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SCIENTIFIC SCORE
Possibly Effective
Based on 33 Researches
7.4
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 3 Soft Gels
Amount Per Serving
%DV
Calories
35
Total Fat
3 g
4%
Saturated Fat
0.5 g
3%
Trans Fat
0 g
†
Cholesterol
15 mg
5%
Vitamin A
30 mcg RAE
3%
Total Omega-3s
750 mg
†
EPA (Eicosapentaenoic Acid)
240 mg
†
DHA (Docosahexaenoic Acid)
360 mg
†
Other Omega-3s
150 mg
†
Top Medical Research Studies
8
EPA benefits psoriatic skin health
Eicosapentaenoic Acid Influences the Lipid Profile of an In Vitro Psoriatic Skin Model Produced with T Cells.
Direct effect on psoriasis treatment
We aimed to understand how eicosapentaenoic acid (EPA) affects psoriasis, a skin condition known for causing redness, irritation, and thickened skin. By creating skin models that reflect both healthy and psoriatic conditions, we were able to assess the impact of EPA directly on lipid profiles—a key factor in skin health.
Our research revealed that in psoriatic skin models, there was a notable increase in certain fatty acids linked to inflammation, such as arachidonic acid (AA) and linoleic acid (LA). However, when we supplemented the media with EPA, we noticed a significant shift. The levels of beneficial omega-3 fatty acids, including EPA, docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA), rose in both epidermal and dermal tissues.
More importantly, the addition of EPA helped to balance the production of lipid mediators in the skin. We observed increases in several anti-inflammatory molecules, such as prostaglandin E (PGE) and 12-hydroxyeicosapentaenoic acid (12-HEPE), indicating a move toward a more stable and healthier skin environment. These results suggest that EPA could play an important role in managing psoriasis by promoting a healthier lipid balance in the skin, potentially easing symptoms and encouraging skin healing.
Our research revealed that in psoriatic skin models, there was a notable increase in certain fatty acids linked to inflammation, such as arachidonic acid (AA) and linoleic acid (LA). However, when we supplemented the media with EPA, we noticed a significant shift. The levels of beneficial omega-3 fatty acids, including EPA, docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA), rose in both epidermal and dermal tissues.
More importantly, the addition of EPA helped to balance the production of lipid mediators in the skin. We observed increases in several anti-inflammatory molecules, such as prostaglandin E (PGE) and 12-hydroxyeicosapentaenoic acid (12-HEPE), indicating a move toward a more stable and healthier skin environment. These results suggest that EPA could play an important role in managing psoriasis by promoting a healthier lipid balance in the skin, potentially easing symptoms and encouraging skin healing.
Read More
9
Eicosapentaenoic acid benefits psoriasis
n-3 fatty acids in psoriasis.
Directly explores EPA's effects
We assessed the effects of eicosapentaenoic acid (EPA), an omega-3 fatty acid, on psoriasis through intravenous administration in a series of studies. The investigation aimed to understand whether replacing arachidonic acid, which has pro-inflammatory properties, with EPA could be beneficial for patients suffering from psoriasis.
Participants received daily infusions of either an EPA-based lipid emulsion or a conventional n-6 lipid emulsion. Throughout the studies, we closely monitored the clinical progression of psoriasis, along with specific inflammatory markers in the blood.
Our findings were notable: the group receiving the n-3 fatty acid treatment showed a significantly higher response rate. We observed a remarkable tenfold increase in specific products derived from neutrophils, indicating enhanced benefits from EPA. Additionally, plasma levels of EPA rose swiftly within just a few days of treatment.
In summary, our research suggests that intravenous administration of n-3 fatty acids effectively reduces psoriasis symptoms, likely due to alterations in inflammatory processes. This rapid response contrasts sharply with slower improvements seen with oral supplementation of fatty acids.
Participants received daily infusions of either an EPA-based lipid emulsion or a conventional n-6 lipid emulsion. Throughout the studies, we closely monitored the clinical progression of psoriasis, along with specific inflammatory markers in the blood.
Our findings were notable: the group receiving the n-3 fatty acid treatment showed a significantly higher response rate. We observed a remarkable tenfold increase in specific products derived from neutrophils, indicating enhanced benefits from EPA. Additionally, plasma levels of EPA rose swiftly within just a few days of treatment.
In summary, our research suggests that intravenous administration of n-3 fatty acids effectively reduces psoriasis symptoms, likely due to alterations in inflammatory processes. This rapid response contrasts sharply with slower improvements seen with oral supplementation of fatty acids.
Read More
9
DHA shows promise for psoriasis treatment
Comparison of the dietary omega-3 fatty acids impact on murine psoriasis-like skin inflammation and associated lipid dysfunction.
Focus on DHA's specific effects
We aimed to understand how docosahexaenoic acid (DHA), one of the omega-3 fatty acids, affects psoriasis, particularly looking at its anti-inflammatory properties. The research focused on a mouse model designed to replicate psoriasis-like skin conditions. Over a 12-week period, we compared the effects of diets rich in either DHA or eicosapentaenoic acid (EPA) on skin inflammation and related lipid issues.
Our findings revealed that DHA treatment led to significant improvements. We noted a decrease in pro-inflammatory cytokines and bioactive lipid mediators circulating in the body. Moreover, DHA resulted in the skin showing higher levels of specific molecules like resolvin D5 and protectin DX, which help with resolving inflammation. On the other hand, while EPA also had some beneficial effects, they were not as pronounced as those from DHA, particularly in reducing harmful skin compounds.
Overall, our results suggest that DHA might be the more effective option when considering dietary interventions for managing psoriasis. This enhances our understanding of how omega-3 fatty acids can contribute positively to inflammatory skin conditions.
Our findings revealed that DHA treatment led to significant improvements. We noted a decrease in pro-inflammatory cytokines and bioactive lipid mediators circulating in the body. Moreover, DHA resulted in the skin showing higher levels of specific molecules like resolvin D5 and protectin DX, which help with resolving inflammation. On the other hand, while EPA also had some beneficial effects, they were not as pronounced as those from DHA, particularly in reducing harmful skin compounds.
Overall, our results suggest that DHA might be the more effective option when considering dietary interventions for managing psoriasis. This enhances our understanding of how omega-3 fatty acids can contribute positively to inflammatory skin conditions.
Read More
Most Useful Reviews
8.8
Helps scalp psoriasis
The lemon-flavoured Nordic Naturals Cod Liver Oil has no fishy aftertaste, which is a delightful surprise. Despite the large size of the capsule, I find this supplement is the best I’ve tried, effectively supplying Omega 3s to both me and my son, who uses it to soothe his scalp psoriasis.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 33 Researches
7.4
9.5
DHA shows promise for psoriasis
Effects of dietary supplementation with polyunsaturated ethyl ester lipids (Angiosan) in patients with psoriasis and psoriatic arthritis.
Combination treatment complicates evaluation
We evaluated the impact of docosahexaenoic acid (DHA) supplementation, alongside eicosapentaenoic acid (EPA), in patients suffering from chronic, stable psoriasis. This study involved 80 participants, 34 of whom also had psoriatic arthritis, and they were given specific doses of fatty acid ethyl esters for a period of eight weeks.
The results showed a noteworthy decrease in the Psoriasis Area Severity Index (PASI) scores, which went from an average of 3.56 before treatment to 1.24 after eight weeks. This significant reduction illustrates the potential effectiveness of DHA for managing symptoms of psoriasis, such as itching and plaque scaling.
It was particularly encouraging to see that seven patients were completely healed, with many others experiencing significant improvement. The majority of those with psoriatic arthritis reported feeling less joint pain during the study. Through our observations, it became clear that polyunsaturated ethyl ester lipids, like DHA, may serve as a valuable complement to traditional therapies for both psoriasis and psoriatic arthritis.
The results showed a noteworthy decrease in the Psoriasis Area Severity Index (PASI) scores, which went from an average of 3.56 before treatment to 1.24 after eight weeks. This significant reduction illustrates the potential effectiveness of DHA for managing symptoms of psoriasis, such as itching and plaque scaling.
It was particularly encouraging to see that seven patients were completely healed, with many others experiencing significant improvement. The majority of those with psoriatic arthritis reported feeling less joint pain during the study. Through our observations, it became clear that polyunsaturated ethyl ester lipids, like DHA, may serve as a valuable complement to traditional therapies for both psoriasis and psoriatic arthritis.
Read More
9
Eicosapentaenoic acid benefits psoriasis
n-3 fatty acids in psoriasis.
Directly explores EPA's effects
We assessed the effects of eicosapentaenoic acid (EPA), an omega-3 fatty acid, on psoriasis through intravenous administration in a series of studies. The investigation aimed to understand whether replacing arachidonic acid, which has pro-inflammatory properties, with EPA could be beneficial for patients suffering from psoriasis.
Participants received daily infusions of either an EPA-based lipid emulsion or a conventional n-6 lipid emulsion. Throughout the studies, we closely monitored the clinical progression of psoriasis, along with specific inflammatory markers in the blood.
Our findings were notable: the group receiving the n-3 fatty acid treatment showed a significantly higher response rate. We observed a remarkable tenfold increase in specific products derived from neutrophils, indicating enhanced benefits from EPA. Additionally, plasma levels of EPA rose swiftly within just a few days of treatment.
In summary, our research suggests that intravenous administration of n-3 fatty acids effectively reduces psoriasis symptoms, likely due to alterations in inflammatory processes. This rapid response contrasts sharply with slower improvements seen with oral supplementation of fatty acids.
Participants received daily infusions of either an EPA-based lipid emulsion or a conventional n-6 lipid emulsion. Throughout the studies, we closely monitored the clinical progression of psoriasis, along with specific inflammatory markers in the blood.
Our findings were notable: the group receiving the n-3 fatty acid treatment showed a significantly higher response rate. We observed a remarkable tenfold increase in specific products derived from neutrophils, indicating enhanced benefits from EPA. Additionally, plasma levels of EPA rose swiftly within just a few days of treatment.
In summary, our research suggests that intravenous administration of n-3 fatty acids effectively reduces psoriasis symptoms, likely due to alterations in inflammatory processes. This rapid response contrasts sharply with slower improvements seen with oral supplementation of fatty acids.
Read More
9
DHA shows promise for psoriasis treatment
Comparison of the dietary omega-3 fatty acids impact on murine psoriasis-like skin inflammation and associated lipid dysfunction.
Focus on DHA's specific effects
We aimed to understand how docosahexaenoic acid (DHA), one of the omega-3 fatty acids, affects psoriasis, particularly looking at its anti-inflammatory properties. The research focused on a mouse model designed to replicate psoriasis-like skin conditions. Over a 12-week period, we compared the effects of diets rich in either DHA or eicosapentaenoic acid (EPA) on skin inflammation and related lipid issues.
Our findings revealed that DHA treatment led to significant improvements. We noted a decrease in pro-inflammatory cytokines and bioactive lipid mediators circulating in the body. Moreover, DHA resulted in the skin showing higher levels of specific molecules like resolvin D5 and protectin DX, which help with resolving inflammation. On the other hand, while EPA also had some beneficial effects, they were not as pronounced as those from DHA, particularly in reducing harmful skin compounds.
Overall, our results suggest that DHA might be the more effective option when considering dietary interventions for managing psoriasis. This enhances our understanding of how omega-3 fatty acids can contribute positively to inflammatory skin conditions.
Our findings revealed that DHA treatment led to significant improvements. We noted a decrease in pro-inflammatory cytokines and bioactive lipid mediators circulating in the body. Moreover, DHA resulted in the skin showing higher levels of specific molecules like resolvin D5 and protectin DX, which help with resolving inflammation. On the other hand, while EPA also had some beneficial effects, they were not as pronounced as those from DHA, particularly in reducing harmful skin compounds.
Overall, our results suggest that DHA might be the more effective option when considering dietary interventions for managing psoriasis. This enhances our understanding of how omega-3 fatty acids can contribute positively to inflammatory skin conditions.
Read More
9
DHA improves psoriatic skin symptoms
Biological action of docosahexaenoic acid in a 3D tissue-engineered psoriatic skin model: Focus on the PPAR signaling pathway.
Study focuses on DHA's effects
We explored the role of docosahexaenoic acid (DHA) in treating psoriasis using a 3D tissue-engineered skin model. Our goal was to understand how DHA might influence the symptoms of psoriasis, particularly through its impact on skin cell behavior and inflammation.
In the study, we created skin substitutes that mimic both healthy and psoriatic skin, adding 10 μM of DHA to the culture media. What we found was quite promising; the presence of DHA helped improve the abnormal cell behavior seen in psoriatic skin. Specifically, we observed increased expression of important skin proteins, like filaggrin and keratin 10, which are crucial for healthy skin function.
Additionally, DHA was integrated into the skin cell membranes and converted into another beneficial fatty acid, eicosapentaenoic acid (EPA). Notably, we saw a reduction in harmful inflammatory substances derived from other fatty acids, including prostaglandin E (PGE) and 12-hydroxyeicosatetraenoic acid (12-HETE).
Furthermore, DHA supplementation appeared to rebalance the expression of important receptors involved in cellular signaling and reduced the secretion of the inflammatory cytokine TNF-α. Overall, our findings suggest that DHA can help ease the symptoms of psoriasis by promoting healthier skin cell activity and curbing inflammation.
In the study, we created skin substitutes that mimic both healthy and psoriatic skin, adding 10 μM of DHA to the culture media. What we found was quite promising; the presence of DHA helped improve the abnormal cell behavior seen in psoriatic skin. Specifically, we observed increased expression of important skin proteins, like filaggrin and keratin 10, which are crucial for healthy skin function.
Additionally, DHA was integrated into the skin cell membranes and converted into another beneficial fatty acid, eicosapentaenoic acid (EPA). Notably, we saw a reduction in harmful inflammatory substances derived from other fatty acids, including prostaglandin E (PGE) and 12-hydroxyeicosatetraenoic acid (12-HETE).
Furthermore, DHA supplementation appeared to rebalance the expression of important receptors involved in cellular signaling and reduced the secretion of the inflammatory cytokine TNF-α. Overall, our findings suggest that DHA can help ease the symptoms of psoriasis by promoting healthier skin cell activity and curbing inflammation.
Read More
9
Rapid improvement in psoriasis
A double-blind, randomized, placebo-controlled trial of n-3 fatty acid based lipid infusion in acute, extended guttate psoriasis. Rapid improvement of clinical manifestations and changes in neutrophil leukotriene profile.
Strong relevance to treated condition
We explored the effectiveness of a specialized treatment regimen involving docosahexaenoic acid (DHA) as part of an n-3 fatty acid lipid infusion for patients suffering from acute guttate psoriasis. This study included twenty hospitalized individuals with significant skin involvement and was conducted in a randomized, double-blind, placebo-controlled manner to ensure reliable results.
Participants received either a daily infusion of the n-3 fatty acid emulsion, which contained DHA and eicosapentaenoic acid (EPA), or a conventional n-6 lipid emulsion lacking significant benefits from omega-3s. We recorded clinical changes over ten days, assessing factors such as skin redness, swelling, and peeling, along with patients' subjective feelings about their symptoms.
The results were telling: those receiving the n-3 infusion showed a remarkable improvement in their psoriasis symptoms—between 45% and 76%—within just ten days. In contrast, the n-6 group experienced only moderate improvement, around 16-25%. Furthermore, we noted significant changes in the patients' immune response. The n-3 group had an increased production of beneficial leukotriene products, while inflammatory markers decreased, suggesting a positive modulation of the body's inflammatory response by DHA and EPA.
Overall, our investigation highlights a potential rapid benefit of using n-3 fatty acids, particularly DHA, in treating acute psoriasis. This indicates a promising avenue for improving the lives of those affected by this challenging skin condition.
Participants received either a daily infusion of the n-3 fatty acid emulsion, which contained DHA and eicosapentaenoic acid (EPA), or a conventional n-6 lipid emulsion lacking significant benefits from omega-3s. We recorded clinical changes over ten days, assessing factors such as skin redness, swelling, and peeling, along with patients' subjective feelings about their symptoms.
The results were telling: those receiving the n-3 infusion showed a remarkable improvement in their psoriasis symptoms—between 45% and 76%—within just ten days. In contrast, the n-6 group experienced only moderate improvement, around 16-25%. Furthermore, we noted significant changes in the patients' immune response. The n-3 group had an increased production of beneficial leukotriene products, while inflammatory markers decreased, suggesting a positive modulation of the body's inflammatory response by DHA and EPA.
Overall, our investigation highlights a potential rapid benefit of using n-3 fatty acids, particularly DHA, in treating acute psoriasis. This indicates a promising avenue for improving the lives of those affected by this challenging skin condition.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Helps scalp psoriasis
The lemon-flavoured Nordic Naturals Cod Liver Oil has no fishy aftertaste, which is a delightful surprise. Despite the large size of the capsule, I find this supplement is the best I’ve tried, effectively supplying Omega 3s to both me and my son, who uses it to soothe his scalp psoriasis.
Read More
