We assessed how iron supplementation impacts blood donors who may suffer from low iron levels. Our analysis included thirty studies with nearly 4,700 participants, focusing on the differences between those receiving iron and those who didn’t.
We found that iron supplements reduced the chances of donors being deferred due to low hemoglobin levels and helped elevate their hemoglobin and iron stores. However, we also noted more side effects, like constipation and nausea, among those taking iron.
These side effects hinder its widespread use, suggesting iron supplements should be targeted to at-risk individuals only.
Read More
8
Infant formula impacts stool consistency
Formula tolerance in postbreastfed and exclusively formula-fed infants.
We evaluated how different infant formulas affect the stool characteristics of infants. Two clinical studies focused on infants transitioning from exclusive breastfeeding to formula feeding and those already on formula.
Parents recorded each infant's feeding tolerance, spit-up occurrences, and stool characteristics during the trials. Our findings revealed that the composition of the formula impacts stool consistency.
Specifically, infants consuming formula A exhibited softer stools and more frequent bowel movements compared to those on formula B, which may help lessen concerns about constipation associated with iron-fortified options.
Read More
5
Constipation prevalence linked to iron
Constipation in pregnancy: prevalence, symptoms, and risk factors.
We investigated the prevalence and contributing factors of constipation among healthy pregnant women over the course of their pregnancy. Our longitudinal study showed that constipation affects about 24% of women during various stages of pregnancy and even postpartum.
Notably, we found that iron supplementation was linked to a higher risk of constipation. This means that while iron is an important nutrient during pregnancy, it may also contribute to discomfort for some women.
These findings highlight the importance of monitoring bowel health as part of prenatal care.
Read More
Most Useful Reviews
10
Effective for cancer patients
12 people found this helpful
This Iron is the BEST! Recommended for my mother undergoing treatment for stage 4 lung cancer. The store-bought iron caused her nausea and constipation. This has been wonderful—she loves the taste, has experienced no nausea or constipation, and maintained her blood counts through treatment. My daughter also benefits from it for her anaemia, with no side effects!
Read More
9
Stomach friendly
2 people found this helpful
Womens iron support. I appreciate this iron supplement; it doesn’t upset my stomach or cause constipation.
Read More
10
No constipation
1 people found this helpful
Awesome! This product works a treat. It effectively aids iron absorption in the body without causing constipation. I highly recommend it.
We assessed how iron supplementation impacts blood donors who may suffer from low iron levels. Our analysis included thirty studies with nearly 4,700 participants, focusing on the differences between those receiving iron and those who didn’t.
We found that iron supplements reduced the chances of donors being deferred due to low hemoglobin levels and helped elevate their hemoglobin and iron stores. However, we also noted more side effects, like constipation and nausea, among those taking iron.
These side effects hinder its widespread use, suggesting iron supplements should be targeted to at-risk individuals only.
Read More
8
Iron deficiency linked to constipation
Gastrointestinal symptoms are closely associated with depression in iron deficiency anemia: a comparative study.
This study examined the connection between gastrointestinal issues, particularly constipation, and depression in patients with iron deficiency anemia (IDA).
Conducted at Trakya University, the case-control study involved 125 IDA patients and 57 healthy individuals.
We found that IDA patients reported constipation significantly more often than the control group, with 56% experiencing this symptom. Additionally, their self-reported intensity of bloating and dyspepsia was notably higher, indicating a clear link between IDA, gastrointestinal discomfort, and potential mental health challenges.
Read More
8
Infant formula impacts stool consistency
Formula tolerance in postbreastfed and exclusively formula-fed infants.
We evaluated how different infant formulas affect the stool characteristics of infants. Two clinical studies focused on infants transitioning from exclusive breastfeeding to formula feeding and those already on formula.
Parents recorded each infant's feeding tolerance, spit-up occurrences, and stool characteristics during the trials. Our findings revealed that the composition of the formula impacts stool consistency.
Specifically, infants consuming formula A exhibited softer stools and more frequent bowel movements compared to those on formula B, which may help lessen concerns about constipation associated with iron-fortified options.
Read More
7
Iron's minimal effect on constipation
Low-Dose Prophylactic Oral Iron Supplementation (Ferrous Fumarate, Ferrous Bisglycinate, and Ferrous Sulphate) in Pregnancy Is Not Associated With Clinically Significant Gastrointestinal Complaints: Results From Two Randomized Studies.
We explored the effects of low-dose iron supplementation on gastrointestinal complaints, particularly constipation, in pregnant women. Conducting two randomized studies, we aimed to determine how different forms of iron—ferrous fumarate, ferrous bisglycinate, and ferrous sulphate—would affect the frequency of GI issues among healthy women throughout their pregnancy.
Through our investigations, we found that constipation was only significantly associated with higher doses of ferrous fumarate (80 mg/day). Interestingly, women taking lower doses of ferrous fumarate (20-60 mg/day) did not report more GI side effects, indicating that manageable doses of iron may be tolerated without significant worry about constipation.
Among the iron formulas tested, ferrous bisglycinate at 25 mg showed the best profile, resulting in fewer GI complaints overall compared to the others. In fact, it was linked to a lower incidence of black stools, which can often be associated with iron intake. Ultimately, we observed that while low-dose iron supplementation might incur some side effects, they are generally not severe enough to warrant a change in dosage or interruption of treatment.
Read More
7
Lactoferrin aids iron-deficiency anemia
Lactoferrin as treatment for iron-deficiency anemia in children: a systematic review.
We carefully looked at the impact of lactoferrin (Lf) on treating iron deficiency anemia (IDA) in children, especially focusing on its connection to constipation. In an extensive review of 11 studies, including 10 randomized controlled trials, we saw promising results where children receiving Lf showed notable improvements in their hemoglobin and serum ferritin levels compared to those who only received iron or a placebo.
Interestingly, we found that while some adverse effects like constipation, vomiting, and abdominal pain were reported, those treated with Lf experienced a significant decrease in constipation. This suggests that Lf not only helps in boosting iron levels but may also be easier on the digestive system than traditional iron supplements.
Overall, our exploration indicates that incorporating lactoferrin in the treatment of IDA in children not only helps address anemia effectively but also might provide a gentler alternative for the gut. Users considering iron supplements for their children might find lactoferrin to be a beneficial option.
This Iron is the BEST! Recommended for my mother undergoing treatment for stage 4 lung cancer. The store-bought iron caused her nausea and constipation. This has been wonderful—she loves the taste, has experienced no nausea or constipation, and maintained her blood counts through treatment. My daughter also benefits from it for her anaemia, with no side effects!
Read More
9
Stomach friendly
2 people found this helpful
Womens iron support. I appreciate this iron supplement; it doesn’t upset my stomach or cause constipation.
Read More
10
No constipation
1 people found this helpful
Awesome! This product works a treat. It effectively aids iron absorption in the body without causing constipation. I highly recommend it.
Read More
10
Gentle on stomach
1 people found this helpful
Easy on the stomach! I highly recommend New Chapter Iron Supplement. Normally, I struggle with the taste and digestion of supplements, but this one has been fantastic—easy on my stomach, with zero back taste and no constipation.
Read More
10
Easy to swallow
1 people found this helpful
Great! Thank goodness for these. No constipation, flavourless, and easy to swallow!
Constipation is a common condition characterized by infrequent bowel movements or difficulty passing stools. It is typically defined as having fewer than three bowel movements per week, leading to hard, dry stools that are painful or difficult to expel. This condition can be caused by a variety of factors, including diet, dehydration, lack of physical activity, and certain medications. Stress and lifestyle changes can also contribute, making it essential for individuals to identify the root causes of their constipation for effective relief.
To alleviate constipation, it’s recommended to increase fiber intake by consuming more fruits, vegetables, whole grains, and legumes, as well as ensuring adequate hydration throughout the day. Regular exercise can also promote healthy bowel function. If over-the-counter solutions such as fiber supplements or laxatives aren't effective, it's advisable to consult a healthcare provider, as chronic constipation can lead to complications and indicate underlying health issues. Keeping a consistent eating and bathroom schedule can also help regulate bowel movements.
Iron is a chemical element with the symbol Fe, derived from the Latin word "ferrum." It is a metal that is known for its strength and versatility, making it one of the most widely used materials in construction, manufacturing, and various industrial applications. Iron is the fourth most abundant element in the universe by mass and is primarily obtained through the mining of iron ores, such as hematite and magnetite. Once mined, it undergoes processes like smelting and refining to produce usable forms like cast iron, wrought iron, and steel.
In addition to its industrial uses, iron is also crucial for human health, as it plays a significant role in the production of hemoglobin, the protein in red blood cells responsible for transporting oxygen throughout the body. A deficiency in iron can lead to anemia, characterized by fatigue and weakened immunity. Overall, iron is a fundamental element that supports modern infrastructure and is vital for maintaining good health.
Iron is an essential mineral that plays a vital role in various bodily functions, including the production of hemoglobin. However, when it comes to constipation, the relationship is somewhat complex. While iron itself does not directly alleviate constipation, certain forms of iron supplements, particularly ferrous sulfate, are known to cause gastrointestinal side effects, including constipation in some individuals. If you are considering iron supplementation, it’s essential to monitor your bowel movements and address any side effects you may encounter.
To mitigate constipation related to iron supplementation, it's advisable to combine your iron intake with a diet high in fiber, along with adequate hydration. Foods like fruits, vegetables, and whole grains can help maintain regular bowel movements. Additionally, if you experience persistent constipation while taking iron supplements, consult with a healthcare provider. They may recommend adjusting your dosage or trying a different formulation that is less likely to cause digestive issues.
Based on user reviews, the time it takes to see results from this supplement, particularly in relation to constipation, can vary significantly. Some users report immediate effects, noting improvements in digestive health and reduced constipation almost right away. For instance, one user mentioned feeling less tired and experiencing improved digestive health with reduced constipation shortly after starting the supplement Read Review.
However, other users indicate that it may take longer to notice any significant changes. One reviewer stated that they had used the product for a month and did not feel a major improvement in their energy levels, although they appreciated that it did not cause them constipation Read Review. Furthermore, one user highlighted that they still experienced constipation, despite having hoped for better results from this particular formula Read Review. Overall, while some users notice benefits almost immediately, a more common timeframe for others seems to be a few weeks for observing any change in their digestive health.
The effectiveness of various iron supplements in addressing constipation issues has been researched, particularly in specific populations like pregnant women and children. For instance, a study involving low-dose iron supplementation in pregnant women found that higher doses of ferrous fumarate increased instances of constipation, while lower doses (20-60 mg/day) did not significantly impact gastrointestinal complaints [1]. Furthermore, intermittent iron supplementation was associated with reduced constipation risk compared to daily doses, with an adjusted odds ratio indicating nearly double the risk for those on daily iron regimens [2].
In children, lactoferrin was shown to reduce constipation occurrences while improving iron levels, suggesting it may be a gentler alternative to traditional iron supplements [3]. Conversely, a systematic review indicated that patient populations, such as blood donors and pregnant women, often experienced side effects like constipation following iron supplementation [7], [9]. Ultimately, while some iron supplements can exacerbate constipation risk, particularly in higher doses, others, like lactoferrin, show promise in mitigating this side effect. Thus, it's essential for individuals considering iron supplementation to consult healthcare professionals to determine the best approach based on their specific health needs.
Based on user reviews, many individuals have reported noticeable improvements in their symptoms when using this iron supplement. A significant number of users highlight that this product does not cause constipation, a common side effect associated with iron supplements. For example, one user expressed appreciation that the supplement did not upset their stomach or lead to constipation, making their experience more pleasant Read Review. Another user noted they experienced a considerable increase in their ferritin levels without the typical constipation issues that often accompany iron supplementation Read Review.
In addition to digestive comfort, some users have reported increased energy levels and improvements in mood. One reviewer mentioned that they felt more energetic upon waking, had reduced anxiety, and noticed improvements in their skin and hair quality Read Review. However, it's important to note that individual results can vary, as evidenced by a user who continued to experience constipation despite their hopes for a better outcome with this supplement Read Review. Overall, while many find this particular iron supplement effective and tolerable, others might encounter different experiences.
Based on user reviews, many individuals have positively noted the compatibility of this iron supplement with other supplements when addressing constipation. One user mentioned taking it alongside New Chapter Wholemega Fish Oil over the course of a month, remarking that while immediate energy improvements were not as pronounced as anticipated, they did appreciate that the iron supplement did not induce constipation, a common concern with iron medications Read Review.
However, it’s important to note that experiences can vary widely among users. One individual expressed disappointment with their ongoing constipation despite their belief that the formula would mitigate this issue Read Review. Overall, while many users find this iron supplement to be non-constipating and easy to combine with other supplements, some still report struggles with digestive health, indicating that individual responses may differ.
When it comes to iron supplementation and its connection to constipation, research suggests that lower doses are generally more tolerable for most individuals. A study focused on pregnant women found that lower doses of ferrous fumarate, specifically within the range of 20-60 mg/day, did not significantly increase gastrointestinal issues, including constipation [1]. Additionally, iron bisglycinate at 25 mg showed an even better profile with fewer side effects [1]. Thus, those looking to supplement iron should consider doses in this range to minimize the likelihood of constipation.
Furthermore, it's worth noting that daily iron supplementation was associated with a higher risk of constipation compared to intermittent doses, indicating that spreading out doses may be a better approach for those who are sensitive to gastrointestinal side effects [2]. Overall, for those managing iron deficiency while minimizing constipation, a low-dose regimen of iron, particularly in the form of bisglycinate or taking iron intermittently, may be the best course of action.
6
Digestive health improved
I feel more energetic when I wake up and less tired throughout the day. My mood swings and anxiety have lessened, my digestive health has improved with less constipation or discomfort, and my skin condition has gotten better while my hair shines more.
9
Mood improvement noted
It's not perfect, but it's acceptable. I've been using this for one month along with New Chapter Wholemega Fish Oil. I anticipated feeling more energetic than before, but I haven’t experienced significant improvement, likely due to the short duration I've been consuming the supplement. However, I’ve noticed my mood has become more positive. This product is excellent as it doesn't cause me constipation, unlike other supplements or medications I’ve tried. I have no issues taking it on an empty stomach.
2
Still constipated
1 people found this helpful
Iron and Constipation. I appreciate "Every Woman's Iron Support," but I still experience constipation from the iron. I hoped this formula would be more effective, but the issue persists.
9
Stomach friendly
2 people found this helpful
Womens iron support. I appreciate this iron supplement; it doesn’t upset my stomach or cause constipation.
7.5
Effective results
1 people found this helpful
Greatly raised ferritin levels. I recently learned that ferritin needs to be checked even with normal haemoglobin. This supplement didn’t cause constipation and worked effectively.
7
Iron's minimal effect on constipation
Low-Dose Prophylactic Oral Iron Supplementation (Ferrous Fumarate, Ferrous Bisglycinate, and Ferrous Sulphate) in Pregnancy Is Not Associated With Clinically Significant Gastrointestinal Complaints: Results From Two Randomized Studies.
We explored the effects of low-dose iron supplementation on gastrointestinal complaints, particularly constipation, in pregnant women. Conducting two randomized studies, we aimed to determine how different forms of iron—ferrous fumarate, ferrous bisglycinate, and ferrous sulphate—would affect the frequency of GI issues among healthy women throughout their pregnancy.
Through our investigations, we found that constipation was only significantly associated with higher doses of ferrous fumarate (80 mg/day). Interestingly, women taking lower doses of ferrous fumarate (20-60 mg/day) did not report more GI side effects, indicating that manageable doses of iron may be tolerated without significant worry about constipation.
Among the iron formulas tested, ferrous bisglycinate at 25 mg showed the best profile, resulting in fewer GI complaints overall compared to the others. In fact, it was linked to a lower incidence of black stools, which can often be associated with iron intake. Ultimately, we observed that while low-dose iron supplementation might incur some side effects, they are generally not severe enough to warrant a change in dosage or interruption of treatment.
4
Iron supplementation effects on constipation
Efficacy of daily versus intermittent oral iron supplementation for prevention of anaemia among pregnant women: a systematic review and meta-analysis.
We examined how different types of iron supplementation affect pregnant women, particularly focusing on potential constipation as a side effect. In a systematic review and meta-analysis, we gathered data from 26 studies involving nearly 4,400 participants to compare daily and intermittent iron supplementation.
Interestingly, we found that daily oral iron supplementation was associated with a higher occurrence of constipation compared to intermittent supplementation. The adjusted odds ratio for constipation was 1.95, indicating a nearly two-fold increase in risk for those taking daily iron. However, our analysis revealed that both daily and intermittent iron supplements could increase hemoglobin levels effectively, showing no significant difference in overall efficacy.
Ultimately, while daily iron supplementation led to better ferritin levels, women experienced more adverse effects such as nausea, diarrhea, and constipation. This suggests that intermittent iron supplementation could be a more favorable option, especially for those who are sensitive to the side effects associated with daily doses.
7
Lactoferrin aids iron-deficiency anemia
Lactoferrin as treatment for iron-deficiency anemia in children: a systematic review.
We carefully looked at the impact of lactoferrin (Lf) on treating iron deficiency anemia (IDA) in children, especially focusing on its connection to constipation. In an extensive review of 11 studies, including 10 randomized controlled trials, we saw promising results where children receiving Lf showed notable improvements in their hemoglobin and serum ferritin levels compared to those who only received iron or a placebo.
Interestingly, we found that while some adverse effects like constipation, vomiting, and abdominal pain were reported, those treated with Lf experienced a significant decrease in constipation. This suggests that Lf not only helps in boosting iron levels but may also be easier on the digestive system than traditional iron supplements.
Overall, our exploration indicates that incorporating lactoferrin in the treatment of IDA in children not only helps address anemia effectively but also might provide a gentler alternative for the gut. Users considering iron supplements for their children might find lactoferrin to be a beneficial option.
9
Iron supplements reduce donor deferral
Oral or parenteral iron supplementation to reduce deferral, iron deficiency and/or anaemia in blood donors.
We assessed how iron supplementation impacts blood donors who may suffer from low iron levels. Our analysis included thirty studies with nearly 4,700 participants, focusing on the differences between those receiving iron and those who didn’t.
We found that iron supplements reduced the chances of donors being deferred due to low hemoglobin levels and helped elevate their hemoglobin and iron stores. However, we also noted more side effects, like constipation and nausea, among those taking iron.
These side effects hinder its widespread use, suggesting iron supplements should be targeted to at-risk individuals only.
5
Constipation prevalence linked to iron
Constipation in pregnancy: prevalence, symptoms, and risk factors.
We investigated the prevalence and contributing factors of constipation among healthy pregnant women over the course of their pregnancy. Our longitudinal study showed that constipation affects about 24% of women during various stages of pregnancy and even postpartum.
Notably, we found that iron supplementation was linked to a higher risk of constipation. This means that while iron is an important nutrient during pregnancy, it may also contribute to discomfort for some women.
These findings highlight the importance of monitoring bowel health as part of prenatal care.
References
Milman NT, Bergholt T. Low-Dose Prophylactic Oral Iron Supplementation (Ferrous Fumarate, Ferrous Bisglycinate, and Ferrous Sulphate) in Pregnancy Is Not Associated With Clinically Significant Gastrointestinal Complaints: Results From Two Randomized Studies. J Pregnancy. 2024;2024:1716798. 10.1155/2024/1716798
Banerjee A, Athalye S, Shingade P, Khargekar V, Mahajan N, et al. Efficacy of daily versus intermittent oral iron supplementation for prevention of anaemia among pregnant women: a systematic review and meta-analysis. EClinicalMedicine. 2024;74:102742. 10.1016/j.eclinm.2024.102742
June D, Konstantin AT, Lumbanradja LA, Aryani A, Hengky A. Lactoferrin as treatment for iron-deficiency anemia in children: a systematic review. Turk J Pediatr. 2023;65:543. 10.24953/turkjped.2022.670
Suzuki D, Ichie T, Hayashi H, Sugiura Y, Sugiyama T. Efficacy of sucroferric oxyhydroxide treatment in Japanese hemodialysis patients and its effect on gastrointestinal symptoms. Pharmazie. 2017;72:118. 10.1691/ph.2017.6848
Abdel Moety GAF, Ali AM, Fouad R, Ramadan W, Belal DS, et al. Amino acid chelated iron versus an iron salt in the treatment of iron deficiency anemia with pregnancy: A randomized controlled study. Eur J Obstet Gynecol Reprod Biol. 2017;210:242. 10.1016/j.ejogrb.2017.01.003
Pamuk GE, Uyanik MS, Top MS, Tapan U, Ak R, et al. Gastrointestinal symptoms are closely associated with depression in iron deficiency anemia: a comparative study. Ann Saudi Med. 2015;35:31. 10.5144/0256-4947.2015.31
Smith GA, Fisher SA, Doree C, Di Angelantonio E, Roberts DJ. Oral or parenteral iron supplementation to reduce deferral, iron deficiency and/or anaemia in blood donors. Cochrane Database Syst Rev. 2014;2014:CD009532. 10.1002/14651858.CD009532.pub2
Pereira DI, Couto Irving SS, Lomer MC, Powell JJ. A rapid, simple questionnaire to assess gastrointestinal symptoms after oral ferrous sulphate supplementation. BMC Gastroenterol. 2014;14:103. 10.1186/1471-230X-14-103
Bradley CS, Kennedy CM, Turcea AM, Rao SS, Nygaard IE. Constipation in pregnancy: prevalence, symptoms, and risk factors. Obstet Gynecol. 2007;110:1351.
Singhal A, Morley R, Abbott R, Fairweather-Tait S, Stephenson T, et al. Clinical safety of iron-fortified formulas. Pediatrics. 2000;105:E38.
Lloyd B, Halter RJ, Kuchan MJ, Baggs GE, Ryan AS, et al. Formula tolerance in postbreastfed and exclusively formula-fed infants. Pediatrics. 1999;103:E7.