We delved into how elderberry, specifically from the black elderberry fruit, impacts the flu virus, H1N1. Using an innovative technique called Direct Analysis in Real Time Mass Spectrometry (DART TOF-MS), we were able to identify the powerful anti-viral properties of elderberry extract without the need for complicated processes like separation or derivatization.
Our findings revealed that elderberry extract does indeed inhibit H1N1 infection in a lab setting, with an effective concentration (IC50) of 252 micrograms per milliliter. Interestingly, we discovered that flavonoids present in the elderberry bind to H1N1 virions—essentially blocking their ability to infect host cells.
Among the compounds, two key flavonoids emerged: the 5,7,3',4'-tetra-O-methylquercetin and dihydromyricetin. These compounds not only bound to the virus but also effectively prevented infection. Notably, the tetra-O-methylquercetin demonstrated an impressive IC50 of just 0.13 micrograms per milliliter, which is comparable to well-known antiviral medications like Oseltamivir and Amantadine.
In summary, elderberry shows promising potential as a natural remedy against the H1N1 flu, offering a fascinating area for further research and utilization in flu prevention strategies.
Read More
8
Elderberry effective against flu pathogens
Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses.
We aimed to investigate the effectiveness of a standardized elderberry extract against influenza viruses and respiratory bacterial pathogens. The study utilized liquid cultures to examine how various concentrations of the elderberry extract—specifically 5%, 10%, 15%, and 20%—inhibited bacterial growth.
Our findings revealed that the elderberry extract is not just a potential ally against flu viruses, but also demonstrates activity against several harmful bacteria. We specifically tested its effects on both H5N1-type influenza A and influenza B viruses using reputable laboratory methods.
The results suggest that elderberry could offer additional strategies for combating infections, particularly during the flu season when complications often arise from bacterial super-infections following viral illnesses. These findings encourage the exploration of natural products like elderberry as a supportive treatment for respiratory infections.
Read More
9
Elderberry shows promise for flu symptoms
Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials.
We delved into the effectiveness of black elderberry (Sambucus nigra) as a treatment for upper respiratory symptoms. This meta-analysis included 180 participants and aimed to provide insight into its benefits, particularly in relation to vaccination status and specific health conditions.
Our findings showed that elderberry supplementation significantly reduced symptoms associated with colds and flu. This suggests that elderberry could serve as a safer alternative to antibiotics and other prescription medications for managing these common viral infections.
Read More
Most Useful Reviews
9
Stay flu-free
258 people found this helpful
I have read many articles on Black Elderberry's benefits for the immune system. For the first time in 33 years of working in public education, I did not catch a single cold, sniffle, sinus infection, flu, or bronchitis. I cannot believe it. While it may be luck or other factors, I firmly believe that incorporating Black Elderberry into my daily routine has been key to maintaining my health.
Read More
9
Effective antiviral
135 people found this helpful
Elderberry has demonstrated its effectiveness in clinical trials as an antiviral against Influenza A and B, as well as H1N1. A notable study boasted that 93% of flu patients treated with Elderberry were symptom-free in two days, compared to six days for those receiving a placebo. This research has been published across several reputable journals. The findings suggest that Elderberry could aid immune systems, notably in individuals with compromised immunity.
Read More
9
Rapid recovery
76 people found this helpful
It's essential not to overlook this must-have supplement. I swear by elderberry! I began taking it at the start of the year after falling ill with influenza B. I started on it as soon as it arrived, and I was feeling like myself again in no time. I now take it consistently to keep my immunity strong. As a teacher, I cannot afford to be ill, and thankfully, I have not been! Even when I catch a common cold, I recover faster than those around me.
We delved into the effectiveness of black elderberry (Sambucus nigra) as a treatment for upper respiratory symptoms. This meta-analysis included 180 participants and aimed to provide insight into its benefits, particularly in relation to vaccination status and specific health conditions.
Our findings showed that elderberry supplementation significantly reduced symptoms associated with colds and flu. This suggests that elderberry could serve as a safer alternative to antibiotics and other prescription medications for managing these common viral infections.
Read More
9
Elderberry enhances immune response
Polysaccharides from European Black Elderberry Extract Enhance Dendritic Cell Mediated T Cell Immune Responses.
We explored how European black elderberry affects the immune response, particularly regarding flu infections. Through comparing its water extract and polysaccharide fractions to a traditional alcoholic extract, we focused on the role of dendritic cells (DCs), which are crucial for triggering strong T cell responses.
Our findings showed that the water extract and its polysaccharide components effectively matured DCs, enhancing their ability to stimulate T cells significantly. In contrast, the traditional alcoholic extract did not demonstrate any capacity to induce T cell stimulation.
We also observed that the water extracts promoted the production of key inflammatory cytokines like IL-6, TNF-α, and IFN-γ, contributing to a robust immune response, which may be beneficial in fighting off viruses like influenza. Thus, it appears that the polysaccharides from elderberry extracts can play a significant role in modulating the immune system, potentially equipping us to better combat viral threats.
Read More
9
Elderberry inhibits H1N1 flu infection
Elderberry flavonoids bind to and prevent H1N1 infection in vitro.
We delved into how elderberry, specifically from the black elderberry fruit, impacts the flu virus, H1N1. Using an innovative technique called Direct Analysis in Real Time Mass Spectrometry (DART TOF-MS), we were able to identify the powerful anti-viral properties of elderberry extract without the need for complicated processes like separation or derivatization.
Our findings revealed that elderberry extract does indeed inhibit H1N1 infection in a lab setting, with an effective concentration (IC50) of 252 micrograms per milliliter. Interestingly, we discovered that flavonoids present in the elderberry bind to H1N1 virions—essentially blocking their ability to infect host cells.
Among the compounds, two key flavonoids emerged: the 5,7,3',4'-tetra-O-methylquercetin and dihydromyricetin. These compounds not only bound to the virus but also effectively prevented infection. Notably, the tetra-O-methylquercetin demonstrated an impressive IC50 of just 0.13 micrograms per milliliter, which is comparable to well-known antiviral medications like Oseltamivir and Amantadine.
In summary, elderberry shows promising potential as a natural remedy against the H1N1 flu, offering a fascinating area for further research and utilization in flu prevention strategies.
Read More
8
Elderberry enhances immune response
The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines.
We explored how Sambucol, a black elderberry extract, affects the immune system's response to influenza. This double-blind, placebo-controlled study revealed that Sambucol not only shortens flu symptoms but also boosts the production of inflammatory cytokines, which are key in fighting infections.
In our findings, the elderberry extract significantly elevated levels of specific cytokines, particularly TNF-alpha. This suggests that Sambucol could enhance immune activity, making it potentially beneficial for those with various health conditions, including cancer and AIDS.
Read More
8
Elderberry shows limited flu benefits
Echinacea and elderberry-should they be used against upper respiratory tract infections during pregnancy?
We examined how elderberry might impact flu treatment based on several studies. From 1995 to 2013, three clinical trials looked specifically at different elderberry preparations, and all concluded that elderberry could be effective against influenza. However, it's important to note that these studies involved only 77 people, which is quite small for drawing definitive conclusions.
While the potential for elderberry's effectiveness seems promising, the limited sample size means we should be cautious in making broad claims about its benefits. There were no human or animal studies mentioned that specifically researched the safety of elderberry during pregnancy, presenting a gap in knowledge that is concerning for pregnant women considering herbal treatments for flu.
Overall, while elderberry appears effective against the flu based on the small trials, we need much more comprehensive research to better understand its efficacy and safety, particularly for vulnerable populations like pregnant women.
I have read many articles on Black Elderberry's benefits for the immune system. For the first time in 33 years of working in public education, I did not catch a single cold, sniffle, sinus infection, flu, or bronchitis. I cannot believe it. While it may be luck or other factors, I firmly believe that incorporating Black Elderberry into my daily routine has been key to maintaining my health.
Read More
9
Effective antiviral
135 people found this helpful
Elderberry has demonstrated its effectiveness in clinical trials as an antiviral against Influenza A and B, as well as H1N1. A notable study boasted that 93% of flu patients treated with Elderberry were symptom-free in two days, compared to six days for those receiving a placebo. This research has been published across several reputable journals. The findings suggest that Elderberry could aid immune systems, notably in individuals with compromised immunity.
Read More
9
Rapid recovery
76 people found this helpful
It's essential not to overlook this must-have supplement. I swear by elderberry! I began taking it at the start of the year after falling ill with influenza B. I started on it as soon as it arrived, and I was feeling like myself again in no time. I now take it consistently to keep my immunity strong. As a teacher, I cannot afford to be ill, and thankfully, I have not been! Even when I catch a common cold, I recover faster than those around me.
Read More
9
Effective for flu
3 people found this helpful
This herb has changed my life regarding flu-like symptoms. I've struggled with a weak immune system since childhood, falling ill four times a winter. However, after taking black elderberry for over eight years, I now get ill less frequently, with symptoms lasting just 48 hours. When I notice the first signs, I quickly take two pills and another two every two hours, totalling six a day. More than that, however, makes my stomach upset.
Read More
9
Immunity success
3 people found this helpful
Between October and December, I suffered several colds. I decided it was time to boost my immune system with supplements. After some research, I found that Elderberry is excellent for immunity. I now take two capsules daily alongside another immune-boosting vitamin, and I haven’t gotten sick since. Even my husband and daughter (who received the flu shot) came down with the flu, but I remained unaffected. I highly recommend this supplement for immunity enhancement; it’s far more economical than a doctor's copay.
The flu, short for influenza, is a contagious respiratory illness caused by influenza viruses. It affects the nose, throat, and sometimes the lungs, leading to a range of symptoms that can vary in severity. Common symptoms include fever, chills, muscle aches, cough, congestion, runny nose, headaches, and fatigue. The flu can lead to serious complications, particularly in vulnerable populations such as young children, the elderly, pregnant women, and those with underlying health conditions.
The flu virus spreads primarily through respiratory droplets when an infected person coughs, sneezes, or talks. It can also be transmitted by touching surfaces contaminated with the virus and then touching one's face. Vaccination is the most effective way to prevent the flu, and the vaccine is typically updated annually to provide protection against the most common circulating strains. In addition to vaccination, practicing good hygiene, such as frequent handwashing and respiratory etiquette, can help minimize the risk of infection.
Elderberry (Sambucus) refers to a genus of flowering plants in the family Adoxaceae, comprising several species known for their small berries and traditional medicinal uses. The most commonly recognized species is the European elder, Sambucus nigra, which has been utilized in folk medicine for centuries due to its rich nutrient profile, including antioxidants, vitamins A and C, and dietary fiber. Elderberries are typically fragrant clusters of small, dark purple to black berries that are used in a variety of culinary applications, such as jams, syrups, and wine.
In recent years, elderberry has gained popularity for its potential health benefits, particularly for supporting immune health. Many people consume elderberry supplements or syrups to help alleviate symptoms of colds and flu, with some studies suggesting they may reduce the duration and severity of viral infections. However, it’s important to note that raw elderberries, as well as other parts of the elderberry plant, can be toxic if consumed in large amounts. Therefore, it's recommended to use elderberry products that are properly processed and prepared to ensure safety and efficacy.
Sambucus elderberry is often touted as a natural remedy for flu and cold symptoms. Some studies suggest that elderberry extract may help reduce the duration and severity of flu symptoms by enhancing immune response and inhibiting the replication of certain strains of the influenza virus. The compounds in elderberry, such as flavonoids and phenolic acids, are believed to have anti-inflammatory and antioxidant properties, which can support your immune system during bouts of illness.
However, while elderberry may offer some benefits, it should not be relied upon as a substitute for medical treatment or preventive measures such as vaccinations. It's essential to consult with a healthcare professional for appropriate advice, particularly for managing flu symptoms or for individuals with underlying health conditions. Always choose a high-quality elderberry product and follow the recommended dosages for safety and efficacy.
Based on user reviews, it appears that the timing for seeing results from black elderberry supplementation for flu can vary, especially depending on how early you start taking it. Many users report that beginning the supplement at the first sign of flu-like symptoms is crucial for efficacy. For instance, one user noted that their symptoms vanished within a day after starting to take the capsules when feeling unwell Read Review. Another review mentioned that flu symptoms disappeared completely within three days of starting the supplement Read Review.
Additionally, several users have emphasized the importance of early intervention. For example, one user pointed out that by taking elderberry as soon as they felt unwell, they were able to prevent the flu from developing Read Review. Overall, while some users experienced rapid relief in as little as 24 hours, it seems starting the supplement at the onset of symptoms significantly influences the duration and severity of flu symptoms.
Scientific research supports the potential efficacy of elderberry as a supplement for combatting flu symptoms. Multiple studies, including a systematic review, indicated that elderberry might help reduce the duration and severity of flu symptoms, providing a more natural remedy for those looking to manage their illness without traditional medications [4]. Elderberry extracts have shown promise in boosting immune responses, enhancing the activity of dendritic cells, and influencing cytokine production, all of which may contribute to a stronger defense against viral infections, including influenza [3].
Additionally, elderberry has demonstrated antiviral properties in laboratory settings, notably inhibiting the replication of various strains of influenza, including H1N1 and H5N1. The extract's ability to bind to viral particles and potentially block their entry into cells suggests that it could play a role in flu prevention [9]. While current findings are encouraging, it's important to note that many studies emphasize the need for further research to solidify these claims and understand the conditions under which elderberry is most effective. Thus, while elderberry shows potential, individuals should approach its use cautiously, particularly in conjunction with other treatments [6].
Users have reported a range of improvements in their symptoms after taking black elderberry supplements, particularly in relation to flu and cold ailments. Many anecdotal accounts suggest that black elderberry can significantly reduce the duration and severity of symptoms. For instance, one user indicated that upon feeling unwell, symptoms receded within a day after starting to take the capsules Read Review. Another experienced a complete disappearance of flu symptoms within three days of use Read Review. Additionally, some users noted that early intervention is critical; one user shared that taking black elderberry at the first signs of illness helps to prevent the flu from developing altogether Read Review.
Furthermore, several reviewers emphasize long-term benefits, mentioning a general increase in overall immunity and a significant reduction in illness frequency. One user reported experiencing considerably fewer illnesses over the winter season after consistent use, stating that they now recover much faster with symptoms lasting only about 48 hours Read Review. Overall, while individual results may vary, the majority of user experiences suggest that black elderberry serves as an effective and valuable ally during the cold and flu season.
Based on user reviews, combining black elderberry supplements with other immune-boosting items, particularly vitamin C, appears to be a popular strategy among users aiming to handle flu symptoms. Many users have noted the efficacy of taking elderberry capsules alongside vitamin C to enhance its effectiveness. For instance, one reviewer mentioned that they double their dosage of elderberry every four hours while also taking vitamin C at the first signs of flu to maintain their health Read Review. Another user reinforced this sentiment, emphasizing that combining elderberry with vitamin C served as an excellent remedy when cold symptoms first appeared Read Review.
Additionally, users have praised black elderberry for its robust immune system support, often taking it in conjunction with other holistic approaches to manage colds and flu. For example, one user explained that their family has included elderberry in their medicine cabinet for emergencies, indicating a reliance on its benefits every flu season Read Review. The general consensus is that, when taken early and potentially paired with immune-enhancing supplements like vitamin C, black elderberry can significantly mitigate flu severity and duration, making it a valued part of many users' seasonal health regimens.
According to research, the optimal dosage for Elderberry Sambucus in treating flu symptoms is still a topic of ongoing investigation, with varying concentrations suggested across studies. One significant study found that higher concentrations, particularly around 40 to 80 μg/mL, resulted in a marked reduction of virus replication and an enhanced immune response in vitro [5]. In addition, another study indicated that concentrated elderberry juice administered to mice demonstrated significant antiviral effects against influenza, suggesting that higher molecular weights of the extract might offer stronger protective benefits [7].
While specific dosages for humans can vary and there is no universally accepted "optimal" dose yet, some trials indicate that elderberry can effectively reduce symptoms and possibly shorten the duration of flu, supporting its candidacy as a natural remedy [4]. However, due to differences in individual responses and the need for further targeted research, consulting with a healthcare professional before starting any new supplement regimen, especially at higher doses, is advisable.
9
Effective for flu
3 people found this helpful
This herb has changed my life regarding flu-like symptoms. I've struggled with a weak immune system since childhood, falling ill four times a winter. However, after taking black elderberry for over eight years, I now get ill less frequently, with symptoms lasting just 48 hours. When I notice the first signs, I quickly take two pills and another two every two hours, totalling six a day. More than that, however, makes my stomach upset.
5
Elderberry’s uncertain flu benefits
Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review.
We explored the effectiveness of elderberry in treating and potentially preventing flu-related illness. This involved a systematic review of five randomized trials, which helped us examine whether elderberry could play a beneficial role in combatting viruses like the flu.
The findings suggest that while elderberry might not lower the risk of catching the common cold, it could potentially reduce the duration and severity of cold symptoms. We learned that elderberry may also shorten the duration of influenza, but the certainty of these benefits is still uncertain.
Interestingly, when comparing elderberry to oseltamivir, a common antiviral medication, elderberry appeared linked to a lower risk of influenza complications and side effects. However, we found no substantial evidence connecting elderberry to significant inflammatory outcomes. Some studies hinted that elderberry might influence certain inflammatory markers, but this effect may lessen with prolonged use.
Overall, we did not find strong, clear-cut benefits from elderberry in treating flu, stressing the need for more research to confirm these findings. Though it seems to be a safe option without overstimulating the immune system, the evidence remains inconclusive, and more studies are essential to draw firmer conclusions.
9
Elderberry enhances immune response
Polysaccharides from European Black Elderberry Extract Enhance Dendritic Cell Mediated T Cell Immune Responses.
We explored how European black elderberry affects the immune response, particularly regarding flu infections. Through comparing its water extract and polysaccharide fractions to a traditional alcoholic extract, we focused on the role of dendritic cells (DCs), which are crucial for triggering strong T cell responses.
Our findings showed that the water extract and its polysaccharide components effectively matured DCs, enhancing their ability to stimulate T cells significantly. In contrast, the traditional alcoholic extract did not demonstrate any capacity to induce T cell stimulation.
We also observed that the water extracts promoted the production of key inflammatory cytokines like IL-6, TNF-α, and IFN-γ, contributing to a robust immune response, which may be beneficial in fighting off viruses like influenza. Thus, it appears that the polysaccharides from elderberry extracts can play a significant role in modulating the immune system, potentially equipping us to better combat viral threats.
9
Elderberry inhibits H1N1 flu infection
Elderberry flavonoids bind to and prevent H1N1 infection in vitro.
We delved into how elderberry, specifically from the black elderberry fruit, impacts the flu virus, H1N1. Using an innovative technique called Direct Analysis in Real Time Mass Spectrometry (DART TOF-MS), we were able to identify the powerful anti-viral properties of elderberry extract without the need for complicated processes like separation or derivatization.
Our findings revealed that elderberry extract does indeed inhibit H1N1 infection in a lab setting, with an effective concentration (IC50) of 252 micrograms per milliliter. Interestingly, we discovered that flavonoids present in the elderberry bind to H1N1 virions—essentially blocking their ability to infect host cells.
Among the compounds, two key flavonoids emerged: the 5,7,3',4'-tetra-O-methylquercetin and dihydromyricetin. These compounds not only bound to the virus but also effectively prevented infection. Notably, the tetra-O-methylquercetin demonstrated an impressive IC50 of just 0.13 micrograms per milliliter, which is comparable to well-known antiviral medications like Oseltamivir and Amantadine.
In summary, elderberry shows promising potential as a natural remedy against the H1N1 flu, offering a fascinating area for further research and utilization in flu prevention strategies.
8
Elderberry shows limited flu benefits
Echinacea and elderberry-should they be used against upper respiratory tract infections during pregnancy?
We examined how elderberry might impact flu treatment based on several studies. From 1995 to 2013, three clinical trials looked specifically at different elderberry preparations, and all concluded that elderberry could be effective against influenza. However, it's important to note that these studies involved only 77 people, which is quite small for drawing definitive conclusions.
While the potential for elderberry's effectiveness seems promising, the limited sample size means we should be cautious in making broad claims about its benefits. There were no human or animal studies mentioned that specifically researched the safety of elderberry during pregnancy, presenting a gap in knowledge that is concerning for pregnant women considering herbal treatments for flu.
Overall, while elderberry appears effective against the flu based on the small trials, we need much more comprehensive research to better understand its efficacy and safety, particularly for vulnerable populations like pregnant women.
7
Elderberry's variable effectiveness against influenza
Interfering With Lipid Raft Association: A Mechanism to Control Influenza Virus Infection By .
We investigated the effects of elderberry fruit on flu viruses, specifically how it interacts with the H9N2 influenza strain in human epithelial cell cultures. Our approach involved treating the virus and cells with various concentrations of elderberry extract before and after infection to see its influence on virus replication.
During our experiments, we noticed that at lower doses of elderberry extract, the viral activity actually increased. This indicated that the herb didn’t stop the virus from replicating. However, when we applied higher concentrations—specifically 40 and 80 μg/mL—we observed a significant reduction in both the amount of virus present and the production of viral proteins. This suggests elderberry may interfere with how viruses enter cells or how they release from them.
Importantly, the results hint that elderberry's effectiveness might stem from its interaction with lipid rafts in cell membranes. These rafts are crucial for the viruses' fusion and budding processes. Our findings underscore the importance of dosage and timing when using elderberry for treating influenza, highlighting the complexity of herbal treatments.
7
Elderberry juice boosts immunity
Anti-influenza virus effects of elderberry juice and its fractions.
We evaluated the effectiveness of elderberry juice, specifically concentrated juice (CJ-E), in combating the human influenza A virus (IFV). Our experiments involved administering CJ-E to mice infected with IFV to observe any potential antiviral effects. While we found that CJ-E had a strong impact on the mice, its antiviral action was less impressive when tested in a controlled cell culture environment.
To further assess its effects, we separated CJ-E into different fractions using ultrafiltration and anion-exchange chromatography. We concentrated on the high-molecular-weight fractions of CJ-E, which appeared to significantly suppress viral replication in the mice's bronchoalveolar lavage fluids (BALFs). Moreover, these fractions seemed to boost the production of IFV-specific neutralizing antibodies in the serum, along with increasing secretory IgA levels in BALFs and feces.
Particularly, one fraction, Fr. II from the high-molecular-weight group, which contained acidic polysaccharides, showed notable strength in defending against the flu infection. In conclusion, our findings suggest that CJ-E can stimulate the immune response and may play a preventative role against the influenza virus infection.
References
Hawkins J, Baker C, Cherry L, Dunne E. Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials. Complement Ther Med. 2019;42:361. 10.1016/j.ctim.2018.12.004
Barak V, Halperin T, Kalickman I. The effect of Sambucol, a black elderberry-based, natural product, on the production of human cytokines: I. Inflammatory cytokines. Eur Cytokine Netw. 2001;12:290. PubMed
Stich L, Plattner S, McDougall G, Austin C, Steinkasserer A. Polysaccharides from European Black Elderberry Extract Enhance Dendritic Cell Mediated T Cell Immune Responses. Int J Mol Sci. 2022;23. 10.3390/ijms23073949
Wieland LS, Piechotta V, Feinberg T, Ludeman E, Hutton B, et al. Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review. BMC Complement Med Ther. 2021;21:112. 10.1186/s12906-021-03283-5
Shahsavandi S, Ebrahimi MM, Hasaninejad Farahani A. Interfering With Lipid Raft Association: A Mechanism to Control Influenza Virus Infection By . Iran J Pharm Res. 2017;16:1147. PubMed
Holst L, Havnen GC, Nordeng H. Echinacea and elderberry-should they be used against upper respiratory tract infections during pregnancy?. Front Pharmacol. 2014;5:31. 10.3389/fphar.2014.00031
Kinoshita E, Hayashi K, Katayama H, Hayashi T, Obata A. Anti-influenza virus effects of elderberry juice and its fractions. Biosci Biotechnol Biochem. 2012;76:1633. PubMed
Krawitz C, Mraheil MA, Stein M, Imirzalioglu C, Domann E, et al. Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses. BMC Complement Altern Med. 2011;11:16. 10.1186/1472-6882-11-16
Roschek B, Fink RC, McMichael MD, Li D, Alberte RS. Elderberry flavonoids bind to and prevent H1N1 infection in vitro. Phytochemistry. 2009;70:1255. 10.1016/j.phytochem.2009.06.003