Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.6
USERS' SCORE
Good
Based on 16 Reviews
8.7
Supplement Facts
Serving Size: 1 Tablet
Serving Per Container: 275
Amount Per Serving
%DV
Total Carbohydrates
1 g
<1%**
Calcium (as Calcium Carbonate)
98 mg
8%
Proprietary BlendCascara Sagrada powder (bark), Fennel powder (seed), Psyllium powder (seed husk), Ginger powder (rhizome), Acacia Gum, Barley Grass powder (aerial), Beet powder (root), Glucomannan, Karaya Gum, Lemon Peel powder (peel), Oat Bran powder, Peppermint powder (leaf), Red Raspberry (Rubus idaeus) powder (leaf), Slippery Elm powder (bark), Chlorella powder, Guar Gum, Lactobacillus acidophilus (1 million/g *** )
542 mg
†
Top Medical Research Studies
9
Lubiprostone improves constipation outcomes
We investigated how lubiprostone—a treatment for chronic constipation—affects bowel habits and small intestinal bacterial overgrowth (SIBO).
Over two weeks, 29 women took lubiprostone and reported improved bowel movement frequency and softer stools. We measured different gut transit times and assessed SIBO status with a breath test.
The results revealed that lubiprostone not only speeds up intestinal movement but also helps reduce SIBO, likely due to increased fluid and motility in the intestines.
Over two weeks, 29 women took lubiprostone and reported improved bowel movement frequency and softer stools. We measured different gut transit times and assessed SIBO status with a breath test.
The results revealed that lubiprostone not only speeds up intestinal movement but also helps reduce SIBO, likely due to increased fluid and motility in the intestines.
Read More
9
We examined whether a 2-week probiotics treatment could help constipated patients by improving bowel cleansing before colonoscopy. The study involved two groups: one received probiotics while the other got a placebo. Our findings showed that those on probiotics experienced significantly better bowel preparation and fewer post-procedure symptoms compared to the placebo group. Interestingly, patients with normal bowel habits also participated but did not see a difference between treatments. Overall, probiotics can enhance the colonoscopy experience for constipated individuals.
Read More
9
We explored if polyethylene glycol electrolyte lavage solution (PEG-ELS) could help with chronic constipation. In a controlled, double-blind study involving 32 patients, we switched between PEG-ELS and a placebo, analyzing their bowel movements and stool consistency over five days.
The results were promising! PEG-ELS significantly improved both stool frequency and consistency compared to the placebo. The best outcomes were seen with a daily dosage of 16 ounces. Fortunately, any side effects were minimal. Overall, PEG-ELS appears to be an effective option for managing chronic constipation.
The results were promising! PEG-ELS significantly improved both stool frequency and consistency compared to the placebo. The best outcomes were seen with a daily dosage of 16 ounces. Fortunately, any side effects were minimal. Overall, PEG-ELS appears to be an effective option for managing chronic constipation.
Read More
Most Useful Reviews
9
Effective relief
10 people found this helpful
Constipation has been a long-standing issue for me, causing irritation throughout the day. I would only manage to defecate twice a week, which was extremely painful. However, since I began using Nature's Secret, Multi-Herb Colon Cleanse, I now go twice a day. I feel much lighter and comfortable, no longer cranky in the mornings. I've shared my positive experience with others.
Read More
9
High recommendation
5 people found this helpful
I wholeheartedly recommend this product to anyone suffering from constipation. It’s truly exceptional and the best pills I have ever used.
Read More
10
Fast-acting
2 people found this helpful
Upon receiving the product, I eagerly took a tablet at night. The very next morning, my constipation was resolved, and my intestines felt cleared. I've tried various remedies before, but none were as effective as this.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.6
- All Researches
9.5
Lactobacillus improves IBS-C symptoms
We investigated how a cultured milk drink containing Lactobacillus acidophilus affects symptoms of constipation in individuals with irritable bowel syndrome (IBS-C). Over 30 days, participants consumed the drink daily.
At the end of the study, an impressive 97.4% of IBS-C participants reported improvement in their constipation-related symptoms. We also noticed reductions in intestinal transit time and pro-inflammatory cytokines linked to IBS. Overall, this suggests that including this cultured milk drink may be a beneficial addition to IBS-C treatment plans.
At the end of the study, an impressive 97.4% of IBS-C participants reported improvement in their constipation-related symptoms. We also noticed reductions in intestinal transit time and pro-inflammatory cytokines linked to IBS. Overall, this suggests that including this cultured milk drink may be a beneficial addition to IBS-C treatment plans.
Read More
9
We investigated how Moringa oleifera leaves might help alleviate constipation, particularly in rats fed a low-fiber diet. By using a variety of methods, including hormone analysis and histological evaluations, we observed that the hot water extract of Moringa leaves showed potential laxative effects.
The study indicated that this effect could involve specific signaling pathways affecting gastrointestinal motility. However, it is essential to note that these findings were based on a rat model, which may not directly translate to human experiences with constipation.
The study indicated that this effect could involve specific signaling pathways affecting gastrointestinal motility. However, it is essential to note that these findings were based on a rat model, which may not directly translate to human experiences with constipation.
Read More
9
Lubiprostone improves constipation outcomes
We investigated how lubiprostone—a treatment for chronic constipation—affects bowel habits and small intestinal bacterial overgrowth (SIBO).
Over two weeks, 29 women took lubiprostone and reported improved bowel movement frequency and softer stools. We measured different gut transit times and assessed SIBO status with a breath test.
The results revealed that lubiprostone not only speeds up intestinal movement but also helps reduce SIBO, likely due to increased fluid and motility in the intestines.
Over two weeks, 29 women took lubiprostone and reported improved bowel movement frequency and softer stools. We measured different gut transit times and assessed SIBO status with a breath test.
The results revealed that lubiprostone not only speeds up intestinal movement but also helps reduce SIBO, likely due to increased fluid and motility in the intestines.
Read More
9
This study investigated how the Peristeen transanal irrigation system could help manage constipation in young patients with anorectal malformations and spinal cord lesions.
Eight paediatric centers in Italy participated, enrolling children aged 6 to 17 with unsatisfactory bowel management. Over three months, we saw marked improvements.
Constipation rates dropped significantly—69% to 25.6% in anorectal malformations and 92.7% to 41.5% in spinal cord lesions. Notably, we also observed an increase in independence and overall quality of life.
Eight paediatric centers in Italy participated, enrolling children aged 6 to 17 with unsatisfactory bowel management. Over three months, we saw marked improvements.
Constipation rates dropped significantly—69% to 25.6% in anorectal malformations and 92.7% to 41.5% in spinal cord lesions. Notably, we also observed an increase in independence and overall quality of life.
Read More
9
We examined whether a 2-week probiotics treatment could help constipated patients by improving bowel cleansing before colonoscopy. The study involved two groups: one received probiotics while the other got a placebo. Our findings showed that those on probiotics experienced significantly better bowel preparation and fewer post-procedure symptoms compared to the placebo group. Interestingly, patients with normal bowel habits also participated but did not see a difference between treatments. Overall, probiotics can enhance the colonoscopy experience for constipated individuals.
Read More
User Reviews
USERS' SCORE
Good
Based on 16 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
9
Effective relief
10 people found this helpful
Constipation has been a long-standing issue for me, causing irritation throughout the day. I would only manage to defecate twice a week, which was extremely painful. However, since I began using Nature's Secret, Multi-Herb Colon Cleanse, I now go twice a day. I feel much lighter and comfortable, no longer cranky in the mornings. I've shared my positive experience with others.
Read More
9
High recommendation
5 people found this helpful
I wholeheartedly recommend this product to anyone suffering from constipation. It’s truly exceptional and the best pills I have ever used.
Read More
10
Fast-acting
2 people found this helpful
Upon receiving the product, I eagerly took a tablet at night. The very next morning, my constipation was resolved, and my intestines felt cleared. I've tried various remedies before, but none were as effective as this.
Read More
10
Effective relief
1 people found this helpful
No constipation! After ten days of use, I have one or two bowel movements a day, and my stomach feels much easier.
Read More
10
Digestive aid
1 people found this helpful
The best for digestion and constipation! This is the most effective product I have ever tried. With just one or two meals each day, I forget about my constipation and digestion problems.
Read More
Frequently Asked Questions
10
Fast-acting
2 people found this helpful
Upon receiving the product, I eagerly took a tablet at night. The very next morning, my constipation was resolved, and my intestines felt cleared. I've tried various remedies before, but none were as effective as this.
10
Effective relief
1 people found this helpful
No constipation! After ten days of use, I have one or two bowel movements a day, and my stomach feels much easier.
10
Decades of relief
1 people found this helpful
The best remedy I've encountered over many decades as I've suffered from constipation since I was ten years old. Now at 62, I find it safe and non-addictive. It yields predictable improvements; even with serious issues, one caplet twice a day suffices. I'm just amazed! I have purchased a second jar and intend to buy more.
9
Immediate help
1 people found this helpful
These are effective! I purchased them as a last-ditch effort to tackle my constipation issues. I only needed to take two a day, and it helped immediately. I highly recommend them.
9
Effective relief
10 people found this helpful
Constipation has been a long-standing issue for me, causing irritation throughout the day. I would only manage to defecate twice a week, which was extremely painful. However, since I began using Nature's Secret, Multi-Herb Colon Cleanse, I now go twice a day. I feel much lighter and comfortable, no longer cranky in the mornings. I've shared my positive experience with others.
9
Resolved constipation issue
After using this colon supplement, I no longer have issues with my constipation.
9
Recommended fibre
5 people found this helpful
My doctor suggested I stay on a fibre product due to my constipation. I've tried many, but they were either difficult to take or ineffective. This product has worked wonders for years, providing great results.
7.5
Strong effectiveness
2 people found this helpful
This product is astonishing! I had quite obstinate constipation, but after using it, the results were impressive. I initially tried with one tablet, but upon increasing to two, the improvement was remarkable. My stomach does feel a bit distended, but overall, the impact is significant.
9
Probiotics improve constipation symptoms
We conducted a randomized, placebo-controlled trial involving 92 children aged 4 to 12 with functional constipation. Over four weeks, we provided one group with a probiotic chewable tablet containing specific strains and compared their experiences to a placebo group.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
The findings were promising; the probiotic group reported a significant improvement in stool frequency and a decrease in hard defecation. Specifically, hard stools decreased from 43% to 14%, while normal defecation increased from 56% to 80%. This study highlights the potential of probiotics as a valuable option for managing constipation in children.
7
We evaluated how adding dietary fiber to multistrain probiotics affects constipation in IBS. In our study, 142 participants were split into two groups: one received probiotic milk only, and the other had the same milk infused with dietary fiber for four weeks.
Both groups reported improvements, but those who consumed the fiber-enriched milk showed better results in defecation frequency and straining. This suggests that dietary fiber enhances the constipation relief provided by probiotics, especially for those with constipation-predominant IBS.
Both groups reported improvements, but those who consumed the fiber-enriched milk showed better results in defecation frequency and straining. This suggests that dietary fiber enhances the constipation relief provided by probiotics, especially for those with constipation-predominant IBS.
7
We explored the impact of multistrain probiotics, including Lactobacillus acidophilus, on functional constipation in elderly individuals living in a nursing home. In a controlled study with 60 participants, those receiving the probiotic mixture for 12 weeks showed a slight increase in stool frequency compared to the placebo group.
While the improvement was not significant overall, it became notable by the 71st day when not considering laxative use. This suggests that lactobacillus treatment could help constipation in seniors, although the effects may vary.
While the improvement was not significant overall, it became notable by the 71st day when not considering laxative use. This suggests that lactobacillus treatment could help constipation in seniors, although the effects may vary.
8
We aimed to evaluate how effective different colon cleanse techniques could be for those suffering from constipation. By comparing low-dose polyethylene glycol (PEG) mixed with various doses of linaclotide, we conducted a study involving 753 patients assigned to three different groups.
The results underscored that the 2LPEG + 2L combination was the most effective for bowel cleansing, especially in patients with chronic constipation. However, while this method showed better results, we found no major benefits over a standard regimen.
Overall, those with chronic constipation and irritable bowel syndrome reported improved tolerance and effectiveness from the 2LPEG + 2L treatment.
The results underscored that the 2LPEG + 2L combination was the most effective for bowel cleansing, especially in patients with chronic constipation. However, while this method showed better results, we found no major benefits over a standard regimen.
Overall, those with chronic constipation and irritable bowel syndrome reported improved tolerance and effectiveness from the 2LPEG + 2L treatment.
9
We explored if polyethylene glycol electrolyte lavage solution (PEG-ELS) could help with chronic constipation. In a controlled, double-blind study involving 32 patients, we switched between PEG-ELS and a placebo, analyzing their bowel movements and stool consistency over five days.
The results were promising! PEG-ELS significantly improved both stool frequency and consistency compared to the placebo. The best outcomes were seen with a daily dosage of 16 ounces. Fortunately, any side effects were minimal. Overall, PEG-ELS appears to be an effective option for managing chronic constipation.
The results were promising! PEG-ELS significantly improved both stool frequency and consistency compared to the placebo. The best outcomes were seen with a daily dosage of 16 ounces. Fortunately, any side effects were minimal. Overall, PEG-ELS appears to be an effective option for managing chronic constipation.
References
- Liu WQ, Shu L, Zhou X, Wang XF, Liu S, et al. Evaluation of the efficacy of polyethylene glycol in combination with different doses of linaclotide in a fractionated bowel preparation for colonoscopy: a prospective randomized controlled study. Int J Colorectal Dis. 2024;39:143. doi:10.1007/s00384-024-04718-4
- Wang L, Zhang Y, Li J, Ran Y, Wang X, et al. Efficacy of Polyethylene Glycol Electrolyte Powder Combined With Linaclotide for Colon Cleansing in Patients With Chronic Constipation Undergoing Colonoscopy: A Multicenter, Single-Blinded, Randomized Controlled Trial. Clin Transl Gastroenterol. 2024;15:e1. doi:10.14309/ctg.0000000000000708
- Li Z, Li X, Tang S, Gao Q, Li C, et al. Moringa oleifera Lam. Leaf improves constipation of rats induced by low-fiber-diet: A proteomics study. J Ethnopharmacol. 2024;318:116936. doi:10.1016/j.jep.2023.116936
- Sarosiek I, Bashashati M, Alvarez A, Hall M, Shankar N, et al. Lubiprostone Accelerates Intestinal Transit and Alleviates Small Intestinal Bacterial Overgrowth in Patients With Chronic Constipation. Am J Med Sci. 2016;352:231. doi:10.1016/j.amjms.2016.05.012
- Vollebregt PF, Elfrink AK, Meijerink WJ, Felt-Bersma RJ. Results of long-term retrograde rectal cleansing in patients with constipation or fecal incontinence. Tech Coloproctol. 2016;20:633. doi:10.1007/s10151-016-1502-y
- Quitadamo P, Thapar N, Staiano A, Tambucci R, Saliakellis E, et al. Effect of Bowel Cleansing on Colonic Transit Time Measurement in Children with Chronic Constipation. J Pediatr. 2015;167:1440. doi:10.1016/j.jpeds.2015.09.035
- Midrio P, Mosiello G, Ausili E, Gamba P, Marte A, et al. Peristeen(®) transanal irrigation in paediatric patients with anorectal malformations and spinal cord lesions: a multicentre Italian study. Colorectal Dis. 2016;18:86. doi:10.1111/codi.13101
- Parente F, Vailati C, Bargiggia S, Manes G, Fontana P, et al. 2-Litre polyethylene glycol-citrate-simethicone plus bisacodyl versus 4-litre polyethylene glycol as preparation for colonoscopy in chronic constipation. Dig Liver Dis. 2015;47:857. doi:10.1016/j.dld.2015.06.008
- Pereyra L, Cimmino D, González Malla C, Laporte M, Rotholtz N, et al. Colonic preparation before colonoscopy in constipated and non-constipated patients: a randomized study. World J Gastroenterol. 2013;19:5103. doi:10.3748/wjg.v19.i31.5103
- Lee H, Kim YH, Kim JH, Chang DK, Kim JY, et al. A feasibility study of probiotics pretreatment as a bowel preparation for colonoscopy in constipated patients. Dig Dis Sci. 2010;55:2344. doi:10.1007/s10620-009-1011-1
- Wong AL, Kravarusic D, Wong SL. Impact of cecostomy and antegrade colonic enemas on management of fecal incontinence and constipation: ten years of experience in pediatric population. J Pediatr Surg. 2008;43:1445. doi:10.1016/j.jpedsurg.2007.12.051
- Koszutski T, Bohosiewicz J, Kudela G, Owczarek K. [Diagnostics and treatment of chronic constipation in children--the experience of the department of paediatric surgery]. Wiad Lek. 2004;57:193.
- Sloots CE, Felt-Bersma RJ. Effect of bowel cleansing on colonic transit in constipation due to slow transit or evacuation disorder. Neurogastroenterol Motil. 2002;14:55.
- Rajapakse R, Warman J, Korelitz BI. Colchicine for persistent constipation after total abdominal colectomy with ileorectostomy for colonic inertia. J Clin Gastroenterol. 2001;33:81.
- Arezzo A. Prospective randomized trial comparing bowel cleaning preparations for colonoscopy. Surg Laparosc Endosc Percutan Tech. 2000;10:215.
- Andorsky RI, Goldner F. Colonic lavage solution (polyethylene glycol electrolyte lavage solution) as a treatment for chronic constipation: a double-blind, placebo-controlled study. Am J Gastroenterol. 1990;85:261.
- Liao Y, Wang Y, Huang W, Wang J, Guo M, et al. L. acidophilus/L. johnsonii ratio affects slow transit constipation in rats. Sci Rep. 2024;14:21088. doi:10.1038/s41598-024-71945-8
- Mitelmão FCR, Häckel K, Bergamaschi CC, Gerenutti M, Silva MT, et al. The effect of probiotics on functional constipation in adults: A randomized, double-blind controlled trial. Medicine (Baltimore). 2022;101:e31185. doi:10.1097/MD.0000000000031185
- Gan D, Chen J, Tang X, Xiao L, Martoni CJ, et al. Impact of a probiotic chewable tablet on stool habits and microbial profile in children with functional constipation: A randomized controlled clinical trial. Front Microbiol. 2022;13:985308. doi:10.3389/fmicb.2022.985308
- Šola KF, Vladimir-Knežević S, Hrabač P, Mucalo I, Saso L, et al. The effect of multistrain probiotics on functional constipation in the elderly: a randomized controlled trial. Eur J Clin Nutr. 2022;76:1675. doi:10.1038/s41430-022-01189-0
- Lydia A, Indra TA, Rizka A, Abdullah M. The effects of synbiotics on indoxyl sulphate level, constipation, and quality of life associated with constipation in chronic haemodialysis patients: a randomized controlled trial. BMC Nephrol. 2022;23:259. doi:10.1186/s12882-022-02890-9
- Lin B, Zhao F, Liu Y, Wu X, Feng J, et al. Randomized Clinical Trial: Probiotics Alleviated Oral-Gut Microbiota Dysbiosis and Thyroid Hormone Withdrawal-Related Complications in Thyroid Cancer Patients Before Radioiodine Therapy Following Thyroidectomy. Front Endocrinol (Lausanne). 2022;13:834674. doi:10.3389/fendo.2022.834674
- Mokhtar NM, Jaafar NM, Alfian E, Mohd Rathi ND, Abdul Rani R, et al. Clinical assessment and cytokines level in constipation-predominant irritable bowel syndrome participants treated with Lactobacillus-containing cultured milk drink. Acta Gastroenterol Belg. 2021;84:585. doi:10.51821/84.4.009
- Martoni CJ, Evans M, Chow CT, Chan LS, Leyer G. Impact of a probiotic product on bowel habits and microbial profile in participants with functional constipation: A randomized controlled trial. J Dig Dis. 2019;20:435. doi:10.1111/1751-2980.12797
- Airaksinen K, Yeung N, Lyra A, Lahtinen SJ, Huttunen T, et al. The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: a double blind, randomised, placebo controlled 2-week trial. Benef Microbes. 2019;10:617. doi:10.3920/BM2018.0163
- Leventogiannis K, Gkolfakis P, Spithakis G, Tsatali A, Pistiki A, et al. Effect of a Preparation of Four Probiotics on Symptoms of Patients with Irritable Bowel Syndrome: Association with Intestinal Bacterial Overgrowth. Probiotics Antimicrob Proteins. 2019;11:627. doi:10.1007/s12602-018-9401-3
- Kim BK, Choi IS, Kim J, Han SH, Suh HJ, et al. Effects of Fermented Milk with Mixed Strains as a Probiotic on the Inhibition of Loperamide-Induced Constipation. Korean J Food Sci Anim Resour. 2017;37:906. doi:10.5851/kosfa.2017.37.6.906
- Magro DO, de Oliveira LM, Bernasconi I, Ruela Mde S, Credidio L, et al. Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation. Nutr J. 2014;13:75. doi:10.1186/1475-2891-13-75
- Ohigashi S, Hoshino Y, Ohde S, Onodera H. Functional outcome, quality of life, and efficacy of probiotics in postoperative patients with colorectal cancer. Surg Today. 2011;41:1200. doi:10.1007/s00595-010-4450-6
- Choi SC, Kim BJ, Rhee PL, Chang DK, Son HJ, et al. Probiotic Fermented Milk Containing Dietary Fiber Has Additive Effects in IBS with Constipation Compared to Plain Probiotic Fermented Milk. Gut Liver. 2011;5:22. doi:10.5009/gnl.2011.5.1.22
- Nova E, Viadel B, Wärnberg J, Carreres JE, Marcos A. Beneficial effects of a synbiotic supplement on self-perceived gastrointestinal well-being and immunoinflammatory status of healthy adults. J Med Food. 2011;14:79. doi:10.1089/jmf.2008.0328
- Jeon JR, Choi JH. Lactic acid fermentation of germinated barley fiber and proliferative function of colonic epithelial cells in loperamide-induced rats. J Med Food. 2010;13:950. doi:10.1089/jmf.2009.1307
