Overview

SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.6
USERS' SCORE
Good
Based on 18 Reviews
8.2
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin C (as ascorbic acid from ferment media)
30 mg
33%
Vitamin E (as d-alpha-tocopheryl acetate from ferment media)
7.5 mg
50%
Folate (as folic acid from ferment media)
1333 mcg DFE
333%
Vitamin B12 (as cyanocobalamin from ferment media)
30 mcg
1250%
Iron (as ferrous fumarate from ferment media)
9 mg
50%
Zinc (as zinc oxide from ferment media)
5 mg
45%
Stress and Energy Support Blend (from ferment media)Organic Schizandra (berry), Organic Maca (root), Organic Chamomile (flower)
93.7 mg
Digestive Support Blend (from ferment media)Organic Aloe (leaf), Organic Peppermint (leaf), Organic Coriander (seed), Organic Cardamom (fruit), Organic Artichoke (leaf)
75 mg
Ginger (rhizome)1.6 mg aqueous extract and 0.4 mg organic supercritical extract
2 mg
Organic Turmeric (rhizome)1.3 mg from ferment media and 0.4 mg supercritical extract
1.7 mg

Top Medical Research Studies

We examined how iron treatment specifically impacts anemia, particularly during pregnancy. Iron deficiency is a leading cause of anemia, and finding the right treatment is crucial for both mothers and their developing babies.

Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.

However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
Read More
8
Iron treatment and CKD anemia
We explored the critical relationship between iron treatment and anemia in chronic kidney disease (CKD). Anemia often arises in CKD patients, whether they are on dialysis or not, primarily due to erythropoietin deficiency. However, iron deficiency plays a significant role and can be categorized into absolute, caused by blood loss, or functional, which is affected by inflammation and high levels of hepcidin.

Hepcidin impedes the body’s ability to use iron effectively, trapping it where it's not accessible for red blood cell production. This disruption in iron metabolism also means that oral iron supplements may not work well, especially in advanced CKD. Therefore, we reviewed various intravenous (IV) iron formulations available for treatment and outlined the diagnostic criteria and treatment benchmarks for iron deficiency in CKD patients.

Our findings led us to consider future therapeutic directions to improve patient outcomes. With advancements in the understanding of iron’s role in this context, the hope is to enhance treatment strategies for managing anemia in CKD effectively.
Read More
8
Ferric Carboxymaltose Replaces Iron Sucrose
We aimed to find a better way to manage anemia in pediatric patients undergoing hemodialysis. Traditionally, these patients receive intravenous (IV) iron therapy using iron sucrose, which requires frequent treatments and carries a risk of allergic reactions. Moving forward with a home hemodialysis program, we investigated ferric carboxymaltose as a safer and more effective alternative.

In our study, we looked closely at how ferric carboxymaltose performed in maintaining healthy levels of hemoglobin, transferrin saturation, and reticulocyte hemoglobin content over a 12-month period. We also compared its efficacy against traditional iron sucrose treatments. The results were encouraging, showing that ferric carboxymaltose not only matched the effectiveness of iron sucrose but also required fewer hospital visits, significantly easing the treatment burden on families.

Overall, our findings suggest that ferric carboxymaltose is both clinically effective and cost-efficient. By reducing the frequency of administration, this approach can enhance the quality of life for pediatric patients with anemia due to chronic kidney disease who depend on hemodialysis. We believe this innovation presents a promising shift in anemia management for this vulnerable population.
Read More

Most Useful Reviews

8
Rapid positive change
47 people found this helpful
Quick effects! I've been diagnosed with anemia for four years as a result of being vegan since 2011. Recently, I felt fatigued despite eating well. After just three days of taking these supplements, even during my menstrual cycle, I felt a significant improvement. I have a doctor's appointment soon to confirm my results. If all goes well, I'll definitely buy more!
Read More
7.5
Gentle on stomach
18 people found this helpful
This is about Anemia and the New Chapter Iron Complex. I have severe, chronic iron deficiency anemia, and this is the only oral supplement I can take without irritating my stomach. It's gentle enough to take without food, and I also combine it with a multivitamin for fatigue. When I ran out, I felt the difference. Several days without it left me unable to wake easily. I highly recommend consulting a hematologist for proper care alongside this supplement.
Read More
10
Returned to normal
17 people found this helpful
Best iron supplement. I went from severe anemia to completely normal within just a couple of weeks of use. I still take it daily, which has restored colour to my face and skin, transforming me from grey to a healthy hue.
Read More

Medical Researches

SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.6
  • All Researches
We examined how iron treatment specifically impacts anemia, particularly during pregnancy. Iron deficiency is a leading cause of anemia, and finding the right treatment is crucial for both mothers and their developing babies.

Our study focused on just the effects of iron without looking at other treatments. This clear approach allowed us to isolate the benefits of iron supplementation. The results were insightful, showing that iron treatment had measurable effects on reducing anemia.

However, we must be careful about overgeneralizing these findings. While our results indicate improvements, it's important to recognize that individual responses to iron may vary. Our findings highlight the importance of monitoring iron levels in pregnant women to effectively address anemia.
Read More
9.5
Identifying and treating hookworm infection
We explored the challenges of diagnosing hookworm infections, particularly in severe cases. By using both morphological and molecular methods, we successfully identified a 75-year-old woman suffering from anemia linked to the hookworm species, Necator americanus. After confirming the infection through various tests, we initiated treatment with albendazole. Following this, we observed a significant improvement in her condition, with both the hookworm and her anemia effectively resolved.
Read More
9
Iron supplementation effects on anemia
We explored the impact of iron and folic acid supplementation on children suffering from mild-to-moderate anemia in India. This study specifically aimed to assess how effective iron treatments are in improving overall hemoglobin levels and reducing anemia symptoms.

The research consisted of controlled trials where groups of children received iron supplements, while others did not. By comparing these groups, we aimed to determine if there was a significant difference in the rates of recovery from anemia.

While we hoped for positive outcomes from the supplementation, the findings showed mixed results. In some cases, we observed improvements in hemoglobin levels, but the overall effectiveness was not as pronounced as anticipated. It's essential to take these findings into account when considering future strategies for combating anemia in children.

Our analysis highlights that while iron supplementation is a crucial piece of the puzzle for treating anemia, it’s also clear that additional factors may play significant roles in achieving optimal health outcomes for affected children.
Read More
9
Serum hepcidin aids anemia diagnosis
We explored the effectiveness of serum hepcidin levels in diagnosing types of anemia in elderly patients, specifically focusing on iron deficiency anemia (IDA) and anemia of chronic disease (ACD). By studying a group of 100 elderly patients alongside 15 healthy controls, we aimed to find a less invasive way to distinguish between these two common conditions.

Through our evaluation, we observed significant differences in iron levels and hepcidin concentrations between patients with IDA and those with ACD. We discovered that serum hepcidin could effectively differentiate between the two types of anemia, boasting a remarkable sensitivity of 93.9% and a specificity of 92.2%. This points to hepcidin as a promising alternative to the traditional bone marrow iron study.

Interestingly, while hepcidin is a valuable marker, relying solely on it can lead to misdiagnoses, similar concerns arise with ferritin levels. Our findings suggest that combining hepcidin with the iron profile provides a more accurate assessment and could potentially replace more invasive diagnostic methods for anemia in the elderly. Overall, we find this combined approach to be a vital step forward in understanding and treating anemia related to iron levels.
Read More
We investigated the combination of Roxadustat, a newer treatment for anemia related to chronic kidney disease (CKD), alongside polysaccharide-iron complex (PIC) in rats. By dividing them into different groups, we observed how various doses of iron impacted hemoglobin levels and kidney function. The results showed that this combination significantly improved hemoglobin levels and kidney health. Importantly, adequate iron supply early on was crucial for effective anemia treatment. Combining these therapies appears beneficial in addressing anemia in CKD effectively.
Read More

User Reviews

USERS' SCORE
Good
Based on 18 Reviews
8.2
  • All Reviews
  • Positive Reviews
  • Negative Reviews
8
Rapid positive change
47 people found this helpful
Quick effects! I've been diagnosed with anemia for four years as a result of being vegan since 2011. Recently, I felt fatigued despite eating well. After just three days of taking these supplements, even during my menstrual cycle, I felt a significant improvement. I have a doctor's appointment soon to confirm my results. If all goes well, I'll definitely buy more!
Read More
7.5
Gentle on stomach
18 people found this helpful
This is about Anemia and the New Chapter Iron Complex. I have severe, chronic iron deficiency anemia, and this is the only oral supplement I can take without irritating my stomach. It's gentle enough to take without food, and I also combine it with a multivitamin for fatigue. When I ran out, I felt the difference. Several days without it left me unable to wake easily. I highly recommend consulting a hematologist for proper care alongside this supplement.
Read More
10
Returned to normal
17 people found this helpful
Best iron supplement. I went from severe anemia to completely normal within just a couple of weeks of use. I still take it daily, which has restored colour to my face and skin, transforming me from grey to a healthy hue.
Read More
9
Improved blood counts
12 people found this helpful
This Iron is the BEST! This product was recommended for my mother undergoing treatment for stage 4 lung cancer with radiation and chemotherapy. Her store-bought iron caused nausea and constipation. She finds this one delightful, tasting of blueberries with no aftertaste. It has completely eliminated her nausea and constipation, maintaining her blood counts throughout treatment and surgery, ensuring she never missed chemotherapy due to low blood counts. Additionally, my daughter, who has an anemia issue, has seen her levels improve without side effects, making her more compliant with her regimen!
Read More
9
Boosted energy quickly
3 people found this helpful
Really happy with my recent purchase. I experienced severe fatigue, hair loss, a racing heartbeat, shortness of breath, and restless legs due to iron deficiency anaemia. After just five days on this supplement, I feel a significant improvement in energy, and my other symptoms have disappeared. It's well worth the cost, so I've subscribed for refills every two months.
Read More

Frequently Asked Questions

9
Eliminated symptoms
My husband experienced anaemia and light-headedness after exercising, but those symptoms have vanished since he began taking this supplement!
7.5
Helps with dizziness
This product has significantly aided my iron deficiency/anemia. Previously, I would feel dizzy and nearly pass out when standing up, but now I can stand without issues and continue walking.
2
Not suitable for anemia
2 people found this helpful
After ingestion, my iron levels remained below normal. This supplement seems suitable only as a prophylactic measure. If one has anaemia, it’s definitely not adequate.
8
Effective iron solution
1 people found this helpful
I love this iron supplement! I've been taking it for over a year after my doctor diagnosed me with iron deficiency anaemia. The prescription was a nightmare, so I switched to this product and it has been fantastic.
8
Ferric Carboxymaltose Replaces Iron Sucrose
We aimed to find a better way to manage anemia in pediatric patients undergoing hemodialysis. Traditionally, these patients receive intravenous (IV) iron therapy using iron sucrose, which requires frequent treatments and carries a risk of allergic reactions. Moving forward with a home hemodialysis program, we investigated ferric carboxymaltose as a safer and more effective alternative.

In our study, we looked closely at how ferric carboxymaltose performed in maintaining healthy levels of hemoglobin, transferrin saturation, and reticulocyte hemoglobin content over a 12-month period. We also compared its efficacy against traditional iron sucrose treatments. The results were encouraging, showing that ferric carboxymaltose not only matched the effectiveness of iron sucrose but also required fewer hospital visits, significantly easing the treatment burden on families.

Overall, our findings suggest that ferric carboxymaltose is both clinically effective and cost-efficient. By reducing the frequency of administration, this approach can enhance the quality of life for pediatric patients with anemia due to chronic kidney disease who depend on hemodialysis. We believe this innovation presents a promising shift in anemia management for this vulnerable population.
4
Iron supplementation alone sufficient
We set out to understand how iron supplementation affects anemia in children by comparing the effects of iron-folic acid with and without additional multiple micronutrients. Conducted as a randomized controlled trial in rural Haryana, India, we included children aged 6 to 59 months with mild to moderate anemia.

Participants were divided into two groups: one received daily iron and folic acid along with multiple micronutrients, while the other was given just iron and folic acid for 90 days. Our aim was to evaluate changes in hemoglobin levels and the rate of recovery from anemia at the end of the study.

After tracking 1,300 children, we found that there was no significant difference in the effectiveness of the two treatments regarding hemoglobin concentration or the proportion of children who were cured of anemia. In fact, compliance with the treatment was high in both groups, but additional micronutrients did not lead to improved outcomes compared to iron and folic acid alone.

Ultimately, our findings suggest that focusing on ensuring children get their necessary iron and folic acid could effectively address anemia, without the need for extra micronutrients.
4
Anaemia treatment's unclear effect
We examined the relationship between iron treatment and improvements in anemia among pregnant women and how these changes might affect the risk of postpartum depression. The study involved 438 pregnant women in Lagos, Nigeria, who were treated for anemia—defined as having a hemoglobin concentration below 11 g/dL—either through intravenous or oral iron supplements.

After four weeks of treatment, participants were reassessed for anemia and iron levels, and their mental health was evaluated using a well-known depression survey two weeks after giving birth. Despite our hopes, we found that while there was a slight non-significant trend suggesting that improvement in anemia was linked to lower risk of postpartum depression, we did not see any notable association with improvements in iron levels.

This suggests that while treating anemia in late pregnancy could potentially lessen the risk of postpartum depression, the evidence remains inconclusive, particularly due to the limitations of our sample size. Our findings highlight the complex relationship between physical health and mental well-being during pregnancy and postpartum periods.
8
Improved anemia management with iron
We explored how iron treatment impacts functional iron-deficiency anemia (FIDA) in cancer patients undergoing chemotherapy. The study compared darbepoetin alfa alone with its combination with ferric derisomaltose.

We found that those receiving the iron and darbepoetin alfa combination had improved hemoglobin, transferrin saturation, and ferritin levels compared to the monotherapy group.

However, both treatments showed no significant impact on cell death related to chemotherapy drugs. Overall, combining iron with darbepoetin alfa yielded better anemia management for cancer patients.

References

  1. Preston R, Theodorou D, Sinnott K, Wallace D, Kaur A. A cost-effective innovation in anaemia management for paediatric patients with haemodialysis-dependent chronic kidney disease. Pediatr Nephrol. 2025. 10.1007/s00467-025-06680-x
  2. Upadhyay RP, Chowdhury R, Mundra S, Taneja S, Jacob M, et al. Comparative effectiveness of daily therapeutic supplementation with multiple micronutrients and iron-folic acid versus iron-folic acid alone in children with mild-to-moderate anaemia in rural India: an open-label, randomised controlled trial. Lancet Glob Health. 2025;13:e497. 10.1016/S2214-109X(24)00559-X
  3. Thomas T, Kurpad A. Childhood iron-folic acid supplementation in India for mild-to-moderate anaemia. Lancet Glob Health. 2025;13:e383. 10.1016/S2214-109X(25)00053-1
  4. Babah OA, Beňová L, Larsson EC, Hanson C, Afolabi BB. Is an improvement in anaemia and iron levels associated with the risk of early postpartum depression? A cohort study from Lagos, Nigeria. BMC Public Health. 2025;25:808. 10.1186/s12889-025-21942-x
  5. Crispell EH, Cassianni CE, Burt JM, Gonzalez JA, Petsch JL, et al. Design and Staged Implementation of a Multidisciplinary Preoperative Anemia Clinic at a Tertiary Care Medical Center. Anesth Analg. 2025. 10.1213/ANE.0000000000007435
  6. Akpan IJ, Narang M, Zampaglione E, Marshall S, Stefanik D. Iron deficiency anemia in patients with heavy menstrual bleeding: The patients' perspective from diagnosis to treatment. Womens Health (Lond). 2025;21:17455057251321221. 10.1177/17455057251321221
  7. Khalaf K, Fujiyoshi Y, Bechara R. Endoscopic and clinical characteristics of autoimmune atrophic gastritis: Retrospective study. Endosc Int Open. 2025;13:a24774666. 10.1055/a-2477-4666
  8. White F, Polakowski N, Merlington E, Leimanis M, Dudick B, et al. Intravenous Sodium Ferric Gluconate Complex for Hospitalized Pediatric Patients with Iron Deficiency Anemia. Children (Basel). 2025;12. 10.3390/children12020189
  9. Maidana D, Arroyo-Álvarez A, Barreres-Martín G, Arenas-Loriente A, Cepas-Guillen P, et al. Targeting Inflammation and Iron Deficiency in Heart Failure: A Focus on Older Adults. Biomedicines. 2025;13. 10.3390/biomedicines13020462
  10. McDonnell T, Kalra PA. Iron in Chronic Kidney Disease and End-Stage Kidney Disease-Current Trends and Future Direction. Br J Hosp Med (Lond). 2025;86:1. 10.12968/hmed.2024.0619
  11. Orlova P, Meshkov I, Sharikov S, Frolov V, Skuredina A, et al. Amidated and Aminated PMSSO-Hydrogels as a Promising Enzyme-Sensitive Vehicle for Antianemic Drugs. Gels. 2025;11. 10.3390/gels11020118
  12. Al Kindi S, Al-Mamari A, Al-Zadjali S, Al-Rawahi M, Al Madhani A, et al. Case report: A novel 11-bp deletion in exon 11 causing a frameshift in the C-terminal of the gene leading to X-linked sideroblastic anemia-a family study. Front Med (Lausanne). 2024;11:1452873. 10.3389/fmed.2024.1452873
  13. Manna S, Chakrabarti SS, Singh R, Gambhir IS. Serum hepcidin level with iron profile assay might replace bone marrow iron study as a diagnostic tool for evaluation of anemia in elderly without chronic renal disease. J Family Med Prim Care. 2025;14:356. 10.4103/jfmpc.jfmpc_34_24
  14. Kranke P, Weiniger CF, Sultan P, Achebe MO, Filipescu D, et al. Iron deficiency and anemia in pregnancy: a call to action!: -"If you don't take a temperature, you can't find a fever". Int J Obstet Anesth. 2024;62:104298. 10.1016/j.ijoa.2024.104298
  15. Larson LM, Baldi A, Hasan MI, Jones N, Pickle EO, et al. Role of hepcidin on benefits and risks of supplementation with iron syrup and multiple micronutrient powders in Bangladeshi children: a sub-study to a randomized controlled trial. Am J Clin Nutr. 2025. 10.1016/j.ajcnut.2025.02.018
  16. Fijn R, Ablij HC, Knoester PD, Witte AMC. Real-world evaluation of an intravenous iron service for the treatment of iron deficiency with or without anemia. Sci Rep. 2025;15:12093. 10.1038/s41598-025-85880-9
  17. Bhutta ZA, Keats EC, Owais A, González-Fernández D, Udomkesmalee E, et al. What works for anemia reduction among women of reproductive age? Synthesized findings from the exemplars in anemia project. Am J Clin Nutr. 2025;121 Suppl 1:S68. 10.1016/j.ajcnut.2024.11.031
  18. Owais A, Habib A, Ahsan H, Merritt CE, Lee C, et al. Drivers of anemia reduction among women of reproductive age in Pakistan: a mixed-methods country case study. Am J Clin Nutr. 2025;121 Suppl 1:S46. 10.1016/j.ajcnut.2024.04.037
  19. Duan Y, Xu Y, Wei Y, Liu T, Xu T, et al. Bilateral segmental testicular infarction secondary to iron deficiency anemia: a case report. BMC Urol. 2025;25:70. 10.1186/s12894-025-01756-0
  20. Warner MA, Johnson ML, Hanson AC, Fortune E, Flaby GW, et al. Practical Anemia Bundle and Hemoglobin Recovery in Critical Illness: A Randomized Clinical Trial. JAMA Netw Open. 2025;8:e252353. 10.1001/jamanetworkopen.2025.2353
  21. Hidayat MT, Khadijah Maharani SN, Ramadhany ID, Khairani NI, Rahman NA, et al. Controlled release of deferiprone using iron-responsive nanoparticles integrated with dissolving microneedle for novel alternative treatments of β-thalassemia major. Eur J Pharm Biopharm. 2025;210:114702. 10.1016/j.ejpb.2025.114702
  22. Al-Taiar A, Ziyab AH, Hammoud MS, Al-Sabah R, Akhtar S. Anemia in pregnant women: findings from Kuwait birth cohort study. BMC Pregnancy Childbirth. 2025;25:326. 10.1186/s12884-025-07439-w
  23. Sohn SH, Sul H, Kim B, Zang D. Effects of Darbepoetin Alfa and Ferric Derisomaltose Plus Darbepoetin Alfa in Functional Iron-Deficiency Anemia. Int J Mol Sci. 2025;26. 10.3390/ijms26052203
  24. Nagao T, Takahashi K, Takahashi S, Yokomizo R, Samura O, et al. Low-dose ferric carboxymaltose vs. oral iron for improving hemoglobin levels in postpartum East Asian women: A randomized controlled trial. PLoS One. 2025;20:e0319795. 10.1371/journal.pone.0319795
  25. Ozeki Y, Kato J, Ohta Y, Taida T, Horio R, et al. [Efficacy and safety of ferric carboxymaltose in patients with inflammatory bowel disease]. Nihon Shokakibyo Gakkai Zasshi. 2025;122:196. 10.11405/nisshoshi.122.196
  26. Gao Z, Gao Y, Wang Q, Wang Q, Lu P, et al. Study on HIF-PHI combined with iron supplement in treatment of renal anemia in rats. BMC Nephrol. 2025;26:125. 10.1186/s12882-025-04045-y
  27. Liu X, Sun A, Zheng X, Xia M, Liu Y, et al. Combined morphological and molecular approaches to the clinical diagnosis of Necator americanus infection: a case report. J Med Case Rep. 2025;19:100. 10.1186/s13256-025-05105-5
  28. Zhang H, Sun W, Qi J, Qayum A, Li J, et al. Antianemic Activity, Inhibition of Oxidative Stress, and Iron Supplementation in Mice with Iron-Deficiency Anemia through HG-Hawthorn Pectin-Iron(III) Complexes. ACS Appl Bio Mater. 2025;8:2419. 10.1021/acsabm.4c01905
  29. Dogan Y, Dede AM, Erdoğan A. An unusual association: gastric xanthelasma presenting with iron deficiency anemia: a case report. J Med Case Rep. 2025;19:98. 10.1186/s13256-025-05133-1
image