We explored how lactobacillus acidophilus can enhance chemodynamic therapy for cancer. By coupling the probiotic with specialized nanosheets loaded with calcium oxide nanoparticles, we observed a notable reduction in tumor size.
This innovative approach led to a significant boost in hydroxyl radical production within the tumor microenvironment, resulting in a remarkable tumor inhibition rate of 96.4%.
The findings suggest that probiotics can help target tumors more effectively and improve treatment outcomes.
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We explored the effects of combined treatments with Lactobacillus acidophilus, calcium citrate, and Moringa oleifera extract on colon cancer induced in rats. The study involved administering a carcinogen, DMH, while observing the impact of these treatments over a four-week period.
Results showed that the combined therapy significantly reduced markers of tumor initiation and improved liver histology. Importantly, these treatments maintained normal function in liver and kidney markers. This suggests that Lactobacillus acidophilus, along with calcium and Moringa, could play a promising role in cancer prevention.
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Probiotics show promise against colorectal cancerAnalyzing of colorectal cancerrelated genes and microRNAs expression profiles in response to probiotics Lactobacillus acidophilus and Saccharomyces cerevisiae in colon cancer cell lines.
High relevance for cancer research
This study focused on how Lactobacillus acidophilus and Saccharomyces cerevisiae might affect colorectal cancer cells. We discovered that these probiotics could effectively reduce the growth of cancer cells in two specific lines, HT29 and SW480.
Notably, the probiotics influenced the expression of key genes related to cell death and cancer growth, showing an upregulation of tumor-suppressing genes and microRNAs, while downregulating oncogenes. This suggests they could play a significant role in fighting colorectal cancer and contributing to prevention.
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We investigated whether Lactobacillus acidophilus can help prevent liver cancer associated with non-alcoholic fatty liver disease (NAFLD-HCC).
Our study involved various mouse models treated with a specific diet and liver cancer-inducing compounds.
We found that L. acidophilus significantly reduced the occurrence of NAFLD-HCC and inhibited the growth of cancer cells by producing a key metabolite called valeric acid.
This suggests that L. acidophilus may serve as a protective supplement against this type of cancer, improving liver health and function.
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Lactobacillus acidophilus shows promiseExpanding CYLD protein in NF-κβ/TNF-α signaling pathway in response to Lactobacillus acidophilus in non-metastatic rectal cancer patients.
Study shows strong relevance score
We explored the effect of Lactobacillus acidophilus on non-metastatic rectal cancer by studying its influence on the CYLD protein and signaling pathways. In a randomized trial involving 110 patients, those consuming L. acidophilus showed a significant increase in tumor-suppressing CYLD protein and related genes, alongside a decrease in inflammation-related factors compared to a placebo. Impressively, the probiotic group had a higher survival rate after five years. These findings suggest that L. acidophilus can positively influence cancer by modulating inflammatory pathways.
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