'
Nordic Naturals Omega-3
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
20
 
Total Fat
2 g
3%
Total Omega-3s♢
690 mg
EPA (Eicosapentaenoic Acid)
330 mg
DHA (Docosahexaenoic Acid)
220 mg

The product is found useful for the following medical conditions

Eczema details

SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.1
USERS' SCORE
Excellent
Based on 7 Reviews
9.1
9
Eicosapentaenoic Acid reduces eczema
Evaluating the Effect of Eicosapentaenoic Acid in Children With Atopic Dermatitis: A Randomized Triple-Blind Clinical Trial.
Most Relevant Research
We embarked on a study to find out how dietary eicosapentaenoic acid (EPA) could help children suffering from atopic dermatitis, a common form of eczema. In a randomized triple-blind clinical trial, 48 children with this condition were divided into two groups—one received 250 mg of EPA twice daily, while the other received a placebo for four weeks.

Our observations showed noticeable improvements in those who took EPA. After just two weeks, participants in the EPA group reported a reduction in their SCORAD scores, which are used to measure the severity of atopic dermatitis. The scores went down significantly compared to the placebo group. After four weeks, the number of children needing corticosteroids to manage their symptoms was also lower in the EPA group.

Despite these positive results, both groups reported few adverse effects, indicating that EPA supplementation is generally well-received. Overall, we conclude that adding EPA to the diet may be an effective and safe strategy for reducing eczema severity in children.
10
Eczema elimination
Most Useful Review
I didn't realise just HOW good this is! I usually don't write reviews, but I had to for this. I originally bought this product for my pregnancy after thorough research. While I expected benefits for myself and my baby, after 2-3 weeks, the severe eczema on my face and neck disappeared completely. My skin became clear, smooth, and hydrated, a look I hadn't seen for years! I struggled with eczema for five years, trying an $180 cream that eventually stopped working. I discovered that fish oil is significantly more effective on eczema than any prescription cream. This was initially for my pregnancy, but I intend to use it for life!

Allergies details

SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.9
USERS' SCORE
Excellent
Based on 11 Reviews
9
8
Omega-3s and skin allergies
ω3 fatty acid metabolite, 12-hydroxyeicosapentaenoic acid, alleviates contact hypersensitivity by downregulation of CXCL1 and CXCL2 gene expression in keratinocytes via retinoid X receptor α.
Most Relevant Research
We uncovered intriguing insights into how eicosapentaenoic acid (EPA) and its metabolite, 12-hydroxyeicosapentaenoic acid (12-HEPE), play a role in managing allergic responses, particularly in the skin. Our study revealed that when mice consumed an omega-3 fatty acid-rich diet, 12-HEPE became a significant metabolite in their skin.

Interestingly, we observed that the enzymes responsible for producing 12-HEPE were more active in the skin compared to other organs. This effective metabolite appeared to reduce inflammation caused by contact hypersensitivity. Specifically, we found that applying 12-HEPE topically limited the influx of neutrophils, a type of white blood cell involved in inflammatory responses.

Taking our research a step further, we investigated the effects of 12-HEPE on human skin cells, or keratinocytes, in lab conditions. Our findings showed that 12-HEPE inhibited two specific genes that cause neutrophils to be attracted to the site of inflammation, showcasing its potential as a therapeutic agent for allergy management. Overall, we identified 12-HEPE as a potent metabolite in the skin, suggesting that dietary omega-3 fatty acids could be a beneficial strategy in controlling allergic reactions.
9.5
Happy with product
Most Useful Review
The quality is consistently top-notch, with fish oil sourced from cold waters. Allergies have not affected anyone, and everyone is pleased.

Autoimmune Disorder details

SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.6
USERS' SCORE
Good
Based on 7 Reviews
8.9
8
Eicosapentaenoic acid benefits MS
The therapeutic effect of PEGlated nanoliposome of pistachio unsaturated oils and its efficacy to attenuate inflammation in multiple sclerosis: A randomized, double-blind, placebo-controlled clinical trial phase I.
Most Relevant Research
We conducted a randomized, double-blind, placebo-controlled clinical trial to explore the effects of PEGlated nanoliposome of pistachio unsaturated oils on inflammation in multiple sclerosis (MS). During the study, we treated MS patients with these nanoliposomes enriched with eicosapentaenoic acid, a type of omega-3 fatty acid known for its potential health benefits.

After the treatment, we observed significant improvements in various markers of inflammation. Notably, the levels of docosahexaenoic and eicosapentaenoic acids increased, while the level of matrix metallopeptidase-9, an enzyme linked to inflammation, decreased. This shift indicates a favorable response in how the patients’ bodies were managing inflammation.

Moreover, we noted a Th2-biased response in cytokine levels, which typically suggests a less inflammatory environment. The results showed a significant reduction in the frequency of relapses, lower disability scores, and fewer T2 lesions in patients treated with the nanoliposomes. Overall, our findings suggest that eicosapentaenoic acid treatment may offer promising benefits for managing inflammation associated with multiple sclerosis.
9.5
Mood improvement
Most Useful Review
This is my favourite so far. I received two cans and found the price quite reasonable for 120 capsules, lasting two months. I experienced a slight citrus burp instead of the usual fishy aftertaste, which is a plus. My hair and nails improved significantly, and it helped alleviate post-COVID depression. The capsules are large but easy to swallow.

Common Cold details

SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 10 Reviews
8.8
8
DHA reduces infant cold symptoms
Prenatal docosahexaenoic acid supplementation and infant morbidity: randomized controlled trial.
Most Relevant Research
We conducted a double-blind randomized controlled trial to understand how prenatal supplementation of docosahexaenoic acid (DHA) might influence infant health, particularly concerning the common cold. Pregnant women were given either a daily dose of 400 mg of DHA or a placebo starting at 18 to 22 weeks of gestation until childbirth.

Caregivers then reported on their infants’ health at 1, 3, and 6 months, sharing details about common illness symptoms. We found that DHA supplementation appeared to reduce the number of colds at one month and also seemed to lessen the duration of various cold symptoms in infants. Specifically, infants in the DHA group experienced fewer cold symptoms and had shorter durations of cough and wheezing.

While the overall occurrence of specific illness symptoms was similar between the DHA and placebo groups, DHA did bring about noteworthy benefits. At 1 month, infants in the DHA group had a 26% shorter duration of cough and 30% shorter wheezing; however, they experienced a longer duration of rash.

Furthermore, by the time the infants reached 3 months, those whose mothers took DHA were ill for 14% less time overall. At 6 months, the DHA group showed significantly reduced durations of several illness indicators, although they did experience longer episodes of vomiting.

This study suggests that prenatal DHA not only seems to impact the occurrence of colds in children but may also play a role in the duration of symptoms over the first half-year of life.
9.5
Cold-free winter
Most Useful Review
I have been taking this product for months and it's the first time I've never had that horrible 'fishy' taste after swallowing the pills. I’ve remained cold and flu free during winter in New Zealand, and my hair, nails, and skin appear fantastic. I highly recommend this product to anyone.

Acne details

SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
USERS' SCORE
Good
Based on 6 Reviews
8.7
9
Eicosapentaenoic acid helps acne
Exploring the potential of omega-3 fatty acids in acne patients: A prospective intervention study.
Most Relevant Research
We focused our research on the potential benefits of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, for individuals suffering from acne. Over a period of 16 weeks, we encouraged 60 patients to follow a Mediterranean diet while taking algae-derived EPA and docosahexaenoic acid (DHA) supplements. Our goal was to see if increasing their omega-3 levels could improve acne symptoms.

At the start of the study, an impressive 98.3% of the participants were found to have low levels of EPA/DHA. By the end of the study, we observed a significant increase in their omega-3 levels from an average of 4.9% to 8.3%. This boost correlated with noticeable improvements in both inflammatory and non-inflammatory acne lesions.

Interestingly, we noted that while individual perceptions of appearance varied—some reporting no improvement—overall quality of life for the participants enhanced significantly, particularly in those with papulopustular acne. Alongside dietary changes, participants reduced their intake of cow’s milk and dairy products, and we did not encounter any negative side effects from the intervention.

Ultimately, our findings suggest that boosting omega-3 fatty acids, particularly EPA, through diet and supplementation can effectively help manage acne severity in patients.
9.5
Clear skin achieved
Most Useful Review
I’ve been taking this omega-3 daily for half a year, and my acne-prone skin is now clear!

Arthritis details

SCIENTIFIC SCORE
Possibly Effective
Based on 30 Researches
7.3
USERS' SCORE
Good
Based on 3 Reviews
8.7
8
Eicosapentaenoic acid aids arthritis
Effects of omega-3 supplementation on lipid metabolism, inflammation, and disease activity in rheumatoid arthritis: a meta-analysis of randomized controlled trials.
Most Relevant Research
We explored the effects of eicosapentaenoic acid (EPA), a key component of omega-3 fatty acids, on patients with rheumatoid arthritis (RA). This analysis gathered data from eighteen randomized controlled trials involving over a thousand RA patients, ensuring a comprehensive look at its impact.

Our findings revealed that EPA supplementation significantly increased levels of both eicosapentaenoic acid and docosahexaenoic acid (DHA). Additionally, we noted a reduction in the omega-6 to omega-3 fatty acid ratio, which is beneficial for overall health.

Moreover, we observed that EPA led to a decrease in triglyceride levels and tender joint counts among RA patients. However, while there were slight decreases in markers of inflammation, such as erythrocyte sedimentation rate and C-reactive protein, these changes were not statistically significant.

Overall, our analysis supports the idea that EPA has positive effects on lipid profiles and joint tenderness for those with RA, although not all inflammatory markers showed significant improvement.
8.8
Improved arthritic joint
Most Useful Review
Excellent! There is just a slight lemony aftertaste, which is not unpleasant. I've only been taking this for a short time, so I'm not sure yet about my cholesterol. However, within a few days, I noticed a significant improvement in my arthritic finger joint, which had been troublesome due to the cold winter weather. Despite the drastic changes in temperature, my joint feels fine. Additionally, I have experienced better energy levels and digestion. I take one in the morning and one before dinner, and I'm very pleased with the results!

Bloating details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.7
9.5
No bloating noted
Most Useful Review
Super omega is fantastic! I've ordered a second jar as I feel brilliant after taking them. There’s no heartburn, bloating, or abdominal pain, and belching has ceased. I’ll order again, even though the price isn't ideal.

Blood Clot details

SCIENTIFIC SCORE
Possibly Effective
Based on 25 Researches
7.6
USERS' SCORE
Good
Based on 4 Reviews
8.7
9
Eicosapentaenoic acid influences clotting
Emergence of omega-3 fatty acids in biomedical research.
Most Relevant Research
We explored how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, influences blood clotting processes. The interest in EPA grew substantially after the 1970s when researchers Dyerberg and Bang noted that Greenland Eskimos had lower rates of coronary disease linked to their diet rich in marine lipids.

Their findings suggested that the higher levels of EPA led to reduced platelet aggregation, which essentially means that the blood clots less easily. This anti-clotting effect is significant since blood clots can lead to serious health issues like heart attacks and strokes.

Although studies have shown these promising effects, it’s crucial to note that much of the initial acclaim came from dietary observations rather than controlled clinical trials. This means that while we can relate high EPA intake to lower health risks in specific populations, we still need more rigorous studies to fully understand the impact of EPA on blood clotting across diverse groups.
9.5
Helps lower cholesterol
Most Useful Review
Thanks to Nordic Naturals for such a fantastic product. This fish oil is in Triglyceride Form, which my body quickly accepts. Other brands mostly use the Ethyl Ester form, which takes longer to convert and can waste some of the omega-3 fatty acids. The TG form helps to lower bad cholesterol levels effectively without wasting nutrients, making it worthwhile despite the slightly higher price. I highly recommend Nordic Naturals or any reputable TG fish oil brand with the necessary certifications.

Chronic Fatigue Syndrome details

SCIENTIFIC SCORE
Possibly Effective
Based on 7 Researches
7.9
USERS' SCORE
Good
Based on 5 Reviews
8.7
9.5
Eicosapentaenoic acid benefits CFS
Eicosapentaenoic acid-rich essential fatty acid supplementation in chronic fatigue syndrome associated with symptom remission and structural brain changes.
Most Relevant Research
We explored the potential benefits of eicosapentaenoic acid (EPA), an essential fatty acid, in treating chronic fatigue syndrome (CFS). A female patient with a six-year history of persistent CFS symptoms participated in the study, receiving a daily supplement rich in EPA.

After measuring her brain structure through high-resolution magnetic resonance imaging both at the beginning and 16 weeks later, we observed significant improvements in her symptoms starting just six to eight weeks into the treatment. Most notably, the patient's lateral ventricular volume—a key indicator of brain health—decreased from 28,940 mm³ to 23,660 mm³, indicating structural changes in her brain.

This research hints at the promising role of EPA in alleviating symptoms of chronic fatigue syndrome while also suggesting positive brain changes associated with treatment. The findings encourage further investigation into fatty acid supplementation's potential as an effective therapeutic strategy for CFS.
9.5
No more fatigue
Most Useful Review
Finally, I decided to try omega and fill my body with essential elements. I was initially concerned that these capsules might not suit me, but they are remarkable! No smell or unpleasant aftertaste. Yes, they are large, yet easy to swallow with water. I've been taking them twice a day for a month now, alongside other necessary vitamins. My general condition is excellent: there’s no fatigue typical of winter, no apathy, and no daytime sleepiness. I am pleased and plan to continue taking them.

Heart Attack details

SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.7
USERS' SCORE
Good
Based on 4 Reviews
8.7
9
Eicosapentaenoic acid aids heart recovery
Eicosapentaenoic Acid Preserves Mitochondrial Quality and Attenuates Cardiac Remodeling After Myocardial Infarction in Rats.
Most Relevant Research
We investigated how eicosapentaenoic acid (EPA) may help improve heart health after a heart attack. In our study, we induced myocardial infarction (MI) in male rats by ligating their coronary artery. Some of these rats received daily treatment with EPA, while others did not, allowing us to compare the effects.

Over 12 weeks, we observed that the rats treated with EPA showed better left ventricular function—essentially, their hearts were working more efficiently. Moreover, these rats had higher levels of EPA in their mitochondria, which are the energy factories of cells. Despite the damage caused by the heart attack, the EPA treatment helped maintain crucial energy levels and kept the mitochondrial function from declining, preserving a specific protein linked to cellular health.

Our findings suggest that including EPA in the diet can bolster mitochondrial quality and support heart function after an MI. This could mean that EPA may serve as an important dietary addition for promoting heart health following heart events.
9.5
Reduces heart attack risk
Most Useful Review
After three weeks of taking this supplement, my hair has scarcely fallen out. My skin feels much less dry, even in the heating season. Omega-3 contributes to heart health by reducing “bad” cholesterol and lowering the risk of heart attack. It also aids in joint health, cognitive function, and managing stress. Additionally, vitamins A, E, and D enrich the skin and bones.

Heartburn details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 6 Reviews
8.7
9.5
Highly recommended product
Most Useful Review
Excellent quality goods! The dosage is ideal. After taking it, I do not experience any discomfort—no heartburn or belching! I highly recommend it.

High Cholesterol details

SCIENTIFIC SCORE
Possibly Effective
Based on 29 Researches
7.8
USERS' SCORE
Good
Based on 20 Reviews
8.7
9
Eicosapentaenoic acid benefits cholesterol
Omega-3 eicosapentaenoic polar-lipid rich extract from microalgae decreases plasma triglycerides and cholesterol in a real-world normolipidemic supplement consumer population.
Most Relevant Research
We explored the effects of eicosapentaenoic acid (EPA), a specific type of omega-3 fatty acid, on cholesterol levels in a recent study involving real-world supplement consumers. Participants took AlmegaPL capsules, which contain high amounts of EPA and are free of the other omega-3 fatty acid, DHA. This setup allowed us to gain insights from those who are already incorporating EPA into their diets.

Throughout the study, we monitored key health markers such as triglycerides, total cholesterol, and various types of cholesterol at different stages of supplementation. We observed that after six months of taking this supplement, participants showed a significant reduction in remnant cholesterol and maintained healthy triglyceride levels. Notably, this decrease in cholesterol did not come at the expense of raising low-density lipoprotein (LDL) levels, which is often a concern with other treatments.

These encouraging results reveal that EPA can be a beneficial addition for individuals looking to manage their cholesterol levels effectively. Importantly, our findings highlight AlmegaPL's unique position as a natural, over-the-counter option for those seeking to improve their lipid profiles.
9
Meets safety standards
Most Useful Review
Choosing Omega-3 was important for me. Key factors include the composition of EPA and DHA, the source of ingredients, and the form of absorption. This product meets all safety standards and is beneficial, although it’s not cheap. High-quality products usually come with a higher price.

Osteoporosis details

SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.5
USERS' SCORE
Good
Based on 7 Reviews
8.7
9
DHA's role in osteoporosis treatment
Comparative study of DHA-enriched phosphatidylcholine and EPA-enriched phosphatidylcholine on ameliorating high bone turnover regulation of the osteogenesis-related Wnt/β-catenin pathway in ovariectomized mice.
Most Relevant Research
We recently looked into how docosahexaenoic acid (DHA), through its enriched phosphatidylcholine form (DHA-PC), affects osteoporosis. Using a model that simulates the condition in women after ovariectomy, we compared the impact of DHA-PC with eicosapentaenoic acid (EPA) enriched phosphatidylcholine (EPA-PC). Our findings revealed that both DHA-PC and EPA-PC significantly improved the structural quality of trabecular bone, boosted the rate of new bone formation, and elevated bone mineral density, which are crucial factors in combating osteoporosis.

We also discovered that both compounds worked to regulate bone formation by down-regulating the overactive Wnt/β-catenin signaling pathway, which is key to osteogenesis. This means that rather than allowing excessive bone growth, DHA-PC and EPA-PC help bring osteogenesis back to normal levels. Thus, our results suggest that incorporating DHA and EPA phosphatidylcholine could potentially serve as a beneficial strategy in osteoporosis management, highlighting their promising role in health and nutrition.

Overall, this study offers valuable insights into the anti-osteoporotic effects of DHA-PC and EPA-PC and supports their further exploration as functional foods in our diets.
9.5
Highly effective
Most Useful Review
Great! Omega-3 fatty acids prevent the development of osteoporosis, maintain healthy joints, and relieve pain during exacerbations. They fight bone loss, alleviate rheumatoid arthritis symptoms, and slow down the destruction of cartilage in arthrosis. The quality is exceptional, with natural ingredients and optimal effectiveness.

Anxiety details

SCIENTIFIC SCORE
Possibly Effective
Based on 24 Researches
7.4
USERS' SCORE
Good
Based on 2 Reviews
8.6
8
DHA improves milk and reduces anxiety
DHA Supplementation of Obese Rats throughout Pregnancy and Lactation Modifies Milk Composition and Anxiety Behavior of Offspring.
Most Relevant Research
We explored how supplementing obese mothers with docosahexaenoic acid (DHA) affects milk composition and the anxiety behavior of their offspring. In a study involving female Wistar rats, some were placed on a high-fat diet while others ate regular chow. We supplemented half of the mothers from one month before mating until they weaned their pups with DHA. The goal was to see if this supplementation could improve the quality of their milk and influence the anxiety levels of their babies.

Our findings indicated that the obese mother rats exhibited higher weight and fat levels and their milk contained less beneficial DHA but more corticosterone and leptin. Notably, their offspring showed a higher ratio of omega-6 to omega-3 fatty acids in the milk they consumed, which correlates to increased anxiety levels, especially in female pups. In contrast, those mothers who received DHA supplements had lower body weight and fat and produced milk with higher DHA content. Their offspring not only had a better balance of omega-6 to omega-3 fatty acids but also demonstrated reduced anxiety compared to those from mothers without supplementation.

Overall, this study highlights the significant positive impact of DHA supplementation during pregnancy and lactation in obese rats, as it not only improves the nutritional quality of their milk but also helps decrease anxiety levels in the offspring in a sex-dependent manner.
8.8
Eases anxiety
Most Useful Review
Really good! I started taking Omega-3 when I was working out a few years ago and noticed being more easy-going throughout the day. When I began taking it during periods of depression and anxiety, I experienced moments of happiness and peace, which improved over time with other supplements like vitamin D, L-theanine, and saffron.

Bone Pain details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 2 Reviews
8.6
9.5
Improved bone pain
Most Useful Review
After three weeks, my hair stopped falling out and my skin is less dry this winter, which is a relief. Omega-3 triglycerides have numerous benefits, including reducing bone pain, enhancing heart function, and improving joint flexibility. They help regulate hormones and reduce stress, which has positively impacted my overall wellbeing. Fish oil also contains vitamins A, E, and D, supporting skin condition, vision, and bone health. Thank you for this product.

Cardiovascular Disease details

SCIENTIFIC SCORE
Possibly Effective
Based on 31 Researches
7.4
USERS' SCORE
Good
Based on 6 Reviews
8.6
9
EPA's role in diabetic heart health
Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy.
Most Relevant Research
We explored the impact of eicosapentaenoic acid (EPA), a nutrient known for its heart benefits, on diabetic cardiomyopathy (DC), a condition leading to heart failure. Our study focused on diabetic mice and revealed that EPA plays a protective role against DC, particularly by reducing harmful M1-polarized macrophages in the heart.

In our experiments, we found that EPA not only reduces cardiomyocyte injury caused by M1-polarized macrophages but also encourages a shift in macrophages' behavior from M1 to a protective Mox state—not M2. This shift is crucial because Mox macrophages help mitigate the damage inflicted by their M1 counterparts.

We identified heme oxygenase 1 (HO-1) as a key player in maintaining the Mox phenotype. EPA promotes HO-1, which helps curb macrophage M1 polarization and the resulting cardiomyocyte injury. Interestingly, our findings also showed that EPA fosters this protective Mox polarization in monocyte-derived macrophages from diabetic patients, suggesting a broader application for this treatment strategy.

Overall, our study highlights the potential of EPA as a novel approach to combat diabetic cardiomyopathy, emphasizing the importance of macrophage Mox polarization in maintaining heart health in diabetes.
9.5
Reduces hair loss
Most Useful Review
After three weeks of taking omega, my hair has stopped falling out completely; now it's only two to five strands during shampooing. My skin has also become less dry despite the heating season, which I appreciate greatly. Omega-3 triglycerides are essential nutrients contributing to various bodily functions. They help lower "bad" cholesterol, reducing the risk of vascular atherosclerosis and myocardial infarction. Omega-3 supports hormone regulation, improves heart muscle function, and increases cognitive functions. It also enhances the immune system, reduces inflammation, and promotes lean muscle growth, among other benefits.

Cold Sores details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 5 Reviews
8.6
9.5
No sores experienced
Most Useful Review
I have tried various Omega-3 brands but often suffered from cold sores until now. With this one, there’s no fishy taste, and I've completely forgotten about my worries concerning cold sores. I highly recommend it!

Hypertension details

SCIENTIFIC SCORE
Possibly Effective
Based on 27 Researches
7.6
USERS' SCORE
Good
Based on 2 Reviews
8.6
9
Eicosapentaenoic acid benefits hypertension
5,6-diHETE lactone (EPA-L) mediates hypertensive microvascular dilation by activating the endothelial GPR-PLC-IP signaling pathway.
Most Relevant Research
We investigated the impact of eicosapentaenoic acid (EPA) on hypertension, a condition characterized by elevated blood pressure that can lead to serious health issues. The study focused on a special compound called 5,6-diHETE lactone (EPA-L), derived from EPA, which we observed to promote better blood vessel function. This compound was tested on hypertensive rats and showed a significant reduction in blood pressure.

Interestingly, we found that the way EPA-L works isn’t through increasing levels of nitric oxide like some may expect. Instead, we discovered that it triggers a unique signaling pathway involving G-protein-coupled receptors. This pathway activates key cellular processes in the endothelial cells lining our blood vessels, allowing them to relax and dilate, thereby contributing to lower blood pressure. In vitro experiments on human endothelial cells confirmed these findings, providing further evidence for the effectiveness of EPA-L.

Overall, our research positions EPA-L as a promising metabolite from eicosapentaenoic acid, demonstrating potential benefits in managing hypertension and promoting vascular health.
9.5
Reduced blood pressure
Most Useful Review
This is the best omega supplement for seniors with hypertension. It has significantly cleansed my blood vessels, resulting in fewer blood pressure drops.

Pelvic Pain details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.6
9.5
Reduced pelvic pain
Most Useful Review
After three weeks of taking this product, my hair stopped falling out and my skin has improved. Omega-3 triglycerides are essential nutrients that can help reduce pelvic pain and lower cholesterol, thus decreasing the risk of serious health issues. They also support joint health, improve cognitive functions, and enhance the immune system. Fish oil's vitamins A, E, and D contribute positively to skin condition and overall well-being.

Chest Pain details

SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.5
USERS' SCORE
Good
Based on 3 Reviews
8.5
7
Eicosapentaenoic acid showed mixed results
Improvement of coronary vasomotion with eicosapentaenoic acid does not inhibit acetylcholine-induced coronary vasospasm in patients with variant angina.
Most Relevant Research
We examined how eicosapentaenoic acid (EPA), a key ingredient found in fish oil, impacts chest pain in patients with variant angina. Our study followed 22 individuals with this condition, where we infused acetylcholine, a substance known to cause coronary vasospasm, both before and after a four-month course of EPA treatment (1.8 g/day for 12 patients).

In the group that did not receive EPA, we observed no changes in how their coronary arteries responded to acetylcholine over time. However, for those treated with EPA, the results were quite intriguing. In non-spastic areas, the response shifted from vasoconstriction (narrowing) to vasodilation (widening). This indicates a notable improvement in how these arteries are functioning.

Yet, when it came to spastic sites where vasospasm had occurred, the coronary arteries remained responsive to acetylcholine, and the vasospasm persisted despite the EPA treatment. Thus, while EPA enhanced coronary responsiveness in some areas, it did not eliminate the acetylcholine-induced coronary vasospasms associated with variant angina.
8.8
Joint relief
Most Useful Review
High-quality omega-3 fatty acids are effective in preventing osteoporosis, maintaining healthy joints, and relieving pain during flare-ups. These fatty acids combat bone loss and reduce inflammation, helping to alleviate the symptoms of rheumatoid arthritis and slow the deterioration of articular cartilage during arthrosis.

Heart Disease details

SCIENTIFIC SCORE
Possibly Effective
Based on 32 Researches
7.3
USERS' SCORE
Good
Based on 17 Reviews
8.5
9
Omega-3 lowers coronary risk
A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events.
Most Relevant Research
We explored the impact of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, on heart disease through a significant study known as the VITAL trial. This study involved nearly 26,000 older adults in the U.S. and aimed to determine the effects of daily EPA supplementation on cardiovascular events over an average follow-up of 5.3 years.

Initially, the results from VITAL seemed to show that omega-3 supplementation had no significant effect on major cardiovascular disease (CVD) events. However, by applying Bayesian methods and considering prior research in the field, we observed a more nuanced outcome. Our analysis suggested that taking EPA regularly could significantly reduce the risk of coronary heart disease events, while not showing similar benefits for stroke.

This finding supports the use of omega-3 fatty acids as a preventive measure for heart health, especially regarding coronary events. Although we didn't find evidence of a benefit for all types of cardiovascular events, the enhanced understanding gained from this reanalysis contributes valuable insights for both clinicians and patients considering omega-3 supplementation for heart disease prevention.
9.5
Improves child's heart
Most Useful Review
We only use this omega for my child, as it's regularly tested for toxins and heavy metals. The triglyceride form meets strict purity standards, and the capsules are easy to swallow with no fishy taste. I’ve noticed improvements in my child's activity and fatigue levels.

Sleep Apnea details

SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 4 Reviews
8.5
8
DHA levels linked to OSA severity
Membrane level of omega-3 docosahexaenoic acid is associated with severity of obstructive sleep apnea.
Most Relevant Research
We investigated how the omega-3 fatty acid docosahexaenoic acid (DHA) impacts the severity of obstructive sleep apnea (OSA) in 350 patients undergoing sleep studies. Our study aimed to determine if there is a relationship between the levels of DHA in red blood cells (RBC) and the severity of sleep apnea, categorized as none/mild, moderate, or severe based on apnea hypopnea index (AHI) scores.

Our findings revealed that lower levels of DHA are linked to more severe cases of OSA. For each standard deviation increase in DHA, patients were about 50% less likely to be classified in the severe apnea category. Specifically, we noted decreased odds of falling into the severe OSA group when DHA levels were higher, suggesting that DHA may play an important role in the severity of this condition.

These insights imply that maintaining healthy DHA levels could potentially influence OSA severity and could aid in developing treatment strategies. We believe that future research should explore the potential benefits of DHA supplementation for those suffering from sleep apnea.
8.3
Promotes calmness
Most Useful Review
This omega 3 fish oil supplement is of the best quality, in triglyceride form for better absorption. It aids in achieving deep, refreshing sleep without side effects. It also reduces inflammation and lowers cortisol levels, thus managing anxiety and stress effectively. Just one soft gel daily suffices, and I highly recommend giving it a try for its calming effects and benefits on sleep.

Back Pain details

SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.7
USERS' SCORE
Good
Based on 13 Reviews
8.4
9
Eicosapentaenoic acid alleviates back pain
Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis.
Most Relevant Research
We explored how eicosapentaenoic acid (EPA) might help in treating intervertebral disc degeneration (IDD), a major contributor to back pain. Research highlights that this condition often involves endoplasmic reticulum (ER) stress and breakdown of the extracellular matrix (ECM), key processes that worsen IDD. Our investigation demonstrated that EPA can promote autophagy, a process that helps cells clean up and maintain balance within the ECM.

Through our experiments, we treated nucleus pulposus cells—cells in the discs that often suffer from degeneration—with EPA. We observed that EPA not only boosted autophagy but also suppressed the harmful effects of ER stress, reducing cell death and limiting ECM degradation. Additionally, we utilized a rat model of IDD to see if these protective effects translated into a real-world setting. The findings indicated that EPA improved the health of the discs and effectively slowed down the progression of IDD in these rats.

In summary, this research highlights the potential of EPA as a therapeutic option for managing back pain related to disc degeneration. Our results suggest that EPA could play an important role in supporting the health of intervertebral discs and mitigating some of the common issues associated with chronic back pain.
9.5
Pain relief achieved
Most Useful Review
After developing stomach ulcers from pain medications, I switched to Nordic Naturals and noticed a significant improvement. My knee swelling and pain disappeared shortly after starting them. I highly recommend this product as it works better than any other brands I've tried, plus it has no unpleasant aftertaste.

Irritable Bowel Syndrome details

SCIENTIFIC SCORE
Questionable
Based on 2 Researches
5
USERS' SCORE
Good
Based on 4 Reviews
8.3
5
Fatty acids affect IBS metabolism
Bifidobacterium breve with α-linolenic acid and linoleic acid alters fatty acid metabolism in the maternal separation model of irritable bowel syndrome.
Most Relevant Research
Our study focused on understanding how eicosapentaenoic acid, alongside other fatty acids, influences irritable bowel syndrome (IBS). We designed an experiment where we treated both maternally separated and non-separated rats with Bifidobacterium breve and explored its effect on colonic sensitivity and fatty acid metabolism over a period of seven weeks.

Throughout our research, we observed significant changes in fatty acid profiles, especially in liver and serum tissues, after administering Bifidobacterium breve. Notably, in the maternally separated rats, the treatment appeared to enhance levels of palmitoleic acid, arachidonic acid, and docosahexaenoic acid in various tissues, which are fatty acids that others believe could be influential in managing symptoms related to IBS.

However, while eicosapentaenoic acid was present in the research context, it was largely studied in combination with other treatments. This made it challenging to evaluate its isolated effect on IBS directly. Thus, while we noted some positive metabolic changes with our treatment approach, the specific impact of eicosapentaenoic acid on IBS symptoms wasn’t definitively established.

Overall, our findings suggest that while Bifidobacterium breve and fatty acid supplementation may influence host fatty acid metabolism, further focused studies are necessary to clarify the role of eicosapentaenoic acid in managing irritable bowel syndrome.
9.5
No gastrointestinal issues
Most Useful Review
Decent Omega-3! This is an excellent source of pure omega-3 from a reputable manufacturer. My gastrointestinal tract tends to be sensitive, but thankfully, I experienced no negative reactions while taking this omega, which is a significant achievement for me. There was no belching or upset stomach whatsoever. I will buy it again.

Leg Cramps details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Good
Based on 3 Reviews
8.1
9.5
Painful cramps relieved
Most Useful Review
My husband used to suffer from severe leg cramps which caused him considerable pain. Following a nutritionist's advice, he began taking Nordic Omega Fish Oil—three capsules daily. Remarkably, his cramps vanished within a week. I also decided to take one capsule daily and noticed relief from my painful leg cramps. I highly recommend this product.

Headache details

SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.2
USERS' SCORE
Moderately Good
Based on 6 Reviews
7.9
9.5
Eicosapentaenoic acid reduces migraines
A 12-week randomized double-blind clinical trial of eicosapentaenoic acid intervention in episodic migraine.
Most Relevant Research
We conducted a 12-week study to explore how eicosapentaenoic acid (EPA) affects individuals suffering from episodic migraines. In our trial, 70 participants were randomly split into two groups—one received 2 grams of fish oil with 1.8 grams of pure EPA daily, while the other group got a placebo made of soybean oil.

The results were quite promising. Those taking EPA reported a significant reduction in the number of migraine days per month, averaging about 4.4 fewer days compared to just 0.6 fewer days in the placebo group. We also noticed a decline in the usage of medication to treat headache symptoms among those taking EPA.

Additionally, participants experienced less severe headaches and improved psychological wellbeing, as indicated by better scores in anxiety, depression, and overall quality of life measures. Notably, women seemed to benefit even more from EPA.

Overall, it appears that high-dose EPA can be an effective preventive treatment for episodic migraines, helping to ease frequency, severity, and even the emotional toll associated with chronic headaches. Importantly, the treatment was well tolerated, with no significant adverse effects reported.
10
Eliminated headaches
Most Useful Review
Best Omega-3s I've taken for years. The eye strain headaches I used to experience have vanished, and my dry skin rashes have significantly improved. My eye doctor has even noted that my eyes are well lubricated for my age (60 years). If I could only choose one supplement, this would be it, although Cherry Extract capsules come a close second.

Nausea details

SCIENTIFIC SCORE
Possibly Effective
Based on 1 Research
7
USERS' SCORE
Moderately Good
Based on 14 Reviews
7.9
7
Dysmenorrhea influences pregnancy nausea
Association of the Verbal Rating Scale-Measured Dysmenorrhea with Nausea and Vomiting in Pregnancy: A Retrospective Cohort Study.
Most Relevant Research
We conducted a retrospective cohort study to investigate the relationship between nausea and vomiting in pregnancy (NVP) and dysmenorrhea measured by a verbal rating scale. Our research included 443 pregnant women, divided into those experiencing NVP and a control group.

From our findings, we noticed a clear association between moderate to severe dysmenorrhea and a heightened risk of NVP, especially during the first trimester. This suggests that those with painful menstrual symptoms may face an increased likelihood of nausea and vomiting as part of their pregnancy experience.

Importantly, we also examined the impact of periconceptional supplementation with docosahexaenoic acid (DHA). Our results indicated that taking DHA could potentially lower the risk of NVP, offering a glimmer of hope for managing nausea during pregnancy. This suggests that combining DHA with standard prenatal care might be beneficial for those who struggle with these symptoms.

Overall, our study sheds light on the intricate connections between menstrual pain and pregnancy-related nausea, emphasizing the potential protective role of DHA in improving women's health during this time.
9.5
No nausea
Most Useful Review
The best omega! The pure composition and pleasant taste really stand out. The capsules are large but easily swallowed, with no unpleasant belching and no nausea, which I often experienced with other omega brands. The quality of my skin has improved significantly, and the jars last for two months.

Reflux details

SCIENTIFIC SCORE
No researches found
N/A
USERS' SCORE
Moderately Good
Based on 4 Reviews
7.5
9.5
Effective for reflux
Most Useful Review
No reflux! I love the quality of the brand, and the fishy flavour doesn’t constantly repeat itself, which is great.
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