Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.8
USERS' SCORE
Good
Based on 5 Reviews
8.6
Supplement Facts
Serving Size: 3 Caplets
Amount Per Serving
%DV
Vitamin D (as D3 Cholecalciferol)
15 mcg (600 IU)
75%
Calcium (as Calcium Carbonate and Calcium Gluconate)
1,000 mg
77%
Magnesium (as Magnesium Oxide and Magnesium Gluconate)
400 mg
95%
Zinc (as Zinc Gluconate and Zinc Citrate)
25 mg
227%
Sodium
10 mg
<1%
Top Medical Research Studies
8
Magnesium alloy inhibits cancer growth
We explored how magnesium alloy, particularly a variant containing 1% calcium, impacts cervical cancer cells. Our investigation revealed that this alloy has promising antitumor properties which could pave the way for new treatments.
In our experiments, we tested the effects of the Mg-1%Ca alloy both in laboratory settings and in living organisms. This alloy was found to release magnesium ions and hydroxide ions more slowly than expected. We observed that it effectively inhibited the growth of cervical cancer cells, specifically SiHa and HeLa cell lines.
Additionally, the presence of the alloy induced apoptosis, or programmed cell death, in the cancer cells, disrupted their structural integrity, and hindered their ability to migrate and invade other tissues. Importantly, the Mg-1%Ca alloy was seen to influence key molecular pathways, specifically the MAPK/ERK signaling pathway, which plays a role in cancer cell proliferation.
With these results, it's evident that magnesium alloy could serve as a useful adjunct to current cervical cancer therapies, potentially helping to prevent both cancer growth and metastasis.
In our experiments, we tested the effects of the Mg-1%Ca alloy both in laboratory settings and in living organisms. This alloy was found to release magnesium ions and hydroxide ions more slowly than expected. We observed that it effectively inhibited the growth of cervical cancer cells, specifically SiHa and HeLa cell lines.
Additionally, the presence of the alloy induced apoptosis, or programmed cell death, in the cancer cells, disrupted their structural integrity, and hindered their ability to migrate and invade other tissues. Importantly, the Mg-1%Ca alloy was seen to influence key molecular pathways, specifically the MAPK/ERK signaling pathway, which plays a role in cancer cell proliferation.
With these results, it's evident that magnesium alloy could serve as a useful adjunct to current cervical cancer therapies, potentially helping to prevent both cancer growth and metastasis.
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8
We explored how zinc levels impact cancer cells and immune function, particularly focusing on macrophages, which are crucial for our body’s defense against tumors. Our research revealed that cancer cells often have decreased expression of specific genes tied to immune response, and this links to resistance against therapies designed to unblock immune checkpoints.
By upregulating a zinc importer known as SLC39A9, these cancer cells manage to hoard zinc for themselves, leaving the surrounding tumor microenvironment (TME) depleted of this vital nutrient. This competition for zinc results in macrophages becoming zinc-starved, which diminishes their ability to perform essential tasks like engulfing and destroying cancer cells.
Interestingly, we found that when we replenished zinc levels in the TME—through a dietary intervention—these macrophages could regain their pro-phagocytic function. This change significantly improved the response of certain tumors to immunotherapy treatments. Notably, T cells weren’t required for this transformation, indicating that macrophages alone play a pivotal role.
Our results are clinically relevant, showing that cancer patients with reduced zinc levels in their body tend to experience worse outcomes. Overall, we identified a new mechanism by which cancer cells can disrupt immune function, highlighting zinc’s critical role in both tumor environments and immunotherapy effectiveness.
By upregulating a zinc importer known as SLC39A9, these cancer cells manage to hoard zinc for themselves, leaving the surrounding tumor microenvironment (TME) depleted of this vital nutrient. This competition for zinc results in macrophages becoming zinc-starved, which diminishes their ability to perform essential tasks like engulfing and destroying cancer cells.
Interestingly, we found that when we replenished zinc levels in the TME—through a dietary intervention—these macrophages could regain their pro-phagocytic function. This change significantly improved the response of certain tumors to immunotherapy treatments. Notably, T cells weren’t required for this transformation, indicating that macrophages alone play a pivotal role.
Our results are clinically relevant, showing that cancer patients with reduced zinc levels in their body tend to experience worse outcomes. Overall, we identified a new mechanism by which cancer cells can disrupt immune function, highlighting zinc’s critical role in both tumor environments and immunotherapy effectiveness.
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9
We investigated an innovative approach to cancer treatment by using a special nanomedicine that combines zinc with a compound called 2,5-dihydroxyterephthalic acid (DHT). This combination aims to target the cancer stem-like cells, which are known for their role in tumor recurrence and spread.
The nanomedicine works by effectively pulling in the cancer's own iron and releasing zinc. This process not only helps in reducing the iron levels in tumors but also enhances the production of reactive oxygen species (ROS), which are crucial for damaging cancer cells. By lowering iron, we push the cancer stem cells towards differentiation, while the increased ROS levels help trigger cell death.
What's especially compelling about our findings is that this treatment appears to tackle both aggressive cancer stem-like cells and the bulk of the tumor, showing promise in preventing cancer growth, recurrence, and metastasis. The results have been especially notable in cases of triple-negative breast tumors, providing an exciting potential path for future cancer therapies that take advantage of these properties.
The nanomedicine works by effectively pulling in the cancer's own iron and releasing zinc. This process not only helps in reducing the iron levels in tumors but also enhances the production of reactive oxygen species (ROS), which are crucial for damaging cancer cells. By lowering iron, we push the cancer stem cells towards differentiation, while the increased ROS levels help trigger cell death.
What's especially compelling about our findings is that this treatment appears to tackle both aggressive cancer stem-like cells and the bulk of the tumor, showing promise in preventing cancer growth, recurrence, and metastasis. The results have been especially notable in cases of triple-negative breast tumors, providing an exciting potential path for future cancer therapies that take advantage of these properties.
Read More
Most Useful Reviews
8.8
Cancer prevention support
Calcium and magnesium, along with zinc, are essential for immune support, bones, and overall health. These elements are vital for bone, teeth, and muscle tone health. Zinc bolsters immune functions, aids in healing, and is crucial for the prostate and reproductive systems. The combination with Vitamin D3 enhances calcium absorption. However, I find taking these tablets three times daily rather inconvenient. The blend plays an essential role in cancer prevention.
Read More
9.5
Supports nerve health
Promoting muscle tone and boosting immunity, this composition is essential for thyroid function and normal blood clotting. It aids in restoring the protective sheaths around nerves and regulates blood pressure and heartbeat, while also preventing cancer cell growth.
Read More
8.8
Boosts immunity
The composition contains vitamin D, which strengthens bone tissue, reduces the risk of osteoporosis, boosts immunity, improves mood, and lowers the chances of cardiovascular disease, diabetes, autoimmune diseases, and cancer. It works exceptionally well in the overall complex.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 17 Researches
7.8
- All Researches
9
We explored the potential of vitamin D-based micelles designed to deliver paclitaxel, a key chemotherapy drug, specifically for pancreatic cancer treatment. This study focuses on developing enzyme-responsive micelles that not only carry paclitaxel but also utilize vitamin D as an integral part of the delivery system.
The micelles are made by combining vitamin D with polyethylene glycol, resulting in tiny structures that can release their drug load when interacting with enzymes typically found in pancreatic cancer cells. We observed that these micelles showed promising results in laboratory settings, enhancing the effectiveness of paclitaxel against aggressive pancreatic cancer cells compared to using paclitaxel alone.
Moreover, we noted that the vitamin D in the micelles may play a dual role: serving as both a hydrophobic core for drug delivery and a contributor to synergetic therapeutic effects. Our findings suggest that leveraging vitamin D in this way could increase the efficacy of existing treatment options for pancreatic cancer patients, which is particularly significant given the challenges currently faced in treating this disease.
The micelles are made by combining vitamin D with polyethylene glycol, resulting in tiny structures that can release their drug load when interacting with enzymes typically found in pancreatic cancer cells. We observed that these micelles showed promising results in laboratory settings, enhancing the effectiveness of paclitaxel against aggressive pancreatic cancer cells compared to using paclitaxel alone.
Moreover, we noted that the vitamin D in the micelles may play a dual role: serving as both a hydrophobic core for drug delivery and a contributor to synergetic therapeutic effects. Our findings suggest that leveraging vitamin D in this way could increase the efficacy of existing treatment options for pancreatic cancer patients, which is particularly significant given the challenges currently faced in treating this disease.
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9
We looked into the question of how magnesium levels might affect cancer treatment outcomes, especially for patients receiving immune checkpoint blockers. The study pointed out that elevated serum magnesium levels corresponded with more favorable results in these patients, suggesting that magnesium could play a positive role in their treatment journey.
However, the findings did not specifically isolate the effects of magnesium from those of other treatments. This means that while we observed a correlation between high magnesium levels and improved outcomes, we can't definitively say that magnesium alone caused these results. It’s important to note that further research is needed to clarify this relationship and understand how magnesium interacts with cancer therapies.
Overall, while the presence of sufficient magnesium appears to be beneficial, the intricate connection between magnesium levels and cancer treatment success is still not fully understood.
However, the findings did not specifically isolate the effects of magnesium from those of other treatments. This means that while we observed a correlation between high magnesium levels and improved outcomes, we can't definitively say that magnesium alone caused these results. It’s important to note that further research is needed to clarify this relationship and understand how magnesium interacts with cancer therapies.
Overall, while the presence of sufficient magnesium appears to be beneficial, the intricate connection between magnesium levels and cancer treatment success is still not fully understood.
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9
We examined how magnesium plays a role in enhancing T cell-mediated cancer immunotherapy. The study focused on a unique magnesium peroxide-based nanoigniter designed to disrupt the tumors' defenses. By combating the challenging immunosuppressive environment surrounding tumors, this innovative treatment aims to allow T cells to attack more effectively.
The nanoigniter is loaded with doxorubicin and metformin, and it works doubly by breaking down the tough extracellular matrix (ECM) that makes it difficult for T cells to infiltrate tumors. We observed that this approach not only promotes stronger responses from CD8 T cells — a critical type of immune cell in our bodies — but also boosts their effectiveness and prevents their fatigue under harsh conditions.
While the study highlights magnesium's supportive role in improving immunotherapy outcomes, it does not isolate the mineral's direct impact on cancer. Therefore, while we see promising interactions, determining magnesium's specific effects remains complex and linked to the overall treatment plan.
The nanoigniter is loaded with doxorubicin and metformin, and it works doubly by breaking down the tough extracellular matrix (ECM) that makes it difficult for T cells to infiltrate tumors. We observed that this approach not only promotes stronger responses from CD8 T cells — a critical type of immune cell in our bodies — but also boosts their effectiveness and prevents their fatigue under harsh conditions.
While the study highlights magnesium's supportive role in improving immunotherapy outcomes, it does not isolate the mineral's direct impact on cancer. Therefore, while we see promising interactions, determining magnesium's specific effects remains complex and linked to the overall treatment plan.
Read More
9
We investigated how magnesium might enhance the effectiveness of cytotoxic T lymphocytes (CTLs) in fighting glioblastoma, a particularly aggressive form of brain cancer. CTLs, although present in glioblastoma, often struggle to infiltrate tumors effectively and are hampered by various inhibitory markers, notably NK1.1.
This study introduced a novel method using a specially designed nanoeditor, named Mg@MK-8931@MPP. This editor combines magnesium with a specific drug that helps empower CTLs and encourages their infiltration into the tumor while addressing the challenges of delivering treatment safely in the brain.
We observed that once the magnesium-based nanoeditor localized within glioblastoma, it enabled the effective release of MK-8931. This release repolarized M2-like macrophages, promoting a more significant CTL presence within the tumor site. Furthermore, magnesium worked to amplify the immune response, boosting the production of crucial antitumor cytokines and proteins.
Additionally, we found that blocking the NK1.1 receptor on CTLs extended their cytotoxic activity, enhancing treatment outcomes. Research on both T-cell-deficient and standard mouse models validated the potential of this magnesium-driven metalloimmunotherapy approach in treating glioblastoma effectively.
Overall, this strategy not only broadens the application of metalloimmunotherapy to glioblastoma but also emphasizes the importance of ensuring the functionality of CTLs in the fight against cancer.
This study introduced a novel method using a specially designed nanoeditor, named Mg@MK-8931@MPP. This editor combines magnesium with a specific drug that helps empower CTLs and encourages their infiltration into the tumor while addressing the challenges of delivering treatment safely in the brain.
We observed that once the magnesium-based nanoeditor localized within glioblastoma, it enabled the effective release of MK-8931. This release repolarized M2-like macrophages, promoting a more significant CTL presence within the tumor site. Furthermore, magnesium worked to amplify the immune response, boosting the production of crucial antitumor cytokines and proteins.
Additionally, we found that blocking the NK1.1 receptor on CTLs extended their cytotoxic activity, enhancing treatment outcomes. Research on both T-cell-deficient and standard mouse models validated the potential of this magnesium-driven metalloimmunotherapy approach in treating glioblastoma effectively.
Overall, this strategy not only broadens the application of metalloimmunotherapy to glioblastoma but also emphasizes the importance of ensuring the functionality of CTLs in the fight against cancer.
Read More
9
Zinc enhances TNBC treatment efficacy
We developed an innovative treatment approach for triple-negative breast cancer (TNBC) using zinc-copper bimetallic nanoplatforms. These specially designed nanostructures help promote a type of cell death known as cuproptosis while also boosting the immune system's response to tumors. By leveraging these properties, we aimed to find a way to make existing immune therapies more effective against TNBC, which is notoriously difficult to treat.
The mechanism behind this approach involves the nanoplatforms releasing both zinc and copper ions within the acidic environment of tumors. This releases hydroxyl radicals and impacts certain proteins in cancer cells, disrupting their function and leading to cell death. Additionally, the released mitochondrial DNA works alongside zinc to activate pathways that boost the immune response, ultimately helping to improve the effectiveness of anti-PD-L1 treatments.
Furthermore, we observed that using a near-infrared laser significantly enhances these effects. Together, the combination of our nanoplatforms and immune therapies results in a powerful treatment strategy, showcasing zinc's potential role in fighting TNBC.
Overall, our findings suggest a promising new direction for TNBC therapy by uniting the benefits of cuproptosis, immune activation, and laser therapy.
The mechanism behind this approach involves the nanoplatforms releasing both zinc and copper ions within the acidic environment of tumors. This releases hydroxyl radicals and impacts certain proteins in cancer cells, disrupting their function and leading to cell death. Additionally, the released mitochondrial DNA works alongside zinc to activate pathways that boost the immune response, ultimately helping to improve the effectiveness of anti-PD-L1 treatments.
Furthermore, we observed that using a near-infrared laser significantly enhances these effects. Together, the combination of our nanoplatforms and immune therapies results in a powerful treatment strategy, showcasing zinc's potential role in fighting TNBC.
Overall, our findings suggest a promising new direction for TNBC therapy by uniting the benefits of cuproptosis, immune activation, and laser therapy.
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User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
8.8
Cancer prevention support
Calcium and magnesium, along with zinc, are essential for immune support, bones, and overall health. These elements are vital for bone, teeth, and muscle tone health. Zinc bolsters immune functions, aids in healing, and is crucial for the prostate and reproductive systems. The combination with Vitamin D3 enhances calcium absorption. However, I find taking these tablets three times daily rather inconvenient. The blend plays an essential role in cancer prevention.
Read More
9.5
Supports nerve health
Promoting muscle tone and boosting immunity, this composition is essential for thyroid function and normal blood clotting. It aids in restoring the protective sheaths around nerves and regulates blood pressure and heartbeat, while also preventing cancer cell growth.
Read More
8.8
Boosts immunity
The composition contains vitamin D, which strengthens bone tissue, reduces the risk of osteoporosis, boosts immunity, improves mood, and lowers the chances of cardiovascular disease, diabetes, autoimmune diseases, and cancer. It works exceptionally well in the overall complex.
Read More
8.8
Promotes overall health
This mineral complex is excellent! The combination of these three components is crucial for maintaining healthy bones, teeth, hair, skin, and muscle tone. Zinc supports the immune system and overall health. The tablets are easy to swallow, and calcium is vital for heart rhythm, cholesterol reduction, and cancer prevention. Magnesium optimises calcium absorption, and zinc enhances immune response and healing.
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8
Heart health support
The composition is superb! Magnesium aids calcium absorption, working in harmony with it. It's beneficial for the heart, memory, and nervous system and strengthens nails. It reduces the risk of certain ailments like osteoporosis and rectal cancer. I highly appreciated this formulation, especially after the doctor's recommendation.
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Frequently Asked Questions
No FAQs are available for this product and symptom.
References
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- Sun L, Lin X, Li N, Zhang Q, Jiang Y, et al. Effects of vitamin D and calcium supplementation on bone of young adults after thyroidectomy of differentiated thyroid carcinoma. Endocrine. 2025. doi:10.1007/s12020-025-04195-x
- Morris K, Masri S, Schnoor B, Papa AL. Calcium levels modulate platelet function, platelet-cancer cell interaction, and cancer cell invasion. Sci Rep. 2025;15:7750. doi:10.1038/s41598-024-79280-8
- Len-Tayon K, Metzger D, Laverny G. [New insights of vitamin D-based therapy for prostate cancer]. Med Sci (Paris). 2025;41:154. doi:10.1051/medsci/2025011
- Soni D, Tiwari A, Kushwah PS, Dubey S, Khan S. Levels of Serum 25-Hydroxy Vitamin D in Benign and Malignant Breast Disease Patients: An Observational Study. Cureus. 2025;17:e78283. doi:10.7759/cureus.78283
- Peixoto D, Ravasco JM, Blanco-Fernandez B, Veiga F, Concheiro A, et al. Enzyme-responsive vitamin D-based micelles for paclitaxel-controlled delivery and synergistic pancreatic cancer therapy. Mater Today Bio. 2025;31:101555. doi:10.1016/j.mtbio.2025.101555
- Ouyang Y, Cao L, Zhao Q, Yang W, Lin C. Biodegradable Mg-1%Ca alloy inhibits the growth of cervical cancer. Biomed Mater. 2025. doi:10.1088/1748-605X/adb2cc
- Wang Z, Wang Z. Letter Re: Elevated serum magnesium levels prompt favourable outcomes in cancer patients treated with immune checkpoint blockers. Eur J Cancer. 2025;216:115187. doi:10.1016/j.ejca.2024.115187
- Kitapli S, Alkan A, Tanriverdi O. Elevated serum magnesium levels prompt favourable outcomes in cancer patients treated with immune checkpoint blockers. Eur J Cancer. 2025;216:115188. doi:10.1016/j.ejca.2024.115188
- Hao H, Sun S, Fu Y, Wen S, Wen Y, et al. Magnesium peroxide-based biomimetic nanoigniter degrades extracellular matrix to awake T cell-mediated cancer immunotherapy. Biomaterials. 2025;317:123043. doi:10.1016/j.biomaterials.2024.123043
- Li W, Tian H, Yan Z, Yu X, Li B, et al. Magnesium-Phenolic Nanoeditor Refining Gliomatous T Cells for Metalloimmunotherapy. ACS Nano. 2025;19:1222. doi:10.1021/acsnano.4c13388
- Chu Z, Zheng W, Fu W, Liang J, Wang W, et al. Implanted Microneedles Loaded with Sparfloxacin and Zinc-Manganese Sulfide Nanoparticles Activates Immunity for Postoperative Triple-Negative Breast Cancer to Prevent Recurrence and Metastasis. Adv Sci (Weinh). 2025. doi:10.1002/advs.202416270
- Jin X, Tong W, Sun L, Lu S, Sun P, et al. Association of composite dietary antioxidant index with high risk of prostate cancer in middle-aged and elderly men: insights from NHANES. Front Immunol. 2025;16:1530174. doi:10.3389/fimmu.2025.1530174
- Agare GI, Chidike Ezeorba TP, Michael DC, Emmanuel A, Clement AO, et al. Zinc Shield: Efficacy in Mitigating Oral Mucositis in Head and Neck Cancer Patients Undergoing Radiotherapy and Chemoradiotherapy - A Systematic Review. Clin Nutr ESPEN. 2025. doi:10.1016/j.clnesp.2025.02.011
- Zhou B, Chen M, Hao Z, Li L, Zhang Y, et al. Zinc-copper bimetallic nanoplatforms trigger photothermal-amplified cuproptosis and cGAS-STING activation for enhancing triple-negative breast cancer immunotherapy. J Nanobiotechnology. 2025;23:137. doi:10.1186/s12951-025-03186-4
- Buj R, Cole AR, Danielson J, Xu J, Hurd D, et al. cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance. bioRxiv. 2025. doi:10.1101/2025.02.08.637227
- Chen J, Wang Y, Huang J, Yang Z, Niu H, et al. Cascade specific endogenous Fe interference and catalysis for tumor therapy with stemness suppression. Natl Sci Rev. 2025;12:nwae434. doi:10.1093/nsr/nwae434
