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SCIENTIFIC SCORE
Possibly Effective
Based on 35 Researches
7.3
USERS' SCORE
Good
Based on 2 Reviews
8.4
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
†
Vitamin D3 (cholecalciferol)
10 mcg (400 IU)
67%
Total Omega-3s♦
830 mg
†
EPA (Eicosapentaenoic Acid)
205 mg
†
DHA (Docosahexaenoic Acid)
480 mg
†
Top Medical Research Studies
7
Vitamin D3's role in anemia
Effect of vitamin D3-fortified fruit juice supplementation of 4000 IU daily on the recovery of iron status in childbearing-aged women with marginally low iron stores: Protocol for an 8-week, parallel group, double-blind randomized controlled trial.
Directly studies vitamin D3 and anemia
We conducted a study to see how vitamin D3 might help improve iron levels in women of childbearing age who had marginally low iron stores. Our approach involved a carefully designed 8-week randomized controlled trial, where 120 women aged between 19 and 40 were divided into two groups. One group received fruit juice fortified with 4000 IU of vitamin D3 daily, while the other had a placebo juice.
Throughout the study, we collected blood samples and monitored various health indicators every four weeks. We aimed to find out if the vitamin D3 supplementation could positively influence the iron status of the participants compared to the placebo.
Given the promising role of vitamin D in enhancing iron absorption, we hoped to uncover new insights into dietary strategies for managing iron deficiency. By observing the interaction over time between vitamin D levels and iron status, we aimed to provide valuable information on whether this fortification could serve as a practical alternative to traditional iron supplements.
As we gathered data, we explored the potential of vitamin D3 beyond its usual role, assessing if it could indeed help improve the anemia indicators in our target group.
Throughout the study, we collected blood samples and monitored various health indicators every four weeks. We aimed to find out if the vitamin D3 supplementation could positively influence the iron status of the participants compared to the placebo.
Given the promising role of vitamin D in enhancing iron absorption, we hoped to uncover new insights into dietary strategies for managing iron deficiency. By observing the interaction over time between vitamin D levels and iron status, we aimed to provide valuable information on whether this fortification could serve as a practical alternative to traditional iron supplements.
As we gathered data, we explored the potential of vitamin D3 beyond its usual role, assessing if it could indeed help improve the anemia indicators in our target group.
Read More
9
Vitamin D3 improves iron status
An 8-Week Vitamin D3-Fortified Fruit Drink Supplementation Increases Serum Ferritin Concentration: A Randomized Controlled Trial in Malaysian Women With Low Iron Stores.
Direct evaluation of vitamin D3
We conducted an 8-week, double-blind randomized controlled trial to see how vitamin D3-fortified fruit drinks affect iron levels in women with low iron stores. Our subjects, a group of 45 healthy women aged between 18 and 40, received either the vitamin D3 drink or a placebo, helping us assess the impact of this nutrient on their health.
Throughout the study, we measured key biomarkers such as serum ferritin, which indicates iron stores, and 25-hydroxyvitamin D, the active form of vitamin D in the body. After the 8 weeks, we noted a significant increase in both vitamin D levels and serum ferritin among those who participated in the vitamin D3-fortified drink regimen. This suggests that supplementing with vitamin D3 can indeed help improve iron stores in women who are iron deficient.
Given these findings, it becomes clear that there is potential for vitamin D to play a role in managing anemia. However, we also recognize the need for further research to confirm these effects and explore the safety and practicality of such fortifications across different populations.
Throughout the study, we measured key biomarkers such as serum ferritin, which indicates iron stores, and 25-hydroxyvitamin D, the active form of vitamin D in the body. After the 8 weeks, we noted a significant increase in both vitamin D levels and serum ferritin among those who participated in the vitamin D3-fortified drink regimen. This suggests that supplementing with vitamin D3 can indeed help improve iron stores in women who are iron deficient.
Given these findings, it becomes clear that there is potential for vitamin D to play a role in managing anemia. However, we also recognize the need for further research to confirm these effects and explore the safety and practicality of such fortifications across different populations.
Read More
7
Vitamin D3 impacts CKD anemia risk
Relationship between serum vitamin D3 concentration and anaemia in patients with chronic kidney disease in China.
Direct link between vitamin D3 and anemia
We explored how vitamin D3 levels relate to anemia in patients with chronic kidney disease (CKD) in China. In our study, 225 CKD patients were assigned to three groups based on their serum vitamin D3 levels: severe deficiency, deficiency, and sufficiency. Through our analysis, we measured the prevalence of anemia within these groups to identify any potential links.
The results were quite telling. Among the participants, 79.5% of those in the severe deficiency group had anemia, compared to 63.5% in the deficiency group, and 48.0% in the sufficiency group. This shows a clear trend—the more deficient the vitamin D3 levels, the higher the likelihood of experiencing anemia. We also noted that as the stages of CKD progressed, from 1 to 5, the prevalence of anemia increased significantly, peaking at almost 95% in the most advanced stage.
Our findings suggest that vitamin D3 deficiency may indeed elevate the risk of anemia in individuals suffering from CKD. Addressing vitamin D3 levels in these patients could be an essential factor in managing their anemia effectively.
The results were quite telling. Among the participants, 79.5% of those in the severe deficiency group had anemia, compared to 63.5% in the deficiency group, and 48.0% in the sufficiency group. This shows a clear trend—the more deficient the vitamin D3 levels, the higher the likelihood of experiencing anemia. We also noted that as the stages of CKD progressed, from 1 to 5, the prevalence of anemia increased significantly, peaking at almost 95% in the most advanced stage.
Our findings suggest that vitamin D3 deficiency may indeed elevate the risk of anemia in individuals suffering from CKD. Addressing vitamin D3 levels in these patients could be an essential factor in managing their anemia effectively.
Read More
Most Useful Reviews
9.5
Prevented anaemia risks
During my first pregnancy, I neglected vitamins, thinking they were unnecessary. Now, I realise that taking vitamins is crucial for my health and to avoid complications like anaemia after childbirth. I strongly recommend pregnant women to take at least fish oil and iron supplements for their benefit.
Read More
8
Improved vitamin levels
I have been taking these capsules since the start of my pregnancy, and at 26 weeks, I’ve consumed two bottles without noticing any fishy smell. The yellow capsules are easy to swallow. I bought these on my endocrinologist’s advice due to low ferritin, haemoglobin levels, and vitamin D deficiency. My skin is good, and I hope to avoid stretch marks. Besides these vitamins, I am also taking further vitamin D, as my doctor is against high doses, yet the world standards suggest otherwise.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 35 Researches
7.3
9
Vitamin D3 improves iron status
An 8-Week Vitamin D3-Fortified Fruit Drink Supplementation Increases Serum Ferritin Concentration: A Randomized Controlled Trial in Malaysian Women With Low Iron Stores.
Direct evaluation of vitamin D3
We conducted an 8-week, double-blind randomized controlled trial to see how vitamin D3-fortified fruit drinks affect iron levels in women with low iron stores. Our subjects, a group of 45 healthy women aged between 18 and 40, received either the vitamin D3 drink or a placebo, helping us assess the impact of this nutrient on their health.
Throughout the study, we measured key biomarkers such as serum ferritin, which indicates iron stores, and 25-hydroxyvitamin D, the active form of vitamin D in the body. After the 8 weeks, we noted a significant increase in both vitamin D levels and serum ferritin among those who participated in the vitamin D3-fortified drink regimen. This suggests that supplementing with vitamin D3 can indeed help improve iron stores in women who are iron deficient.
Given these findings, it becomes clear that there is potential for vitamin D to play a role in managing anemia. However, we also recognize the need for further research to confirm these effects and explore the safety and practicality of such fortifications across different populations.
Throughout the study, we measured key biomarkers such as serum ferritin, which indicates iron stores, and 25-hydroxyvitamin D, the active form of vitamin D in the body. After the 8 weeks, we noted a significant increase in both vitamin D levels and serum ferritin among those who participated in the vitamin D3-fortified drink regimen. This suggests that supplementing with vitamin D3 can indeed help improve iron stores in women who are iron deficient.
Given these findings, it becomes clear that there is potential for vitamin D to play a role in managing anemia. However, we also recognize the need for further research to confirm these effects and explore the safety and practicality of such fortifications across different populations.
Read More
9
EPA may prevent anemia risk
Prophylaxis for ribavirin-related anemia using eicosapentaenoic acid in chronic hepatitis C patients.
Relevant study on EPA and anemia
We examined the effectiveness of eicosapentaenoic acid (EPA) in preventing anemia caused by ribavirin during hepatitis C treatment. This study involved twelve chronic hepatitis C patients, aged between 3 and 21 years, who were divided into two groups: one receiving EPA and the other acting as a control. Blood samples were collected at various intervals to monitor changes in hemoglobin levels and ribavirin concentrations throughout the treatment period.
Our findings revealed that those who received EPA experienced significantly less reduction in hemoglobin levels compared to the control group. In fact, by weeks eight and sixteen, the protective effects against anemia were clear and statistically significant. While we did not observe any notable differences in ribavirin drug levels between the two groups, one patient in the control group had to lower their ribavirin dosage due to anemia.
Overall, our research underscores the potential of EPA supplementation as a preventative measure against ribavirin-related anemia in young patients undergoing treatment for hepatitis C. This offers a promising strategy to improve treatment adherence and outcomes for this vulnerable population.
Our findings revealed that those who received EPA experienced significantly less reduction in hemoglobin levels compared to the control group. In fact, by weeks eight and sixteen, the protective effects against anemia were clear and statistically significant. While we did not observe any notable differences in ribavirin drug levels between the two groups, one patient in the control group had to lower their ribavirin dosage due to anemia.
Overall, our research underscores the potential of EPA supplementation as a preventative measure against ribavirin-related anemia in young patients undergoing treatment for hepatitis C. This offers a promising strategy to improve treatment adherence and outcomes for this vulnerable population.
Read More
9
Docosahexaenoic acid aids β-thalassemia
Comparative effectiveness of adding omega-3 and Manuka honey combination to conventional therapy in preventing and treating oxidative stress in pediatric β-thalassemia major - a randomized clinical trial.
Score reflects mixed effects.
We conducted a study to explore the effectiveness of docosahexaenoic acid (DHA) when combined with Manuka honey, aimed at improving health outcomes for children suffering from β-thalassemia major. This condition is known for causing significant oxidative stress and iron overload, which can lead to various complications.
In a well-structured, randomized clinical trial involving 165 pediatric patients, we had them placed into three distinct groups. One group received omega-3 fish oil containing DHA along with Manuka honey, while another received only Manuka honey, and the last group continued with conventional therapies like deferasirox and blood transfusions.
Our findings suggested that the combination of omega-3 and Manuka honey was significantly more effective than either Manuka honey on its own or the conventional treatments alone in managing oxidative stress levels in these young patients.
However, it’s important to note that while we observed positive results in combating oxidative stress, we cannot definitively isolate DHA's effects on anemia alone, as it was always paired with the honey and other treatments.
In a well-structured, randomized clinical trial involving 165 pediatric patients, we had them placed into three distinct groups. One group received omega-3 fish oil containing DHA along with Manuka honey, while another received only Manuka honey, and the last group continued with conventional therapies like deferasirox and blood transfusions.
Our findings suggested that the combination of omega-3 and Manuka honey was significantly more effective than either Manuka honey on its own or the conventional treatments alone in managing oxidative stress levels in these young patients.
However, it’s important to note that while we observed positive results in combating oxidative stress, we cannot definitively isolate DHA's effects on anemia alone, as it was always paired with the honey and other treatments.
Read More
9
DHA enhances sickle cell outcomes
SC411 treatment can enhance survival in a mouse model of sickle cell disease.
Study shows mixed fatty acid effects
We explored the potential of docosahexaenoic acid (DHA) as a treatment for anemia in sickle cell disease (SCD). In this study, we utilized a special mouse model that mimics SCD, testing how SC411—a purified form of DHA—affects this condition.
After eight weeks of treatment, we observed that DHA levels, along with eicosapentaenoic acid (EPA), significantly increased in the blood of the SCD mice. Alongside these positive changes, we found that SC411 also reduced levels of arachidonic acid, minimizing the sickling of red blood cells, which is a major issue in SCD.
Notably, mice that received SC411 showcased improvements in blood flow to the brain, a decrease in neuroinflammation, and even an enhancement in working memory. These findings ultimately led to improved survival rates among the treated mice, suggesting that DHA can offer a promising therapeutic avenue for individuals suffering from SCD and its related anemia.
After eight weeks of treatment, we observed that DHA levels, along with eicosapentaenoic acid (EPA), significantly increased in the blood of the SCD mice. Alongside these positive changes, we found that SC411 also reduced levels of arachidonic acid, minimizing the sickling of red blood cells, which is a major issue in SCD.
Notably, mice that received SC411 showcased improvements in blood flow to the brain, a decrease in neuroinflammation, and even an enhancement in working memory. These findings ultimately led to improved survival rates among the treated mice, suggesting that DHA can offer a promising therapeutic avenue for individuals suffering from SCD and its related anemia.
Read More
9
Maresin 1 helps treat anemia
Maresin 1 ameliorates iron-deficient anemia in IL-10(-/-) mice with spontaneous colitis by the inhibition of hepcidin expression though the IL-6/STAT3 pathway.
Study directly investigates MaR1 effects
We focused on how Maresin 1, a compound derived from docosahexaenoic acid, might help improve iron-deficient anemia in mice with chronic colitis. Our research involved IL-10 knockout mice, which are known to develop spontaneous colitis and associated anemia.
Over two weeks, we treated these mice with MaR1, observing several important changes. We found that MaR1 significantly reduced inflammation in the colon and was associated with a boost in hemoglobin levels, increased serum iron, and improved transferrin saturation.
Additionally, we noted that the levels of hepcidin, a protein that regulates iron metabolism and is often elevated during inflammation, decreased after treatment. This suggests that MaR1 helps combat anemia by influencing this protein's expression through the IL-6/STAT3 pathway.
Overall, we uncovered promising evidence that MaR1 has the potential to alleviate anemia connected to inflammatory processes, making it a noteworthy area for further exploration in treating patients with similar conditions.
Over two weeks, we treated these mice with MaR1, observing several important changes. We found that MaR1 significantly reduced inflammation in the colon and was associated with a boost in hemoglobin levels, increased serum iron, and improved transferrin saturation.
Additionally, we noted that the levels of hepcidin, a protein that regulates iron metabolism and is often elevated during inflammation, decreased after treatment. This suggests that MaR1 helps combat anemia by influencing this protein's expression through the IL-6/STAT3 pathway.
Overall, we uncovered promising evidence that MaR1 has the potential to alleviate anemia connected to inflammatory processes, making it a noteworthy area for further exploration in treating patients with similar conditions.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.4
9.5
Prevented anaemia risks
During my first pregnancy, I neglected vitamins, thinking they were unnecessary. Now, I realise that taking vitamins is crucial for my health and to avoid complications like anaemia after childbirth. I strongly recommend pregnant women to take at least fish oil and iron supplements for their benefit.
Read More
8
Improved vitamin levels
I have been taking these capsules since the start of my pregnancy, and at 26 weeks, I’ve consumed two bottles without noticing any fishy smell. The yellow capsules are easy to swallow. I bought these on my endocrinologist’s advice due to low ferritin, haemoglobin levels, and vitamin D deficiency. My skin is good, and I hope to avoid stretch marks. Besides these vitamins, I am also taking further vitamin D, as my doctor is against high doses, yet the world standards suggest otherwise.
Read More
