' 
SCIENTIFIC SCORE
Possibly Effective
Based on 46 Researches
7.5
USERS' SCORE
Good
Based on 6 Reviews
8.6
Supplement Facts
Serving Size: 2 Soft Gels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%
Total Omega-3s♢
690 mg
†
EPA (Eicosapentaenoic Acid)
330 mg
†
DHA (Docosahexaenoic Acid)
220 mg
†
Top Medical Research Studies
9
Omega-3 levels reduce heart failure
Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities.
Significant positive health implications
We investigated the link between plasma omega-3 levels and the risk of heart failure (HF) in a large UK cohort study. Our analysis revealed that higher omega-3 levels were associated with a 21% lower chance of developing HF over nearly 14 years.
For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.
For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.
Read More
9
Omega-3 reduces cardiovascular risk
Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial.
Findings show clear clinical relevance.
We observed the effects of icosapent ethyl on heart health in a significant clinical trial involving statin-treated patients at high risk for cardiovascular events. This post hoc analysis revealed that icosapent ethyl reduced major cardiovascular issues, regardless of whether patients had low-density lipoprotein cholesterol (LDL-C) levels below or above 55 mg/dL.
Notably, those with optimal LDL-C control still benefited from the treatment, showing that this fish oil derivative can be effective in managing heart risks for many patients.
Notably, those with optimal LDL-C control still benefited from the treatment, showing that this fish oil derivative can be effective in managing heart risks for many patients.
Read More
9
EPA's role in diabetic heart health
Eicosapentaenoic acid induces macrophage Mox polarization to prevent diabetic cardiomyopathy.
High relevance to cardiovascular disease
We explored the impact of eicosapentaenoic acid (EPA), a nutrient known for its heart benefits, on diabetic cardiomyopathy (DC), a condition leading to heart failure. Our study focused on diabetic mice and revealed that EPA plays a protective role against DC, particularly by reducing harmful M1-polarized macrophages in the heart.
In our experiments, we found that EPA not only reduces cardiomyocyte injury caused by M1-polarized macrophages but also encourages a shift in macrophages' behavior from M1 to a protective Mox state—not M2. This shift is crucial because Mox macrophages help mitigate the damage inflicted by their M1 counterparts.
We identified heme oxygenase 1 (HO-1) as a key player in maintaining the Mox phenotype. EPA promotes HO-1, which helps curb macrophage M1 polarization and the resulting cardiomyocyte injury. Interestingly, our findings also showed that EPA fosters this protective Mox polarization in monocyte-derived macrophages from diabetic patients, suggesting a broader application for this treatment strategy.
Overall, our study highlights the potential of EPA as a novel approach to combat diabetic cardiomyopathy, emphasizing the importance of macrophage Mox polarization in maintaining heart health in diabetes.
In our experiments, we found that EPA not only reduces cardiomyocyte injury caused by M1-polarized macrophages but also encourages a shift in macrophages' behavior from M1 to a protective Mox state—not M2. This shift is crucial because Mox macrophages help mitigate the damage inflicted by their M1 counterparts.
We identified heme oxygenase 1 (HO-1) as a key player in maintaining the Mox phenotype. EPA promotes HO-1, which helps curb macrophage M1 polarization and the resulting cardiomyocyte injury. Interestingly, our findings also showed that EPA fosters this protective Mox polarization in monocyte-derived macrophages from diabetic patients, suggesting a broader application for this treatment strategy.
Overall, our study highlights the potential of EPA as a novel approach to combat diabetic cardiomyopathy, emphasizing the importance of macrophage Mox polarization in maintaining heart health in diabetes.
Read More
Most Useful Reviews
9.5
Reduces hair loss
After three weeks of taking omega, my hair has stopped falling out completely; now it's only two to five strands during shampooing. My skin has also become less dry despite the heating season, which I appreciate greatly. Omega-3 triglycerides are essential nutrients contributing to various bodily functions. They help lower "bad" cholesterol, reducing the risk of vascular atherosclerosis and myocardial infarction. Omega-3 supports hormone regulation, improves heart muscle function, and increases cognitive functions. It also enhances the immune system, reduces inflammation, and promotes lean muscle growth, among other benefits.
Read More
9.5
Multiple health benefits
This brand is one of the best available, making my choice of omega in triglyceride form worthwhile. I take omega in cycles. Omega-3 positively impacts the cardiovascular and nervous systems, promoting skin, nail, and hair health alongside many other useful properties. It lacks a fishy burp or unpleasant aftertaste and is generally easy to swallow, despite its size. I highly recommend it! 👍
Read More
8.8
Family-friendly omega
A chic-shaped super omega of excellent quality for maintaining health. There is no fishy taste, and it’s especially beneficial for the cardiovascular system. My hair has fallen out less, and the natural ingredients are great. I give it to my children aged 11 and 13, and cholesterol levels have improved according to their analysis.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 46 Researches
7.5
- All Researches
9
Omega-3 reduces cardiovascular risk
Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial.
Findings show clear clinical relevance.
We observed the effects of icosapent ethyl on heart health in a significant clinical trial involving statin-treated patients at high risk for cardiovascular events. This post hoc analysis revealed that icosapent ethyl reduced major cardiovascular issues, regardless of whether patients had low-density lipoprotein cholesterol (LDL-C) levels below or above 55 mg/dL.
Notably, those with optimal LDL-C control still benefited from the treatment, showing that this fish oil derivative can be effective in managing heart risks for many patients.
Notably, those with optimal LDL-C control still benefited from the treatment, showing that this fish oil derivative can be effective in managing heart risks for many patients.
Read More
9
Omega-3 improves heart function
The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.
High relevance and statistical significance
We assessed how omega-3 fatty acids (PUFAs) can support heart failure management through a thorough network meta-analysis of 14 studies with nearly 9,100 participants.
Our findings revealed that high doses (2,000-4,000 mg/day) taken for at least one year significantly improved heart function, particularly the left ventricular ejection fraction and peak oxygen consumption.
However, lower doses and shorter durations were not effective, and we found no major differences in safety measures like dropout rates or overall mortality between those taking omega-3 and those who were not.
Our findings revealed that high doses (2,000-4,000 mg/day) taken for at least one year significantly improved heart function, particularly the left ventricular ejection fraction and peak oxygen consumption.
However, lower doses and shorter durations were not effective, and we found no major differences in safety measures like dropout rates or overall mortality between those taking omega-3 and those who were not.
Read More
9
Omega-3 levels reduce heart failure
Association of Plasma Omega-3 Levels With Incident Heart Failure and Related Mortalities.
Significant positive health implications
We investigated the link between plasma omega-3 levels and the risk of heart failure (HF) in a large UK cohort study. Our analysis revealed that higher omega-3 levels were associated with a 21% lower chance of developing HF over nearly 14 years.
For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.
For individuals already diagnosed with HF, elevated omega-3 levels corresponded to about a 50% reduction in the risk of overall and cardiovascular mortality. These results suggest that boosting omega-3 intake through diet or supplements may help prevent HF and increase longevity for those already facing heart challenges.
Read More
9
Icosapent ethyl reduces cardiovascular risks
Cardiovascular Outcomes With Icosapent Ethyl by Baseline Low-Density Lipoprotein Cholesterol: A Secondary Analysis of the REDUCE-IT Randomized Trial.
Study highlights treatment effectiveness
We explored the effectiveness of icosapent ethyl, a form of eicosapentaenoic acid, in reducing cardiovascular events among statin-treated patients who had high cardiovascular risk and controlled cholesterol levels.
In this analysis of the REDUCE-IT trial, 8,175 patients with elevated triglycerides were observed. These patients were divided based on their low-density lipoprotein cholesterol (LDL-C) levels before treatment. We found that, overall, icosapent ethyl lead to significant reductions in major cardiovascular events, regardless of whether LDL-C was less than or greater than 55 mg/dL.
Specifically, those with LDL-C levels below 55 mg/dL experienced a drop in serious cardiovascular issues from 22.8% to 16.2% when treated with icosapent ethyl. Likewise, patients with LDL-C levels at or above 55 mg/dL showed improvements, with cardiovascular event rates declining from 21.9% to 17.4%. These results indicate that this treatment could be beneficial for patients who maintain good LDL-C levels while having high triglycerides.
Overall, we have strong evidence that icosapent ethyl effectively reduces cardiovascular risks in high-risk patients, which is great news for those looking for additional treatment options alongside statins.
In this analysis of the REDUCE-IT trial, 8,175 patients with elevated triglycerides were observed. These patients were divided based on their low-density lipoprotein cholesterol (LDL-C) levels before treatment. We found that, overall, icosapent ethyl lead to significant reductions in major cardiovascular events, regardless of whether LDL-C was less than or greater than 55 mg/dL.
Specifically, those with LDL-C levels below 55 mg/dL experienced a drop in serious cardiovascular issues from 22.8% to 16.2% when treated with icosapent ethyl. Likewise, patients with LDL-C levels at or above 55 mg/dL showed improvements, with cardiovascular event rates declining from 21.9% to 17.4%. These results indicate that this treatment could be beneficial for patients who maintain good LDL-C levels while having high triglycerides.
Overall, we have strong evidence that icosapent ethyl effectively reduces cardiovascular risks in high-risk patients, which is great news for those looking for additional treatment options alongside statins.
Read More
9
Eicosapentaenoic acid benefits heart health
The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.
Focus on omega-3 effects
We explored the effectiveness of eicosapentaenoic acid (EPA), a type of omega-3 polyunsaturated fatty acid (PUFA), in managing heart failure. By analyzing data from multiple randomized controlled trials, we aimed to identify the best doses and treatment durations for EPA supplementation.
The findings from our network meta-analysis included 14 studies with nearly 9,000 participants, primarily older adults with heart failure. We discovered that high doses of omega-3 PUFAs, specifically between 2000 and 4000 mg per day for at least one year, significantly improved heart function. This was measured by an increase in the left ventricular ejection fraction and peak oxygen consumption.
However, lower doses and shorter supplementation periods did not yield similar benefits. It's worth noting that EPA supplementation did not increase the risk of adverse events, as dropout rates and overall mortality were comparable to control groups.
Our study suggests that long-term, high-dose omega-3 supplementation shows promise for enhancing heart function in individuals with heart failure. Nonetheless, we believe that more in-depth clinical trials are necessary to confirm these results and ensure the findings are robust and reliable.
The findings from our network meta-analysis included 14 studies with nearly 9,000 participants, primarily older adults with heart failure. We discovered that high doses of omega-3 PUFAs, specifically between 2000 and 4000 mg per day for at least one year, significantly improved heart function. This was measured by an increase in the left ventricular ejection fraction and peak oxygen consumption.
However, lower doses and shorter supplementation periods did not yield similar benefits. It's worth noting that EPA supplementation did not increase the risk of adverse events, as dropout rates and overall mortality were comparable to control groups.
Our study suggests that long-term, high-dose omega-3 supplementation shows promise for enhancing heart function in individuals with heart failure. Nonetheless, we believe that more in-depth clinical trials are necessary to confirm these results and ensure the findings are robust and reliable.
Read More
User Reviews
USERS' SCORE
Good
Based on 6 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Reduces hair loss
After three weeks of taking omega, my hair has stopped falling out completely; now it's only two to five strands during shampooing. My skin has also become less dry despite the heating season, which I appreciate greatly. Omega-3 triglycerides are essential nutrients contributing to various bodily functions. They help lower "bad" cholesterol, reducing the risk of vascular atherosclerosis and myocardial infarction. Omega-3 supports hormone regulation, improves heart muscle function, and increases cognitive functions. It also enhances the immune system, reduces inflammation, and promotes lean muscle growth, among other benefits.
Read More
9.5
Multiple health benefits
This brand is one of the best available, making my choice of omega in triglyceride form worthwhile. I take omega in cycles. Omega-3 positively impacts the cardiovascular and nervous systems, promoting skin, nail, and hair health alongside many other useful properties. It lacks a fishy burp or unpleasant aftertaste and is generally easy to swallow, despite its size. I highly recommend it! 👍
Read More
8.8
Family-friendly omega
A chic-shaped super omega of excellent quality for maintaining health. There is no fishy taste, and it’s especially beneficial for the cardiovascular system. My hair has fallen out less, and the natural ingredients are great. I give it to my children aged 11 and 13, and cholesterol levels have improved according to their analysis.
Read More
6.3
Lowers triglyceride levels
One benefit of omega-3 is its ability to lower triglyceride levels. By reducing platelet aggregation and protecting against atherosclerosis, fish oil decreases triglycerides that lead to coronary artery disease. Frankly, it’s not suitable for me, so I cannot rate it.
8.8
Promotes cardiovascular health
Recommend! A very worthy option for quality Omega! Nordic Naturals' fish oil may not be cheap, but I believe it is one of the best. I take it regularly, while others take it in courses. Few can argue about omega's benefits. It positively impacts the cardiovascular, nervous, and reproductive systems, helps keep skin hydrated and elastic, shields it from harmful UV rays, and benefits hair structure. It maintains healthy cartilage and joints as well. There’s no fishy aftertaste, and it avoids the unpleasant “fish burp” effect. The capsules, while large, are soft and easy to swallow, and there’s no lemon taste.
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