Overview
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6
USERS' SCORE
Moderately Good
Based on 21 Reviews
7.7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Iron (as ferrous sulfate)
65 mg
361%
Top Medical Research Studies
9
We assessed how iron supplementation impacts blood donors who may suffer from low iron levels. Our analysis included thirty studies with nearly 4,700 participants, focusing on the differences between those receiving iron and those who didn’t.
We found that iron supplements reduced the chances of donors being deferred due to low hemoglobin levels and helped elevate their hemoglobin and iron stores. However, we also noted more side effects, like constipation and nausea, among those taking iron.
These side effects hinder its widespread use, suggesting iron supplements should be targeted to at-risk individuals only.
We found that iron supplements reduced the chances of donors being deferred due to low hemoglobin levels and helped elevate their hemoglobin and iron stores. However, we also noted more side effects, like constipation and nausea, among those taking iron.
These side effects hinder its widespread use, suggesting iron supplements should be targeted to at-risk individuals only.
Read More
8
Infant formula impacts stool consistency
We evaluated how different infant formulas affect the stool characteristics of infants. Two clinical studies focused on infants transitioning from exclusive breastfeeding to formula feeding and those already on formula.
Parents recorded each infant's feeding tolerance, spit-up occurrences, and stool characteristics during the trials. Our findings revealed that the composition of the formula impacts stool consistency.
Specifically, infants consuming formula A exhibited softer stools and more frequent bowel movements compared to those on formula B, which may help lessen concerns about constipation associated with iron-fortified options.
Parents recorded each infant's feeding tolerance, spit-up occurrences, and stool characteristics during the trials. Our findings revealed that the composition of the formula impacts stool consistency.
Specifically, infants consuming formula A exhibited softer stools and more frequent bowel movements compared to those on formula B, which may help lessen concerns about constipation associated with iron-fortified options.
Read More
5
Constipation prevalence linked to iron
We investigated the prevalence and contributing factors of constipation among healthy pregnant women over the course of their pregnancy. Our longitudinal study showed that constipation affects about 24% of women during various stages of pregnancy and even postpartum.
Notably, we found that iron supplementation was linked to a higher risk of constipation. This means that while iron is an important nutrient during pregnancy, it may also contribute to discomfort for some women.
These findings highlight the importance of monitoring bowel health as part of prenatal care.
Notably, we found that iron supplementation was linked to a higher risk of constipation. This means that while iron is an important nutrient during pregnancy, it may also contribute to discomfort for some women.
These findings highlight the importance of monitoring bowel health as part of prenatal care.
Read More
Most Useful Reviews
9
Increased energy levels
1 people found this helpful
Excellent! I bought Nature Made Iron 65 mg to tackle my iron deficiency issues. After a few weeks, the tablets are easy to swallow and did not cause any issues like constipation. I felt more energetic, and my skin, hair, and nails improved. I followed the recommended dosage, and the price for 180 tablets is quite reasonable. I am very pleased and will continue using it for my health.
Read More
9
No side effects experienced
1 people found this helpful
Excellent for those with iron deficiency. The iron dose is high as a supplement and does not cause side effects such as constipation.
Read More
10
No constipation
I'm really enjoying it! I feel great! There has been no constipation at all.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 11 Researches
6
- All Researches
9
We assessed how iron supplementation impacts blood donors who may suffer from low iron levels. Our analysis included thirty studies with nearly 4,700 participants, focusing on the differences between those receiving iron and those who didn’t.
We found that iron supplements reduced the chances of donors being deferred due to low hemoglobin levels and helped elevate their hemoglobin and iron stores. However, we also noted more side effects, like constipation and nausea, among those taking iron.
These side effects hinder its widespread use, suggesting iron supplements should be targeted to at-risk individuals only.
We found that iron supplements reduced the chances of donors being deferred due to low hemoglobin levels and helped elevate their hemoglobin and iron stores. However, we also noted more side effects, like constipation and nausea, among those taking iron.
These side effects hinder its widespread use, suggesting iron supplements should be targeted to at-risk individuals only.
Read More
8
This study examined the connection between gastrointestinal issues, particularly constipation, and depression in patients with iron deficiency anemia (IDA).
Conducted at Trakya University, the case-control study involved 125 IDA patients and 57 healthy individuals.
We found that IDA patients reported constipation significantly more often than the control group, with 56% experiencing this symptom. Additionally, their self-reported intensity of bloating and dyspepsia was notably higher, indicating a clear link between IDA, gastrointestinal discomfort, and potential mental health challenges.
Conducted at Trakya University, the case-control study involved 125 IDA patients and 57 healthy individuals.
We found that IDA patients reported constipation significantly more often than the control group, with 56% experiencing this symptom. Additionally, their self-reported intensity of bloating and dyspepsia was notably higher, indicating a clear link between IDA, gastrointestinal discomfort, and potential mental health challenges.
Read More
8
Infant formula impacts stool consistency
We evaluated how different infant formulas affect the stool characteristics of infants. Two clinical studies focused on infants transitioning from exclusive breastfeeding to formula feeding and those already on formula.
Parents recorded each infant's feeding tolerance, spit-up occurrences, and stool characteristics during the trials. Our findings revealed that the composition of the formula impacts stool consistency.
Specifically, infants consuming formula A exhibited softer stools and more frequent bowel movements compared to those on formula B, which may help lessen concerns about constipation associated with iron-fortified options.
Parents recorded each infant's feeding tolerance, spit-up occurrences, and stool characteristics during the trials. Our findings revealed that the composition of the formula impacts stool consistency.
Specifically, infants consuming formula A exhibited softer stools and more frequent bowel movements compared to those on formula B, which may help lessen concerns about constipation associated with iron-fortified options.
Read More
7
Iron's minimal effect on constipation
We explored the effects of low-dose iron supplementation on gastrointestinal complaints, particularly constipation, in pregnant women. Conducting two randomized studies, we aimed to determine how different forms of iron—ferrous fumarate, ferrous bisglycinate, and ferrous sulphate—would affect the frequency of GI issues among healthy women throughout their pregnancy.
Through our investigations, we found that constipation was only significantly associated with higher doses of ferrous fumarate (80 mg/day). Interestingly, women taking lower doses of ferrous fumarate (20-60 mg/day) did not report more GI side effects, indicating that manageable doses of iron may be tolerated without significant worry about constipation.
Among the iron formulas tested, ferrous bisglycinate at 25 mg showed the best profile, resulting in fewer GI complaints overall compared to the others. In fact, it was linked to a lower incidence of black stools, which can often be associated with iron intake. Ultimately, we observed that while low-dose iron supplementation might incur some side effects, they are generally not severe enough to warrant a change in dosage or interruption of treatment.
Through our investigations, we found that constipation was only significantly associated with higher doses of ferrous fumarate (80 mg/day). Interestingly, women taking lower doses of ferrous fumarate (20-60 mg/day) did not report more GI side effects, indicating that manageable doses of iron may be tolerated without significant worry about constipation.
Among the iron formulas tested, ferrous bisglycinate at 25 mg showed the best profile, resulting in fewer GI complaints overall compared to the others. In fact, it was linked to a lower incidence of black stools, which can often be associated with iron intake. Ultimately, we observed that while low-dose iron supplementation might incur some side effects, they are generally not severe enough to warrant a change in dosage or interruption of treatment.
Read More
7
We carefully looked at the impact of lactoferrin (Lf) on treating iron deficiency anemia (IDA) in children, especially focusing on its connection to constipation. In an extensive review of 11 studies, including 10 randomized controlled trials, we saw promising results where children receiving Lf showed notable improvements in their hemoglobin and serum ferritin levels compared to those who only received iron or a placebo.
Interestingly, we found that while some adverse effects like constipation, vomiting, and abdominal pain were reported, those treated with Lf experienced a significant decrease in constipation. This suggests that Lf not only helps in boosting iron levels but may also be easier on the digestive system than traditional iron supplements.
Overall, our exploration indicates that incorporating lactoferrin in the treatment of IDA in children not only helps address anemia effectively but also might provide a gentler alternative for the gut. Users considering iron supplements for their children might find lactoferrin to be a beneficial option.
Interestingly, we found that while some adverse effects like constipation, vomiting, and abdominal pain were reported, those treated with Lf experienced a significant decrease in constipation. This suggests that Lf not only helps in boosting iron levels but may also be easier on the digestive system than traditional iron supplements.
Overall, our exploration indicates that incorporating lactoferrin in the treatment of IDA in children not only helps address anemia effectively but also might provide a gentler alternative for the gut. Users considering iron supplements for their children might find lactoferrin to be a beneficial option.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 21 Reviews
7.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Increased energy levels
1 people found this helpful
Excellent! I bought Nature Made Iron 65 mg to tackle my iron deficiency issues. After a few weeks, the tablets are easy to swallow and did not cause any issues like constipation. I felt more energetic, and my skin, hair, and nails improved. I followed the recommended dosage, and the price for 180 tablets is quite reasonable. I am very pleased and will continue using it for my health.
Read More
9
No side effects experienced
1 people found this helpful
Excellent for those with iron deficiency. The iron dose is high as a supplement and does not cause side effects such as constipation.
Read More
10
No constipation
I'm really enjoying it! I feel great! There has been no constipation at all.
Read More
10
No constipation
The quantity is substantial, and the quality is excellent. It quickly raises iron levels and does not cause constipation. I believe it's the best iron pill.
Read More
10
No constipation
This mild iron supplement is perfect for anaemia and iron deficiencies. It's easily absorbed and does not cause constipation.
Read More
Frequently Asked Questions
9
No constipation
I've been using it for two weeks and haven't had any tummy issues like cramps. I also haven't experienced constipation, unlike with other brands.
9
Improves excretion
1 people found this helpful
This excellent product did not cause constipation when taken daily. I've noticed an improvement in general excretion and my blood tests. I recommend it.
0
Causes constipation
Good quality product with a plentiful quantity. I took it while pregnant, but it caused terrible constipation. I didn't really consider switching to a different type, to be honest.
2
Causes constipation issues
4 people found this helpful
It’s not nice on the stomach; I used it almost every day since I wanted to increase my ferritin level, but I noticed it causes constipation. The pills are easy to swallow, it’s good except for that side effect. I plan to try another brand next time, insha'Allah.
9
Increased energy levels
1 people found this helpful
Excellent! I bought Nature Made Iron 65 mg to tackle my iron deficiency issues. After a few weeks, the tablets are easy to swallow and did not cause any issues like constipation. I felt more energetic, and my skin, hair, and nails improved. I followed the recommended dosage, and the price for 180 tablets is quite reasonable. I am very pleased and will continue using it for my health.
0
Exacerbates constipation
While it's beneficial for iron deficiency, I wouldn't recommend it for those with constipation, as it makes the issue worse.
10
No constipation
An excellent supplement! The small pill is easy to digest, doesn't cause constipation, and effectively boosts energy and hemoglobin levels. Love it!
7
Iron's minimal effect on constipation
We explored the effects of low-dose iron supplementation on gastrointestinal complaints, particularly constipation, in pregnant women. Conducting two randomized studies, we aimed to determine how different forms of iron—ferrous fumarate, ferrous bisglycinate, and ferrous sulphate—would affect the frequency of GI issues among healthy women throughout their pregnancy.
Through our investigations, we found that constipation was only significantly associated with higher doses of ferrous fumarate (80 mg/day). Interestingly, women taking lower doses of ferrous fumarate (20-60 mg/day) did not report more GI side effects, indicating that manageable doses of iron may be tolerated without significant worry about constipation.
Among the iron formulas tested, ferrous bisglycinate at 25 mg showed the best profile, resulting in fewer GI complaints overall compared to the others. In fact, it was linked to a lower incidence of black stools, which can often be associated with iron intake. Ultimately, we observed that while low-dose iron supplementation might incur some side effects, they are generally not severe enough to warrant a change in dosage or interruption of treatment.
Through our investigations, we found that constipation was only significantly associated with higher doses of ferrous fumarate (80 mg/day). Interestingly, women taking lower doses of ferrous fumarate (20-60 mg/day) did not report more GI side effects, indicating that manageable doses of iron may be tolerated without significant worry about constipation.
Among the iron formulas tested, ferrous bisglycinate at 25 mg showed the best profile, resulting in fewer GI complaints overall compared to the others. In fact, it was linked to a lower incidence of black stools, which can often be associated with iron intake. Ultimately, we observed that while low-dose iron supplementation might incur some side effects, they are generally not severe enough to warrant a change in dosage or interruption of treatment.
4
Iron supplementation effects on constipation
We examined how different types of iron supplementation affect pregnant women, particularly focusing on potential constipation as a side effect. In a systematic review and meta-analysis, we gathered data from 26 studies involving nearly 4,400 participants to compare daily and intermittent iron supplementation.
Interestingly, we found that daily oral iron supplementation was associated with a higher occurrence of constipation compared to intermittent supplementation. The adjusted odds ratio for constipation was 1.95, indicating a nearly two-fold increase in risk for those taking daily iron. However, our analysis revealed that both daily and intermittent iron supplements could increase hemoglobin levels effectively, showing no significant difference in overall efficacy.
Ultimately, while daily iron supplementation led to better ferritin levels, women experienced more adverse effects such as nausea, diarrhea, and constipation. This suggests that intermittent iron supplementation could be a more favorable option, especially for those who are sensitive to the side effects associated with daily doses.
Interestingly, we found that daily oral iron supplementation was associated with a higher occurrence of constipation compared to intermittent supplementation. The adjusted odds ratio for constipation was 1.95, indicating a nearly two-fold increase in risk for those taking daily iron. However, our analysis revealed that both daily and intermittent iron supplements could increase hemoglobin levels effectively, showing no significant difference in overall efficacy.
Ultimately, while daily iron supplementation led to better ferritin levels, women experienced more adverse effects such as nausea, diarrhea, and constipation. This suggests that intermittent iron supplementation could be a more favorable option, especially for those who are sensitive to the side effects associated with daily doses.
7
We carefully looked at the impact of lactoferrin (Lf) on treating iron deficiency anemia (IDA) in children, especially focusing on its connection to constipation. In an extensive review of 11 studies, including 10 randomized controlled trials, we saw promising results where children receiving Lf showed notable improvements in their hemoglobin and serum ferritin levels compared to those who only received iron or a placebo.
Interestingly, we found that while some adverse effects like constipation, vomiting, and abdominal pain were reported, those treated with Lf experienced a significant decrease in constipation. This suggests that Lf not only helps in boosting iron levels but may also be easier on the digestive system than traditional iron supplements.
Overall, our exploration indicates that incorporating lactoferrin in the treatment of IDA in children not only helps address anemia effectively but also might provide a gentler alternative for the gut. Users considering iron supplements for their children might find lactoferrin to be a beneficial option.
Interestingly, we found that while some adverse effects like constipation, vomiting, and abdominal pain were reported, those treated with Lf experienced a significant decrease in constipation. This suggests that Lf not only helps in boosting iron levels but may also be easier on the digestive system than traditional iron supplements.
Overall, our exploration indicates that incorporating lactoferrin in the treatment of IDA in children not only helps address anemia effectively but also might provide a gentler alternative for the gut. Users considering iron supplements for their children might find lactoferrin to be a beneficial option.
9
We assessed how iron supplementation impacts blood donors who may suffer from low iron levels. Our analysis included thirty studies with nearly 4,700 participants, focusing on the differences between those receiving iron and those who didn’t.
We found that iron supplements reduced the chances of donors being deferred due to low hemoglobin levels and helped elevate their hemoglobin and iron stores. However, we also noted more side effects, like constipation and nausea, among those taking iron.
These side effects hinder its widespread use, suggesting iron supplements should be targeted to at-risk individuals only.
We found that iron supplements reduced the chances of donors being deferred due to low hemoglobin levels and helped elevate their hemoglobin and iron stores. However, we also noted more side effects, like constipation and nausea, among those taking iron.
These side effects hinder its widespread use, suggesting iron supplements should be targeted to at-risk individuals only.
References
- Milman NT, Bergholt T. Low-Dose Prophylactic Oral Iron Supplementation (Ferrous Fumarate, Ferrous Bisglycinate, and Ferrous Sulphate) in Pregnancy Is Not Associated With Clinically Significant Gastrointestinal Complaints: Results From Two Randomized Studies. J Pregnancy. 2024;2024:1716798. doi:10.1155/2024/1716798
- Banerjee A, Athalye S, Shingade P, Khargekar V, Mahajan N, et al. Efficacy of daily versus intermittent oral iron supplementation for prevention of anaemia among pregnant women: a systematic review and meta-analysis. EClinicalMedicine. 2024;74:102742. doi:10.1016/j.eclinm.2024.102742
- June D, Konstantin AT, Lumbanradja LA, Aryani A, Hengky A. Lactoferrin as treatment for iron-deficiency anemia in children: a systematic review. Turk J Pediatr. 2023;65:543. doi:10.24953/turkjped.2022.670
- Suzuki D, Ichie T, Hayashi H, Sugiura Y, Sugiyama T. Efficacy of sucroferric oxyhydroxide treatment in Japanese hemodialysis patients and its effect on gastrointestinal symptoms. Pharmazie. 2017;72:118. doi:10.1691/ph.2017.6848
- Abdel Moety GAF, Ali AM, Fouad R, Ramadan W, Belal DS, et al. Amino acid chelated iron versus an iron salt in the treatment of iron deficiency anemia with pregnancy: A randomized controlled study. Eur J Obstet Gynecol Reprod Biol. 2017;210:242. doi:10.1016/j.ejogrb.2017.01.003
- Pamuk GE, Uyanik MS, Top MS, Tapan U, Ak R, et al. Gastrointestinal symptoms are closely associated with depression in iron deficiency anemia: a comparative study. Ann Saudi Med. 2015;35:31. doi:10.5144/0256-4947.2015.31
- Smith GA, Fisher SA, Doree C, Di Angelantonio E, Roberts DJ. Oral or parenteral iron supplementation to reduce deferral, iron deficiency and/or anaemia in blood donors. Cochrane Database Syst Rev. 2014;2014:CD009532. doi:10.1002/14651858.CD009532.pub2
- Pereira DI, Couto Irving SS, Lomer MC, Powell JJ. A rapid, simple questionnaire to assess gastrointestinal symptoms after oral ferrous sulphate supplementation. BMC Gastroenterol. 2014;14:103. doi:10.1186/1471-230X-14-103
- Bradley CS, Kennedy CM, Turcea AM, Rao SS, Nygaard IE. Constipation in pregnancy: prevalence, symptoms, and risk factors. Obstet Gynecol. 2007;110:1351.
- Singhal A, Morley R, Abbott R, Fairweather-Tait S, Stephenson T, et al. Clinical safety of iron-fortified formulas. Pediatrics. 2000;105:E38.
- Lloyd B, Halter RJ, Kuchan MJ, Baggs GE, Ryan AS, et al. Formula tolerance in postbreastfed and exclusively formula-fed infants. Pediatrics. 1999;103:E7.
