Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
USERS' SCORE
Moderately Good
Based on 22 Reviews
7.9
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
St. John's Wort Extract(Hypericum perforatum) (aerial) (Standardized to contain 0.3% Dianthrones measured as Hypericin by UV-Vis testing, 0.9 mg)
300 mg
**
Top Medical Research Studies
8
We examined the effectiveness of Hypericum perforatum, commonly known as St. John's Wort, specifically for anxiety treatment in elderly patients aged 60 and above. This analysis was based on data from randomized, controlled clinical trials, which provided a robust framework for our observations.
In our exploration, we focused on how this herbal remedy compares to placebo treatments. The findings indicated that Hypericum extract demonstrated significant benefits for anxiety, showing better results on established measures of anxiety symptoms.
Importantly, the effects we observed were consistent across the board, matching the outcomes seen in studies that included younger populations as well. This confirms that Hypericum perforatum is a viable option for managing anxiety in older adults.
Overall, this herbal treatment stands out as a well-tolerated and effective alternative to more conventional, synthetic medications, offering hope for those seeking natural solutions to anxiety.
In our exploration, we focused on how this herbal remedy compares to placebo treatments. The findings indicated that Hypericum extract demonstrated significant benefits for anxiety, showing better results on established measures of anxiety symptoms.
Importantly, the effects we observed were consistent across the board, matching the outcomes seen in studies that included younger populations as well. This confirms that Hypericum perforatum is a viable option for managing anxiety in older adults.
Overall, this herbal treatment stands out as a well-tolerated and effective alternative to more conventional, synthetic medications, offering hope for those seeking natural solutions to anxiety.
Read More
8
Hypericum extracts alleviate anxiety symptoms
We set out to evaluate how extracts from Hypericum perforatum (HP), commonly known as St. John’s Wort, along with quercetin (Q), could impact anxiety and overall brain health. In this study, we used a rat model to observe various biological effects, particularly focusing on oxidative stress and inflammation, both of which can influence anxiety levels.
The rats were divided into different groups, receiving either a control treatment, a known anxiety-inducing agent, or our test compounds. Over a period of 21 days, we administered HP and Q and monitored several brain and serum markers associated with anxiety. Our findings revealed that HP and Q showed promising anti-inflammatory and antioxidant properties.
Specifically, we noted reductions in inflammatory cytokines and oxidative stress markers in the brain, which could indicate a protective effect against anxiety. These results suggest that HP may indeed help improve anxiety-like behaviors by modulating key processes in the brain. Overall, the inclusion of Hypericum extracts in a natural compounds-rich diet may offer beneficial effects for mental health.
The rats were divided into different groups, receiving either a control treatment, a known anxiety-inducing agent, or our test compounds. Over a period of 21 days, we administered HP and Q and monitored several brain and serum markers associated with anxiety. Our findings revealed that HP and Q showed promising anti-inflammatory and antioxidant properties.
Specifically, we noted reductions in inflammatory cytokines and oxidative stress markers in the brain, which could indicate a protective effect against anxiety. These results suggest that HP may indeed help improve anxiety-like behaviors by modulating key processes in the brain. Overall, the inclusion of Hypericum extracts in a natural compounds-rich diet may offer beneficial effects for mental health.
Read More
8
Hypericum perforatum alleviates post-MI anxiety
We investigated the effects of Hypericum perforatum, commonly known as St. John's Wort, on anxiety that follows a heart attack. Our research focused on measuring how this herbal treatment could help in not just relieving anxiety, but also improving heart functions after a myocardial infarction (MI).
To enhance the absorption and efficacy of HP, we formulated it into a self-nanoemulsifying self-nanosuspension (HP.SNESNS). In our study, we used a group of rats that had experienced MI and observed that HP.SNESNS significantly reduced anxiety and depressive-like behaviors, alongside cognitive dysfunction.
Notably, it increased levels of essential neurotransmitters like norepinephrine and serotonin in the brain, which are known to play a vital role in mood regulation. Additionally, we found that HP.SNESNS helped protect heart tissues by reducing inflammation markers and restoring heart architecture. Overall, these improvements were comparable to those seen with higher doses of unformulated HP.
In conclusion, our findings indicate that HP.SNESNS not only helps manage anxiety in a post-MI context but also offers cardio-protective benefits, making it a promising candidate for further research.
To enhance the absorption and efficacy of HP, we formulated it into a self-nanoemulsifying self-nanosuspension (HP.SNESNS). In our study, we used a group of rats that had experienced MI and observed that HP.SNESNS significantly reduced anxiety and depressive-like behaviors, alongside cognitive dysfunction.
Notably, it increased levels of essential neurotransmitters like norepinephrine and serotonin in the brain, which are known to play a vital role in mood regulation. Additionally, we found that HP.SNESNS helped protect heart tissues by reducing inflammation markers and restoring heart architecture. Overall, these improvements were comparable to those seen with higher doses of unformulated HP.
In conclusion, our findings indicate that HP.SNESNS not only helps manage anxiety in a post-MI context but also offers cardio-protective benefits, making it a promising candidate for further research.
Read More
Most Useful Reviews
9
Significant mood improvement
12 people found this helpful
It works! I’m on my third bottle and noticed a significant difference. I previously tried Prozac but found it dreadful. This supplement feels much more gentle compared to conventional antidepressants. After a while, I appreciated a lighter mood, more optimism, and significantly less irritation overall. It assists with my PMDD symptoms, and I’ve experienced no side effects, especially concerning anxiety. This really works for me!
Read More
9
Effective and affordable treatment
10 people found this helpful
Affordable relief from severe depression. Having tried various supplements for moderate to severe anxiety, St John's wort was effective by the second day. I started with one pill twice daily and noticed improvements in my anxiety without side effects. It's an effective and affordable treatment, particularly during these times of long-term isolation. Highly recommend it!
Read More
9
Natural anxiety relief
7 people found this helpful
This product genuinely helps alleviate anxiety and depression. It is natural and lacks bad side effects; however, vigilance regarding sun exposure is essential due to potential photo-sensitivity. It’s worth the investment for those with moderate anxiety or depression. My doctor recommended it over regular antidepressants, and taking three a day yields fruitful results.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
- All Researches
8
Hypericum perforatum alleviates post-MI anxiety
We investigated the effects of Hypericum perforatum, commonly known as St. John's Wort, on anxiety that follows a heart attack. Our research focused on measuring how this herbal treatment could help in not just relieving anxiety, but also improving heart functions after a myocardial infarction (MI).
To enhance the absorption and efficacy of HP, we formulated it into a self-nanoemulsifying self-nanosuspension (HP.SNESNS). In our study, we used a group of rats that had experienced MI and observed that HP.SNESNS significantly reduced anxiety and depressive-like behaviors, alongside cognitive dysfunction.
Notably, it increased levels of essential neurotransmitters like norepinephrine and serotonin in the brain, which are known to play a vital role in mood regulation. Additionally, we found that HP.SNESNS helped protect heart tissues by reducing inflammation markers and restoring heart architecture. Overall, these improvements were comparable to those seen with higher doses of unformulated HP.
In conclusion, our findings indicate that HP.SNESNS not only helps manage anxiety in a post-MI context but also offers cardio-protective benefits, making it a promising candidate for further research.
To enhance the absorption and efficacy of HP, we formulated it into a self-nanoemulsifying self-nanosuspension (HP.SNESNS). In our study, we used a group of rats that had experienced MI and observed that HP.SNESNS significantly reduced anxiety and depressive-like behaviors, alongside cognitive dysfunction.
Notably, it increased levels of essential neurotransmitters like norepinephrine and serotonin in the brain, which are known to play a vital role in mood regulation. Additionally, we found that HP.SNESNS helped protect heart tissues by reducing inflammation markers and restoring heart architecture. Overall, these improvements were comparable to those seen with higher doses of unformulated HP.
In conclusion, our findings indicate that HP.SNESNS not only helps manage anxiety in a post-MI context but also offers cardio-protective benefits, making it a promising candidate for further research.
Read More
8
Hypericum extracts alleviate anxiety symptoms
We set out to evaluate how extracts from Hypericum perforatum (HP), commonly known as St. John’s Wort, along with quercetin (Q), could impact anxiety and overall brain health. In this study, we used a rat model to observe various biological effects, particularly focusing on oxidative stress and inflammation, both of which can influence anxiety levels.
The rats were divided into different groups, receiving either a control treatment, a known anxiety-inducing agent, or our test compounds. Over a period of 21 days, we administered HP and Q and monitored several brain and serum markers associated with anxiety. Our findings revealed that HP and Q showed promising anti-inflammatory and antioxidant properties.
Specifically, we noted reductions in inflammatory cytokines and oxidative stress markers in the brain, which could indicate a protective effect against anxiety. These results suggest that HP may indeed help improve anxiety-like behaviors by modulating key processes in the brain. Overall, the inclusion of Hypericum extracts in a natural compounds-rich diet may offer beneficial effects for mental health.
The rats were divided into different groups, receiving either a control treatment, a known anxiety-inducing agent, or our test compounds. Over a period of 21 days, we administered HP and Q and monitored several brain and serum markers associated with anxiety. Our findings revealed that HP and Q showed promising anti-inflammatory and antioxidant properties.
Specifically, we noted reductions in inflammatory cytokines and oxidative stress markers in the brain, which could indicate a protective effect against anxiety. These results suggest that HP may indeed help improve anxiety-like behaviors by modulating key processes in the brain. Overall, the inclusion of Hypericum extracts in a natural compounds-rich diet may offer beneficial effects for mental health.
Read More
8
We explored the effectiveness of a treatment combining lifestyle changes with herbal medicine in managing symptoms of Polycystic Ovary Syndrome (PCOS) in overweight women. In our study, we specifically assessed how a blend of herbal ingredients, including Hypericum perforatum, influenced anxiety levels.
Although we found that women receiving the combination treatment showed significant improvements in various health markers—such as hormonal balance and quality of life—the specific effects of Hypericum perforatum on anxiety couldn't be isolated. It was included in a mixture with other herbs, making it challenging to determine its individual impact.
At the three-month mark, participants taking the combination treatment reported reductions in menstruation irregularities and improved well-being. However, since the results were derived from a combination treatment, we can't definitively state how much Hypericum perforatum itself contributed to anxiety mitigation. This caveat is essential for anyone considering this herbal supplement for anxiety management.
Although we found that women receiving the combination treatment showed significant improvements in various health markers—such as hormonal balance and quality of life—the specific effects of Hypericum perforatum on anxiety couldn't be isolated. It was included in a mixture with other herbs, making it challenging to determine its individual impact.
At the three-month mark, participants taking the combination treatment reported reductions in menstruation irregularities and improved well-being. However, since the results were derived from a combination treatment, we can't definitively state how much Hypericum perforatum itself contributed to anxiety mitigation. This caveat is essential for anyone considering this herbal supplement for anxiety management.
Read More
8
We explored how an extract from Hypericum scabrum, known for its antioxidant properties, affects anxiety levels in rats subjected to a long-term high-fat diet (HFD). Our study involved sixty male Wistar rats, which we divided into six groups—some fed a standard diet while others received a high-fat diet, with certain groups supplemented with varying doses of the extract. Over three months, we assessed anxiety levels using the elevated plus-maze test, a common method for studying anxious behaviors in animals.
Our findings indicated that the rats on the high-fat diet showed increased anxiety behaviors compared to those on the standard diet, evidenced by spending less time in the open arms of the maze. However, the inclusion of H. scabrum extract significantly improved these anxiety measures, suggesting a potential anxiolytic effect. We also observed notable changes in oxidative stress markers: the HFD diet increased harmful compounds in the serum while reducing protective antioxidants, but the extract supplementation helped normalize these levels.
In essence, our study suggests that H. scabrum not only alleviates anxiety behaviors associated with a high-fat diet but also counters oxidative stress. This reinforces the possibility that dietary components and natural extracts like H. scabrum could play important roles in managing anxiety and overall mental health.
Our findings indicated that the rats on the high-fat diet showed increased anxiety behaviors compared to those on the standard diet, evidenced by spending less time in the open arms of the maze. However, the inclusion of H. scabrum extract significantly improved these anxiety measures, suggesting a potential anxiolytic effect. We also observed notable changes in oxidative stress markers: the HFD diet increased harmful compounds in the serum while reducing protective antioxidants, but the extract supplementation helped normalize these levels.
In essence, our study suggests that H. scabrum not only alleviates anxiety behaviors associated with a high-fat diet but also counters oxidative stress. This reinforces the possibility that dietary components and natural extracts like H. scabrum could play important roles in managing anxiety and overall mental health.
Read More
8
We examined the effectiveness of Hypericum perforatum, commonly known as St. John's Wort, specifically for anxiety treatment in elderly patients aged 60 and above. This analysis was based on data from randomized, controlled clinical trials, which provided a robust framework for our observations.
In our exploration, we focused on how this herbal remedy compares to placebo treatments. The findings indicated that Hypericum extract demonstrated significant benefits for anxiety, showing better results on established measures of anxiety symptoms.
Importantly, the effects we observed were consistent across the board, matching the outcomes seen in studies that included younger populations as well. This confirms that Hypericum perforatum is a viable option for managing anxiety in older adults.
Overall, this herbal treatment stands out as a well-tolerated and effective alternative to more conventional, synthetic medications, offering hope for those seeking natural solutions to anxiety.
In our exploration, we focused on how this herbal remedy compares to placebo treatments. The findings indicated that Hypericum extract demonstrated significant benefits for anxiety, showing better results on established measures of anxiety symptoms.
Importantly, the effects we observed were consistent across the board, matching the outcomes seen in studies that included younger populations as well. This confirms that Hypericum perforatum is a viable option for managing anxiety in older adults.
Overall, this herbal treatment stands out as a well-tolerated and effective alternative to more conventional, synthetic medications, offering hope for those seeking natural solutions to anxiety.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 22 Reviews
7.9
- All Reviews
- Positive Reviews
- Negative Reviews
9
Significant mood improvement
12 people found this helpful
It works! I’m on my third bottle and noticed a significant difference. I previously tried Prozac but found it dreadful. This supplement feels much more gentle compared to conventional antidepressants. After a while, I appreciated a lighter mood, more optimism, and significantly less irritation overall. It assists with my PMDD symptoms, and I’ve experienced no side effects, especially concerning anxiety. This really works for me!
Read More
9
Effective and affordable treatment
10 people found this helpful
Affordable relief from severe depression. Having tried various supplements for moderate to severe anxiety, St John's wort was effective by the second day. I started with one pill twice daily and noticed improvements in my anxiety without side effects. It's an effective and affordable treatment, particularly during these times of long-term isolation. Highly recommend it!
Read More
9
Natural anxiety relief
7 people found this helpful
This product genuinely helps alleviate anxiety and depression. It is natural and lacks bad side effects; however, vigilance regarding sun exposure is essential due to potential photo-sensitivity. It’s worth the investment for those with moderate anxiety or depression. My doctor recommended it over regular antidepressants, and taking three a day yields fruitful results.
Read More
7.5
Anxiety nearly gone
7 people found this helpful
I feel like myself again! I definitely recommend these. Sadness, anxiety, and depression plagued me too often. However, since taking these for a while, I rarely experience anxiety or depression. I truly feel like myself again.
Read More
10
Reduced anxiety significantly
4 people found this helpful
Fixed my anxiety and a bit more. I am bipolar and had been facing anxiety. I began taking these three times daily alongside my prescribed medications, and since then, my anxiety has vanished. I also feel a more positive mood and better overall well-being. I will definitely be getting another bottle when this one runs low.
Read More
Frequently Asked Questions
8
Antidepressant effects
4 people found this helpful
Helps with increased anxiety, depression, and apathy. After two weeks on St. John's wort, I experienced effects comparable to those of antidepressants, which was surprising. Research indicates that St. John's wort has a mechanism similar to fluoxetine, confirming it’s not merely a placebo effect. There were no side effects; it’s a beneficial remedy.
8.5
Natural approach
1 people found this helpful
Excellent! Initially, I didn't notice a change, but after 10 days, the results became apparent. I have anxiety and transitioned from anxiolytics to this natural remedy, which has significantly helped me. Thank you.
6
Improved mood
3 people found this helpful
I felt a very good effect after two weeks of administration. Initially, I experienced minor side effects like dry mouth, a rapid heartbeat, and anxiety, but these went away after two weeks. Now, I feel fine and continue taking it.
9
Calm and collected
1 people found this helpful
As someone who frequently deals with anxiety, my doctor recommended this instead of an extreme alternative. I was hesitant at first, but it genuinely helped me immensely. I remained calm, cool, and collected, and I noticed a change quickly. Even after ceasing for a few days, I didn’t revert to being overwhelmed by anxiety.
9
Highly recommended
1 people found this helpful
Having taken it for over a year, it has greatly alleviated my anxiety. It's a high-quality product that I highly recommend!
9
Significant improvement
1 people found this helpful
I felt the effects quickly. I take one after lunch and one after dinner. Along with Ashwagandha, it significantly improved my anxiety and depression without causing sleepiness. My husband feels similarly. Many brands are good; it's a matter of experimenting.
8
We examined the effectiveness of Hypericum perforatum, commonly known as St. John's Wort, specifically for anxiety treatment in elderly patients aged 60 and above. This analysis was based on data from randomized, controlled clinical trials, which provided a robust framework for our observations.
In our exploration, we focused on how this herbal remedy compares to placebo treatments. The findings indicated that Hypericum extract demonstrated significant benefits for anxiety, showing better results on established measures of anxiety symptoms.
Importantly, the effects we observed were consistent across the board, matching the outcomes seen in studies that included younger populations as well. This confirms that Hypericum perforatum is a viable option for managing anxiety in older adults.
Overall, this herbal treatment stands out as a well-tolerated and effective alternative to more conventional, synthetic medications, offering hope for those seeking natural solutions to anxiety.
In our exploration, we focused on how this herbal remedy compares to placebo treatments. The findings indicated that Hypericum extract demonstrated significant benefits for anxiety, showing better results on established measures of anxiety symptoms.
Importantly, the effects we observed were consistent across the board, matching the outcomes seen in studies that included younger populations as well. This confirms that Hypericum perforatum is a viable option for managing anxiety in older adults.
Overall, this herbal treatment stands out as a well-tolerated and effective alternative to more conventional, synthetic medications, offering hope for those seeking natural solutions to anxiety.
8
Hypericum perforatum alleviates post-MI anxiety
We investigated the effects of Hypericum perforatum, commonly known as St. John's Wort, on anxiety that follows a heart attack. Our research focused on measuring how this herbal treatment could help in not just relieving anxiety, but also improving heart functions after a myocardial infarction (MI).
To enhance the absorption and efficacy of HP, we formulated it into a self-nanoemulsifying self-nanosuspension (HP.SNESNS). In our study, we used a group of rats that had experienced MI and observed that HP.SNESNS significantly reduced anxiety and depressive-like behaviors, alongside cognitive dysfunction.
Notably, it increased levels of essential neurotransmitters like norepinephrine and serotonin in the brain, which are known to play a vital role in mood regulation. Additionally, we found that HP.SNESNS helped protect heart tissues by reducing inflammation markers and restoring heart architecture. Overall, these improvements were comparable to those seen with higher doses of unformulated HP.
In conclusion, our findings indicate that HP.SNESNS not only helps manage anxiety in a post-MI context but also offers cardio-protective benefits, making it a promising candidate for further research.
To enhance the absorption and efficacy of HP, we formulated it into a self-nanoemulsifying self-nanosuspension (HP.SNESNS). In our study, we used a group of rats that had experienced MI and observed that HP.SNESNS significantly reduced anxiety and depressive-like behaviors, alongside cognitive dysfunction.
Notably, it increased levels of essential neurotransmitters like norepinephrine and serotonin in the brain, which are known to play a vital role in mood regulation. Additionally, we found that HP.SNESNS helped protect heart tissues by reducing inflammation markers and restoring heart architecture. Overall, these improvements were comparable to those seen with higher doses of unformulated HP.
In conclusion, our findings indicate that HP.SNESNS not only helps manage anxiety in a post-MI context but also offers cardio-protective benefits, making it a promising candidate for further research.
8
We explored how an extract from Hypericum scabrum, known for its antioxidant properties, affects anxiety levels in rats subjected to a long-term high-fat diet (HFD). Our study involved sixty male Wistar rats, which we divided into six groups—some fed a standard diet while others received a high-fat diet, with certain groups supplemented with varying doses of the extract. Over three months, we assessed anxiety levels using the elevated plus-maze test, a common method for studying anxious behaviors in animals.
Our findings indicated that the rats on the high-fat diet showed increased anxiety behaviors compared to those on the standard diet, evidenced by spending less time in the open arms of the maze. However, the inclusion of H. scabrum extract significantly improved these anxiety measures, suggesting a potential anxiolytic effect. We also observed notable changes in oxidative stress markers: the HFD diet increased harmful compounds in the serum while reducing protective antioxidants, but the extract supplementation helped normalize these levels.
In essence, our study suggests that H. scabrum not only alleviates anxiety behaviors associated with a high-fat diet but also counters oxidative stress. This reinforces the possibility that dietary components and natural extracts like H. scabrum could play important roles in managing anxiety and overall mental health.
Our findings indicated that the rats on the high-fat diet showed increased anxiety behaviors compared to those on the standard diet, evidenced by spending less time in the open arms of the maze. However, the inclusion of H. scabrum extract significantly improved these anxiety measures, suggesting a potential anxiolytic effect. We also observed notable changes in oxidative stress markers: the HFD diet increased harmful compounds in the serum while reducing protective antioxidants, but the extract supplementation helped normalize these levels.
In essence, our study suggests that H. scabrum not only alleviates anxiety behaviors associated with a high-fat diet but also counters oxidative stress. This reinforces the possibility that dietary components and natural extracts like H. scabrum could play important roles in managing anxiety and overall mental health.
8
We explored the effectiveness of a treatment combining lifestyle changes with herbal medicine in managing symptoms of Polycystic Ovary Syndrome (PCOS) in overweight women. In our study, we specifically assessed how a blend of herbal ingredients, including Hypericum perforatum, influenced anxiety levels.
Although we found that women receiving the combination treatment showed significant improvements in various health markers—such as hormonal balance and quality of life—the specific effects of Hypericum perforatum on anxiety couldn't be isolated. It was included in a mixture with other herbs, making it challenging to determine its individual impact.
At the three-month mark, participants taking the combination treatment reported reductions in menstruation irregularities and improved well-being. However, since the results were derived from a combination treatment, we can't definitively state how much Hypericum perforatum itself contributed to anxiety mitigation. This caveat is essential for anyone considering this herbal supplement for anxiety management.
Although we found that women receiving the combination treatment showed significant improvements in various health markers—such as hormonal balance and quality of life—the specific effects of Hypericum perforatum on anxiety couldn't be isolated. It was included in a mixture with other herbs, making it challenging to determine its individual impact.
At the three-month mark, participants taking the combination treatment reported reductions in menstruation irregularities and improved well-being. However, since the results were derived from a combination treatment, we can't definitively state how much Hypericum perforatum itself contributed to anxiety mitigation. This caveat is essential for anyone considering this herbal supplement for anxiety management.
References
- Khalil HMA, Mahmoud DB, El-Shiekh RA, Bakr AF, Boseila AA, et al. Antidepressant and Cardioprotective Effects of Self-Nanoemulsifying Self-Nanosuspension Loaded with Hypericum perforatum on Post-Myocardial Infarction Depression in Rats. AAPS PharmSciTech. 2022;23:243. 10.1208/s12249-022-02387-6
- Sevastre-Berghian AC, Toma VA, Sevastre B, Hanganu D, Vlase L, et al. Characterization and biological effects of Hypericum extracts on experimentally-induced - anxiety, oxidative stress and inflammation in rats. J Physiol Pharmacol. 2018;69. 10.26402/jpp.2018.5.13
- Arentz S, Smith CA, Abbott J, Fahey P, Cheema BS, et al. Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial. Phytother Res. 2017;31:1330. 10.1002/ptr.5858
- Ganji A, Salehi I, Sarihi A, Shahidi S, Komaki A. Effects of Hypericum Scabrum extract on anxiety and oxidative stress biomarkers in rats fed a long-term high-fat diet. Metab Brain Dis. 2017;32:503. 10.1007/s11011-016-9940-9
- Kasper S. Phytopharmaceutical treatment of anxiety, depression, and dementia in the elderly: evidence from randomized, controlled clinical trials. Wien Med Wochenschr. 2015;165:217. 10.1007/s10354-015-0360-y
