Lactobacillus improves vaginal healthEffect of ultra-low-dose estriol and lactobacilli vaginal tablets (Gynoflor®) on inflammatory and infectious markers of the vaginal ecosystem in postmenopausal women with breast cancer on aromatase inhibitors.
Study relevant to postmenopausal women
We examined how a combination of ultra-low-dose estriol and lactobacilli affects vaginal health in postmenopausal women dealing with severe atrophic vaginitis while on aromatase inhibitors. Over 28 days, 16 breast cancer survivors used Gynoflor®, improving their vaginal flora. Remarkably, the lactobacillary grades increased significantly, alongside reductions in inflammatory markers like leukocytes and parabasal cells.
Although we observed a temporary spike in Candida colonization, it quickly returned to normal levels. Overall, these findings suggest that this treatment can effectively enhance vaginal health while being safe for women facing similar challenges.
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L. acidophilus inhibits C. albicansLactobacillus acidophilus ATCC 4356 inhibits biofilm formation by C. albicans and attenuates the experimental candidiasis in Galleria mellonella.
Relevant support for probiotics
We explored how Lactobacillus acidophilus ATCC 4356 impacts yeast infections caused by Candida albicans. The study used both in vitro and in vivo models, with tests on biofilm formation and filamentation in lab settings and survival analysis in Galleria mellonella larvae.
Our findings revealed that L. acidophilus was effective in inhibiting C. albicans biofilm and filament formation in vitro. Additionally, the injections into infected larvae significantly improved their survival rates and reduced yeast counts compared to a control group. Overall, L. acidophilus demonstrated promising protective effects against yeast infections.
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Lactobacilli may reduce Candida virulenceLactobacillus acidophilus, L. plantarum, L. rhamnosus, and L. reuteri Cell-Free Supernatants Inhibit Candida parapsilosis Pathogenic Potential upon Infection of Vaginal Epithelial Cells Monolayer and in a Transwell Coculture System .
Promising alternative yeast infection prevention
We examined how cell-free supernatants from lactobacilli, specifically L. acidophilus, L. plantarum, L. rhamnosus, and L. reuteri, affect the virulence traits of Candida parapsilosis in the context of vulvovaginal candidiasis. Our findings indicated that these lactobacilli can reduce the growth and harmful effects of C. parapsilosis, helping to enhance the vaginal lining's resistance to infection. This suggests that incorporating these lactobacilli could be beneficial in preventing yeast infections caused by non-albicans species like C. parapsilosis, although more research is needed to fully understand their effectiveness.
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We examined the antifungal properties of lactic acid bacteria, specifically Lactobacillus acidophilus and others, isolated from healthy women's vaginas. Through a method called agar diffusion, we identified how effective these bacteria were against Candida species, known to cause yeast infections.
Our findings showed promising antifungal activity among several Lactobacillus strains, including L. acidophilus, against various Candida strains. This indicates that these lactic acid bacteria could be valuable as probiotics in preventing and managing vaginal candidiasis. Further research in this area will continue to explore these benefits.
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Probiotics inhibit Candida biofilm growthProbiotic lactobacilli inhibit early stages of Candida albicans biofilm development by reducing their growth, cell adhesion, and filamentation.
Study demonstrates probiotic effectiveness
We investigated how probiotics, particularly Lactobacillus acidophilus and its relatives, affect the development of Candida albicans biofilms. Our findings revealed that these probiotics notably decreased biofilm growth and altered the yeast's growth behavior.
Specifically, Lactobacillus rhamnosus effectively diminished early biofilm stages. However, it didn't significantly influence mature biofilms. Overall, the lactobacilli hindered the transition of Candida from yeast to fungal forms and reduced its ability to form biofilms.
This research highlights the potential of using probiotics as a supportive treatment for yeast infections.
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