We conducted a study to see if omega-3 fatty acids could help people with major depressive disorder as a standalone treatment. Over 12 weeks, 60 participants took either omega-3 supplements or a placebo.
Results showed that those taking omega-3 had lower depression scores at various points throughout the study. While there were hints of improved outcomes in terms of remission and response rates, these weren't statistically significant.
Overall, omega-3 fatty acids could be a promising alternative, but further research is necessary to confirm their effectiveness.
Read More
9
Omega-3s mitigate juvenile depression
Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression.
We utilized a novel approach to study how eicosapentaenoic acid (EPA), part of the omega-3 fatty acids, impacts depression in young mice. By subjecting juvenile mice to different ultrasound frequencies known to induce stress, we effectively created a model that mimics the symptoms of juvenile depression.
Throughout three weeks, we monitored the behavior of these mice, some receiving an EPA and docosahexaenoic acid (DHA) supplement while others did not. We found that the stressed mice given the omega-3 supplement showed no signs of depression or anxiety, which was a stark contrast to the vehicle group that did experience these symptoms.
Additionally, the study indicated that the omega-3 supplementation helped in mitigating the stress responses, such as reduced inflammation in the brain and changes in metabolism. This finding suggests that omega-3 fatty acids could have a therapeutic potential for addressing juvenile depression.
Overall, our observation sheds light on the significant benefits of incorporating eicosapentaenoic acid into diets, especially for young individuals facing mental health challenges.
Read More
8
Omega-3s may enhance mental health
Plasma Polyunsaturated Fatty Acid Levels and Mental Health in Middle-Aged and Elderly Adults.
We explored the relationship between omega-3 fatty acids and mental health using data from over 102,000 participants in the UK Biobank. Our analysis showed that higher plasma levels of omega-3s were linked to a lower risk of depression and anxiety. Specifically, those with the highest levels exhibited a significant reduction in depressive symptoms and better brain white matter microstructure. This suggests that omega-3 fatty acids may play an important role in enhancing mental well-being, supporting their use as a potential intervention for mental health issues.
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Most Useful Reviews
9
Improved mood
96 people found this helpful
This product is my favourite so far. With two cans and following the instructions to take 2 capsules daily, it lasts for exactly two months, making it quite affordable. I experienced a slight burp, but it was citrus rather than the fishy taste common with many others, which is definitely a plus. After taking it, I noticed that my quality of life improved, with my hair and nails getting better. Following covid, I had a slight depression and a depressed state, but this omega resolved those issues effectively. The capsules are large, straw-yellow, and easy to swallow.
Read More
9
Mental clarity
6 people found this helpful
Many thanks for your product. After years of suffering from clinical depression and mental confusion, fish oil has remarkably improved my brain health. I can now function normally, a significant change for me.
Read More
9
Boosted energy
Our family consumes Omega-3 from California Gold Nutrition. These high-quality capsules are essential as we rarely eat sea fish. I’ve noticed an improvement in my depression and memory, along with increased energy levels. It has transformed my morning energy and overall mood throughout the day.
Exosomes Derived from DPA-treated UCMSCs Attenuated Depression-like Behaviors and Neuroinflammation in a Model of Depression Induced by Chronic Stress.
We explored the therapeutic benefits of eicosapentaenoic acid (DPA) in treating depression, particularly in relation to exosomes derived from human umbilical cord mesenchymal stem cells. Chronic unpredictable mild stress (CUMS) was used to induce depression-like behaviors in the study, which highlighted the role of neuroinflammation and neurotransmitter deficiencies in this condition.
Through our analysis, we observed that DPA not only improved the effectiveness of exosomes but also significantly alleviated symptoms of depression. The therapy showed a remarkable ability to suppress the harmful activation of specific immune cells in the brain, known as M1 microglia, which are often linked to inflammation. Additionally, DPA helped restore levels of important neurotransmitters, including serotonin and dopamine.
Furthermore, in laboratory tests, the exosomes treated with DPA demonstrated better protective effects against cell death and inflammation-induced damage. Mechanistically, this positive outcome was attributed to DPA’s ability to enhance the expression of a particular microRNA that plays a role in reducing inflammation pathways.
Overall, our findings suggest that DPA treatment combined with exosomes not only addresses neuroinflammation but also promotes overall brain health. This makes it a promising avenue for developing more effective depression treatments.
Read More
9
Omega-3s mitigate juvenile depression
Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression.
We utilized a novel approach to study how eicosapentaenoic acid (EPA), part of the omega-3 fatty acids, impacts depression in young mice. By subjecting juvenile mice to different ultrasound frequencies known to induce stress, we effectively created a model that mimics the symptoms of juvenile depression.
Throughout three weeks, we monitored the behavior of these mice, some receiving an EPA and docosahexaenoic acid (DHA) supplement while others did not. We found that the stressed mice given the omega-3 supplement showed no signs of depression or anxiety, which was a stark contrast to the vehicle group that did experience these symptoms.
Additionally, the study indicated that the omega-3 supplementation helped in mitigating the stress responses, such as reduced inflammation in the brain and changes in metabolism. This finding suggests that omega-3 fatty acids could have a therapeutic potential for addressing juvenile depression.
Overall, our observation sheds light on the significant benefits of incorporating eicosapentaenoic acid into diets, especially for young individuals facing mental health challenges.
Read More
9
DHA alleviates epilepsy-related depression
DHA and EPA Alleviate Epileptic Depression in PTZ-Treated Young Mice Model by Inhibiting Neuroinflammation through Regulating Microglial M2 Polarization and Improving Mitochondrial Metabolism.
We explored the impact of docosahexaenoic acid (DHA) on depressive symptoms associated with epilepsy in a young mouse model. Through our investigation, we fed mice a diet enriched with DHA and administered pentylenetetrazole (PTZ) to induce epilepsy. Notably, our findings indicated that both DHA and eicosapentaenoic acid (EPA) significantly reduced depressive symptoms in this model, with EPA showing even greater effectiveness.
Analyzing the underlying mechanisms revealed that DHA and EPA helped repair neuronal damage and improve myelin structure in the hippocampus—the brain region vital for mood regulation. Furthermore, they tackled neuroinflammation by encouraging the polarizing of microglial cells toward a protective state and suppressing harmful inflammatory responses.
Additionally, we observed that both fatty acids decreased oxidative stress and improved mitochondrial function, which are crucial aspects of brain health. These results suggest that integrating DHA (and EPA) into dietary interventions could offer a promising strategy to alleviate depression in children with epilepsy, providing a potential pathway to enhance their quality of life.
Read More
8
EPA shows promise for depression
GPR120 internalization: a key mechanism for EPA in antidepressant action.
We investigated how eicosapentaenoic acid (EPA), an omega-3 fatty acid found in fish oil, can influence depression. In our study with mice, we observed that administering EPA for five weeks helped reduce stress-induced neuronal damage and improved brain synaptic functions.
Additionally, EPA demonstrated its ability to lower neuroinflammation linked to depressive behaviors. The findings highlight the potential of EPA as an effective option for managing depression related to inflammation. While further research is needed, these results are promising for its future clinical applications.
Read More
8
Omega-3 improves maternal behavior
Exploring the ameliorative effects of omega-3 fatty acid supplementation on maternal behavioral abnormalities induced by prenatal chronic restraint stress.
We aimed to understand how omega-3 fatty acids could benefit maternal behaviors affected by chronic stress during pregnancy. Our study involved three groups of rats: a control, a stress group, and a group receiving omega-3 supplementation.
The results showed that stressed rats displayed poor maternal behaviors, but omega-3 supplementation significantly improved their care for pups. It appeared to enhance the serotonin system, reduce inflammation, and aid in restoring neuronal function.
This research suggests that omega-3 fish oil might offer a promising approach to help mothers dealing with stress-related behavioral issues.
This product is my favourite so far. With two cans and following the instructions to take 2 capsules daily, it lasts for exactly two months, making it quite affordable. I experienced a slight burp, but it was citrus rather than the fishy taste common with many others, which is definitely a plus. After taking it, I noticed that my quality of life improved, with my hair and nails getting better. Following covid, I had a slight depression and a depressed state, but this omega resolved those issues effectively. The capsules are large, straw-yellow, and easy to swallow.
Read More
9
Mental clarity
6 people found this helpful
Many thanks for your product. After years of suffering from clinical depression and mental confusion, fish oil has remarkably improved my brain health. I can now function normally, a significant change for me.
Read More
9
Boosted energy
Our family consumes Omega-3 from California Gold Nutrition. These high-quality capsules are essential as we rarely eat sea fish. I’ve noticed an improvement in my depression and memory, along with increased energy levels. It has transformed my morning energy and overall mood throughout the day.
Read More
8
Happiness moments
This product is wonderful! I began taking Omega while working out a few years ago and found I felt more easy-going. When I experienced depression and anxiety, it helped me find moments of happiness and peace alongside other supplements like vitamin D and l-theanine.
Read More
7.5
Skin improvement
2 people found this helpful
I really like this brand, especially Carlson’s liquid version. It has no fishy aftertaste due to the zesty lemon flavour, making it a favourite in my supplement regime. It has enhanced the appearance of my skin, eyes, and hair, and also alleviated joint aches and depression.
Depression is a common and serious mental health condition characterized by persistent feelings of sadness, hopelessness, and a lack of interest or pleasure in activities that were once enjoyable. It can affect anyone, regardless of age, gender, or background, and it goes beyond just feeling down; it can interfere significantly with daily life, impacting relationships, work performance, and overall well-being. Symptoms of depression may include changes in appetite or weight, sleep disturbances, fatigue, difficulty concentrating, and thoughts of worthlessness or suicide.
The causes of depression are complex and may involve a combination of genetic, biological, environmental, and psychological factors. While it's a serious condition that can be debilitating, the good news is that it is treatable. Various treatment options are available, including therapy, medication, lifestyle changes, and support groups. If you or someone you know is struggling with depression, seeking help from a healthcare professional is a crucial step toward recovery.
Omega-3 fish oil is a nutritional supplement derived from the fatty tissues of fish, particularly fatty fish like salmon, mackerel, and sardines. It is rich in omega-3 fatty acids, which are essential fats that the body cannot produce on its own. The most significant types of omega-3s found in fish oil are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), both of which are known for their numerous health benefits. These include reducing inflammation, supporting heart health, and promoting brain function.
Incorporating omega-3 fish oil into your diet can be beneficial if you don’t consume enough fish regularly. Many health experts recommend oily fish as a part of a balanced diet due to their high omega-3 content. For those who find it difficult to include fish in their meals, fish oil supplements can offer a convenient alternative, providing the same essential fatty acids in concentrated form. However, it’s essential to choose high-quality supplements that are third-party tested for purity and potency to avoid contaminants such as heavy metals or other toxins that can impact health.
The relationship between Omega-3 fish oil and depression has garnered considerable interest over the years, and some studies suggest that Omega-3 fatty acids may have a beneficial effect on mood and mental well-being. Omega-3s, particularly EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), are thought to contribute to brain health and may play a role in the regulation of neurotransmitters such as serotonin and dopamine, which are often linked to mood disorders. Some clinical trials have indicated that supplementation with Omega-3s can lead to reductions in depressive symptoms for certain individuals, particularly in those with major depressive disorder.
However, it's essential to understand that while Omega-3 fish oil can be a useful part of an overall treatment plan, it is not a panacea for depression. Responses to supplementation can vary from person to person, and more research is needed to establish precise recommendations. It is always advisable for individuals experiencing depression to consult with a healthcare professional to develop a comprehensive treatment approach tailored to their specific needs, which may include therapy, lifestyle changes, and possibly dietary supplements like Omega-3 fish oil.
Based on user reviews, many individuals taking omega-3 supplements for depression report noticeable improvements in their mood and overall mental health within a few weeks of consistent use. For instance, one user shared that fish oil significantly improved their brain health after years of struggling with clinical depression and mental confusion, allowing them to function normally (Read Review). Similarly, another reviewer mentioned that they experienced positive changes in their depression and energy levels, contributing to a better overall mood during their daily routine (Read Review).
Users generally emphasize that while specific timelines may vary, consistent supplementation often leads to improvements in as little as a few weeks. Reports suggest that those who combine fish oil with other supplements, such as vitamin D, have also noted enhanced feelings of happiness and peace, indicating a multifaceted approach could facilitate quicker results (Read Review). Overall, it appears that taking omega-3 regularly can contribute positively to alleviating symptoms of depression fairly quickly.
Research indicates that omega-3 fatty acids, particularly eicosapentaenoic acid (EPA), show promise in alleviating depression symptoms. A review of studies has demonstrated that higher doses of EPA can lead to significant improvements, especially in individuals with conditions related to inflammation, younger populations, and those experiencing mild depression ([3]). Additionally, a study focusing on older adults found that omega-3 supplementation was associated with a moderate decrease in depression scores, suggesting its potential as a complementary treatment for this demographic as well ([1]).
However, while the evidence suggests beneficial effects, results have been varied across different studies, indicating that more research is needed to optimize dosages and determine specific treatment durations ([7]). Some trials have reported minimal benefits of omega-3 supplementation compared to placebo, particularly in children and adolescents ([9]). Overall, although omega-3 fatty acids, particularly EPA, may offer a supportive role in the management of depression, the variability in outcomes highlights the necessity for further investigations to clarify their effectiveness and application in diverse populations ([14]).
Based on user reviews, many individuals have reported significant improvements in their symptoms after taking omega-3 supplements. One user highlighted that the omega-3 helped them overcome feelings of depression experienced after a COVID-19 infection, enhancing their overall quality of life and even boosting the health of their hair and nails (Read Review). Similarly, another reviewer shared that after years of battling clinical depression and mental confusion, they noticed remarkable improvement in their brain health, allowing them to function normally (Read Review).
Anecdotal experiences also suggest that many users have observed enhanced mood and energy levels. For instance, one family member noted increased memory and a transformed morning energy, crediting the supplement for an uplifted overall state throughout the day (Read Review). Others have reported feeling more easy-going and finding moments of happiness amidst challenges, especially when combined with other supplements (Read Review). Overall, while individual results may vary, a number of users suggest that omega-3 supplementation has benefited their mental health in various ways.
Users report positive experiences when combining omega-3 supplements with other supplements for managing depression. One reviewer indicated that taking omega-3 alongside vitamin D and l-theanine helped them discover moments of happiness and peace during challenging times of depression and anxiety (Read Review). Another user noted improvements in mood, energy levels, and memory, contributing to a transformed overall state when they incorporated omega-3 into their daily routine (Read Review).
Overall, combining omega-3 with other supportive supplements appears to enhance its effectiveness, with users highlighting a multifaceted approach in managing their mental health. The anecdotal evidence suggests that this strategy can facilitate quicker and more noticeable improvements in mood and energy levels, thereby potentially increasing adherence to a holistic wellness routine.
Recent research suggests that eicosapentaenoic acid (EPA), a specific type of omega-3 fatty acid found in fish oil, may be particularly effective in treating depression, especially at higher doses. Various studies indicate that a daily dose of 1000 to 1500 mg of EPA can lead to significant improvements in depressive symptoms, particularly in younger populations and in individuals with inflammation-related depression [17]. Other studies have also shown positive results with doses exceeding 1 gram per day, highlighting the potential of EPA as an adjunct treatment alongside traditional antidepressants [3].
It's important to note, however, that while these findings are promising, the research still exhibits considerable variability in results and responses. Factors such as the individual's nutritional status and the balance between EPA and another omega-3, docosahexaenoic acid (DHA), can significantly influence outcomes [14]. Overall, while EPA and omega-3 fatty acids show potential for alleviating depressive symptoms, a clearer understanding of optimal dosing strategies and individualized treatment plans will be necessary to enhance their effectiveness in clinical settings.
9
Mental clarity
6 people found this helpful
Many thanks for your product. After years of suffering from clinical depression and mental confusion, fish oil has remarkably improved my brain health. I can now function normally, a significant change for me.
9
Boosted energy
Our family consumes Omega-3 from California Gold Nutrition. These high-quality capsules are essential as we rarely eat sea fish. I’ve noticed an improvement in my depression and memory, along with increased energy levels. It has transformed my morning energy and overall mood throughout the day.
8
Happiness moments
This product is wonderful! I began taking Omega while working out a few years ago and found I felt more easy-going. When I experienced depression and anxiety, it helped me find moments of happiness and peace alongside other supplements like vitamin D and l-theanine.
9
Improved mood
96 people found this helpful
This product is my favourite so far. With two cans and following the instructions to take 2 capsules daily, it lasts for exactly two months, making it quite affordable. I experienced a slight burp, but it was citrus rather than the fishy taste common with many others, which is definitely a plus. After taking it, I noticed that my quality of life improved, with my hair and nails getting better. Following covid, I had a slight depression and a depressed state, but this omega resolved those issues effectively. The capsules are large, straw-yellow, and easy to swallow.
7
Omega-3s show promise in depression
Omega-3 polyunsaturated fatty acids in depression: insights from recent clinical trials.
We examined recent clinical trials investigating omega-3 polyunsaturated fatty acids (PUFAs) to see how they might help with major depressive disorder (MDD).
The analysis focused on high doses of eicosapentaenoic acid (EPA), showing improvements especially in patients with inflammation-related depression and younger individuals.
Although results are encouraging, particularly for specific subpopulations, establishing the best doses and treatment durations requires further research.
7
Omega-3 shows potential for depression
Anti-inflammatory interventions for the treatment and prevention of depression among older adults: a systematic review and meta-analysis.
We set out to understand how omega-3 fish oil and other anti-inflammatory treatments affect depression in older adults. This comprehensive review analyzed 31 randomized controlled trials to see if these interventions could reduce depressive symptoms. The findings showed that older adults had a moderate decrease in depression scores, particularly benefiting from omega-3 treatments. While this suggests a positive impact, it's important to note the studies had some variability in results. This calls for more focused research to pinpoint the best treatments for depression in this age group.
7
Omega-3s linked to reduced depression
Long-chain omega-3 polyunsaturated fatty acids are associated with brain connectivity and mood in young adults with subthreshold depression: A preliminary study.
We explored how omega-3 fatty acids, specifically DHA and EPA, might influence mood and brain connectivity in young adults showing signs of mild depression. In a study involving 15 participants aged 18 to 29, we found that those with higher levels of omega-3 fatty acids had lower depression scores. This suggests that omega-3s may enhance connections in brain regions associated with mood regulation. While promising, further research is needed to deepen our understanding of these effects on subthreshold depression.
4
Uncertain effectiveness of omega-3s
Omega-3 fatty acid supplementation for depression in children and adolescents.
We analyzed five trials involving 228 participants to investigate the effects of omega-3 fatty acids on depression in children and adolescents. While omega-3 supplementation showed a potential to reduce self-reported depression symptoms, the evidence is quite uncertain.
In fact, there's little to no difference observed in the reduction of clinical depression symptoms when compared to a placebo.
Additionally, attrition rates and adverse effects between groups were similar, with mild issues reported. Overall, while omega-3s may help some, more rigorous studies are needed to better understand their role in treating adolescent depression.
4
Mixed evidence on omega-3 treatment
Omega-3 Polyunsaturated Fatty Acids in Depression.
We delved into the effects of omega-3 fatty acids, like EPA and DHA, on depression. While some research highlights their potential to reduce depressive symptoms, others found little to no effect. Factors like dosage and individual nutritional needs seem to influence these outcomes. Additionally, omega-3s may complement traditional antidepressants but results aren’t consistent across various studies. Overall, there's still a need for more research to create clear guidelines for omega-3 use in treating depression.
4
EPA shows potential in depression
Exploration of the optimized portrait of omega-3 polyunsaturated fatty acids in treating depression: A meta-analysis of randomized-controlled trials.
We examined the effectiveness of eicosapentaenoic acid (EPA), a type of omega-3 polyunsaturated fatty acid, in treating depression. After analyzing 36 well-structured studies, we found some positive outcomes and also observed notable variability in the results. The overall findings suggested that EPA could offer benefits for depression, yielding a small but statistically significant improvement in symptoms.
It's particularly interesting to note that for Asian patients experiencing mild to moderate depression, the best results seemed to emerge with a daily dosage of 1000 to 1500 mg of omega-3s over eight weeks. This intake should ideally have a specific balance of EPA to another omega-3, docosahexaenoic acid (DHA), set at between 1:1 and 2:1 ratios. However, despite these encouraging indications, our analysis also revealed that EPA isn’t better than a placebo for achieving response or remission rates or for adverse events.
Overall, while omega-3 PUFAs like EPA may hold promise for managing depressive symptoms, we must approach the findings with caution. Further research is warranted to deepen our understanding of how to harness the potential benefits of these fatty acids in treating depression.
References
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Yu Q, Li H, Chen M, Pan Y, Zhou L, et al. GPR120 internalization: a key mechanism for EPA in antidepressant action. Food Funct. 2025;16:2893. doi:10.1039/d5fo00252d
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Campisi SC, Zasowski C, Bradley-Ridout G, Schumacher A, Szatmari P, et al. Omega-3 fatty acid supplementation for depression in children and adolescents. Cochrane Database Syst Rev. 2024;11:CD014803. doi:10.1002/14651858.CD014803.pub2
Wu SK, Yang KJ, Liu WC, Malau IA, Zailani H, et al. The Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Nutrients. 2024;16. doi:10.3390/nu16213688
Jastrzebska J, Frankowska M, Wesołowska J, Filip M, Smaga I. Dietary Intervention with Omega-3 Fatty Acids Mitigates Maternal High-Fat Diet-Induced Behavioral and Myelin-Related Alterations in Adult Offspring. Curr Neuropharmacol. 2025;23:329. doi:10.2174/1570159X23666241014164940
Chen L, Yang Y, Zhang N, Che H, Wang Z, et al. DHA and EPA alleviate depressive-like behaviors in chronic sleep-deprived mice: Involvement of iron metabolism, oligodendrocyte-lipids peroxidation and the LCN2-NLRP3 signaling axis. Free Radic Biol Med. 2024;225:654. doi:10.1016/j.freeradbiomed.2024.10.298
Cheng YC, Chen WY, Lin C, Lee SH, Chiu CC, et al. The N-3 polyunsaturated fatty acids supplementation to prevent depression recurrence in patients with late-life depression: A 52-week double-blind, placebo-controlled trial. J Affect Disord. 2025;369:8. doi:10.1016/j.jad.2024.09.129
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Lam C, Han L, McIntyre RS, Teopiz KM, Cao B. Comparative Efficacy of Omega-3 Fatty Acid with Other Interventions for Depression in Children and Adolescents: A Systematic Review and Network Meta-Analysis. J Child Adolesc Psychopharmacol. 2024;34:282. doi:10.1089/cap.2024.0017
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Kong L, Zhang Q, Wang H, Xu Y, Xu C, et al. Exploration of the optimized portrait of omega-3 polyunsaturated fatty acids in treating depression: A meta-analysis of randomized-controlled trials. J Affect Disord. 2025. doi:10.1016/j.jad.2025.03.006
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Strekalova T, Radford-Smith D, Dunstan IK, Gorlova A, Svirin E, et al. Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression. Neurobiol Stress. 2024;31:100646. doi:10.1016/j.ynstr.2024.100646
Lou F, Luo S, Kang N, Yan L, Long H, et al. Oral microbiota dysbiosis alters chronic restraint stress-induced depression-like behaviors by modulating host metabolism. Pharmacol Res. 2024;204:107214. doi:10.1016/j.phrs.2024.107214
Zhang C, Hou B, Xu Y, Zeng S, Luo X, et al. Association between eicosapentaenoic acid consumption and the risk of depressive symptoms in US adults: Analyses from NHANES 2005-2018. J Affect Disord. 2024;354:62. doi:10.1016/j.jad.2024.03.055
Huang S, Guo J, Jiang R, Ma K, Lin F, et al. Four-way decomposition of the effects of nutrient supplement and physical exercise on depression among older Chinese: a nationwide cross-sectional analysis. BMC Public Health. 2024;24:3469. doi:10.1186/s12889-024-20995-8
Wang M, Yan X, Li Y, Li Q, Xu Y, et al. Association between plasma polyunsaturated fatty acids and depressive among US adults. Front Nutr. 2024;11:1342304. doi:10.3389/fnut.2024.1342304
Chang YY, Ting B, Chen DT, Hsu WT, Lin SC, et al. Omega-3 Fatty Acids for Depression in the Elderly and Patients with Dementia: A Systematic Review and Meta-Analysis. Healthcare (Basel). 2024;12. doi:10.3390/healthcare12050536
Suneson K, Söderberg Veibäck G, Lindahl J, Tjernberg J, Ståhl D, et al. Omega-3 fatty acids for inflamed depression - A match/mismatch study. Brain Behav Immun. 2024;118:192. doi:10.1016/j.bbi.2024.02.029
Xue Y, Wang L, Liu T, Zhao T, Xie K, et al. Omega-3 polyunsaturated fatty acids supplementation improves memory in first-diagnosed, drug-naïve patients with depression: Secondary analysis of data from a randomized controlled trial. J Affect Disord. 2024;350:403. doi:10.1016/j.jad.2024.01.149
Yang Y, Chen L, Zhang N, Zhao Y, Che H, et al. DHA and EPA Alleviate Epileptic Depression in PTZ-Treated Young Mice Model by Inhibiting Neuroinflammation through Regulating Microglial M2 Polarization and Improving Mitochondrial Metabolism. Antioxidants (Basel). 2023;12. doi:10.3390/antiox12122079