' 
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
7.3
USERS' SCORE
Very Good
Based on 8 Reviews
8.9
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
**
Polyunsaturated Fat
0.5 g
**
Monounsaturated Fat
0 g
**
Cholesterol
10 mg
3%
Omega-3 Fish Oil
1000 mg
**
EPA (Eicosapentaenoic Acid)
180 mg
**
DHA (Docosahexaenoic Acid)
120 mg
**
Top Medical Research Studies
9
Eicosapentaenoic acid protects bone health
Eicosapentaenoic acid supplementation modulates the osteoblast/osteoclast balance in inflammatory environments and protects against estrogen deficiency-induced bone loss in mice.
Directly addresses osteoporosis treatment
We evaluated the effects of eicosapentaenoic acid (EPA) on osteoporosis, particularly in how it impacts the balance between osteoblasts (the cells that build bone) and osteoclasts (the cells that break down bone). In an experimental setup, we used mouse bone marrow stem cells and macrophages to study how EPA could counteract the negative effects of inflammation, which can lead to osteoporosis.
By simulating an inflammatory environment with TNF-α, we discovered that EPA helped restore the ability of stem cells to differentiate into osteoblasts, which is crucial for bone formation. Furthermore, we explored how EPA influenced the communication between osteoblasts and osteoclasts, finding that it regulated important factors involved in bone resorption.
When we tested the effects of EPA in a mouse model of estrogen deficiency—an established cause of bone loss in postmenopausal women—we observed significant protective effects against osteoporosis. This suggests that EPA could play a valuable role in maintaining bone health and preventing bone loss related to hormonal changes, providing a promising avenue for future osteoporosis treatments.
By simulating an inflammatory environment with TNF-α, we discovered that EPA helped restore the ability of stem cells to differentiate into osteoblasts, which is crucial for bone formation. Furthermore, we explored how EPA influenced the communication between osteoblasts and osteoclasts, finding that it regulated important factors involved in bone resorption.
When we tested the effects of EPA in a mouse model of estrogen deficiency—an established cause of bone loss in postmenopausal women—we observed significant protective effects against osteoporosis. This suggests that EPA could play a valuable role in maintaining bone health and preventing bone loss related to hormonal changes, providing a promising avenue for future osteoporosis treatments.
Read More
9
Eicosapentaenoic Acid Benefits Bone Health
Positive correlation between erythrocyte levels of n-3 polyunsaturated fatty acids and bone mass in postmenopausal Korean women with osteoporosis.
Significant correlation found
We explored the relationship between eicosapentaenoic acid (EPA), a type of n-3 polyunsaturated fatty acid, and osteoporosis risk in postmenopausal Korean women. Our study involved fifty women diagnosed with osteoporosis and a control group of one hundred women without the condition. By measuring erythrocyte levels of EPA and examining fish intake, we aimed to see how they correlate with bone mass and the risk of osteoporosis.
The results were promising. We found that higher levels of EPA, as well as other n-3 fatty acids, were positively associated with better bone density, particularly in the femoral neck region. This suggests that incorporating more fish and EPA into the diet may help improve bone health, particularly for women who are postmenopausal and at risk for osteoporosis.
Notably, the findings revealed that while saturated fatty acids negatively impacted bone health, EPA and its companion docosahexaenoic acid (DHA) appeared to protect against osteoporosis. This gives us encouraging insights into how dietary choices can play a significant role in managing bone health.
Overall, our findings highlight the potential benefits of increasing n-3 fatty acid intake, especially EPA, to help reduce osteoporosis risk among postmenopausal women. The connection suggests that a simple dietary change could positively influence bone mass and health.
The results were promising. We found that higher levels of EPA, as well as other n-3 fatty acids, were positively associated with better bone density, particularly in the femoral neck region. This suggests that incorporating more fish and EPA into the diet may help improve bone health, particularly for women who are postmenopausal and at risk for osteoporosis.
Notably, the findings revealed that while saturated fatty acids negatively impacted bone health, EPA and its companion docosahexaenoic acid (DHA) appeared to protect against osteoporosis. This gives us encouraging insights into how dietary choices can play a significant role in managing bone health.
Overall, our findings highlight the potential benefits of increasing n-3 fatty acid intake, especially EPA, to help reduce osteoporosis risk among postmenopausal women. The connection suggests that a simple dietary change could positively influence bone mass and health.
Read More
9
CFO improves bone density
Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content.
Focus on EPA and DHA
We investigated how concentrated fish oil (CFO), which is rich in eicosapentaenoic acid (EPA) and DHA, impacts bone health, particularly in relation to osteoporosis. In our study, we utilized a group of twelve-month-old female mice and provided them with different dietary options including 1% and 4% CFO, a 4% safflower oil (SFO) diet, and a regular fish oil diet over a span of twelve months.
At the conclusion of the dietary intervention, we measured bone mineral density (BMD) to assess bone health. Our findings indicated that the group consuming the 4% CFO had significantly improved BMD compared to the SFO group, while those on the 1% CFO showed only a mild positive effect. Intriguingly, the 1% CFO group even outperformed the regular fish oil group in terms of BMD.
Additionally, we observed that CFO supplementation led to decreased levels of some markers related to bone loss and inflammation. It encouraged the production of beneficial substances like IL-10 and reduced harmful levels of TNF-α and IL-6. These results suggest that higher concentrations of CFO, especially starting from middle age, could enhance bone health during aging.
At the conclusion of the dietary intervention, we measured bone mineral density (BMD) to assess bone health. Our findings indicated that the group consuming the 4% CFO had significantly improved BMD compared to the SFO group, while those on the 1% CFO showed only a mild positive effect. Intriguingly, the 1% CFO group even outperformed the regular fish oil group in terms of BMD.
Additionally, we observed that CFO supplementation led to decreased levels of some markers related to bone loss and inflammation. It encouraged the production of beneficial substances like IL-10 and reduced harmful levels of TNF-α and IL-6. These results suggest that higher concentrations of CFO, especially starting from middle age, could enhance bone health during aging.
Read More
Most Useful Reviews
8.8
Supports joint health
Omega-3s support joint health and help prevent osteoporosis. They reduce inflammation and fight bone loss, alleviating joint pain, and mitigate symptoms of rheumatoid arthritis while slowing cartilage degradation in arthrosis. The fish oil is of high quality with no side effects like heartburn. I take it regularly and find it excellent value for money.
Read More
8.8
Heart health benefits
The quality of the fish oil is excellent, with robust packaging and a large jar that lasts long. Omega-3s support heart and blood vessel health as well as joint health, proving effective during winter. I appreciate the effects it has on maintaining my health and preventing osteoporosis.
Read More
9.5
Effective for children
Omega-3 fatty acids prevent osteoporosis while ensuring healthy joints. They fight bone loss and ease inflammation, addressing rheumatoid arthritis symptoms and slowing cartilage degradation in arthrosis. I purchased this for my children on a nutritionist's advice. There was no unpleasant aftertaste, and they consume it happily.
Read More
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Medical Researches
SCIENTIFIC SCORE
Most Likely Effective
Based on 16 Researches
7.3
9
Eicosapentaenoic acid protects bone health
Eicosapentaenoic acid supplementation modulates the osteoblast/osteoclast balance in inflammatory environments and protects against estrogen deficiency-induced bone loss in mice.
Directly addresses osteoporosis treatment
We evaluated the effects of eicosapentaenoic acid (EPA) on osteoporosis, particularly in how it impacts the balance between osteoblasts (the cells that build bone) and osteoclasts (the cells that break down bone). In an experimental setup, we used mouse bone marrow stem cells and macrophages to study how EPA could counteract the negative effects of inflammation, which can lead to osteoporosis.
By simulating an inflammatory environment with TNF-α, we discovered that EPA helped restore the ability of stem cells to differentiate into osteoblasts, which is crucial for bone formation. Furthermore, we explored how EPA influenced the communication between osteoblasts and osteoclasts, finding that it regulated important factors involved in bone resorption.
When we tested the effects of EPA in a mouse model of estrogen deficiency—an established cause of bone loss in postmenopausal women—we observed significant protective effects against osteoporosis. This suggests that EPA could play a valuable role in maintaining bone health and preventing bone loss related to hormonal changes, providing a promising avenue for future osteoporosis treatments.
By simulating an inflammatory environment with TNF-α, we discovered that EPA helped restore the ability of stem cells to differentiate into osteoblasts, which is crucial for bone formation. Furthermore, we explored how EPA influenced the communication between osteoblasts and osteoclasts, finding that it regulated important factors involved in bone resorption.
When we tested the effects of EPA in a mouse model of estrogen deficiency—an established cause of bone loss in postmenopausal women—we observed significant protective effects against osteoporosis. This suggests that EPA could play a valuable role in maintaining bone health and preventing bone loss related to hormonal changes, providing a promising avenue for future osteoporosis treatments.
Read More
9
CFO improves bone density
Bone Benefits of Fish Oil Supplementation Depend on its EPA and DHA Content.
Focus on EPA and DHA
We investigated how concentrated fish oil (CFO), which is rich in eicosapentaenoic acid (EPA) and DHA, impacts bone health, particularly in relation to osteoporosis. In our study, we utilized a group of twelve-month-old female mice and provided them with different dietary options including 1% and 4% CFO, a 4% safflower oil (SFO) diet, and a regular fish oil diet over a span of twelve months.
At the conclusion of the dietary intervention, we measured bone mineral density (BMD) to assess bone health. Our findings indicated that the group consuming the 4% CFO had significantly improved BMD compared to the SFO group, while those on the 1% CFO showed only a mild positive effect. Intriguingly, the 1% CFO group even outperformed the regular fish oil group in terms of BMD.
Additionally, we observed that CFO supplementation led to decreased levels of some markers related to bone loss and inflammation. It encouraged the production of beneficial substances like IL-10 and reduced harmful levels of TNF-α and IL-6. These results suggest that higher concentrations of CFO, especially starting from middle age, could enhance bone health during aging.
At the conclusion of the dietary intervention, we measured bone mineral density (BMD) to assess bone health. Our findings indicated that the group consuming the 4% CFO had significantly improved BMD compared to the SFO group, while those on the 1% CFO showed only a mild positive effect. Intriguingly, the 1% CFO group even outperformed the regular fish oil group in terms of BMD.
Additionally, we observed that CFO supplementation led to decreased levels of some markers related to bone loss and inflammation. It encouraged the production of beneficial substances like IL-10 and reduced harmful levels of TNF-α and IL-6. These results suggest that higher concentrations of CFO, especially starting from middle age, could enhance bone health during aging.
Read More
9
Eicosapentaenoic Acid Benefits Bone Health
Positive correlation between erythrocyte levels of n-3 polyunsaturated fatty acids and bone mass in postmenopausal Korean women with osteoporosis.
Significant correlation found
We explored the relationship between eicosapentaenoic acid (EPA), a type of n-3 polyunsaturated fatty acid, and osteoporosis risk in postmenopausal Korean women. Our study involved fifty women diagnosed with osteoporosis and a control group of one hundred women without the condition. By measuring erythrocyte levels of EPA and examining fish intake, we aimed to see how they correlate with bone mass and the risk of osteoporosis.
The results were promising. We found that higher levels of EPA, as well as other n-3 fatty acids, were positively associated with better bone density, particularly in the femoral neck region. This suggests that incorporating more fish and EPA into the diet may help improve bone health, particularly for women who are postmenopausal and at risk for osteoporosis.
Notably, the findings revealed that while saturated fatty acids negatively impacted bone health, EPA and its companion docosahexaenoic acid (DHA) appeared to protect against osteoporosis. This gives us encouraging insights into how dietary choices can play a significant role in managing bone health.
Overall, our findings highlight the potential benefits of increasing n-3 fatty acid intake, especially EPA, to help reduce osteoporosis risk among postmenopausal women. The connection suggests that a simple dietary change could positively influence bone mass and health.
The results were promising. We found that higher levels of EPA, as well as other n-3 fatty acids, were positively associated with better bone density, particularly in the femoral neck region. This suggests that incorporating more fish and EPA into the diet may help improve bone health, particularly for women who are postmenopausal and at risk for osteoporosis.
Notably, the findings revealed that while saturated fatty acids negatively impacted bone health, EPA and its companion docosahexaenoic acid (DHA) appeared to protect against osteoporosis. This gives us encouraging insights into how dietary choices can play a significant role in managing bone health.
Overall, our findings highlight the potential benefits of increasing n-3 fatty acid intake, especially EPA, to help reduce osteoporosis risk among postmenopausal women. The connection suggests that a simple dietary change could positively influence bone mass and health.
Read More
9
Fish oils may combat osteoporosis
Inhibition of osteoporosis due to restricted food intake by the fish oils DHA and EPA and perilla oil in the rat.
Highlights multiple oil effects
We explored the impact of eicosapentaenoic acid (EPA) and other fish oils on osteoporosis in a study involving female rats. The rats consumed a restricted diet that included triglycerides such as docosahexaenoic acid (DHA), EPA, and perilla oil. This was an interesting approach, particularly because their food intake was cut by half.
The results were encouraging; we observed that the rats receiving EPA and the other oils experienced significant increases in bone mineral density and fracture strength. Additionally, there was a notable decline in urinary calcium and a marker associated with bone breakdown, indicating improved bone health.
While these findings suggest a potential protective effect of fish oils and perilla oil against osteoporosis resulting from restricted diets, it is important to note that the study included multiple oils. This makes it challenging to pinpoint the isolated effect of EPA. However, the depressed excretion of urinary calcium points to a possible mechanism for how these oils could be beneficial in managing osteoporosis.
The results were encouraging; we observed that the rats receiving EPA and the other oils experienced significant increases in bone mineral density and fracture strength. Additionally, there was a notable decline in urinary calcium and a marker associated with bone breakdown, indicating improved bone health.
While these findings suggest a potential protective effect of fish oils and perilla oil against osteoporosis resulting from restricted diets, it is important to note that the study included multiple oils. This makes it challenging to pinpoint the isolated effect of EPA. However, the depressed excretion of urinary calcium points to a possible mechanism for how these oils could be beneficial in managing osteoporosis.
Read More
8
Eicosapentaenoic acid's potential effects
Is there a role for essential fatty acids in osteoporosis?
Limited clarity on EPA impact
We explored the connection between eicosapentaenoic acid (EPA) and osteoporosis to understand how this essential fatty acid may influence bone health. Research suggests that osteoporosis, particularly in postmenopausal women and the elderly, might be linked to low-grade systemic inflammation.
Although glucocorticoids are strong anti-inflammatory agents, their use has been shown to induce osteoporosis instead of preventing it. This strange finding points to a more complex mechanism involving pro-inflammatory cytokines and hormones like estrogen.
It appears that eicosapentaenoic acid play a role as a mediator in this process. Supporting evidence shows that people with osteoporosis often have lower levels of unsaturated fatty acids, including EPA. Some studies imply that long-chain metabolites of EFAs, such as arachidonic acid and lipoxin A4, can benefit bone health.
However, the specifics of EPA's effectiveness in isolation from other essential fatty acids remain unclear, as it was not assessed separately in the studies reviewed. Nevertheless, the potential for EPA to contribute positively to osteoporosis management is a discussion worth continuing.
Although glucocorticoids are strong anti-inflammatory agents, their use has been shown to induce osteoporosis instead of preventing it. This strange finding points to a more complex mechanism involving pro-inflammatory cytokines and hormones like estrogen.
It appears that eicosapentaenoic acid play a role as a mediator in this process. Supporting evidence shows that people with osteoporosis often have lower levels of unsaturated fatty acids, including EPA. Some studies imply that long-chain metabolites of EFAs, such as arachidonic acid and lipoxin A4, can benefit bone health.
However, the specifics of EPA's effectiveness in isolation from other essential fatty acids remain unclear, as it was not assessed separately in the studies reviewed. Nevertheless, the potential for EPA to contribute positively to osteoporosis management is a discussion worth continuing.
Read More
User Reviews
USERS' SCORE
Very Good
Based on 8 Reviews
8.9
9.5
Effective for children
Omega-3 fatty acids prevent osteoporosis while ensuring healthy joints. They fight bone loss and ease inflammation, addressing rheumatoid arthritis symptoms and slowing cartilage degradation in arthrosis. I purchased this for my children on a nutritionist's advice. There was no unpleasant aftertaste, and they consume it happily.
Read More
8.8
Supports joint health
Omega-3s support joint health and help prevent osteoporosis. They reduce inflammation and fight bone loss, alleviating joint pain, and mitigate symptoms of rheumatoid arthritis while slowing cartilage degradation in arthrosis. The fish oil is of high quality with no side effects like heartburn. I take it regularly and find it excellent value for money.
Read More
8.8
Heart health benefits
The quality of the fish oil is excellent, with robust packaging and a large jar that lasts long. Omega-3s support heart and blood vessel health as well as joint health, proving effective during winter. I appreciate the effects it has on maintaining my health and preventing osteoporosis.
Read More
8.8
Joint inflammation relief
The taste is enjoyable! Omega-3 fatty acids prevent osteoporosis, especially beneficial for women during menopause. They also support cardiovascular health while improving joint flexibility. The anti-inflammatory properties help alleviate rheumatoid arthritis symptoms, effectively reducing swelling and joint stiffness.
Read More
8.8
Cholesterol management
Age brings challenges, but omega benefits are well-known. Omega-3 fatty acids help maintain normal cholesterol levels and support heart health. They also alleviate pain linked to osteoporosis and improve joint health, making movement easier. The packaging is decent—highly recommended.
Read More
