Probiotics may aid gluten digestionNovel probiotic preparation with gluten-degrading activity and potential modulatory effects on the gut microbiota.
We examined a promising new probiotic preparation designed to break down gluten and assist people with celiac disease. Our study included a randomized double-blind placebo-controlled trial with 70 volunteers over a 42-day period, where participants consumed increasing amounts of gluten following a gluten-free diet.
Those who took the probiotics showed significantly lower levels of residual gluten in their feces compared to the placebo group. Additionally, the probiotics appeared to enhance gut microbiota health, promoting beneficial microbial communities. However, despite these findings, we must proceed cautiously, as the overall impact on celiac disease management remains to be fully determined.
Read More
Probiotic shows limited celiac benefitsA gluten degrading probiotic Bacillus subtilis LZU-GM relieve adverse effect of gluten additive food and balances gut microbiota in mice.
We explored the effects of Bacillus subtilis LZU-GM, a probiotic isolated from traditional Pakistani sourdough, on gluten-related issues in celiac disease. Remarkably, this strain degraded 73.7% of gluten in lab tests and showed threefold more gluten breakdown in mice models compared to untreated groups.
However, while it improved gut health by promoting beneficial bacteria, and reducing inflammatory markers, it didn't eliminate the formation of antibodies associated with gluten sensitivity. Thus, we found that although LZU-GM has potential, it may not be a complete solution for managing celiac disease.
Read More
Brazilian cassava cultivars enhance probioticsCassava (Manihot esculenta) Brazilian cultivars have different chemical compositions, present prebiotic potential, and beneficial effects on the colonic microbiota of celiac individuals.
We examined the prebiotic effects of Brazilian cassava cultivars on celiac individuals. Focusing on two selected varieties, OUR and UPI, we observed their ability to promote growth in beneficial probiotic strains. This was evident in the increased population of helpful bacteria compared to established prebiotics like fructooligosaccharides. Our findings indicate that these cassava cultivars can positively influence the gut microbiota in celiacs, suggesting their potential use as prebiotic ingredients in functional foods and supplements.
Read More
Probiotic shows potential in celiacProtective effects of Acetobacter ghanensis against gliadin toxicity in intestinal epithelial cells with immunoregulatory and gluten-digestive properties.
We explored whether Acetobacter ghanensis could reduce gliadin-induced toxicity in intestinal cells from celiac disease patients. Using a cell culture model, we found that gliadin disrupts the intestinal barrier and raises inflammatory markers like IL-6 and TNFα. However, when A. ghanensis was introduced, it showed potential in restoring barrier function and digesting gluten peptides. This study highlights A. ghanensis as a promising candidate for improving gut health in those affected by celiac disease, although more research is needed to confirm these findings.
Read More
NLS-SS probiotics show symptom reliefEffect of NLS super strain in symptomatic coeliac disease patients on long-term gluten-free diet - an exploratory study.
We investigated the effectiveness of the NLS super strain (NLS-SS) probiotic on alleviating gastrointestinal symptoms in patients with celiac disease (CD) who have been on a gluten-free diet for at least two years. Through a carefully designed randomized, double-blind, placebo-controlled trial, we found that those with severe symptoms experienced improved relief from their CD symptoms after taking NLS-SS.
This probiotic also influenced gut microbiota diversity in these patients without significant side effects. While promising, more extensive studies are necessary to fully validate these results.
Read More