Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.1
USERS' SCORE
Good
Based on 2 Reviews
8.1
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
†
Vitamin D3 (cholecalciferol)
10 mcg (400 IU)
67%
Total Omega-3s♦
830 mg
†
EPA (Eicosapentaenoic Acid)
205 mg
†
DHA (Docosahexaenoic Acid)
480 mg
†
Top Medical Research Studies
We conducted a study to see how vitamin D3 might help improve iron levels in women of childbearing age who had marginally low iron stores. Our approach involved a carefully designed 8-week randomized controlled trial, where 120 women aged between 19 and 40 were divided into two groups. One group received fruit juice fortified with 4000 IU of vitamin D3 daily, while the other had a placebo juice.
Throughout the study, we collected blood samples and monitored various health indicators every four weeks. We aimed to find out if the vitamin D3 supplementation could positively influence the iron status of the participants compared to the placebo.
Given the promising role of vitamin D in enhancing iron absorption, we hoped to uncover new insights into dietary strategies for managing iron deficiency. By observing the interaction over time between vitamin D levels and iron status, we aimed to provide valuable information on whether this fortification could serve as a practical alternative to traditional iron supplements.
As we gathered data, we explored the potential of vitamin D3 beyond its usual role, assessing if it could indeed help improve the anemia indicators in our target group.
Throughout the study, we collected blood samples and monitored various health indicators every four weeks. We aimed to find out if the vitamin D3 supplementation could positively influence the iron status of the participants compared to the placebo.
Given the promising role of vitamin D in enhancing iron absorption, we hoped to uncover new insights into dietary strategies for managing iron deficiency. By observing the interaction over time between vitamin D levels and iron status, we aimed to provide valuable information on whether this fortification could serve as a practical alternative to traditional iron supplements.
As we gathered data, we explored the potential of vitamin D3 beyond its usual role, assessing if it could indeed help improve the anemia indicators in our target group.
Read More
9
We conducted an 8-week, double-blind randomized controlled trial to see how vitamin D3-fortified fruit drinks affect iron levels in women with low iron stores. Our subjects, a group of 45 healthy women aged between 18 and 40, received either the vitamin D3 drink or a placebo, helping us assess the impact of this nutrient on their health.
Throughout the study, we measured key biomarkers such as serum ferritin, which indicates iron stores, and 25-hydroxyvitamin D, the active form of vitamin D in the body. After the 8 weeks, we noted a significant increase in both vitamin D levels and serum ferritin among those who participated in the vitamin D3-fortified drink regimen. This suggests that supplementing with vitamin D3 can indeed help improve iron stores in women who are iron deficient.
Given these findings, it becomes clear that there is potential for vitamin D to play a role in managing anemia. However, we also recognize the need for further research to confirm these effects and explore the safety and practicality of such fortifications across different populations.
Throughout the study, we measured key biomarkers such as serum ferritin, which indicates iron stores, and 25-hydroxyvitamin D, the active form of vitamin D in the body. After the 8 weeks, we noted a significant increase in both vitamin D levels and serum ferritin among those who participated in the vitamin D3-fortified drink regimen. This suggests that supplementing with vitamin D3 can indeed help improve iron stores in women who are iron deficient.
Given these findings, it becomes clear that there is potential for vitamin D to play a role in managing anemia. However, we also recognize the need for further research to confirm these effects and explore the safety and practicality of such fortifications across different populations.
Read More
7
We explored how vitamin D3 levels relate to anemia in patients with chronic kidney disease (CKD) in China. In our study, 225 CKD patients were assigned to three groups based on their serum vitamin D3 levels: severe deficiency, deficiency, and sufficiency. Through our analysis, we measured the prevalence of anemia within these groups to identify any potential links.
The results were quite telling. Among the participants, 79.5% of those in the severe deficiency group had anemia, compared to 63.5% in the deficiency group, and 48.0% in the sufficiency group. This shows a clear trend—the more deficient the vitamin D3 levels, the higher the likelihood of experiencing anemia. We also noted that as the stages of CKD progressed, from 1 to 5, the prevalence of anemia increased significantly, peaking at almost 95% in the most advanced stage.
Our findings suggest that vitamin D3 deficiency may indeed elevate the risk of anemia in individuals suffering from CKD. Addressing vitamin D3 levels in these patients could be an essential factor in managing their anemia effectively.
The results were quite telling. Among the participants, 79.5% of those in the severe deficiency group had anemia, compared to 63.5% in the deficiency group, and 48.0% in the sufficiency group. This shows a clear trend—the more deficient the vitamin D3 levels, the higher the likelihood of experiencing anemia. We also noted that as the stages of CKD progressed, from 1 to 5, the prevalence of anemia increased significantly, peaking at almost 95% in the most advanced stage.
Our findings suggest that vitamin D3 deficiency may indeed elevate the risk of anemia in individuals suffering from CKD. Addressing vitamin D3 levels in these patients could be an essential factor in managing their anemia effectively.
Read More
Most Useful Reviews
9
Prevented anaemia risks
5 people found this helpful
During my first pregnancy, I neglected vitamins, thinking they were unnecessary. Now, I realise that taking vitamins is crucial for my health and to avoid complications like anaemia after childbirth. I strongly recommend pregnant women to take at least fish oil and iron supplements for their benefit.
Read More
6
Improved vitamin levels
107 people found this helpful
I have been taking these capsules since the start of my pregnancy, and at 26 weeks, I’ve consumed two bottles without noticing any fishy smell. The yellow capsules are easy to swallow. I bought these on my endocrinologist’s advice due to low ferritin, haemoglobin levels, and vitamin D deficiency. My skin is good, and I hope to avoid stretch marks. Besides these vitamins, I am also taking further vitamin D, as my doctor is against high doses, yet the world standards suggest otherwise.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.1
- All Researches
9
We conducted an 8-week, double-blind randomized controlled trial to see how vitamin D3-fortified fruit drinks affect iron levels in women with low iron stores. Our subjects, a group of 45 healthy women aged between 18 and 40, received either the vitamin D3 drink or a placebo, helping us assess the impact of this nutrient on their health.
Throughout the study, we measured key biomarkers such as serum ferritin, which indicates iron stores, and 25-hydroxyvitamin D, the active form of vitamin D in the body. After the 8 weeks, we noted a significant increase in both vitamin D levels and serum ferritin among those who participated in the vitamin D3-fortified drink regimen. This suggests that supplementing with vitamin D3 can indeed help improve iron stores in women who are iron deficient.
Given these findings, it becomes clear that there is potential for vitamin D to play a role in managing anemia. However, we also recognize the need for further research to confirm these effects and explore the safety and practicality of such fortifications across different populations.
Throughout the study, we measured key biomarkers such as serum ferritin, which indicates iron stores, and 25-hydroxyvitamin D, the active form of vitamin D in the body. After the 8 weeks, we noted a significant increase in both vitamin D levels and serum ferritin among those who participated in the vitamin D3-fortified drink regimen. This suggests that supplementing with vitamin D3 can indeed help improve iron stores in women who are iron deficient.
Given these findings, it becomes clear that there is potential for vitamin D to play a role in managing anemia. However, we also recognize the need for further research to confirm these effects and explore the safety and practicality of such fortifications across different populations.
Read More
9
We examined the effectiveness of eicosapentaenoic acid (EPA) in preventing anemia caused by ribavirin during hepatitis C treatment. This study involved twelve chronic hepatitis C patients, aged between 3 and 21 years, who were divided into two groups: one receiving EPA and the other acting as a control. Blood samples were collected at various intervals to monitor changes in hemoglobin levels and ribavirin concentrations throughout the treatment period.
Our findings revealed that those who received EPA experienced significantly less reduction in hemoglobin levels compared to the control group. In fact, by weeks eight and sixteen, the protective effects against anemia were clear and statistically significant. While we did not observe any notable differences in ribavirin drug levels between the two groups, one patient in the control group had to lower their ribavirin dosage due to anemia.
Overall, our research underscores the potential of EPA supplementation as a preventative measure against ribavirin-related anemia in young patients undergoing treatment for hepatitis C. This offers a promising strategy to improve treatment adherence and outcomes for this vulnerable population.
Our findings revealed that those who received EPA experienced significantly less reduction in hemoglobin levels compared to the control group. In fact, by weeks eight and sixteen, the protective effects against anemia were clear and statistically significant. While we did not observe any notable differences in ribavirin drug levels between the two groups, one patient in the control group had to lower their ribavirin dosage due to anemia.
Overall, our research underscores the potential of EPA supplementation as a preventative measure against ribavirin-related anemia in young patients undergoing treatment for hepatitis C. This offers a promising strategy to improve treatment adherence and outcomes for this vulnerable population.
Read More
9
We focused on how Maresin 1, a compound derived from docosahexaenoic acid, might help improve iron-deficient anemia in mice with chronic colitis. Our research involved IL-10 knockout mice, which are known to develop spontaneous colitis and associated anemia.
Over two weeks, we treated these mice with MaR1, observing several important changes. We found that MaR1 significantly reduced inflammation in the colon and was associated with a boost in hemoglobin levels, increased serum iron, and improved transferrin saturation.
Additionally, we noted that the levels of hepcidin, a protein that regulates iron metabolism and is often elevated during inflammation, decreased after treatment. This suggests that MaR1 helps combat anemia by influencing this protein's expression through the IL-6/STAT3 pathway.
Overall, we uncovered promising evidence that MaR1 has the potential to alleviate anemia connected to inflammatory processes, making it a noteworthy area for further exploration in treating patients with similar conditions.
Over two weeks, we treated these mice with MaR1, observing several important changes. We found that MaR1 significantly reduced inflammation in the colon and was associated with a boost in hemoglobin levels, increased serum iron, and improved transferrin saturation.
Additionally, we noted that the levels of hepcidin, a protein that regulates iron metabolism and is often elevated during inflammation, decreased after treatment. This suggests that MaR1 helps combat anemia by influencing this protein's expression through the IL-6/STAT3 pathway.
Overall, we uncovered promising evidence that MaR1 has the potential to alleviate anemia connected to inflammatory processes, making it a noteworthy area for further exploration in treating patients with similar conditions.
Read More
9
DHA improves RBC flexibility in anemia
We explored the impact of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, on red blood cells (RBCs) in mice with sickle cell disease (SCD). The research focused on whether DHA could improve RBC stiffness and deformability, which are crucial factors in anemia related to SCD.
To conduct our study, sickle cell mice were given diets with either 3% DHA or a control diet rich in total fat for eight weeks. We used advanced methods to assess the stiffness and flexibility of the RBCs, along with analyzing blood smears for the presence of irreversibly sickled RBCs.
Our findings were quite striking. We observed that the mice consuming the DHA diet showed significantly improved RBC flexibility and a reduction in the number of irreversibly sickled cells by approximately 40%, compared to those on the control diet. This suggests that DHA supplementation may have therapeutic potential in enhancing RBC function and potentially alleviating some symptoms of anemia in sickle cell disease.
Overall, our study underscores the role of dietary omega-3 fatty acids like DHA in managing conditions associated with rigid and sickled red blood cells. While more research is needed to fully understand the implications, these results offer a promising perspective on dietary interventions for sickle cell disease.
To conduct our study, sickle cell mice were given diets with either 3% DHA or a control diet rich in total fat for eight weeks. We used advanced methods to assess the stiffness and flexibility of the RBCs, along with analyzing blood smears for the presence of irreversibly sickled RBCs.
Our findings were quite striking. We observed that the mice consuming the DHA diet showed significantly improved RBC flexibility and a reduction in the number of irreversibly sickled cells by approximately 40%, compared to those on the control diet. This suggests that DHA supplementation may have therapeutic potential in enhancing RBC function and potentially alleviating some symptoms of anemia in sickle cell disease.
Overall, our study underscores the role of dietary omega-3 fatty acids like DHA in managing conditions associated with rigid and sickled red blood cells. While more research is needed to fully understand the implications, these results offer a promising perspective on dietary interventions for sickle cell disease.
Read More
8
We examined the impact of cholecalciferol (vitamin D3) supplementation on anemia in hemodialysis patients suffering from vitamin D deficiency and secondary hyperparathyroidism. Our study included 122 patients who had low vitamin D levels and high parathyroid hormone (PTH) levels. We divided the participants into two groups: one received cholecalciferol supplements, while the other served as a control group.
In the group that received cholecalciferol, we observed significant improvements. PTH levels decreased notably, from an average of 476 to 296 pg/mL, indicating better regulation of calcium balance in the body. Alongside this, the 25-hydroxyvitamin D levels rose from 10.3 to 33.5 ng/mL, demonstrating a successful increase in vitamin D status.
More encouragingly, we noticed that hemoglobin levels, which reflect anemia status, increased from 11.6 to 12.2 g/dL in the supplemented group. This rise illustrates a potential benefit of vitamin D3 supplementation in managing anemia among hemodialysis patients. Additionally, the patients needed less paricalcitol, another medication used for managing PTH levels, revealing a positive overall impact on their treatment regimen.
In the group that received cholecalciferol, we observed significant improvements. PTH levels decreased notably, from an average of 476 to 296 pg/mL, indicating better regulation of calcium balance in the body. Alongside this, the 25-hydroxyvitamin D levels rose from 10.3 to 33.5 ng/mL, demonstrating a successful increase in vitamin D status.
More encouragingly, we noticed that hemoglobin levels, which reflect anemia status, increased from 11.6 to 12.2 g/dL in the supplemented group. This rise illustrates a potential benefit of vitamin D3 supplementation in managing anemia among hemodialysis patients. Additionally, the patients needed less paricalcitol, another medication used for managing PTH levels, revealing a positive overall impact on their treatment regimen.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Prevented anaemia risks
5 people found this helpful
During my first pregnancy, I neglected vitamins, thinking they were unnecessary. Now, I realise that taking vitamins is crucial for my health and to avoid complications like anaemia after childbirth. I strongly recommend pregnant women to take at least fish oil and iron supplements for their benefit.
Read More
6
Improved vitamin levels
107 people found this helpful
I have been taking these capsules since the start of my pregnancy, and at 26 weeks, I’ve consumed two bottles without noticing any fishy smell. The yellow capsules are easy to swallow. I bought these on my endocrinologist’s advice due to low ferritin, haemoglobin levels, and vitamin D deficiency. My skin is good, and I hope to avoid stretch marks. Besides these vitamins, I am also taking further vitamin D, as my doctor is against high doses, yet the world standards suggest otherwise.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Ahamed F, Jaiswal A, Sahoo S, Ghosh T, Kaur A, et al. Impact of supplementation with iron-folic acid (IFA) and vitamin D compared with IFA alone on haemoglobin levels in elderly people with mild-to-moderate anaemia: protocol for the double-blind, randomised, placebo-controlled Iron and vitamin D trial in Elderly Anemia (IDEA). BMJ Open. 2024;14:e080303. doi:10.1136/bmjopen-2023-080303
- Suhaimi NA, Loh SP, Ab Manan N, Zalbahar N, Mohamad Alwi MN, et al. An 8-Week Vitamin D3-Fortified Fruit Drink Supplementation Increases Serum Ferritin Concentration: A Randomized Controlled Trial in Malaysian Women With Low Iron Stores. J Acad Nutr Diet. 2024;124:1440. doi:10.1016/j.jand.2024.02.013
- Pistis KD, Westerberg PA, Qureshi AR, Beshara S, Sterner G, et al. The effect of high-dose vitamin D supplementation on hepcidin-25 and erythropoiesis in patients with chronic kidney disease. BMC Nephrol. 2023;24:20. doi:10.1186/s12882-022-03014-z
- Ahmad Fuzi SF, Su Peng L, Zabaha Zalbahar N, Ab Manan N, Mohamad Alwi MN. Effect of vitamin D3-fortified fruit juice supplementation of 4000 IU daily on the recovery of iron status in childbearing-aged women with marginally low iron stores: Protocol for an 8-week, parallel group, double-blind randomized controlled trial. PLoS One. 2022;17:e0265772. doi:10.1371/journal.pone.0265772
- Chailurkit LO, Sritara P, Vathesatogkit P, Yamwong S, Thongmung N, et al. Vitamin D epimers are associated with circulating haemoglobin levels independently of C-reactive protein. Sci Rep. 2021;11:20747. doi:10.1038/s41598-021-00086-z
- Li M, Xu J, Wan Q, He Q, Ma Y, et al. Relationship between serum vitamin D3 concentration and anaemia in patients with chronic kidney disease in China. J Int Med Res. 2021;49:3000605211012231. doi:10.1177/03000605211012231
- Obi Y, Ichimaru N, Sakaguchi Y, Iwadoh K, Ishii D, et al. Correcting anemia and native vitamin D supplementation in kidney transplant recipients: a multicenter, 2 × 2 factorial, open-label, randomized clinical trial. Transpl Int. 2021;34:1212. doi:10.1111/tri.13885
- Obi Y, Yamaguchi S, Hamano T, Sakaguchi Y, Shimomura A, et al. Effect of cholecalciferol on serum hepcidin and parameters of anaemia and CKD-MBD among haemodialysis patients: a randomized clinical trial. Sci Rep. 2020;10:15500. doi:10.1038/s41598-020-72385-w
- Massimetti C, Bellasi A, Feriozzi S. [Cholecalciferol supplementation improves secondary hyperparathyroidism control in hemodialysis patients]. G Ital Nefrol. 2020;37.
- Gamaleldin M, Abraham I, Meabed M, Elberry A, Abdelhalim S, et al. Comparative effectiveness of adding omega-3 and Manuka honey combination to conventional therapy in preventing and treating oxidative stress in pediatric β-thalassemia major - a randomized clinical trial. Eur Rev Med Pharmacol Sci. 2023;27:6058. doi:10.26355/eurrev_202307_32960
- Hayford FEA, Dolman RC, Ozturk M, Nienaber A, Ricci C, et al. Adjunct n-3 Long-Chain Polyunsaturated Fatty Acid Treatment in Tuberculosis Reduces Inflammation and Improves Anemia of Infection More in C3HeB/FeJ Mice With Low n-3 Fatty Acid Status Than Sufficient n-3 Fatty Acid Status. Front Nutr. 2021;8:695452. doi:10.3389/fnut.2021.695452
- Nienaber A, Baumgartner J, Dolman RC, Ozturk M, Zandberg L, et al. Omega-3 Fatty Acid and Iron Supplementation Alone, but Not in Combination, Lower Inflammation and Anemia of Infection in -Infected Mice. Nutrients. 2020;12. doi:10.3390/nu12092897
- Wu CYC, Lopez-Toledano MA, Daak AA, Clemons GA, Citadin CT, et al. SC411 treatment can enhance survival in a mouse model of sickle cell disease. Prostaglandins Leukot Essent Fatty Acids. 2020;158:102110. doi:10.1016/j.plefa.2020.102110
- Morsy KH, Zaghloul A, Mahmoud M. Can eicosapentaenoic acid maintain the original ribavirin dose or affect the response during the treatment course of chronic hepatitis C virus (HCV) patients?. Turk J Gastroenterol. 2016;27:55. doi:10.5152/tjg.2015.150280
- Malan L, Baumgartner J, Calder PC, Zimmermann MB, Smuts CM. n-3 Long-chain PUFAs reduce respiratory morbidity caused by iron supplementation in iron-deficient South African schoolchildren: a randomized, double-blind, placebo-controlled intervention. Am J Clin Nutr. 2015;101:668. doi:10.3945/ajcn.113.081208
- Suzuki M, Inage E, Minowa K, Saito N, Naritaka N, et al. Prophylaxis for ribavirin-related anemia using eicosapentaenoic acid in chronic hepatitis C patients. Pediatr Int. 2012;54:528. doi:10.1111/j.1442-200X.2012.03603.x
- Takaki S, Kawakami Y, Imamura M, Aikata H, Takahashi S, et al. Eicosapentaenoic acid could permit maintenance of the original ribavirin dose in chronic hepatitis C virus patients during the first 12 weeks of combination therapy with pegylated interferon-alpha and ribavirin. A prospective randomized controlled trial. Intervirology. 2007;50:439. doi:10.1159/000114718
- Seki R, Okamura T, Ide T, Kage M, Sata M, et al. Impaired filterability of erythrocytes from patients with chronic hepatitis C and effects of eicosapentaenoic acid on the filterability. J Physiol Sci. 2007;57:43.
- Hino K, Murakami Y, Nagai A, Kitase A, Hara Y, et al. Alpha-tocopherol [corrected] and ascorbic acid attenuates the ribavirin [corrected] induced decrease of eicosapentaenoic acid in erythrocyte membrane in chronic hepatitis C patients. J Gastroenterol Hepatol. 2006;21:1269.
- Ren H, Obike I, Okpala I, Ghebremeskel K, Ugochukwu C, et al. Steady-state haemoglobin level in sickle cell anaemia increases with an increase in erythrocyte membrane n-3 fatty acids. Prostaglandins Leukot Essent Fatty Acids. 2005;72:415.
- Ide T, Okamura T, Kumashiro R, Koga Y, Hino T, et al. A pilot study of eicosapentaenoic acid therapy for ribavirin-related anemia in patients with chronic hepatitis C. Int J Mol Med. 2003;11:729.
- Kumaratilake LM, Robinson BS, Ferrante A, Poulos A. Antimalarial properties of n-3 and n-6 polyunsaturated fatty acids: in vitro effects on Plasmodium falciparum and in vivo effects on P. berghei. J Clin Invest. 1992;89:961.
- Sultanov R, Ermolenko E, Poleschuk T, Denisenko Y, Kasyanov S. Action of alkyl glycerol ethers and n-3 polyunsaturated fatty acids diet on hematological parameters of blood and liver plasmalogen level in aged rats. J Food Sci. 2021;86:2727. doi:10.1111/1750-3841.15756
- Freitas RDS, Muradás TC, Dagnino APA, Rost FL, Costa KM, et al. Targeting FFA1 and FFA4 receptors in cancer-induced cachexia. Am J Physiol Endocrinol Metab. 2020;319:E877. doi:10.1152/ajpendo.00509.2019
- Smuts CM, Matsungo TM, Malan L, Kruger HS, Rothman M, et al. Effect of small-quantity lipid-based nutrient supplements on growth, psychomotor development, iron status, and morbidity among 6- to 12-mo-old infants in South Africa: a randomized controlled trial. Am J Clin Nutr. 2019;109:55. doi:10.1093/ajcn/nqy282
- Daak AA, Dampier CD, Fuh B, Kanter J, Alvarez OA, et al. Double-blind, randomized, multicenter phase 2 study of SC411 in children with sickle cell disease (SCOT trial). Blood Adv. 2018;2:1969. doi:10.1182/bloodadvances.2018021444
- Wang H, Shi P, Huang C, Liu Q. Maresin 1 ameliorates iron-deficient anemia in IL-10(-/-) mice with spontaneous colitis by the inhibition of hepcidin expression though the IL-6/STAT3 pathway. Am J Transl Res. 2016;8:2758.
- Shidfar F, Amani S, Vafa M, Shekarriz R, Hosseini S, et al. Effects of Iron Supplementation With and Without Docosahexaenoic Acid on the Cardiovascular Disease Risk Based on Paraoxonase-1, hs-CRP, and ApoB/ApoA-I Ratio in Women with Iron Deficiency Anemia. Biol Trace Elem Res. 2016;169:34. doi:10.1007/s12011-015-0383-7
- Wandersee NJ, Maciaszek JL, Giger KM, Hanson MS, Zheng S, et al. Dietary supplementation with docosahexanoic acid (DHA) increases red blood cell membrane flexibility in mice with sickle cell disease. Blood Cells Mol Dis. 2015;54:183. doi:10.1016/j.bcmd.2014.11.004
