Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.2
USERS' SCORE
Good
Based on 5 Reviews
8.2
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Zinc (as Zinc bisglycinate)
30 mg
273%
Top Medical Research Studies
8
We explored how zinc levels impact cancer cells and immune function, particularly focusing on macrophages, which are crucial for our body’s defense against tumors. Our research revealed that cancer cells often have decreased expression of specific genes tied to immune response, and this links to resistance against therapies designed to unblock immune checkpoints.
By upregulating a zinc importer known as SLC39A9, these cancer cells manage to hoard zinc for themselves, leaving the surrounding tumor microenvironment (TME) depleted of this vital nutrient. This competition for zinc results in macrophages becoming zinc-starved, which diminishes their ability to perform essential tasks like engulfing and destroying cancer cells.
Interestingly, we found that when we replenished zinc levels in the TME—through a dietary intervention—these macrophages could regain their pro-phagocytic function. This change significantly improved the response of certain tumors to immunotherapy treatments. Notably, T cells weren’t required for this transformation, indicating that macrophages alone play a pivotal role.
Our results are clinically relevant, showing that cancer patients with reduced zinc levels in their body tend to experience worse outcomes. Overall, we identified a new mechanism by which cancer cells can disrupt immune function, highlighting zinc’s critical role in both tumor environments and immunotherapy effectiveness.
By upregulating a zinc importer known as SLC39A9, these cancer cells manage to hoard zinc for themselves, leaving the surrounding tumor microenvironment (TME) depleted of this vital nutrient. This competition for zinc results in macrophages becoming zinc-starved, which diminishes their ability to perform essential tasks like engulfing and destroying cancer cells.
Interestingly, we found that when we replenished zinc levels in the TME—through a dietary intervention—these macrophages could regain their pro-phagocytic function. This change significantly improved the response of certain tumors to immunotherapy treatments. Notably, T cells weren’t required for this transformation, indicating that macrophages alone play a pivotal role.
Our results are clinically relevant, showing that cancer patients with reduced zinc levels in their body tend to experience worse outcomes. Overall, we identified a new mechanism by which cancer cells can disrupt immune function, highlighting zinc’s critical role in both tumor environments and immunotherapy effectiveness.
Read More
9
We investigated an innovative approach to cancer treatment by using a special nanomedicine that combines zinc with a compound called 2,5-dihydroxyterephthalic acid (DHT). This combination aims to target the cancer stem-like cells, which are known for their role in tumor recurrence and spread.
The nanomedicine works by effectively pulling in the cancer's own iron and releasing zinc. This process not only helps in reducing the iron levels in tumors but also enhances the production of reactive oxygen species (ROS), which are crucial for damaging cancer cells. By lowering iron, we push the cancer stem cells towards differentiation, while the increased ROS levels help trigger cell death.
What's especially compelling about our findings is that this treatment appears to tackle both aggressive cancer stem-like cells and the bulk of the tumor, showing promise in preventing cancer growth, recurrence, and metastasis. The results have been especially notable in cases of triple-negative breast tumors, providing an exciting potential path for future cancer therapies that take advantage of these properties.
The nanomedicine works by effectively pulling in the cancer's own iron and releasing zinc. This process not only helps in reducing the iron levels in tumors but also enhances the production of reactive oxygen species (ROS), which are crucial for damaging cancer cells. By lowering iron, we push the cancer stem cells towards differentiation, while the increased ROS levels help trigger cell death.
What's especially compelling about our findings is that this treatment appears to tackle both aggressive cancer stem-like cells and the bulk of the tumor, showing promise in preventing cancer growth, recurrence, and metastasis. The results have been especially notable in cases of triple-negative breast tumors, providing an exciting potential path for future cancer therapies that take advantage of these properties.
Read More
8
We investigated the impact of zinc, specifically when combined with manganese sulfide, on preventing the recurrence of triple-negative breast cancer (TNBC) post-surgery. This approach involved microneedles loaded with Sparfloxacin and zinc-manganese sulfide, which were targeted for localized treatment to enhance immune response while also addressing wound infection risk.
Through this innovative design, we observed that the zinc-manganese formulation not only displayed strong antimicrobial and antibiofilm properties but also played a role in promoting immune activation. This led to significant reductions in tumor growth and lung metastasis, alongside improved wound healing. The therapy activated key immune pathways, particularly the cGAS-STING pathway, which further bolstered the body’s ability to fight cancer cells.
Overall, the results suggest that zinc, paired with manganese, can provide an effective strategy for enhancing both local and systemic immune responses. This has promising implications for preventing cancer recurrence, particularly in challenging cases like TNBC, paving the way for potential new treatment approaches in oncology.
Through this innovative design, we observed that the zinc-manganese formulation not only displayed strong antimicrobial and antibiofilm properties but also played a role in promoting immune activation. This led to significant reductions in tumor growth and lung metastasis, alongside improved wound healing. The therapy activated key immune pathways, particularly the cGAS-STING pathway, which further bolstered the body’s ability to fight cancer cells.
Overall, the results suggest that zinc, paired with manganese, can provide an effective strategy for enhancing both local and systemic immune responses. This has promising implications for preventing cancer recurrence, particularly in challenging cases like TNBC, paving the way for potential new treatment approaches in oncology.
Read More
Most Useful Reviews
7.5
Supports cancer treatment
Good zinc! For those with zinc deficiency, especially men planning to have children, it's crucial. Zinc acts as an antioxidant that neutralises free radicals, preventing cancer, and stimulates blood production while promoting collagen synthesis for wound healing. The quality is excellent, with a high daily content, and the capsules are conveniently sized.
Read More
7.5
Boosts immune system
Zinc is vital for our innate immune system, the body's initial defence against infections and cancer. A deficiency may lead to chronic diseases and autoimmune conditions. Additionally, zinc can help improve skin health due to its anti-inflammatory properties, aiding those with acne.
Read More
7.5
Prevents cancer development
Zinc contributes to the production of numerous enzymes in the body, acting as an antioxidant that protects against cancer. It also supports blood production and collagen synthesis, essential for healing wounds.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 6 Researches
8.2
- All Researches
9
Zinc enhances TNBC treatment efficacy
We developed an innovative treatment approach for triple-negative breast cancer (TNBC) using zinc-copper bimetallic nanoplatforms. These specially designed nanostructures help promote a type of cell death known as cuproptosis while also boosting the immune system's response to tumors. By leveraging these properties, we aimed to find a way to make existing immune therapies more effective against TNBC, which is notoriously difficult to treat.
The mechanism behind this approach involves the nanoplatforms releasing both zinc and copper ions within the acidic environment of tumors. This releases hydroxyl radicals and impacts certain proteins in cancer cells, disrupting their function and leading to cell death. Additionally, the released mitochondrial DNA works alongside zinc to activate pathways that boost the immune response, ultimately helping to improve the effectiveness of anti-PD-L1 treatments.
Furthermore, we observed that using a near-infrared laser significantly enhances these effects. Together, the combination of our nanoplatforms and immune therapies results in a powerful treatment strategy, showcasing zinc's potential role in fighting TNBC.
Overall, our findings suggest a promising new direction for TNBC therapy by uniting the benefits of cuproptosis, immune activation, and laser therapy.
The mechanism behind this approach involves the nanoplatforms releasing both zinc and copper ions within the acidic environment of tumors. This releases hydroxyl radicals and impacts certain proteins in cancer cells, disrupting their function and leading to cell death. Additionally, the released mitochondrial DNA works alongside zinc to activate pathways that boost the immune response, ultimately helping to improve the effectiveness of anti-PD-L1 treatments.
Furthermore, we observed that using a near-infrared laser significantly enhances these effects. Together, the combination of our nanoplatforms and immune therapies results in a powerful treatment strategy, showcasing zinc's potential role in fighting TNBC.
Overall, our findings suggest a promising new direction for TNBC therapy by uniting the benefits of cuproptosis, immune activation, and laser therapy.
Read More
9
We investigated an innovative approach to cancer treatment by using a special nanomedicine that combines zinc with a compound called 2,5-dihydroxyterephthalic acid (DHT). This combination aims to target the cancer stem-like cells, which are known for their role in tumor recurrence and spread.
The nanomedicine works by effectively pulling in the cancer's own iron and releasing zinc. This process not only helps in reducing the iron levels in tumors but also enhances the production of reactive oxygen species (ROS), which are crucial for damaging cancer cells. By lowering iron, we push the cancer stem cells towards differentiation, while the increased ROS levels help trigger cell death.
What's especially compelling about our findings is that this treatment appears to tackle both aggressive cancer stem-like cells and the bulk of the tumor, showing promise in preventing cancer growth, recurrence, and metastasis. The results have been especially notable in cases of triple-negative breast tumors, providing an exciting potential path for future cancer therapies that take advantage of these properties.
The nanomedicine works by effectively pulling in the cancer's own iron and releasing zinc. This process not only helps in reducing the iron levels in tumors but also enhances the production of reactive oxygen species (ROS), which are crucial for damaging cancer cells. By lowering iron, we push the cancer stem cells towards differentiation, while the increased ROS levels help trigger cell death.
What's especially compelling about our findings is that this treatment appears to tackle both aggressive cancer stem-like cells and the bulk of the tumor, showing promise in preventing cancer growth, recurrence, and metastasis. The results have been especially notable in cases of triple-negative breast tumors, providing an exciting potential path for future cancer therapies that take advantage of these properties.
Read More
8
We investigated the impact of zinc, specifically when combined with manganese sulfide, on preventing the recurrence of triple-negative breast cancer (TNBC) post-surgery. This approach involved microneedles loaded with Sparfloxacin and zinc-manganese sulfide, which were targeted for localized treatment to enhance immune response while also addressing wound infection risk.
Through this innovative design, we observed that the zinc-manganese formulation not only displayed strong antimicrobial and antibiofilm properties but also played a role in promoting immune activation. This led to significant reductions in tumor growth and lung metastasis, alongside improved wound healing. The therapy activated key immune pathways, particularly the cGAS-STING pathway, which further bolstered the body’s ability to fight cancer cells.
Overall, the results suggest that zinc, paired with manganese, can provide an effective strategy for enhancing both local and systemic immune responses. This has promising implications for preventing cancer recurrence, particularly in challenging cases like TNBC, paving the way for potential new treatment approaches in oncology.
Through this innovative design, we observed that the zinc-manganese formulation not only displayed strong antimicrobial and antibiofilm properties but also played a role in promoting immune activation. This led to significant reductions in tumor growth and lung metastasis, alongside improved wound healing. The therapy activated key immune pathways, particularly the cGAS-STING pathway, which further bolstered the body’s ability to fight cancer cells.
Overall, the results suggest that zinc, paired with manganese, can provide an effective strategy for enhancing both local and systemic immune responses. This has promising implications for preventing cancer recurrence, particularly in challenging cases like TNBC, paving the way for potential new treatment approaches in oncology.
Read More
8
Our exploration focused on how dietary antioxidants, particularly zinc, relate to prostate cancer risks in middle-aged and older men. We used data from the National Health and Nutrition Examination Survey, which included over 5,600 participants, to investigate these associations.
We discovered that higher levels of a composite dietary antioxidant index, which includes zinc, were linked to a reduced risk of prostate cancer. Specifically, zinc and selenium showed strong protective effects. This implies that including adequate amounts of these nutrients in our diet may help lower prostate cancer risk.
Ultimately, our findings suggest that maintaining a diet rich in antioxidants, like zinc, could offer significant benefits for prostate health, especially among older men. It's a fascinating area of research that underscores the importance of nutrition in cancer prevention.
We discovered that higher levels of a composite dietary antioxidant index, which includes zinc, were linked to a reduced risk of prostate cancer. Specifically, zinc and selenium showed strong protective effects. This implies that including adequate amounts of these nutrients in our diet may help lower prostate cancer risk.
Ultimately, our findings suggest that maintaining a diet rich in antioxidants, like zinc, could offer significant benefits for prostate health, especially among older men. It's a fascinating area of research that underscores the importance of nutrition in cancer prevention.
Read More
8
We explored how zinc levels impact cancer cells and immune function, particularly focusing on macrophages, which are crucial for our body’s defense against tumors. Our research revealed that cancer cells often have decreased expression of specific genes tied to immune response, and this links to resistance against therapies designed to unblock immune checkpoints.
By upregulating a zinc importer known as SLC39A9, these cancer cells manage to hoard zinc for themselves, leaving the surrounding tumor microenvironment (TME) depleted of this vital nutrient. This competition for zinc results in macrophages becoming zinc-starved, which diminishes their ability to perform essential tasks like engulfing and destroying cancer cells.
Interestingly, we found that when we replenished zinc levels in the TME—through a dietary intervention—these macrophages could regain their pro-phagocytic function. This change significantly improved the response of certain tumors to immunotherapy treatments. Notably, T cells weren’t required for this transformation, indicating that macrophages alone play a pivotal role.
Our results are clinically relevant, showing that cancer patients with reduced zinc levels in their body tend to experience worse outcomes. Overall, we identified a new mechanism by which cancer cells can disrupt immune function, highlighting zinc’s critical role in both tumor environments and immunotherapy effectiveness.
By upregulating a zinc importer known as SLC39A9, these cancer cells manage to hoard zinc for themselves, leaving the surrounding tumor microenvironment (TME) depleted of this vital nutrient. This competition for zinc results in macrophages becoming zinc-starved, which diminishes their ability to perform essential tasks like engulfing and destroying cancer cells.
Interestingly, we found that when we replenished zinc levels in the TME—through a dietary intervention—these macrophages could regain their pro-phagocytic function. This change significantly improved the response of certain tumors to immunotherapy treatments. Notably, T cells weren’t required for this transformation, indicating that macrophages alone play a pivotal role.
Our results are clinically relevant, showing that cancer patients with reduced zinc levels in their body tend to experience worse outcomes. Overall, we identified a new mechanism by which cancer cells can disrupt immune function, highlighting zinc’s critical role in both tumor environments and immunotherapy effectiveness.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Supports cancer treatment
Good zinc! For those with zinc deficiency, especially men planning to have children, it's crucial. Zinc acts as an antioxidant that neutralises free radicals, preventing cancer, and stimulates blood production while promoting collagen synthesis for wound healing. The quality is excellent, with a high daily content, and the capsules are conveniently sized.
Read More
7.5
Boosts immune system
Zinc is vital for our innate immune system, the body's initial defence against infections and cancer. A deficiency may lead to chronic diseases and autoimmune conditions. Additionally, zinc can help improve skin health due to its anti-inflammatory properties, aiding those with acne.
Read More
7.5
Prevents cancer development
Zinc contributes to the production of numerous enzymes in the body, acting as an antioxidant that protects against cancer. It also supports blood production and collagen synthesis, essential for healing wounds.
Read More
7.5
High bioavailability
This form of zinc has excellent bioavailability and is crucial for producing many enzymes in the body. It acts as an antioxidant, neutralising free radicals to help prevent cancer, while also promoting blood production and collagen synthesis for effective wound healing.
Read More
7.5
Natural absorption
Zinc is an important mineral for health, involved in enzyme production in the body. It acts as an antioxidant, helping to prevent cancer and stimulating blood production while promoting collagen synthesis necessary for wound healing. The quality is good and I take it a few times a year.
Read More
Frequently Asked Questions
7.5
Boosts immune system
Zinc is vital for our innate immune system, the body's initial defence against infections and cancer. A deficiency may lead to chronic diseases and autoimmune conditions. Additionally, zinc can help improve skin health due to its anti-inflammatory properties, aiding those with acne.
7.5
Supports cancer treatment
Good zinc! For those with zinc deficiency, especially men planning to have children, it's crucial. Zinc acts as an antioxidant that neutralises free radicals, preventing cancer, and stimulates blood production while promoting collagen synthesis for wound healing. The quality is excellent, with a high daily content, and the capsules are conveniently sized.
7.5
Prevents cancer development
Zinc contributes to the production of numerous enzymes in the body, acting as an antioxidant that protects against cancer. It also supports blood production and collagen synthesis, essential for healing wounds.
7.5
Natural absorption
Zinc is an important mineral for health, involved in enzyme production in the body. It acts as an antioxidant, helping to prevent cancer and stimulating blood production while promoting collagen synthesis necessary for wound healing. The quality is good and I take it a few times a year.
8
We investigated the impact of zinc, specifically when combined with manganese sulfide, on preventing the recurrence of triple-negative breast cancer (TNBC) post-surgery. This approach involved microneedles loaded with Sparfloxacin and zinc-manganese sulfide, which were targeted for localized treatment to enhance immune response while also addressing wound infection risk.
Through this innovative design, we observed that the zinc-manganese formulation not only displayed strong antimicrobial and antibiofilm properties but also played a role in promoting immune activation. This led to significant reductions in tumor growth and lung metastasis, alongside improved wound healing. The therapy activated key immune pathways, particularly the cGAS-STING pathway, which further bolstered the body’s ability to fight cancer cells.
Overall, the results suggest that zinc, paired with manganese, can provide an effective strategy for enhancing both local and systemic immune responses. This has promising implications for preventing cancer recurrence, particularly in challenging cases like TNBC, paving the way for potential new treatment approaches in oncology.
Through this innovative design, we observed that the zinc-manganese formulation not only displayed strong antimicrobial and antibiofilm properties but also played a role in promoting immune activation. This led to significant reductions in tumor growth and lung metastasis, alongside improved wound healing. The therapy activated key immune pathways, particularly the cGAS-STING pathway, which further bolstered the body’s ability to fight cancer cells.
Overall, the results suggest that zinc, paired with manganese, can provide an effective strategy for enhancing both local and systemic immune responses. This has promising implications for preventing cancer recurrence, particularly in challenging cases like TNBC, paving the way for potential new treatment approaches in oncology.
8
Our exploration focused on how dietary antioxidants, particularly zinc, relate to prostate cancer risks in middle-aged and older men. We used data from the National Health and Nutrition Examination Survey, which included over 5,600 participants, to investigate these associations.
We discovered that higher levels of a composite dietary antioxidant index, which includes zinc, were linked to a reduced risk of prostate cancer. Specifically, zinc and selenium showed strong protective effects. This implies that including adequate amounts of these nutrients in our diet may help lower prostate cancer risk.
Ultimately, our findings suggest that maintaining a diet rich in antioxidants, like zinc, could offer significant benefits for prostate health, especially among older men. It's a fascinating area of research that underscores the importance of nutrition in cancer prevention.
We discovered that higher levels of a composite dietary antioxidant index, which includes zinc, were linked to a reduced risk of prostate cancer. Specifically, zinc and selenium showed strong protective effects. This implies that including adequate amounts of these nutrients in our diet may help lower prostate cancer risk.
Ultimately, our findings suggest that maintaining a diet rich in antioxidants, like zinc, could offer significant benefits for prostate health, especially among older men. It's a fascinating area of research that underscores the importance of nutrition in cancer prevention.
7
Zinc may alleviate oral mucositis
We examined the impact of zinc supplementation on patients with head and neck cancers undergoing treatment with radiotherapy and chemoradiotherapy. Our focus was on understanding whether zinc could help reduce the occurrence, duration, and severity of oral mucositis—a painful side effect associated with these treatments.
During our search, we looked across multiple databases for studies involving patients receiving treatment from 2013 to 2023. We were particularly interested in clinical trials that specifically tested different types of zinc supplements. Our findings suggest that zinc might indeed play a beneficial role in lessening the pain and discomfort caused by oral mucositis, possibly due to its properties that reduce inflammation and aid in wound healing.
However, we also recognize that more research is essential. It’s important to clarify the best dosages and treatment regimens for zinc to maximize its potential benefits for cancer patients. Overall, while zinc supplementation appears promising, further investigation is needed to confirm its efficacy and optimize its use in clinical settings.
During our search, we looked across multiple databases for studies involving patients receiving treatment from 2013 to 2023. We were particularly interested in clinical trials that specifically tested different types of zinc supplements. Our findings suggest that zinc might indeed play a beneficial role in lessening the pain and discomfort caused by oral mucositis, possibly due to its properties that reduce inflammation and aid in wound healing.
However, we also recognize that more research is essential. It’s important to clarify the best dosages and treatment regimens for zinc to maximize its potential benefits for cancer patients. Overall, while zinc supplementation appears promising, further investigation is needed to confirm its efficacy and optimize its use in clinical settings.
9
We investigated an innovative approach to cancer treatment by using a special nanomedicine that combines zinc with a compound called 2,5-dihydroxyterephthalic acid (DHT). This combination aims to target the cancer stem-like cells, which are known for their role in tumor recurrence and spread.
The nanomedicine works by effectively pulling in the cancer's own iron and releasing zinc. This process not only helps in reducing the iron levels in tumors but also enhances the production of reactive oxygen species (ROS), which are crucial for damaging cancer cells. By lowering iron, we push the cancer stem cells towards differentiation, while the increased ROS levels help trigger cell death.
What's especially compelling about our findings is that this treatment appears to tackle both aggressive cancer stem-like cells and the bulk of the tumor, showing promise in preventing cancer growth, recurrence, and metastasis. The results have been especially notable in cases of triple-negative breast tumors, providing an exciting potential path for future cancer therapies that take advantage of these properties.
The nanomedicine works by effectively pulling in the cancer's own iron and releasing zinc. This process not only helps in reducing the iron levels in tumors but also enhances the production of reactive oxygen species (ROS), which are crucial for damaging cancer cells. By lowering iron, we push the cancer stem cells towards differentiation, while the increased ROS levels help trigger cell death.
What's especially compelling about our findings is that this treatment appears to tackle both aggressive cancer stem-like cells and the bulk of the tumor, showing promise in preventing cancer growth, recurrence, and metastasis. The results have been especially notable in cases of triple-negative breast tumors, providing an exciting potential path for future cancer therapies that take advantage of these properties.
References
- Chu Z, Zheng W, Fu W, Liang J, Wang W, et al. Implanted Microneedles Loaded with Sparfloxacin and Zinc-Manganese Sulfide Nanoparticles Activates Immunity for Postoperative Triple-Negative Breast Cancer to Prevent Recurrence and Metastasis. Adv Sci (Weinh). 2025. doi:10.1002/advs.202416270
- Jin X, Tong W, Sun L, Lu S, Sun P, et al. Association of composite dietary antioxidant index with high risk of prostate cancer in middle-aged and elderly men: insights from NHANES. Front Immunol. 2025;16:1530174. doi:10.3389/fimmu.2025.1530174
- Agare GI, Chidike Ezeorba TP, Michael DC, Emmanuel A, Clement AO, et al. Zinc Shield: Efficacy in Mitigating Oral Mucositis in Head and Neck Cancer Patients Undergoing Radiotherapy and Chemoradiotherapy - A Systematic Review. Clin Nutr ESPEN. 2025. doi:10.1016/j.clnesp.2025.02.011
- Zhou B, Chen M, Hao Z, Li L, Zhang Y, et al. Zinc-copper bimetallic nanoplatforms trigger photothermal-amplified cuproptosis and cGAS-STING activation for enhancing triple-negative breast cancer immunotherapy. J Nanobiotechnology. 2025;23:137. doi:10.1186/s12951-025-03186-4
- Buj R, Cole AR, Danielson J, Xu J, Hurd D, et al. cancer cells outcompete macrophages for microenvironmental zinc to drive immunotherapy resistance. bioRxiv. 2025. doi:10.1101/2025.02.08.637227
- Chen J, Wang Y, Huang J, Yang Z, Niu H, et al. Cascade specific endogenous Fe interference and catalysis for tumor therapy with stemness suppression. Natl Sci Rev. 2025;12:nwae434. doi:10.1093/nsr/nwae434
