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SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.2
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
10
Total Fat
1 g
1%
Saturated Fat
0 g
0%
Trans Fat
0 g
†
Vitamin D3 (cholecalciferol)
10 mcg (400 IU)
67%
Total Omega-3s♦
830 mg
†
EPA (Eicosapentaenoic Acid)
205 mg
†
DHA (Docosahexaenoic Acid)
480 mg
†
Top Medical Research Studies
9
Vitamin D3 reduces thyroid autoimmunity
A Prospective Study to Evaluate the Possible Role of Cholecalciferol Supplementation on Autoimmunity in Hashimoto's Thyroiditis.
Directly relates to hypothyroidism treatment
We explored the potential effects of vitamin D3, or cholecalciferol, on individuals diagnosed with Hashimoto's thyroiditis, a common form of hypothyroidism characterized by autoimmune responses that damage thyroid cells. Our study was a carefully structured clinical trial conducted over one year, which included 100 patients suffering from both Hashimoto's thyroiditis and vitamin D deficiency.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Read More
8
Vitamin D3 improves thyroid function
Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis.
High relevance to hypothyroidism
We evaluated the effects of vitamin D3 supplementation on hypothyroidism, specifically in patients with Hashimoto's thyroiditis (HT). Our analysis involved 12 randomized controlled trials, comparing the outcomes of individuals receiving vitamin D3 against those given a placebo or no treatment at all.
Through this thorough examination, we found that vitamin D3 did promote significant improvements in thyroid function and immune response. Specifically, we observed a reduction in two key antibodies: anti-thyroid peroxidase (TPO-Ab) and thyroglobulin antibody (TG-Ab). These reductions suggest a positive effect on the autoimmune process involved in Hashimoto's thyroiditis.
Additionally, we noted improvements in thyroid hormone levels, including free thyroxine (FT4) and free triiodothyronine (FT3), while thyroid-stimulating hormone (TSH) levels showed a decrease. These findings indicate that vitamin D3 supplementation may benefit thyroid health and help manage hypothyroidism more effectively.
For those considering vitamin D3 as a treatment option, particularly those who have been on vitamin D for longer than 12 weeks, the results suggest a more pronounced effect on improving antibody levels and thyroid function. Thus, there appears to be a compelling case for vitamin D3 as a supportive treatment in managing Hashimoto's thyroiditis and related hypothyroidism.
Through this thorough examination, we found that vitamin D3 did promote significant improvements in thyroid function and immune response. Specifically, we observed a reduction in two key antibodies: anti-thyroid peroxidase (TPO-Ab) and thyroglobulin antibody (TG-Ab). These reductions suggest a positive effect on the autoimmune process involved in Hashimoto's thyroiditis.
Additionally, we noted improvements in thyroid hormone levels, including free thyroxine (FT4) and free triiodothyronine (FT3), while thyroid-stimulating hormone (TSH) levels showed a decrease. These findings indicate that vitamin D3 supplementation may benefit thyroid health and help manage hypothyroidism more effectively.
For those considering vitamin D3 as a treatment option, particularly those who have been on vitamin D for longer than 12 weeks, the results suggest a more pronounced effect on improving antibody levels and thyroid function. Thus, there appears to be a compelling case for vitamin D3 as a supportive treatment in managing Hashimoto's thyroiditis and related hypothyroidism.
Read More
8
Vitamin D3 impacts thyroid health
Vitamin D Treatment in Patients with Hashimoto's Thyroiditis may Decrease the Development of Hypothyroidism.
Significant relevance to Hashimoto's
We evaluated the potential impact of vitamin D3 treatment on patients suffering from Hashimoto's thyroiditis, particularly looking at its effect on the development of hypothyroidism. Our investigation included 75 individuals diagnosed with this autoimmune disorder and a control group of 43 healthy participants. The results showed that patients with Hashimoto's thyroiditis had notably lower vitamin D levels compared to those without the condition.
To address vitamin D deficiency, we administered a weekly dose of 50,000 units of vitamin D3 to those who were lacking it for eight weeks. After this treatment, we observed significant improvements. Thyroid autoantibodies, which indicate inflammation and damage in the thyroid, decreased in those who were treated. Additionally, we found that levels of HDL cholesterol improved, suggesting potential benefits for cardiovascular health.
Our findings point toward vitamin D deficiency being common among those with Hashimoto's thyroiditis. By addressing this deficiency, we may slow down the progression toward hypothyroidism and reduce cardiovascular risks associated with the condition. Therefore, monitoring and supplementing vitamin D could play a crucial role in managing the health of these patients effectively.
To address vitamin D deficiency, we administered a weekly dose of 50,000 units of vitamin D3 to those who were lacking it for eight weeks. After this treatment, we observed significant improvements. Thyroid autoantibodies, which indicate inflammation and damage in the thyroid, decreased in those who were treated. Additionally, we found that levels of HDL cholesterol improved, suggesting potential benefits for cardiovascular health.
Our findings point toward vitamin D deficiency being common among those with Hashimoto's thyroiditis. By addressing this deficiency, we may slow down the progression toward hypothyroidism and reduce cardiovascular risks associated with the condition. Therefore, monitoring and supplementing vitamin D could play a crucial role in managing the health of these patients effectively.
Read More
Most Useful Reviews
8
Improved hair growth
I used this omega supplement during my second trimester of pregnancy and continued while breastfeeding. I have always struggled with thin hair due to genetics and hypothyroidism. Initially, my hair growth was impressive, but I experienced shedding after three months post-delivery. After two months, the shedding stopped, and to my surprise, my hair began to grow longer. Friends even noticed the change after ten years. I also take vitamin D alongside this omega and have not experienced any unpleasant fish oil taste.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 13 Researches
7.2
9
Vitamin D3 reduces thyroid autoimmunity
A Prospective Study to Evaluate the Possible Role of Cholecalciferol Supplementation on Autoimmunity in Hashimoto's Thyroiditis.
Directly relates to hypothyroidism treatment
We explored the potential effects of vitamin D3, or cholecalciferol, on individuals diagnosed with Hashimoto's thyroiditis, a common form of hypothyroidism characterized by autoimmune responses that damage thyroid cells. Our study was a carefully structured clinical trial conducted over one year, which included 100 patients suffering from both Hashimoto's thyroiditis and vitamin D deficiency.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Divided into two groups, one received vitamin D3 supplements while the other was given a placebo. After eight weeks, we measured the levels of anti-thyroid peroxidase antibodies, which indicate autoimmune activity against the thyroid.
Our findings revealed a significant reduction in these antibody levels among patients who received vitamin D3, showcasing a 30.5% decrease compared to just a 16.5% decrease in the placebo group. This suggests that vitamin D3 supplementation may play a beneficial role in managing the autoimmune activity associated with hypothyroidism.
Overall, our research shows that addressing vitamin D deficiency might be an effective strategy to help manage Hashimoto's thyroiditis, which could encourage discussion about incorporating vitamin D as part of treatment plans for patients. Further research will be necessary to confirm these findings and explore the long-term benefits of vitamin D supplementation.
Read More
9
Vitamin D3 and iodine benefits
Increased Epoxyeicosatrienoic Acids and Hydroxyeicosatetraenoic Acids After Treatment of Iodide Intake Adjustment and 1,25-Dihydroxy-Vitamin D Supplementation in High Iodide Intake-Induced Hypothyroid Offspring Rats.
Vitamin D3 effect remains unclear
We investigated the potential benefits of vitamin D3 in treating hypothyroidism caused by high iodide intake in a study involving pregnant rats. The study involved adjusting iodide intake and supplementing with 1,25-dihydroxy-vitamin D (the active form of vitamin D) to see if these interventions could positively impact thyroid function and related complications.
The newborn rats were exposed to high levels of iodide initially, leading to thyroid dysfunction. After some weeks, we provided either iodide adjustment, vitamin D3 supplementation, or both to assess their effects.
Surprisingly, while vitamin D3 was combined with iodide adjustment, the study did not isolate the effect of vitamin D3 alone. However, we observed that both interventions increased levels of beneficial fatty acids, which are linked to improved thyroid function and lessened cholesterol issues in these rats.
These results suggest that implementing a proper iodide intake and vitamin D3 supplementation can improve thyroid health but do not clearly define vitamin D3's individual impact without additional research isolating its effects.
The newborn rats were exposed to high levels of iodide initially, leading to thyroid dysfunction. After some weeks, we provided either iodide adjustment, vitamin D3 supplementation, or both to assess their effects.
Surprisingly, while vitamin D3 was combined with iodide adjustment, the study did not isolate the effect of vitamin D3 alone. However, we observed that both interventions increased levels of beneficial fatty acids, which are linked to improved thyroid function and lessened cholesterol issues in these rats.
These results suggest that implementing a proper iodide intake and vitamin D3 supplementation can improve thyroid health but do not clearly define vitamin D3's individual impact without additional research isolating its effects.
Read More
9
Eicosapentaenoic Acid supports brain development
Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model.
Effectiveness of EPA treatment analyzed
We investigated the role of eicosapentaenoic acid (EPA), an omega-3 fatty acid, in the context of hypothyroidism and its effects on brain development. Our study used a rat model where hypothyroidism was induced, allowing us to examine how EPA influences neuronal health during this critical phase of development.
Through our research, we found that supplementing EPA, along with docosahexaenoic acid (DHA), significantly reduced signs of neuronal apoptosis, which is a controlled process of cell death that can be detrimental when excessive. Specifically, we observed decreases in DNA fragmentation and activation of an important mediator of cell death—caspase-3—in the cerebella of hypothyroid pups.
One of the key findings highlighted that EPA helped counteract increases in a pro-apoptotic protein called Bax. At the same time, levels of protective proteins, such as Bcl-2 and Bcl-x(L), were restored, which are crucial in promoting cell survival. Additionally, EPA supplementation normalized several important signaling pathways affected by thyroid hormone deficiency, which play vital roles in neuronal health.
Overall, our findings contribute valuable insight into how eicosapentaenoic acid can offer protective benefits for brain development during periods of stress caused by hypothyroidism, illuminating potential therapeutic pathways for ongoing investigations.
Through our research, we found that supplementing EPA, along with docosahexaenoic acid (DHA), significantly reduced signs of neuronal apoptosis, which is a controlled process of cell death that can be detrimental when excessive. Specifically, we observed decreases in DNA fragmentation and activation of an important mediator of cell death—caspase-3—in the cerebella of hypothyroid pups.
One of the key findings highlighted that EPA helped counteract increases in a pro-apoptotic protein called Bax. At the same time, levels of protective proteins, such as Bcl-2 and Bcl-x(L), were restored, which are crucial in promoting cell survival. Additionally, EPA supplementation normalized several important signaling pathways affected by thyroid hormone deficiency, which play vital roles in neuronal health.
Overall, our findings contribute valuable insight into how eicosapentaenoic acid can offer protective benefits for brain development during periods of stress caused by hypothyroidism, illuminating potential therapeutic pathways for ongoing investigations.
Read More
9
DHA promotes brain development in hypothyroidism
Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model.
Study highlights DHA's protective role
We explored the effects of docosahexaenoic acid (DHA), a type of omega-3 fatty acid, in a study designed to understand its role in overcoming hypothyroidism-induced neuronal apoptosis, especially during crucial cerebellar development. Our research involved supplementing pregnant and lactating rats with a mixture of DHA and eicosapentaenoic acid (EPA) while inducing hypothyroidism using methimazole.
By examining the cerebellum of pups at postnatal day 16, we observed that DHA supplementation significantly curbed DNA fragmentation and reduced caspase-3 activation, both markers of cell death. This protective effect seemed linked to DHA's ability to lower levels of pro-apoptotic proteins like Bax, which typically rise when thyroid hormones are deficient.
Furthermore, we found that omega-3 fatty acids boosted levels of protective proteins like Bcl-2 and Bcl-x(L), which are usually suppressed in hypothyroid conditions. DHA also helped restore important signaling pathways impacted by hypothyroidism, such as phospho-AKT, phospho-ERK, and phospho-JNK, without affecting myelin basic protein levels, which are responsive to thyroid hormones.
Overall, our findings suggest that omega-3 fatty acids, particularly DHA, have a significant anti-apoptotic role in the developing brain during periods of thyroid hormone deficiency.
By examining the cerebellum of pups at postnatal day 16, we observed that DHA supplementation significantly curbed DNA fragmentation and reduced caspase-3 activation, both markers of cell death. This protective effect seemed linked to DHA's ability to lower levels of pro-apoptotic proteins like Bax, which typically rise when thyroid hormones are deficient.
Furthermore, we found that omega-3 fatty acids boosted levels of protective proteins like Bcl-2 and Bcl-x(L), which are usually suppressed in hypothyroid conditions. DHA also helped restore important signaling pathways impacted by hypothyroidism, such as phospho-AKT, phospho-ERK, and phospho-JNK, without affecting myelin basic protein levels, which are responsive to thyroid hormones.
Overall, our findings suggest that omega-3 fatty acids, particularly DHA, have a significant anti-apoptotic role in the developing brain during periods of thyroid hormone deficiency.
Read More
8
Vitamin D3 improves thyroid function
Effects of vitamin D supplementation on autoantibodies and thyroid function in patients with Hashimoto's thyroiditis: A systematic review and meta-analysis.
High relevance to hypothyroidism
We evaluated the effects of vitamin D3 supplementation on hypothyroidism, specifically in patients with Hashimoto's thyroiditis (HT). Our analysis involved 12 randomized controlled trials, comparing the outcomes of individuals receiving vitamin D3 against those given a placebo or no treatment at all.
Through this thorough examination, we found that vitamin D3 did promote significant improvements in thyroid function and immune response. Specifically, we observed a reduction in two key antibodies: anti-thyroid peroxidase (TPO-Ab) and thyroglobulin antibody (TG-Ab). These reductions suggest a positive effect on the autoimmune process involved in Hashimoto's thyroiditis.
Additionally, we noted improvements in thyroid hormone levels, including free thyroxine (FT4) and free triiodothyronine (FT3), while thyroid-stimulating hormone (TSH) levels showed a decrease. These findings indicate that vitamin D3 supplementation may benefit thyroid health and help manage hypothyroidism more effectively.
For those considering vitamin D3 as a treatment option, particularly those who have been on vitamin D for longer than 12 weeks, the results suggest a more pronounced effect on improving antibody levels and thyroid function. Thus, there appears to be a compelling case for vitamin D3 as a supportive treatment in managing Hashimoto's thyroiditis and related hypothyroidism.
Through this thorough examination, we found that vitamin D3 did promote significant improvements in thyroid function and immune response. Specifically, we observed a reduction in two key antibodies: anti-thyroid peroxidase (TPO-Ab) and thyroglobulin antibody (TG-Ab). These reductions suggest a positive effect on the autoimmune process involved in Hashimoto's thyroiditis.
Additionally, we noted improvements in thyroid hormone levels, including free thyroxine (FT4) and free triiodothyronine (FT3), while thyroid-stimulating hormone (TSH) levels showed a decrease. These findings indicate that vitamin D3 supplementation may benefit thyroid health and help manage hypothyroidism more effectively.
For those considering vitamin D3 as a treatment option, particularly those who have been on vitamin D for longer than 12 weeks, the results suggest a more pronounced effect on improving antibody levels and thyroid function. Thus, there appears to be a compelling case for vitamin D3 as a supportive treatment in managing Hashimoto's thyroiditis and related hypothyroidism.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
8
Improved hair growth
I used this omega supplement during my second trimester of pregnancy and continued while breastfeeding. I have always struggled with thin hair due to genetics and hypothyroidism. Initially, my hair growth was impressive, but I experienced shedding after three months post-delivery. After two months, the shedding stopped, and to my surprise, my hair began to grow longer. Friends even noticed the change after ten years. I also take vitamin D alongside this omega and have not experienced any unpleasant fish oil taste.
Read More
