how EPA might serve as a supportive treatment for Alzheimer’s, especially for managing obesity-related complications in patients.
Read More
Most Useful Reviews
9.5
Memory support
Omega-3 is crucial for preventing Alzheimer's and supporting heart health. I take 2 capsules daily and have also tried a higher dosage. This product is effective, with no fishy aftertaste and a pleasant lemon flavour.
Read More
8.8
Inflammation prevention
Fish oil is vital for reducing inflammation and combatting diseases like Alzheimer's. Most adults don't get enough omega-3 fatty acids from their diet, which can lead to inflammatory issues. I believe that limiting omega-6 intake and increasing fish oil can restore the fatty acid balance. Natrol fish oil provides adequate EPA and DHA for this purpose.
Read More
6.8
Key supplement
The quality is excellent, and I appreciate the lemon flavour. Fish oil supports heart health, brain function, and helps against Alzheimer's. It's important to take it with fats for better absorption. This is one of my essential supplements.
Read More
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6.9
9
Potential retinal benefits in Alzheimer’s
Improvement of retinal function in Alzheimer disease-associated retinopathy by dietary lysophosphatidylcholine-EPA/DHA.
High relevance due to treatment effects
We explored how dietary eicosapentaenoic acid (EPA), in combination with lysophosphatidylcholine and docosahexaenoic acid (DHA), might influence retinal function in Alzheimer’s disease (AD). Our focus was on 5XFAD mice, a commonly used model for studying AD, to see if enriching retinal DHA levels could help alleviate visual impairments associated with the disease.
Our findings revealed that the 5XFAD mice had notably lower levels of retinal DHA compared to their healthy counterparts. Upon feeding them a diet rich in the lysophosphatidylcholine form of DHA and EPA, we observed a rapid normalization of DHA levels and a substantial increase in retinal EPA. In contrast, feeding them traditional forms of these fatty acids produced only modest improvements.
After two months on the special diet, we recorded significant enhancements in retinal function measured through electroretinography, particularly in a-wave and b-wave responses. Additionally, the levels of retinal amyloid beta, a marker associated with AD, were reduced by about 50% with the dietary intervention, compared to a mere 17% reduction with the standard formulation.
Overall, our study suggests that boosting DHA and EPA levels in the retina through a unique dietary method may improve vision-related issues in Alzheimer’s disease, highlighting the potential of these nutrients in supporting retinal health as part of a broader treatment strategy.
Our findings revealed that the 5XFAD mice had notably lower levels of retinal DHA compared to their healthy counterparts. Upon feeding them a diet rich in the lysophosphatidylcholine form of DHA and EPA, we observed a rapid normalization of DHA levels and a substantial increase in retinal EPA. In contrast, feeding them traditional forms of these fatty acids produced only modest improvements.
After two months on the special diet, we recorded significant enhancements in retinal function measured through electroretinography, particularly in a-wave and b-wave responses. Additionally, the levels of retinal amyloid beta, a marker associated with AD, were reduced by about 50% with the dietary intervention, compared to a mere 17% reduction with the standard formulation.
Overall, our study suggests that boosting DHA and EPA levels in the retina through a unique dietary method may improve vision-related issues in Alzheimer’s disease, highlighting the potential of these nutrients in supporting retinal health as part of a broader treatment strategy.
Read More
9
Eicosapentaenoic Acid shows promise
Efficacy and acceptability of anti-inflammatory eicosapentaenoic acid for cognitive function in Alzheimer's dementia: A network meta-analysis of randomized, placebo-controlled trials with omega-3 fatty acids and FDA-approved pharmacotherapy.
Mixed evidence of treatment efficacy
We conducted a comprehensive analysis of how eicosapentaenoic acid (EPA), an omega-3 fatty acid, affects cognitive function in individuals with Alzheimer's dementia (AD). Our research included 52 randomized controlled trials involving over 21,000 participants, making this one of the most extensive evaluations in this field.
The goal was to determine whether high doses of EPA could provide significant improvement in cognitive abilities and how this treatment compares to other FDA-approved medications. After examining the data, we found that long-term use of EPA at doses between 1500 and 2000 mg per day, especially when enhanced with antioxidants, had the greatest potential for improving cognitive function in people with AD.
In terms of acceptability and safety, we observed that EPA was comparable to placebo, meaning that the discontinuation rates and side effects were similar. These insights reinforce the notion that anti-inflammatory properties of EPA could play a significant role in managing cognitive decline among Alzheimer’s patients.
Looking ahead, we believe that future research should investigate different dosages of EPA, focusing on how it might help individuals with varying levels of inflammation and psychiatric symptoms.
The goal was to determine whether high doses of EPA could provide significant improvement in cognitive abilities and how this treatment compares to other FDA-approved medications. After examining the data, we found that long-term use of EPA at doses between 1500 and 2000 mg per day, especially when enhanced with antioxidants, had the greatest potential for improving cognitive function in people with AD.
In terms of acceptability and safety, we observed that EPA was comparable to placebo, meaning that the discontinuation rates and side effects were similar. These insights reinforce the notion that anti-inflammatory properties of EPA could play a significant role in managing cognitive decline among Alzheimer’s patients.
Looking ahead, we believe that future research should investigate different dosages of EPA, focusing on how it might help individuals with varying levels of inflammation and psychiatric symptoms.
Read More
8
Eicosapentaenoic Acid aids Alzheimer's treatment
N-3 polyunsaturated fatty acids attenuate amyloid-beta-induced toxicity in AD transgenic Caenorhabditis elegans via promotion of proteasomal activity and activation of PPAR-gamma.
Highly relevant study on Alzheimer's
We investigated how eicosapentaenoic acid (EPA), an n-3 polyunsaturated fatty acid, affects the toxicity linked to Alzheimer’s disease. Using a model of transgenic Caenorhabditis elegans, we observed that treating these worms with EPA led to a decrease in the harmful effects caused by beta-amyloid (Aβ) accumulation, a key contributor to cognitive decline in Alzheimer’s.
Notably, we found that EPA not only reduced the signs of paralysis associated with Aβ but also lowered the production of reactive oxygen species, which are harmful compounds that can damage cells. Additionally, our findings suggested that EPA restored proteasomal activity, helping clear the Aβ build-up.
We further explored the role of PPAR-gamma, a receptor that appears to be crucial for EPA's protective effects. When we used an inhibitor to block PPAR-gamma, the positive outcomes of EPA treatment were no longer evident. This suggests that EPA’s beneficial effects in fighting Aβ-induced toxicity are linked to its ability to activate PPAR-gamma.
Overall, our research underscores the potential of eicosapentaenoic acid as a promising therapeutic option for mitigating Alzheimer's symptoms by enhancing cellular functions.
Notably, we found that EPA not only reduced the signs of paralysis associated with Aβ but also lowered the production of reactive oxygen species, which are harmful compounds that can damage cells. Additionally, our findings suggested that EPA restored proteasomal activity, helping clear the Aβ build-up.
We further explored the role of PPAR-gamma, a receptor that appears to be crucial for EPA's protective effects. When we used an inhibitor to block PPAR-gamma, the positive outcomes of EPA treatment were no longer evident. This suggests that EPA’s beneficial effects in fighting Aβ-induced toxicity are linked to its ability to activate PPAR-gamma.
Overall, our research underscores the potential of eicosapentaenoic acid as a promising therapeutic option for mitigating Alzheimer's symptoms by enhancing cellular functions.
Read More
8
EPA-PS shows protective effects
A Comparative Study about the Neuroprotective Effects of DHA-Enriched Phosphatidylserine and EPA-Enriched Phosphatidylserine against Oxidative Damage in Primary Hippocampal Neurons.
Key to Alzheimer's research
We explored the effects of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) through their phosphatidylserine (PS) forms on primary hippocampal neurons, particularly in relation to oxidative stress, a key feature in Alzheimer's disease (AD). Our investigation focused on how these compounds could potentially shield neurons from oxidative damage.
We found that both EPA-rich PS and DHA-rich PS significantly improved the morphology of neurons and helped restore their neural networks. Notably, EPA-PS demonstrated stronger effectiveness in some crucial areas, such as inhibiting ERK phosphorylation, which indicated an anti-apoptotic effect. This means EPA-PS may help protect neurons from dying, which is vital in AD progression.
Additionally, EPA-PS boosted the expression of proteins linked to neuroprotection, such as p-TrkB and p-CREB. On the other hand, while EPA-PS enhanced synaptic plasticity by increasing SYN expression, DHA-PS did not show this effect. Both types of PS helped reduce levels of harmful proteins associated with neuron damage.
These findings suggest that incorporating these phospholipids might offer promising strategies for treating neurodegenerative diseases, making them worthy of further exploration for functional food development.
We found that both EPA-rich PS and DHA-rich PS significantly improved the morphology of neurons and helped restore their neural networks. Notably, EPA-PS demonstrated stronger effectiveness in some crucial areas, such as inhibiting ERK phosphorylation, which indicated an anti-apoptotic effect. This means EPA-PS may help protect neurons from dying, which is vital in AD progression.
Additionally, EPA-PS boosted the expression of proteins linked to neuroprotection, such as p-TrkB and p-CREB. On the other hand, while EPA-PS enhanced synaptic plasticity by increasing SYN expression, DHA-PS did not show this effect. Both types of PS helped reduce levels of harmful proteins associated with neuron damage.
These findings suggest that incorporating these phospholipids might offer promising strategies for treating neurodegenerative diseases, making them worthy of further exploration for functional food development.
Read More
8
Omega-3s may reduce Alzheimer's risk
The Relationship of Omega-3 Fatty Acids with Dementia and Cognitive Decline: Evidence from Prospective Cohort Studies of Supplementation, Dietary Intake, and Blood Markers.
Moderate relevance to topic
We aimed to understand the relationship between eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, and the risk of developing Alzheimer's disease (AD). To do this, we analyzed data from over a thousand participants in the Alzheimer's Disease Neuroimaging Initiative cohort who initially showed no signs of dementia.
Our findings revealed that long-term use of omega-3 supplements, particularly those rich in EPA and DHA, was associated with a significant reduction in the risk of developing Alzheimer's. Specifically, we found a striking 64% decrease in AD risk among those who regularly took omega-3 supplements. This may suggest that incorporating these fatty acids into our diet could play a positive role in brain health as we age.
Furthermore, when we looked at dietary intake across 48 studies involving more than 100,000 participants, we observed that consuming more omega-3s could reduce the risk of cognitive decline by about 20%. For every increase of just 0.1 grams per day of either EPA or DHA, the risk of cognitive decline dropped by nearly 9%.
In addition to the dietary findings, higher levels of EPA in the blood and DHA in cell membranes were linked to lower instances of cognitive decline. Overall, this evidence supports the idea that eicosapentaenoic acid and other omega-3 fatty acids might be beneficial for those concerned about Alzheimer's disease or cognitive deterioration.
Our findings revealed that long-term use of omega-3 supplements, particularly those rich in EPA and DHA, was associated with a significant reduction in the risk of developing Alzheimer's. Specifically, we found a striking 64% decrease in AD risk among those who regularly took omega-3 supplements. This may suggest that incorporating these fatty acids into our diet could play a positive role in brain health as we age.
Furthermore, when we looked at dietary intake across 48 studies involving more than 100,000 participants, we observed that consuming more omega-3s could reduce the risk of cognitive decline by about 20%. For every increase of just 0.1 grams per day of either EPA or DHA, the risk of cognitive decline dropped by nearly 9%.
In addition to the dietary findings, higher levels of EPA in the blood and DHA in cell membranes were linked to lower instances of cognitive decline. Overall, this evidence supports the idea that eicosapentaenoic acid and other omega-3 fatty acids might be beneficial for those concerned about Alzheimer's disease or cognitive deterioration.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 3 Reviews
8.2
9.5
Memory support
Omega-3 is crucial for preventing Alzheimer's and supporting heart health. I take 2 capsules daily and have also tried a higher dosage. This product is effective, with no fishy aftertaste and a pleasant lemon flavour.
8.8
Inflammation prevention
Fish oil is vital for reducing inflammation and combatting diseases like Alzheimer's. Most adults don't get enough omega-3 fatty acids from their diet, which can lead to inflammatory issues. I believe that limiting omega-6 intake and increasing fish oil can restore the fatty acid balance. Natrol fish oil provides adequate EPA and DHA for this purpose.
Read More
6.8
Key supplement
The quality is excellent, and I appreciate the lemon flavour. Fish oil supports heart health, brain function, and helps against Alzheimer's. It's important to take it with fats for better absorption. This is one of my essential supplements.
