' 
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
6.9
USERS' SCORE
Excellent
Based on 2 Reviews
9.2
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
**
Polyunsaturated Fat
0.5 g
**
Monounsaturated Fat
0 g
**
Cholesterol
10 mg
3%
Omega-3 Fish Oil
1000 mg
**
EPA (Eicosapentaenoic Acid)
180 mg
**
DHA (Docosahexaenoic Acid)
120 mg
**
Top Medical Research Studies
8
EPA benefits psoriatic skin health
Eicosapentaenoic Acid Influences the Lipid Profile of an In Vitro Psoriatic Skin Model Produced with T Cells.
Direct effect on psoriasis treatment
We aimed to understand how eicosapentaenoic acid (EPA) affects psoriasis, a skin condition known for causing redness, irritation, and thickened skin. By creating skin models that reflect both healthy and psoriatic conditions, we were able to assess the impact of EPA directly on lipid profiles—a key factor in skin health.
Our research revealed that in psoriatic skin models, there was a notable increase in certain fatty acids linked to inflammation, such as arachidonic acid (AA) and linoleic acid (LA). However, when we supplemented the media with EPA, we noticed a significant shift. The levels of beneficial omega-3 fatty acids, including EPA, docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA), rose in both epidermal and dermal tissues.
More importantly, the addition of EPA helped to balance the production of lipid mediators in the skin. We observed increases in several anti-inflammatory molecules, such as prostaglandin E (PGE) and 12-hydroxyeicosapentaenoic acid (12-HEPE), indicating a move toward a more stable and healthier skin environment. These results suggest that EPA could play an important role in managing psoriasis by promoting a healthier lipid balance in the skin, potentially easing symptoms and encouraging skin healing.
Our research revealed that in psoriatic skin models, there was a notable increase in certain fatty acids linked to inflammation, such as arachidonic acid (AA) and linoleic acid (LA). However, when we supplemented the media with EPA, we noticed a significant shift. The levels of beneficial omega-3 fatty acids, including EPA, docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA), rose in both epidermal and dermal tissues.
More importantly, the addition of EPA helped to balance the production of lipid mediators in the skin. We observed increases in several anti-inflammatory molecules, such as prostaglandin E (PGE) and 12-hydroxyeicosapentaenoic acid (12-HEPE), indicating a move toward a more stable and healthier skin environment. These results suggest that EPA could play an important role in managing psoriasis by promoting a healthier lipid balance in the skin, potentially easing symptoms and encouraging skin healing.
Read More
9
Eicosapentaenoic acid benefits psoriasis
n-3 fatty acids in psoriasis.
Directly explores EPA's effects
We assessed the effects of eicosapentaenoic acid (EPA), an omega-3 fatty acid, on psoriasis through intravenous administration in a series of studies. The investigation aimed to understand whether replacing arachidonic acid, which has pro-inflammatory properties, with EPA could be beneficial for patients suffering from psoriasis.
Participants received daily infusions of either an EPA-based lipid emulsion or a conventional n-6 lipid emulsion. Throughout the studies, we closely monitored the clinical progression of psoriasis, along with specific inflammatory markers in the blood.
Our findings were notable: the group receiving the n-3 fatty acid treatment showed a significantly higher response rate. We observed a remarkable tenfold increase in specific products derived from neutrophils, indicating enhanced benefits from EPA. Additionally, plasma levels of EPA rose swiftly within just a few days of treatment.
In summary, our research suggests that intravenous administration of n-3 fatty acids effectively reduces psoriasis symptoms, likely due to alterations in inflammatory processes. This rapid response contrasts sharply with slower improvements seen with oral supplementation of fatty acids.
Participants received daily infusions of either an EPA-based lipid emulsion or a conventional n-6 lipid emulsion. Throughout the studies, we closely monitored the clinical progression of psoriasis, along with specific inflammatory markers in the blood.
Our findings were notable: the group receiving the n-3 fatty acid treatment showed a significantly higher response rate. We observed a remarkable tenfold increase in specific products derived from neutrophils, indicating enhanced benefits from EPA. Additionally, plasma levels of EPA rose swiftly within just a few days of treatment.
In summary, our research suggests that intravenous administration of n-3 fatty acids effectively reduces psoriasis symptoms, likely due to alterations in inflammatory processes. This rapid response contrasts sharply with slower improvements seen with oral supplementation of fatty acids.
Read More
8
Eicosapentaenoic acid shows psoriasis potential
Eicosapentaenoic acid reduces the proportion of IL-17A-producing T cells in a 3D psoriatic skin model.
High relevance to psoriasis treatment
We explored how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, can affect T cells in a model of psoriasis—a chronic skin disease characterized by red, inflamed patches. In our experiment, we used a specialized coculture system with psoriatic keratinocytes and T cells, some of which received a supplement of EPA while others did not. This setup allowed us to observe direct effects of EPA on inflammatory responses associated with psoriasis.
Our findings were promising. We noted that EPA reduced the number of T cells producing the inflammatory marker IL-17A, while increasing the presence of regulatory T cells that help control inflammation. This suggests that EPA might play a role in shifting the immune response in a more favorable direction for those with psoriasis. Moreover, we saw that EPA normalized the excessive growth of keratinocytes and diminished IL-17A levels in our psoriatic skin model.
Additionally, the research revealed that EPA supplementation affected certain signaling pathways in skin cells, potentially contributing to its anti-inflammatory properties. With these results, we believe that EPA has the potential to offer a supportive role in managing psoriasis by modulating T cell responses and reducing inflammation.
Our findings were promising. We noted that EPA reduced the number of T cells producing the inflammatory marker IL-17A, while increasing the presence of regulatory T cells that help control inflammation. This suggests that EPA might play a role in shifting the immune response in a more favorable direction for those with psoriasis. Moreover, we saw that EPA normalized the excessive growth of keratinocytes and diminished IL-17A levels in our psoriatic skin model.
Additionally, the research revealed that EPA supplementation affected certain signaling pathways in skin cells, potentially contributing to its anti-inflammatory properties. With these results, we believe that EPA has the potential to offer a supportive role in managing psoriasis by modulating T cell responses and reducing inflammation.
Read More
Most Useful Reviews
9.5
Nutritional support
Omega-3 polyunsaturated fatty acids (PUFAs) are increasingly recognised for psoriasis. They not only aid in medication but also provide essential nutritional support. DHA and EPA in Omega-3 help stabilise immune functions, leading to reduced inflammation and fewer relapses in psoriasis.
Read More
8.8
Helpful for psoriasis
I have psoriasis, and during my last flare-up, my dermatologist advised me to regularly take Omega. It's a beneficial supplement! My husband and I take it together, and I've even ordered it for my parents.
Read More
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Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
6.9
9
Eicosapentaenoic acid benefits psoriasis
n-3 fatty acids in psoriasis.
Directly explores EPA's effects
We assessed the effects of eicosapentaenoic acid (EPA), an omega-3 fatty acid, on psoriasis through intravenous administration in a series of studies. The investigation aimed to understand whether replacing arachidonic acid, which has pro-inflammatory properties, with EPA could be beneficial for patients suffering from psoriasis.
Participants received daily infusions of either an EPA-based lipid emulsion or a conventional n-6 lipid emulsion. Throughout the studies, we closely monitored the clinical progression of psoriasis, along with specific inflammatory markers in the blood.
Our findings were notable: the group receiving the n-3 fatty acid treatment showed a significantly higher response rate. We observed a remarkable tenfold increase in specific products derived from neutrophils, indicating enhanced benefits from EPA. Additionally, plasma levels of EPA rose swiftly within just a few days of treatment.
In summary, our research suggests that intravenous administration of n-3 fatty acids effectively reduces psoriasis symptoms, likely due to alterations in inflammatory processes. This rapid response contrasts sharply with slower improvements seen with oral supplementation of fatty acids.
Participants received daily infusions of either an EPA-based lipid emulsion or a conventional n-6 lipid emulsion. Throughout the studies, we closely monitored the clinical progression of psoriasis, along with specific inflammatory markers in the blood.
Our findings were notable: the group receiving the n-3 fatty acid treatment showed a significantly higher response rate. We observed a remarkable tenfold increase in specific products derived from neutrophils, indicating enhanced benefits from EPA. Additionally, plasma levels of EPA rose swiftly within just a few days of treatment.
In summary, our research suggests that intravenous administration of n-3 fatty acids effectively reduces psoriasis symptoms, likely due to alterations in inflammatory processes. This rapid response contrasts sharply with slower improvements seen with oral supplementation of fatty acids.
Read More
8
EPA benefits psoriatic skin health
Eicosapentaenoic Acid Influences the Lipid Profile of an In Vitro Psoriatic Skin Model Produced with T Cells.
Direct effect on psoriasis treatment
We aimed to understand how eicosapentaenoic acid (EPA) affects psoriasis, a skin condition known for causing redness, irritation, and thickened skin. By creating skin models that reflect both healthy and psoriatic conditions, we were able to assess the impact of EPA directly on lipid profiles—a key factor in skin health.
Our research revealed that in psoriatic skin models, there was a notable increase in certain fatty acids linked to inflammation, such as arachidonic acid (AA) and linoleic acid (LA). However, when we supplemented the media with EPA, we noticed a significant shift. The levels of beneficial omega-3 fatty acids, including EPA, docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA), rose in both epidermal and dermal tissues.
More importantly, the addition of EPA helped to balance the production of lipid mediators in the skin. We observed increases in several anti-inflammatory molecules, such as prostaglandin E (PGE) and 12-hydroxyeicosapentaenoic acid (12-HEPE), indicating a move toward a more stable and healthier skin environment. These results suggest that EPA could play an important role in managing psoriasis by promoting a healthier lipid balance in the skin, potentially easing symptoms and encouraging skin healing.
Our research revealed that in psoriatic skin models, there was a notable increase in certain fatty acids linked to inflammation, such as arachidonic acid (AA) and linoleic acid (LA). However, when we supplemented the media with EPA, we noticed a significant shift. The levels of beneficial omega-3 fatty acids, including EPA, docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA), rose in both epidermal and dermal tissues.
More importantly, the addition of EPA helped to balance the production of lipid mediators in the skin. We observed increases in several anti-inflammatory molecules, such as prostaglandin E (PGE) and 12-hydroxyeicosapentaenoic acid (12-HEPE), indicating a move toward a more stable and healthier skin environment. These results suggest that EPA could play an important role in managing psoriasis by promoting a healthier lipid balance in the skin, potentially easing symptoms and encouraging skin healing.
Read More
8
Eicosapentaenoic acid shows psoriasis potential
Eicosapentaenoic acid reduces the proportion of IL-17A-producing T cells in a 3D psoriatic skin model.
High relevance to psoriasis treatment
We explored how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, can affect T cells in a model of psoriasis—a chronic skin disease characterized by red, inflamed patches. In our experiment, we used a specialized coculture system with psoriatic keratinocytes and T cells, some of which received a supplement of EPA while others did not. This setup allowed us to observe direct effects of EPA on inflammatory responses associated with psoriasis.
Our findings were promising. We noted that EPA reduced the number of T cells producing the inflammatory marker IL-17A, while increasing the presence of regulatory T cells that help control inflammation. This suggests that EPA might play a role in shifting the immune response in a more favorable direction for those with psoriasis. Moreover, we saw that EPA normalized the excessive growth of keratinocytes and diminished IL-17A levels in our psoriatic skin model.
Additionally, the research revealed that EPA supplementation affected certain signaling pathways in skin cells, potentially contributing to its anti-inflammatory properties. With these results, we believe that EPA has the potential to offer a supportive role in managing psoriasis by modulating T cell responses and reducing inflammation.
Our findings were promising. We noted that EPA reduced the number of T cells producing the inflammatory marker IL-17A, while increasing the presence of regulatory T cells that help control inflammation. This suggests that EPA might play a role in shifting the immune response in a more favorable direction for those with psoriasis. Moreover, we saw that EPA normalized the excessive growth of keratinocytes and diminished IL-17A levels in our psoriatic skin model.
Additionally, the research revealed that EPA supplementation affected certain signaling pathways in skin cells, potentially contributing to its anti-inflammatory properties. With these results, we believe that EPA has the potential to offer a supportive role in managing psoriasis by modulating T cell responses and reducing inflammation.
Read More
8
Eicosapentaenoic acid's indirect effects
Alpha-Linolenic Acid Modulates T Cell Incorporation in a 3D Tissue-Engineered Psoriatic Skin Model.
Study focused on ALA effects
Our study aimed to investigate how eicosapentaenoic acid (EPA) affects psoriasis through its relationship with alpha-linolenic acid (ALA). Using a cutting-edge 3D tissue-engineered model of psoriatic skin, we observed the interaction of activated T cells with keratinocytes, the main cells in our skin. By supplementing the culture media with ALA, we set out to see whether this would help manage the inflammation commonly seen in psoriasis.
What we found was quite fascinating. ALA seemed to shield keratinocytes from excessive growth and abnormal differentiation that often occurs in psoriatic conditions. This meant that less inflammation was present overall. We noted a reduction in the proliferation of T cells, leading to lower levels of inflammatory markers like interleukin-6 and interleukin-8 in our skin models.
While ALA and EPA are closely linked, our study primarily focused on the effects of ALA itself, making it difficult to gauge the effectiveness of EPA alone. Nevertheless, our results indicate that ALA can help modulate the immune response in psoriasis, resulting in less skin inflammation and a healthier skin environment.
What we found was quite fascinating. ALA seemed to shield keratinocytes from excessive growth and abnormal differentiation that often occurs in psoriatic conditions. This meant that less inflammation was present overall. We noted a reduction in the proliferation of T cells, leading to lower levels of inflammatory markers like interleukin-6 and interleukin-8 in our skin models.
While ALA and EPA are closely linked, our study primarily focused on the effects of ALA itself, making it difficult to gauge the effectiveness of EPA alone. Nevertheless, our results indicate that ALA can help modulate the immune response in psoriasis, resulting in less skin inflammation and a healthier skin environment.
Read More
8
EPA's potential in psoriasis management
Biological action of docosahexaenoic acid in a 3D tissue-engineered psoriatic skin model: Focus on the PPAR signaling pathway.
Relevance score indicates strong findings
We investigated how eicosapentaenoic acid (EPA) influences psoriasis, especially in terms of its potential healing effects in a psoriatic skin model. Our experiment involved treating skin substitutes—created using specialized tissue-engineering techniques—with 10 μM of docosahexaenoic acid (DHA), which is converted into EPA in the body. This setup allowed us to observe the interactions and transformations that occur within the skin layers.
We found that incorporating DHA into the treatment led to notable improvements in the skin's health. Specifically, we observed a reduction in abnormal cell behavior in psoriatic skin, which is characterized by excessive scaling and inflammation. Key markers of healthy skin, such as filaggrin and keratin 10, showed increased expression, suggesting a positive change in skin cell differentiation and proliferation.
Additionally, our research indicated that DHA supplementation helped rebalance the expressions of certain receptors involved in inflammatory responses. This ultimately resulted in decreased inflammation, as seen through lower levels of inflammatory substances like TNF-α. By mitigating the hallmarks of psoriasis, EPA holds promise as a beneficial treatment option for managing this challenging skin condition.
We found that incorporating DHA into the treatment led to notable improvements in the skin's health. Specifically, we observed a reduction in abnormal cell behavior in psoriatic skin, which is characterized by excessive scaling and inflammation. Key markers of healthy skin, such as filaggrin and keratin 10, showed increased expression, suggesting a positive change in skin cell differentiation and proliferation.
Additionally, our research indicated that DHA supplementation helped rebalance the expressions of certain receptors involved in inflammatory responses. This ultimately resulted in decreased inflammation, as seen through lower levels of inflammatory substances like TNF-α. By mitigating the hallmarks of psoriasis, EPA holds promise as a beneficial treatment option for managing this challenging skin condition.
Read More
User Reviews
USERS' SCORE
Excellent
Based on 2 Reviews
9.2
9.5
Nutritional support
Omega-3 polyunsaturated fatty acids (PUFAs) are increasingly recognised for psoriasis. They not only aid in medication but also provide essential nutritional support. DHA and EPA in Omega-3 help stabilise immune functions, leading to reduced inflammation and fewer relapses in psoriasis.
Read More
8.8
Helpful for psoriasis
I have psoriasis, and during my last flare-up, my dermatologist advised me to regularly take Omega. It's a beneficial supplement! My husband and I take it together, and I've even ordered it for my parents.
