Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.6
USERS' SCORE
Good
Based on 31 Reviews
8.4
Supplement Facts
Serving Size:  1 Tablet
Amount Per Serving
%DV
Iron (as ferrous sulfate)
65 mg
361%

Top Medical Research Studies

We examined how iron treatment specifically impacts anemia, particularly during pregnancy. Iron deficiency is a leading cause of anemia, and finding the right treatment is crucial for both mothers and their developing babies.

Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.

However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
Read More
8
Iron treatment and CKD anemia
We explored the critical relationship between iron treatment and anemia in chronic kidney disease (CKD). Anemia often arises in CKD patients, whether they are on dialysis or not, primarily due to erythropoietin deficiency. However, iron deficiency plays a significant role and can be categorized into absolute, caused by blood loss, or functional, which is affected by inflammation and high levels of hepcidin.

Hepcidin impedes the body’s ability to use iron effectively, trapping it where it's not accessible for red blood cell production. This disruption in iron metabolism also means that oral iron supplements may not work well, especially in advanced CKD. Therefore, we reviewed various intravenous (IV) iron formulations available for treatment and outlined the diagnostic criteria and treatment benchmarks for iron deficiency in CKD patients.

Our findings led us to consider future therapeutic directions to improve patient outcomes. With advancements in the understanding of iron’s role in this context, the hope is to enhance treatment strategies for managing anemia in CKD effectively.
Read More
8
Ferric Carboxymaltose Replaces Iron Sucrose
We aimed to find a better way to manage anemia in pediatric patients undergoing hemodialysis. Traditionally, these patients receive intravenous (IV) iron therapy using iron sucrose, which requires frequent treatments and carries a risk of allergic reactions. Moving forward with a home hemodialysis program, we investigated ferric carboxymaltose as a safer and more effective alternative.

In our study, we looked closely at how ferric carboxymaltose performed in maintaining healthy levels of hemoglobin, transferrin saturation, and reticulocyte hemoglobin content over a 12-month period. We also compared its efficacy against traditional iron sucrose treatments. The results were encouraging, showing that ferric carboxymaltose not only matched the effectiveness of iron sucrose but also required fewer hospital visits, significantly easing the treatment burden on families.

Overall, our findings suggest that ferric carboxymaltose is both clinically effective and cost-efficient. By reducing the frequency of administration, this approach can enhance the quality of life for pediatric patients with anemia due to chronic kidney disease who depend on hemodialysis. We believe this innovation presents a promising shift in anemia management for this vulnerable population.
Read More

Most Useful Reviews

9
Best brand found
101 people found this helpful
I had been dealing with chronic, sometimes severe anaemia and tried various prescription supplements that caused nausea. Eventually, I discovered these Nature Made iron supplements, which have no side effects. After sufficient time, I no longer feel the effects of anaemia, and my lab results often show normal ranges. I've found that taking one pill every other day maintains my health effectively. If others have not worked for you or made you feel ill, consider giving this brand a try.
Read More
9
Cured pica disorder
26 people found this helpful
Helped with my pica disorder! I am so pleased I decided to start taking iron. I chose this specific supplement because I already occasionally use their melatonin pills. This iron has been incredibly beneficial. After my first pregnancy, I developed a strong urge to consume uncooked rice daily, which has had detrimental effects on my health. Through research, I discovered that I have a condition known as pica, often linked to iron deficiency/anemia. I have been close to anaemic but didn't receive a prescription from my doctor. However, after taking this iron for a week, the desire to eat rice has completely vanished! I'm ecstatic to share this change in my life, as it feels monumental. If you experience similar issues, please consult your doctor before trying this.
Read More
9
Stable anemia
19 people found this helpful
Very effective! I have slight anaemia and an iron supplement was recommended by our family doctor a few years ago. I have used them with good results, and my anaemia has improved and is stable. I would recommend them to anyone needing a boost of iron.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.6
  • All Researches
We examined how iron treatment specifically impacts anemia, particularly during pregnancy. Iron deficiency is a leading cause of anemia, and finding the right treatment is crucial for both mothers and their developing babies.

Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.

However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
Read More
9.5
Identifying and treating hookworm infection
We explored the challenges of diagnosing hookworm infections, particularly in severe cases. By using both morphological and molecular methods, we successfully identified a 75-year-old woman suffering from anemia linked to the hookworm species, Necator americanus. After confirming the infection through various tests, we initiated treatment with albendazole. Following this, we observed a significant improvement in her condition, with both the hookworm and her anemia effectively resolved.
Read More
9
Iron supplementation effects on anemia
We explored the impact of iron and folic acid supplementation on children suffering from mild-to-moderate anemia in India. This study specifically aimed to assess how effective iron treatments are in improving overall hemoglobin levels and reducing anemia symptoms.

The research consisted of controlled trials where groups of children received iron supplements, while others did not. By comparing these groups, we aimed to determine if there was a significant difference in the rates of recovery from anemia.

While we hoped for positive outcomes from the supplementation, the findings showed mixed results. In some cases, we observed improvements in hemoglobin levels, but the overall effectiveness was not as pronounced as anticipated. It's essential to take these findings into account when considering future strategies for combating anemia in children.

Our analysis highlights that while iron supplementation is a crucial piece of the puzzle for treating anemia, it’s also clear that additional factors may play significant roles in achieving optimal health outcomes for affected children.
Read More
9
Serum hepcidin aids anemia diagnosis
We explored the effectiveness of serum hepcidin levels in diagnosing types of anemia in elderly patients, specifically focusing on iron deficiency anemia (IDA) and anemia of chronic disease (ACD). By studying a group of 100 elderly patients alongside 15 healthy controls, we aimed to find a less invasive way to distinguish between these two common conditions.

Through our evaluation, we observed significant differences in iron levels and hepcidin concentrations between patients with IDA and those with ACD. We discovered that serum hepcidin could effectively differentiate between the two types of anemia, boasting a remarkable sensitivity of 93.9% and a specificity of 92.2%. This points to hepcidin as a promising alternative to the traditional bone marrow iron study.

Interestingly, while hepcidin is a valuable marker, relying solely on it can lead to misdiagnoses, similar concerns arise with ferritin levels. Our findings suggest that combining hepcidin with the iron profile provides a more accurate assessment and could potentially replace more invasive diagnostic methods for anemia in the elderly. Overall, we find this combined approach to be a vital step forward in understanding and treating anemia related to iron levels.
Read More
We investigated the combination of Roxadustat, a newer treatment for anemia related to chronic kidney disease (CKD), alongside polysaccharide-iron complex (PIC) in rats. By dividing them into different groups, we observed how various doses of iron impacted hemoglobin levels and kidney function. The results showed that this combination significantly improved hemoglobin levels and kidney health. Importantly, adequate iron supply early on was crucial for effective anemia treatment. Combining these therapies appears beneficial in addressing anemia in CKD effectively.
Read More

User Reviews

USERS' SCORE
Good
Based on 31 Reviews
8.4
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Best brand found
101 people found this helpful
I had been dealing with chronic, sometimes severe anaemia and tried various prescription supplements that caused nausea. Eventually, I discovered these Nature Made iron supplements, which have no side effects. After sufficient time, I no longer feel the effects of anaemia, and my lab results often show normal ranges. I've found that taking one pill every other day maintains my health effectively. If others have not worked for you or made you feel ill, consider giving this brand a try.
Read More
9
Cured pica disorder
26 people found this helpful
Helped with my pica disorder! I am so pleased I decided to start taking iron. I chose this specific supplement because I already occasionally use their melatonin pills. This iron has been incredibly beneficial. After my first pregnancy, I developed a strong urge to consume uncooked rice daily, which has had detrimental effects on my health. Through research, I discovered that I have a condition known as pica, often linked to iron deficiency/anemia. I have been close to anaemic but didn't receive a prescription from my doctor. However, after taking this iron for a week, the desire to eat rice has completely vanished! I'm ecstatic to share this change in my life, as it feels monumental. If you experience similar issues, please consult your doctor before trying this.
Read More
9
Stable anemia
19 people found this helpful
Very effective! I have slight anaemia and an iron supplement was recommended by our family doctor a few years ago. I have used them with good results, and my anaemia has improved and is stable. I would recommend them to anyone needing a boost of iron.
Read More
10
Lifesaver supplement
5 people found this helpful
This has worked wonders for me. I struggled with my anaemia, which caused prolonged bleeding for over 90 days. After I started taking this supplement, I have stopped bleeding and no longer feel exhausted. It's truly a lifesaver. If you need iron support, I highly recommend this!
Read More
7.5
Improved appetite
5 people found this helpful
Those with anemia and poor appetite can benefit from this product. I had anemia, hair loss, and fatigue, but after using it, I felt much better. The key is to continue taking it without experiencing constipation like other iron supplements.
Read More

Frequently Asked Questions

9
Enhanced energy
4 people found this helpful
On the second day, I felt a surge of cheerfulness from this supplement. It works well for my anemia at a low price. My training with weights feels easier now. Thank you for the quick delivery!
7.5
Quick effects
1 people found this helpful
These pills worked quickly for my anemia, with noticeable effects within a week. My skin tone has improved, and energy levels stabilised. Just a tip: take them before meals to avoid stomach pain. Overall, I’m very satisfied.
9
Increased well-being
2 people found this helpful
This product has helped me significantly. With my anemia, I used to feel light-headed and tired. After a week and a half of taking it, I feel much better and would definitely recommend it.
10
Anemia improved
1 people found this helpful
I've used this for several years. I discovered I was suffering from anemia during a health check, and other iron supplements had little effect. After trying American supplements, my anemia improved and disappeared by my next health check the following year. I felt their effects and have continued using them for about four years.
7.5
Reduced fatigue
3 people found this helpful
This supplement greatly benefits those with anemia and a poor appetite. I experienced improvements in hair loss, appetite, and energy levels. It’s essential to take it consistently without the constipation issues of other iron supplements.
7.5
Postpartum recovery
1 people found this helpful
After using this product from pregnancy to postpartum, I feel much better and less susceptible to anemia.
6
Eases symptoms
1 people found this helpful
I noticed the redness on the back of my eyelids increased the next day after consuming these. I have experimented with various remedies for chronic anemia, but initially experienced mild heartburn due to the high iron content.
7.5
Improved appetite
5 people found this helpful
Those with anemia and poor appetite can benefit from this product. I had anemia, hair loss, and fatigue, but after using it, I felt much better. The key is to continue taking it without experiencing constipation like other iron supplements.
7.5
Supports health
A good iron supplement that I can't fault. It's beneficial for anemia and overall health. It’s a gentle option for iron if you're worried about stomach discomfort; I experienced none while taking this compared to past products.
7.5
Eases anemia
I believe the high concentration of iron (65mg) helps alleviate my anemia. The pills are small and easy to take without causing stress. I take them 3-4 times a week as needed rather than daily.
8
Ferric Carboxymaltose Replaces Iron Sucrose
We aimed to find a better way to manage anemia in pediatric patients undergoing hemodialysis. Traditionally, these patients receive intravenous (IV) iron therapy using iron sucrose, which requires frequent treatments and carries a risk of allergic reactions. Moving forward with a home hemodialysis program, we investigated ferric carboxymaltose as a safer and more effective alternative.

In our study, we looked closely at how ferric carboxymaltose performed in maintaining healthy levels of hemoglobin, transferrin saturation, and reticulocyte hemoglobin content over a 12-month period. We also compared its efficacy against traditional iron sucrose treatments. The results were encouraging, showing that ferric carboxymaltose not only matched the effectiveness of iron sucrose but also required fewer hospital visits, significantly easing the treatment burden on families.

Overall, our findings suggest that ferric carboxymaltose is both clinically effective and cost-efficient. By reducing the frequency of administration, this approach can enhance the quality of life for pediatric patients with anemia due to chronic kidney disease who depend on hemodialysis. We believe this innovation presents a promising shift in anemia management for this vulnerable population.
8
Effective iron treatment for anemia
We examined how well low-dose ferric carboxymaltose (FCM) works compared to oral ferrous sulfate for treating anemia in postpartum East Asian women. In a randomized controlled trial, we found that FCM led to a bigger boost in hemoglobin levels after two weeks and improved iron stores at four weeks.

While the overall hemoglobin increase was similar at four weeks, FCM users reported fewer gastrointestinal side effects, like nausea and constipation. This suggests that low-dose FCM could be a better choice for managing postpartum anemia due to its effectiveness and better tolerance.

References

  1. Preston R, Theodorou D, Sinnott K, Wallace D, Kaur A. A cost-effective innovation in anaemia management for paediatric patients with haemodialysis-dependent chronic kidney disease. Pediatr Nephrol. 2025. 10.1007/s00467-025-06680-x
  2. Upadhyay RP, Chowdhury R, Mundra S, Taneja S, Jacob M, et al. Comparative effectiveness of daily therapeutic supplementation with multiple micronutrients and iron-folic acid versus iron-folic acid alone in children with mild-to-moderate anaemia in rural India: an open-label, randomised controlled trial. Lancet Glob Health. 2025;13:e497. 10.1016/S2214-109X(24)00559-X
  3. Thomas T, Kurpad A. Childhood iron-folic acid supplementation in India for mild-to-moderate anaemia. Lancet Glob Health. 2025;13:e383. 10.1016/S2214-109X(25)00053-1
  4. Babah OA, Beňová L, Larsson EC, Hanson C, Afolabi BB. Is an improvement in anaemia and iron levels associated with the risk of early postpartum depression? A cohort study from Lagos, Nigeria. BMC Public Health. 2025;25:808. 10.1186/s12889-025-21942-x
  5. Crispell EH, Cassianni CE, Burt JM, Gonzalez JA, Petsch JL, et al. Design and Staged Implementation of a Multidisciplinary Preoperative Anemia Clinic at a Tertiary Care Medical Center. Anesth Analg. 2025. 10.1213/ANE.0000000000007435
  6. Akpan IJ, Narang M, Zampaglione E, Marshall S, Stefanik D. Iron deficiency anemia in patients with heavy menstrual bleeding: The patients' perspective from diagnosis to treatment. Womens Health (Lond). 2025;21:17455057251321221. 10.1177/17455057251321221
  7. Khalaf K, Fujiyoshi Y, Bechara R. Endoscopic and clinical characteristics of autoimmune atrophic gastritis: Retrospective study. Endosc Int Open. 2025;13:a24774666. 10.1055/a-2477-4666
  8. White F, Polakowski N, Merlington E, Leimanis M, Dudick B, et al. Intravenous Sodium Ferric Gluconate Complex for Hospitalized Pediatric Patients with Iron Deficiency Anemia. Children (Basel). 2025;12. 10.3390/children12020189
  9. Maidana D, Arroyo-Álvarez A, Barreres-Martín G, Arenas-Loriente A, Cepas-Guillen P, et al. Targeting Inflammation and Iron Deficiency in Heart Failure: A Focus on Older Adults. Biomedicines. 2025;13. 10.3390/biomedicines13020462
  10. McDonnell T, Kalra PA. Iron in Chronic Kidney Disease and End-Stage Kidney Disease-Current Trends and Future Direction. Br J Hosp Med (Lond). 2025;86:1. 10.12968/hmed.2024.0619
  11. Orlova P, Meshkov I, Sharikov S, Frolov V, Skuredina A, et al. Amidated and Aminated PMSSO-Hydrogels as a Promising Enzyme-Sensitive Vehicle for Antianemic Drugs. Gels. 2025;11. 10.3390/gels11020118
  12. Al Kindi S, Al-Mamari A, Al-Zadjali S, Al-Rawahi M, Al Madhani A, et al. Case report: A novel 11-bp deletion in exon 11 causing a frameshift in the C-terminal of the gene leading to X-linked sideroblastic anemia-a family study. Front Med (Lausanne). 2024;11:1452873. 10.3389/fmed.2024.1452873
  13. Manna S, Chakrabarti SS, Singh R, Gambhir IS. Serum hepcidin level with iron profile assay might replace bone marrow iron study as a diagnostic tool for evaluation of anemia in elderly without chronic renal disease. J Family Med Prim Care. 2025;14:356. 10.4103/jfmpc.jfmpc_34_24
  14. Kranke P, Weiniger CF, Sultan P, Achebe MO, Filipescu D, et al. Iron deficiency and anemia in pregnancy: a call to action!: -"If you don't take a temperature, you can't find a fever". Int J Obstet Anesth. 2024;62:104298. 10.1016/j.ijoa.2024.104298
  15. Larson LM, Baldi A, Hasan MI, Jones N, Pickle EO, et al. Role of hepcidin on benefits and risks of supplementation with iron syrup and multiple micronutrient powders in Bangladeshi children: a sub-study to a randomized controlled trial. Am J Clin Nutr. 2025. 10.1016/j.ajcnut.2025.02.018
  16. Fijn R, Ablij HC, Knoester PD, Witte AMC. Real-world evaluation of an intravenous iron service for the treatment of iron deficiency with or without anemia. Sci Rep. 2025;15:12093. 10.1038/s41598-025-85880-9
  17. Bhutta ZA, Keats EC, Owais A, González-Fernández D, Udomkesmalee E, et al. What works for anemia reduction among women of reproductive age? Synthesized findings from the exemplars in anemia project. Am J Clin Nutr. 2025;121 Suppl 1:S68. 10.1016/j.ajcnut.2024.11.031
  18. Owais A, Habib A, Ahsan H, Merritt CE, Lee C, et al. Drivers of anemia reduction among women of reproductive age in Pakistan: a mixed-methods country case study. Am J Clin Nutr. 2025;121 Suppl 1:S46. 10.1016/j.ajcnut.2024.04.037
  19. Duan Y, Xu Y, Wei Y, Liu T, Xu T, et al. Bilateral segmental testicular infarction secondary to iron deficiency anemia: a case report. BMC Urol. 2025;25:70. 10.1186/s12894-025-01756-0
  20. Warner MA, Johnson ML, Hanson AC, Fortune E, Flaby GW, et al. Practical Anemia Bundle and Hemoglobin Recovery in Critical Illness: A Randomized Clinical Trial. JAMA Netw Open. 2025;8:e252353. 10.1001/jamanetworkopen.2025.2353
  21. Hidayat MT, Khadijah Maharani SN, Ramadhany ID, Khairani NI, Rahman NA, et al. Controlled release of deferiprone using iron-responsive nanoparticles integrated with dissolving microneedle for novel alternative treatments of β-thalassemia major. Eur J Pharm Biopharm. 2025;210:114702. 10.1016/j.ejpb.2025.114702
  22. Al-Taiar A, Ziyab AH, Hammoud MS, Al-Sabah R, Akhtar S. Anemia in pregnant women: findings from Kuwait birth cohort study. BMC Pregnancy Childbirth. 2025;25:326. 10.1186/s12884-025-07439-w
  23. Sohn SH, Sul H, Kim B, Zang D. Effects of Darbepoetin Alfa and Ferric Derisomaltose Plus Darbepoetin Alfa in Functional Iron-Deficiency Anemia. Int J Mol Sci. 2025;26. 10.3390/ijms26052203
  24. Nagao T, Takahashi K, Takahashi S, Yokomizo R, Samura O, et al. Low-dose ferric carboxymaltose vs. oral iron for improving hemoglobin levels in postpartum East Asian women: A randomized controlled trial. PLoS One. 2025;20:e0319795. 10.1371/journal.pone.0319795
  25. Ozeki Y, Kato J, Ohta Y, Taida T, Horio R, et al. [Efficacy and safety of ferric carboxymaltose in patients with inflammatory bowel disease]. Nihon Shokakibyo Gakkai Zasshi. 2025;122:196. 10.11405/nisshoshi.122.196
  26. Gao Z, Gao Y, Wang Q, Wang Q, Lu P, et al. Study on HIF-PHI combined with iron supplement in treatment of renal anemia in rats. BMC Nephrol. 2025;26:125. 10.1186/s12882-025-04045-y
  27. Liu X, Sun A, Zheng X, Xia M, Liu Y, et al. Combined morphological and molecular approaches to the clinical diagnosis of Necator americanus infection: a case report. J Med Case Rep. 2025;19:100. 10.1186/s13256-025-05105-5
  28. Zhang H, Sun W, Qi J, Qayum A, Li J, et al. Antianemic Activity, Inhibition of Oxidative Stress, and Iron Supplementation in Mice with Iron-Deficiency Anemia through HG-Hawthorn Pectin-Iron(III) Complexes. ACS Appl Bio Mater. 2025;8:2419. 10.1021/acsabm.4c01905
  29. Dogan Y, Dede AM, Erdoğan A. An unusual association: gastric xanthelasma presenting with iron deficiency anemia: a case report. J Med Case Rep. 2025;19:98. 10.1186/s13256-025-05133-1
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