' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
7.1
USERS' SCORE
Very Good
Based on 7 Reviews
8.8
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
**
Polyunsaturated Fat
0.5 g
**
Monounsaturated Fat
0 g
**
Cholesterol
10 mg
3%
Omega-3 Fish Oil
1000 mg
**
EPA (Eicosapentaenoic Acid)
180 mg
**
DHA (Docosahexaenoic Acid)
120 mg
**
Top Medical Research Studies
8
Eicosapentaenoic acid may reduce depression
The Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.
Direct focus on EPA's efficacy
We conducted a study to explore the effectiveness of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, in treating major depressive disorder (MDD). Over the course of 12 weeks, 60 participants suffering from MDD were divided into two groups: one received 3.2 grams of EPA daily, while the other group was given a placebo, which was soybean oil.
Throughout the study, we assessed the severity of depression using the Hamilton Rating Scale for Depression (HRSD). What we found was promising. The group taking EPA experienced significantly lower HRSD scores at various checkpoints—specifically at weeks 4, 6, 8, and 12—indicating a reduction in depressive symptoms. Although the rates of remission and response were higher in the EPA group compared to the placebo group, these findings did not achieve statistical significance.
Overall, while EPA shows potential as a treatment for depression, further research is needed to solidify its role. Our findings suggest that it may be an alternative option for MDD patients seeking additional treatment pathways.
Throughout the study, we assessed the severity of depression using the Hamilton Rating Scale for Depression (HRSD). What we found was promising. The group taking EPA experienced significantly lower HRSD scores at various checkpoints—specifically at weeks 4, 6, 8, and 12—indicating a reduction in depressive symptoms. Although the rates of remission and response were higher in the EPA group compared to the placebo group, these findings did not achieve statistical significance.
Overall, while EPA shows potential as a treatment for depression, further research is needed to solidify its role. Our findings suggest that it may be an alternative option for MDD patients seeking additional treatment pathways.
Read More
5
Potential benefits for depression prevention
The N-3 polyunsaturated fatty acids supplementation to prevent depression recurrence in patients with late-life depression: A 52-week double-blind, placebo-controlled trial.
Focused on eicosapentaenoic acid
We conducted a study to explore whether eicosapentaenoic acid (a type of omega-3 fatty acid) can help prevent depression recurrence in older adults who have previously experienced late-life depression. Our research involved a rigorous 52-week double-blind, placebo-controlled trial with 39 patients who were currently stable and free from depression symptoms.
The participants were randomly assigned to either receive daily doses of eicosapentaenoic acid alongside docosahexaenoic acid or a placebo for the duration of the trial. We wanted to see if this supplementation could not only protect against future depressive episodes but also impact depressive and anxiety symptoms, as well as some inflammatory markers associated with depression.
Interestingly, our findings revealed that eicosapentaenoic acid did indeed show a protective effect against the recurrence of depression, with a significant hazard ratio suggesting that those taking the supplement were less likely to relapse compared to the placebo group. However, we didn't observe any notable improvements in current depressive or anxiety symptoms, nor in the inflammatory markers between the two groups.
While the results are promising regarding the prevention of depression recurrence, it's essential to keep in mind the modest size of our sample when interpreting these findings.
The participants were randomly assigned to either receive daily doses of eicosapentaenoic acid alongside docosahexaenoic acid or a placebo for the duration of the trial. We wanted to see if this supplementation could not only protect against future depressive episodes but also impact depressive and anxiety symptoms, as well as some inflammatory markers associated with depression.
Interestingly, our findings revealed that eicosapentaenoic acid did indeed show a protective effect against the recurrence of depression, with a significant hazard ratio suggesting that those taking the supplement were less likely to relapse compared to the placebo group. However, we didn't observe any notable improvements in current depressive or anxiety symptoms, nor in the inflammatory markers between the two groups.
While the results are promising regarding the prevention of depression recurrence, it's essential to keep in mind the modest size of our sample when interpreting these findings.
Read More
9
EPA alleviates depressive behavior
DHA and EPA alleviate depressive-like behaviors in chronic sleep-deprived mice: Involvement of iron metabolism, oligodendrocyte-lipids peroxidation and the LCN2-NLRP3 signaling axis.
High relevance to depression treatment
We investigated how eicosapentaenoic acid (EPA) impacts depressive-like behaviors in mice that were subject to chronic sleep deprivation. Our findings indicated that EPA is more effective than docosahexaenoic acid (DHA) in alleviating signs of depression, as evidenced by changes in preferences and behaviors observed in these mice.
Both EPA and DHA were shown to reduce myelin damage and support the health of oligodendrocytes, but EPA led to more significant improvements. We noted higher levels of essential proteins related to myelin repair alongside reduced lipid peroxidation in the presence of EPA.
Notably, both compounds inhibited inflammation pathways associated with depression. However, EPA markedly outperformed DHA in curbing microglial activation and correcting imbalances in immune response. Overall, our research supports the understanding of EPA as a particularly promising option in the fight against depression.
Both EPA and DHA were shown to reduce myelin damage and support the health of oligodendrocytes, but EPA led to more significant improvements. We noted higher levels of essential proteins related to myelin repair alongside reduced lipid peroxidation in the presence of EPA.
Notably, both compounds inhibited inflammation pathways associated with depression. However, EPA markedly outperformed DHA in curbing microglial activation and correcting imbalances in immune response. Overall, our research supports the understanding of EPA as a particularly promising option in the fight against depression.
Read More
Most Useful Reviews
9.5
Depression relief
This brand of fish oil has helped lift my permanent depression. There's no unpleasant fish taste or odour, and it works well compared to other Omega-3 brands I've tried.
Read More
8.8
Improved depression
Great quality at a reasonable price! This fish oil has no side effects and effectively addresses depression. I noticed improvements in my cognitive abilities and overall health. My skin has also improved. My husband has benefited as well.
Read More
8.8
Supports depression treatment
This Omega-3 is one of my favourites, with a high dosage and excellent absorption. It helps reduce inflammation and anxiety. I've been taking it daily to support my mental health.
Read More
Most Recommended Products for Depression
Solgar Zinc
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 5 Reviews
9.4
American Health Ester-C with Citrus Bioflavonoids
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 2 Reviews
9.2
Life Extension Magnesium Caps
SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Excellent
Based on 18 Reviews
9.2
Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
7.1
9
EPA alleviates depressive behavior
DHA and EPA alleviate depressive-like behaviors in chronic sleep-deprived mice: Involvement of iron metabolism, oligodendrocyte-lipids peroxidation and the LCN2-NLRP3 signaling axis.
High relevance to depression treatment
We investigated how eicosapentaenoic acid (EPA) impacts depressive-like behaviors in mice that were subject to chronic sleep deprivation. Our findings indicated that EPA is more effective than docosahexaenoic acid (DHA) in alleviating signs of depression, as evidenced by changes in preferences and behaviors observed in these mice.
Both EPA and DHA were shown to reduce myelin damage and support the health of oligodendrocytes, but EPA led to more significant improvements. We noted higher levels of essential proteins related to myelin repair alongside reduced lipid peroxidation in the presence of EPA.
Notably, both compounds inhibited inflammation pathways associated with depression. However, EPA markedly outperformed DHA in curbing microglial activation and correcting imbalances in immune response. Overall, our research supports the understanding of EPA as a particularly promising option in the fight against depression.
Both EPA and DHA were shown to reduce myelin damage and support the health of oligodendrocytes, but EPA led to more significant improvements. We noted higher levels of essential proteins related to myelin repair alongside reduced lipid peroxidation in the presence of EPA.
Notably, both compounds inhibited inflammation pathways associated with depression. However, EPA markedly outperformed DHA in curbing microglial activation and correcting imbalances in immune response. Overall, our research supports the understanding of EPA as a particularly promising option in the fight against depression.
Read More
9
DPA enhances depression treatment efficacy
Exosomes Derived from DPA-treated UCMSCs Attenuated Depression-like Behaviors and Neuroinflammation in a Model of Depression Induced by Chronic Stress.
Combines treatments complicate results
We explored the therapeutic benefits of eicosapentaenoic acid (DPA) in treating depression, particularly in relation to exosomes derived from human umbilical cord mesenchymal stem cells. Chronic unpredictable mild stress (CUMS) was used to induce depression-like behaviors in the study, which highlighted the role of neuroinflammation and neurotransmitter deficiencies in this condition.
Through our analysis, we observed that DPA not only improved the effectiveness of exosomes but also significantly alleviated symptoms of depression. The therapy showed a remarkable ability to suppress the harmful activation of specific immune cells in the brain, known as M1 microglia, which are often linked to inflammation. Additionally, DPA helped restore levels of important neurotransmitters, including serotonin and dopamine.
Furthermore, in laboratory tests, the exosomes treated with DPA demonstrated better protective effects against cell death and inflammation-induced damage. Mechanistically, this positive outcome was attributed to DPA’s ability to enhance the expression of a particular microRNA that plays a role in reducing inflammation pathways.
Overall, our findings suggest that DPA treatment combined with exosomes not only addresses neuroinflammation but also promotes overall brain health. This makes it a promising avenue for developing more effective depression treatments.
Through our analysis, we observed that DPA not only improved the effectiveness of exosomes but also significantly alleviated symptoms of depression. The therapy showed a remarkable ability to suppress the harmful activation of specific immune cells in the brain, known as M1 microglia, which are often linked to inflammation. Additionally, DPA helped restore levels of important neurotransmitters, including serotonin and dopamine.
Furthermore, in laboratory tests, the exosomes treated with DPA demonstrated better protective effects against cell death and inflammation-induced damage. Mechanistically, this positive outcome was attributed to DPA’s ability to enhance the expression of a particular microRNA that plays a role in reducing inflammation pathways.
Overall, our findings suggest that DPA treatment combined with exosomes not only addresses neuroinflammation but also promotes overall brain health. This makes it a promising avenue for developing more effective depression treatments.
Read More
9
Omega-3s mitigate juvenile depression
Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression.
Relevance score indicates strong findings
We utilized a novel approach to study how eicosapentaenoic acid (EPA), part of the omega-3 fatty acids, impacts depression in young mice. By subjecting juvenile mice to different ultrasound frequencies known to induce stress, we effectively created a model that mimics the symptoms of juvenile depression.
Throughout three weeks, we monitored the behavior of these mice, some receiving an EPA and docosahexaenoic acid (DHA) supplement while others did not. We found that the stressed mice given the omega-3 supplement showed no signs of depression or anxiety, which was a stark contrast to the vehicle group that did experience these symptoms.
Additionally, the study indicated that the omega-3 supplementation helped in mitigating the stress responses, such as reduced inflammation in the brain and changes in metabolism. This finding suggests that omega-3 fatty acids could have a therapeutic potential for addressing juvenile depression.
Overall, our observation sheds light on the significant benefits of incorporating eicosapentaenoic acid into diets, especially for young individuals facing mental health challenges.
Throughout three weeks, we monitored the behavior of these mice, some receiving an EPA and docosahexaenoic acid (DHA) supplement while others did not. We found that the stressed mice given the omega-3 supplement showed no signs of depression or anxiety, which was a stark contrast to the vehicle group that did experience these symptoms.
Additionally, the study indicated that the omega-3 supplementation helped in mitigating the stress responses, such as reduced inflammation in the brain and changes in metabolism. This finding suggests that omega-3 fatty acids could have a therapeutic potential for addressing juvenile depression.
Overall, our observation sheds light on the significant benefits of incorporating eicosapentaenoic acid into diets, especially for young individuals facing mental health challenges.
Read More
8
Eicosapentaenoic acid aids mild depression
Efficacy of Pharmacological Interventions in Milder Depression: A Systematic Review and Meta-Analysis.
Relevant but lacks direct comparisons
We focused on the effectiveness of eicosapentaenoic acid (EPA) as a treatment for mild depression. Comprehensive searches led us to several randomized controlled trials that examined how EPA could help those experiencing symptoms of mild depression.
Our analysis highlighted that EPA, found in certain fish oils, shows potential as a therapeutic option for individuals with mild depression. While some studies presented promising findings, we noted that rigorous research explicitly comparing EPA against placebo was limited.
Moreover, our review found that supplements like EPA may contribute positively to symptom relief. However, due to the lack of direct comparisons with antidepressants or detailed isolation of EPA's effects, we do not claim conclusive superiority over existing treatments at this time.
Overall, while there is hope regarding EPA's role in assisting with mild depression, we must call for further studies and more comprehensive research to validate these benefits fully.
Our analysis highlighted that EPA, found in certain fish oils, shows potential as a therapeutic option for individuals with mild depression. While some studies presented promising findings, we noted that rigorous research explicitly comparing EPA against placebo was limited.
Moreover, our review found that supplements like EPA may contribute positively to symptom relief. However, due to the lack of direct comparisons with antidepressants or detailed isolation of EPA's effects, we do not claim conclusive superiority over existing treatments at this time.
Overall, while there is hope regarding EPA's role in assisting with mild depression, we must call for further studies and more comprehensive research to validate these benefits fully.
Read More
8
Eicosapentaenoic acid improves depression
Omega-3 polyunsaturated fatty acids in depression: insights from recent clinical trials.
Directly addresses depression treatment
We examined the therapeutic effects of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, in treating major depressive disorder (MDD). A variety of studies from reputable databases highlighted the promising potential of higher doses of EPA, particularly for individuals with specific conditions like elevated inflammation markers, cardiovascular comorbidities, or those in younger age brackets such as children and adolescents.
Participants who received doses greater than 1 gram per day of EPA showed notable improvements in their depressive symptoms. We also observed that these improvements were linked to increases in beneficial lipid mediators that help reduce inflammation. This suggests that EPA could work as an adjunct treatment, enhancing mood, cognitive functions, and even metabolic health.
Although we see encouraging results, particularly for those with certain types of depression, we acknowledge that more robust research is necessary. Further investigations will help us refine dosing strategies, treatment durations, and identify which patient groups can benefit the most from this therapy. Looking ahead, it will be vital to explore long-term effects and interactions with other treatments as well.
Participants who received doses greater than 1 gram per day of EPA showed notable improvements in their depressive symptoms. We also observed that these improvements were linked to increases in beneficial lipid mediators that help reduce inflammation. This suggests that EPA could work as an adjunct treatment, enhancing mood, cognitive functions, and even metabolic health.
Although we see encouraging results, particularly for those with certain types of depression, we acknowledge that more robust research is necessary. Further investigations will help us refine dosing strategies, treatment durations, and identify which patient groups can benefit the most from this therapy. Looking ahead, it will be vital to explore long-term effects and interactions with other treatments as well.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 7 Reviews
8.8
9.5
Depression relief
This brand of fish oil has helped lift my permanent depression. There's no unpleasant fish taste or odour, and it works well compared to other Omega-3 brands I've tried.
9.5
Beneficial for depression
An outstanding product of high quality that reduces depression and improves circulation, helping with hair thickness and general inflammation. The omega-3 content is beneficial for the heart and blood vessels.
8.8
Improved depression
Great quality at a reasonable price! This fish oil has no side effects and effectively addresses depression. I noticed improvements in my cognitive abilities and overall health. My skin has also improved. My husband has benefited as well.
8.8
Helpful for depression
A good fish oil with no side effects. It effectively treats depression and enhances cognitive function. My skin improved and my gastrointestinal health got better.
8.8
Supports depression treatment
This Omega-3 is one of my favourites, with a high dosage and excellent absorption. It helps reduce inflammation and anxiety. I've been taking it daily to support my mental health.
