Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
USERS' SCORE
Good
Based on 50 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Calcium (as Dibasic Calcium Phosphate)
32 mg
2%
5-HTP (5-Hydroxytryptophan)[from Griffonia simplicifolia) (seed)
100 mg
*
Top Medical Research Studies
8
This study explored how the strain WHH2078 can affect anxiety and depression in mice impacted by chronic stress. By administering WHH2078, researchers observed a significant reduction in anxiety-like behaviors over five weeks.
The analysis revealed improved serotonin levels and a healthier gut microbiome, which may have played a role in alleviating these symptoms. While results are promising, it's important to note that these findings are preliminary and primarily observed in animal models.
The analysis revealed improved serotonin levels and a healthier gut microbiome, which may have played a role in alleviating these symptoms. While results are promising, it's important to note that these findings are preliminary and primarily observed in animal models.
Read More
7
5-HTP boosts social exploration in mice
We focused on how 5-hydroxytryptophan (5-HTP) affects anxiety and social behavior in juvenile BALB/c mice, known for their anxiety traits. After testing different treatment combinations, we found that 5-HTP improved social approach behavior and led to more exploration, suggesting a potential decrease in anxiety.
However, we didn’t see any activation of serotonergic neurons in the dorsal raphe nucleus, indicating that other mechanisms might be responsible for these behavioral changes. This means while 5-HTP shows promise, its exact role in anxiety isn't fully clear yet.
However, we didn’t see any activation of serotonergic neurons in the dorsal raphe nucleus, indicating that other mechanisms might be responsible for these behavioral changes. This means while 5-HTP shows promise, its exact role in anxiety isn't fully clear yet.
Read More
8
We examined the effects of YL-0919, a novel medication that functions as both a selective serotonin reuptake inhibitor and a partial serotonin agonist. Through a variety of tests, including models for anxiety and depression, we observed that YL-0919 boosts serotonin levels more effectively than traditional SSRIs.
Our findings indicated significant antidepressant and anxiolytic effects, suggesting that YL-0919 could be a fast-acting treatment with minimal side effects for those struggling with anxiety.
Our findings indicated significant antidepressant and anxiolytic effects, suggesting that YL-0919 could be a fast-acting treatment with minimal side effects for those struggling with anxiety.
Read More
Most Useful Reviews
9
Life-changing effects
59 people found this helpful
5-HTP changed my life. I genuinely dealt with depression and anxiety, always feeling down. Since I started taking this, I feel "more positive", akin to experiencing something good. It’s exactly what I needed and has significantly improved my life for 5 years. If you're feeling low, invest in this; it will help you. You deserve to feel good.
Read More
9
Best discovery
33 people found this helpful
I stumbled upon this supplement, and it's been a transformative experience. Balancing family and work can be overwhelming, but these pills helped me regain my composure. I dealt with worsening anxiety and apathy post-COVID, and taking these has rejuvenated my spirit. I feel like my old self, but even better.
Read More
10
Miracle supplement
31 people found this helpful
This supplement has been nothing short of a miracle for my insomnia, anxiety, and depression since entering menopause. Unlike other medications, it leaves me feeling positive and balanced without sluggishness. I can finally sleep well and function normally throughout the day.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
- All Researches
8
This study explored how the strain WHH2078 can affect anxiety and depression in mice impacted by chronic stress. By administering WHH2078, researchers observed a significant reduction in anxiety-like behaviors over five weeks.
The analysis revealed improved serotonin levels and a healthier gut microbiome, which may have played a role in alleviating these symptoms. While results are promising, it's important to note that these findings are preliminary and primarily observed in animal models.
The analysis revealed improved serotonin levels and a healthier gut microbiome, which may have played a role in alleviating these symptoms. While results are promising, it's important to note that these findings are preliminary and primarily observed in animal models.
Read More
8
We examined the effects of YL-0919, a novel medication that functions as both a selective serotonin reuptake inhibitor and a partial serotonin agonist. Through a variety of tests, including models for anxiety and depression, we observed that YL-0919 boosts serotonin levels more effectively than traditional SSRIs.
Our findings indicated significant antidepressant and anxiolytic effects, suggesting that YL-0919 could be a fast-acting treatment with minimal side effects for those struggling with anxiety.
Our findings indicated significant antidepressant and anxiolytic effects, suggesting that YL-0919 could be a fast-acting treatment with minimal side effects for those struggling with anxiety.
Read More
7
We investigated how inulin, a prebiotic, could help alleviate anxiety and depression-like behaviors, particularly in the context of alcohol withdrawal. Using a specialized mouse model, we found that inulin enhanced beneficial gut bacteria, increased short-chain fatty acids, and improved serotonin metabolism.
This led to a noticeable improvement in anxiety-related behaviors among the mice. These results suggest that inulin might be a viable nutritional strategy to support mental health in individuals with alcohol dependence by targeting the gut-brain connection.
This led to a noticeable improvement in anxiety-related behaviors among the mice. These results suggest that inulin might be a viable nutritional strategy to support mental health in individuals with alcohol dependence by targeting the gut-brain connection.
Read More
7
5-HTP boosts social exploration in mice
We focused on how 5-hydroxytryptophan (5-HTP) affects anxiety and social behavior in juvenile BALB/c mice, known for their anxiety traits. After testing different treatment combinations, we found that 5-HTP improved social approach behavior and led to more exploration, suggesting a potential decrease in anxiety.
However, we didn’t see any activation of serotonergic neurons in the dorsal raphe nucleus, indicating that other mechanisms might be responsible for these behavioral changes. This means while 5-HTP shows promise, its exact role in anxiety isn't fully clear yet.
However, we didn’t see any activation of serotonergic neurons in the dorsal raphe nucleus, indicating that other mechanisms might be responsible for these behavioral changes. This means while 5-HTP shows promise, its exact role in anxiety isn't fully clear yet.
Read More
User Reviews
USERS' SCORE
Good
Based on 50 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Life-changing effects
59 people found this helpful
5-HTP changed my life. I genuinely dealt with depression and anxiety, always feeling down. Since I started taking this, I feel "more positive", akin to experiencing something good. It’s exactly what I needed and has significantly improved my life for 5 years. If you're feeling low, invest in this; it will help you. You deserve to feel good.
Read More
9
Best discovery
33 people found this helpful
I stumbled upon this supplement, and it's been a transformative experience. Balancing family and work can be overwhelming, but these pills helped me regain my composure. I dealt with worsening anxiety and apathy post-COVID, and taking these has rejuvenated my spirit. I feel like my old self, but even better.
Read More
10
Miracle supplement
31 people found this helpful
This supplement has been nothing short of a miracle for my insomnia, anxiety, and depression since entering menopause. Unlike other medications, it leaves me feeling positive and balanced without sluggishness. I can finally sleep well and function normally throughout the day.
Read More
9
Calm and relaxed
13 people found this helpful
So far, this has been working wonders for me! After quitting nicotine, I was plagued with severe anxiety, but this supplement has helped me feel calm and relaxed throughout the day, bringing me back to my normal self.
Read More
9
Mood improvement noted
10 people found this helpful
Best 5-HTP! This truly is a time-release tablet. Other brands did not satisfy me, but this one does. I achieve restful sleep and wake refreshed. It has significantly helped with my anxiety from PTSD, reducing my need for medication. Others have also noticed my improved mood!
Read More
Frequently Asked Questions
9
Optimism restored
7 people found this helpful
After two weeks of use, my mood has notably improved. I feel a wave of optimism wash over me, relieving anxiety and depression. I strongly encourage others to give it a try; my experience has been very positive.
9
Less worry
6 people found this helpful
Daily use of this product has helped me worry less. In the past, anxiety greatly hindered my daily functions. After about two weeks, it relieved the heaviness of anxiety. While not a substitute for scripts if one suffers from clinical depression, it serves as a valuable alternative for mild to moderate anxiety.
9
Alleviates anxiety
3 people found this helpful
Among drugs of the same name I've tried, this one alleviated my anxiety better than the others. I took half a tablet in the morning and evening, achieving a good prolonged effect. Sometimes just one dose was sufficient for the entire day. I recommend this supplement.
9
Best discovery
33 people found this helpful
I stumbled upon this supplement, and it's been a transformative experience. Balancing family and work can be overwhelming, but these pills helped me regain my composure. I dealt with worsening anxiety and apathy post-COVID, and taking these has rejuvenated my spirit. I feel like my old self, but even better.
10
Life saver
6 people found this helpful
I've battled anxiety for ages, and Natrol has become my lifeline. It not only eases my anxiety but also restores my confidence, which anxiety used to diminish. I feel a significant difference after taking it – my anxiety has largely vanished, and I now possess a sense of joy.
9
Mood improvement
3 people found this helpful
5-Hydroxytryptophan is an amino acid and a precursor of serotonin, which helps remove anxiety, irritability, and aggression while improving overall mood and concentration. This high-quality product from a well-known brand is fairly priced and effective in enhancing performance.
7.5
Effective combo
5-HTP has significantly helped me with my anxiety! Combined with vitamin D, it makes a real difference.
6
Effective for mild symptoms
2 people found this helpful
After using this product for over a year, I've stopped relying on anti-depressants. When symptoms reappear, I take this tablet for two days, and they vanish. It's my go-to for managing mild symptoms of depression and anxiety when necessary.
8
Improved daily life
2 people found this helpful
Taking one tablet in the morning significantly eases my day. I've noticed that incidents causing trouble feel less prolonged, allowing me to switch feelings more swiftly. I am grateful for this medication, especially since I cannot combine it with St John's Wort.
9
Alleviates symptoms
This quality product is effective; taking one tablet daily is sufficient to alleviate symptoms of anxiety and stress.
7
We investigated how inulin, a prebiotic, could help alleviate anxiety and depression-like behaviors, particularly in the context of alcohol withdrawal. Using a specialized mouse model, we found that inulin enhanced beneficial gut bacteria, increased short-chain fatty acids, and improved serotonin metabolism.
This led to a noticeable improvement in anxiety-related behaviors among the mice. These results suggest that inulin might be a viable nutritional strategy to support mental health in individuals with alcohol dependence by targeting the gut-brain connection.
This led to a noticeable improvement in anxiety-related behaviors among the mice. These results suggest that inulin might be a viable nutritional strategy to support mental health in individuals with alcohol dependence by targeting the gut-brain connection.
7
5-HTP boosts social exploration in mice
We focused on how 5-hydroxytryptophan (5-HTP) affects anxiety and social behavior in juvenile BALB/c mice, known for their anxiety traits. After testing different treatment combinations, we found that 5-HTP improved social approach behavior and led to more exploration, suggesting a potential decrease in anxiety.
However, we didn’t see any activation of serotonergic neurons in the dorsal raphe nucleus, indicating that other mechanisms might be responsible for these behavioral changes. This means while 5-HTP shows promise, its exact role in anxiety isn't fully clear yet.
However, we didn’t see any activation of serotonergic neurons in the dorsal raphe nucleus, indicating that other mechanisms might be responsible for these behavioral changes. This means while 5-HTP shows promise, its exact role in anxiety isn't fully clear yet.
8
This study explored how the strain WHH2078 can affect anxiety and depression in mice impacted by chronic stress. By administering WHH2078, researchers observed a significant reduction in anxiety-like behaviors over five weeks.
The analysis revealed improved serotonin levels and a healthier gut microbiome, which may have played a role in alleviating these symptoms. While results are promising, it's important to note that these findings are preliminary and primarily observed in animal models.
The analysis revealed improved serotonin levels and a healthier gut microbiome, which may have played a role in alleviating these symptoms. While results are promising, it's important to note that these findings are preliminary and primarily observed in animal models.
8
We examined the effects of YL-0919, a novel medication that functions as both a selective serotonin reuptake inhibitor and a partial serotonin agonist. Through a variety of tests, including models for anxiety and depression, we observed that YL-0919 boosts serotonin levels more effectively than traditional SSRIs.
Our findings indicated significant antidepressant and anxiolytic effects, suggesting that YL-0919 could be a fast-acting treatment with minimal side effects for those struggling with anxiety.
Our findings indicated significant antidepressant and anxiolytic effects, suggesting that YL-0919 could be a fast-acting treatment with minimal side effects for those struggling with anxiety.
References
- Li K, Wei W, Xu C, Lian X, Bao J, et al. Prebiotic inulin alleviates anxiety and depression-like behavior in alcohol withdrawal mice by modulating the gut microbiota and 5-HT metabolism. Phytomedicine. 2024;135:156181. 10.1016/j.phymed.2024.156181
- Russo AM, Payet JM, Kent S, Lesku JA, Lowry CA, et al. Acute treatment with 5-hydroxytryptophan increases social approach behaviour but does not activate serotonergic neurons in the dorsal raphe nucleus in juvenile male BALB/c mice: A model of human disorders with deficits of sociability. J Psychopharmacol. 2022;36:806. 10.1177/02698811221089039
- Gao K, Farzi A, Ke X, Yu Y, Chen C, et al. Oral administration of WHH2078 alleviates depressive and anxiety symptoms in mice with induced chronic stress. Food Funct. 2022;13:957. 10.1039/d1fo03723d
- Zhang LM, Wang XY, Zhao N, Wang YL, Hu XX, et al. Neurochemical and behavioural effects of hypidone hydrochloride (YL-0919): a novel combined selective 5-HT reuptake inhibitor and partial 5-HT agonist. Br J Pharmacol. 2017;174:769. 10.1111/bph.13675
