Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.8
USERS' SCORE
Good
Based on 8 Reviews
8
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Niacin (Vitamin B-3)(from 640 mg of Inositol Hexanicotinate)
500 mg
3125%
Inositol(from 640 mg of Inositol Hexanicotinate)
135 mg
†
Top Medical Research Studies
8
We conducted a study to understand how inositol, a naturally occurring sugar alcohol, influences anxiety levels in laying hens. Our focus was on the behavior of Lohmann LSL lite hens, which were fed two different diets—one rich and one deficient in protein—while receiving either pure inositol or high levels of phytase.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Read More
8
We evaluated the impact of niacin on anxiety and memory loss by examining its effects in male rats exposed to D-galactose, a chemical known to induce behavioral deficits. In our study, we divided the animals into six groups, with some receiving niacin at different doses (25 mg/kg and 50 mg/kg) and others being treated with D-galactose.
Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.
Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.
Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
Read More
8
We examined user sentiments surrounding treatments for Polycystic Ovary Syndrome (PCOS) through data collected from an extensive subreddit.
Our analysis revealed that lifestyle changes and supplements were viewed positively, while contraceptives often received negative feedback. Notably, inositol was associated with significant improvements in mental health, including reductions in anxiety.
This study highlights the potential of machine learning to analyze patient experiences, offering valuable insights that might complement traditional clinical research.
Our analysis revealed that lifestyle changes and supplements were viewed positively, while contraceptives often received negative feedback. Notably, inositol was associated with significant improvements in mental health, including reductions in anxiety.
This study highlights the potential of machine learning to analyze patient experiences, offering valuable insights that might complement traditional clinical research.
Read More
Most Useful Reviews
8
Helpful for anxiety
11 people found this helpful
Great product! I found this niacin very helpful for anxiety. Thank you.
Read More
9
Easy to take
4 people found this helpful
My daughter’s anxiety was resolved with niacinamide, but my son, who has ADHD, found the taste unpleasant, so we switched to this. I open the capsule and give him the powder, which is nearly tasteless, making it much easier for him to take than niacinamide.
Read More
9
Boosts energy
Niacin is beneficial for anxiety and mental health. It supports adrenal function and provides energy without causing any flushing.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.8
- All Researches
8
We evaluated the impact of niacin on anxiety and memory loss by examining its effects in male rats exposed to D-galactose, a chemical known to induce behavioral deficits. In our study, we divided the animals into six groups, with some receiving niacin at different doses (25 mg/kg and 50 mg/kg) and others being treated with D-galactose.
Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.
Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.
Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
Read More
8
We conducted a study to understand how inositol, a naturally occurring sugar alcohol, influences anxiety levels in laying hens. Our focus was on the behavior of Lohmann LSL lite hens, which were fed two different diets—one rich and one deficient in protein—while receiving either pure inositol or high levels of phytase.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Read More
8
We explored how d-pinitol, a natural compound found in various fruits and legumes, could impact anxiety and related conditions. In our evaluation, we focused on its effects on mice to understand its potential as an anxiolytic agent.
During our study, we observed that when mice were given d-pinitol at doses ranging from 1 to 100 mg/kg, there was notable evidence of anxiolytic-like actions. In particular, at a dose of 70 mg/kg, d-pinitol showed significant effectiveness in reducing anxiety as assessed in specific behavioral tests.
We also investigated the possible mechanisms behind these effects. Our findings suggest that the GABAergic system may play a key role in mediating the anxiolytic benefits of d-pinitol, which indicates a promising direction for further research. It’s important to remember that while our results are encouraging, d-pinitol did not exhibit diuretic effects, which was a secondary focus of the study.
All in all, our study positions d-pinitol as a compelling candidate for alleviating anxiety, with mechanisms worth exploring further for therapeutic applications.
During our study, we observed that when mice were given d-pinitol at doses ranging from 1 to 100 mg/kg, there was notable evidence of anxiolytic-like actions. In particular, at a dose of 70 mg/kg, d-pinitol showed significant effectiveness in reducing anxiety as assessed in specific behavioral tests.
We also investigated the possible mechanisms behind these effects. Our findings suggest that the GABAergic system may play a key role in mediating the anxiolytic benefits of d-pinitol, which indicates a promising direction for further research. It’s important to remember that while our results are encouraging, d-pinitol did not exhibit diuretic effects, which was a secondary focus of the study.
All in all, our study positions d-pinitol as a compelling candidate for alleviating anxiety, with mechanisms worth exploring further for therapeutic applications.
Read More
8
We examined user sentiments surrounding treatments for Polycystic Ovary Syndrome (PCOS) through data collected from an extensive subreddit.
Our analysis revealed that lifestyle changes and supplements were viewed positively, while contraceptives often received negative feedback. Notably, inositol was associated with significant improvements in mental health, including reductions in anxiety.
This study highlights the potential of machine learning to analyze patient experiences, offering valuable insights that might complement traditional clinical research.
Our analysis revealed that lifestyle changes and supplements were viewed positively, while contraceptives often received negative feedback. Notably, inositol was associated with significant improvements in mental health, including reductions in anxiety.
This study highlights the potential of machine learning to analyze patient experiences, offering valuable insights that might complement traditional clinical research.
Read More
7
Myo-Inositol improves anxiety behavior
We aimed to explore the impact of myo-inositol (MI) on anxiety in a mouse model of classic galactosemia. Our research involved a combination of acute and chronic evaluations of MI, particularly looking at its effects over a long-term treatment period. We observed that lower doses of MI suggested notable improvements in motor deficits and anxiety-driven hyperactivity among the GalT-KO mice, which are affected by this condition.
While we conducted a thorough assessment of motor-related behaviors and anxiety levels, it appears that MI holds potential as an adjunct treatment option. These findings indicate that MI may benefit not only physical symptoms but also emotional well-being, particularly in reducing anxiety-related behaviors in this genetically modified model, which helps us understand its role more clearly. The results could point to new avenues for managing anxiety, especially in conditions like classic galactosemia where traditional treatment methods fall short.
While we conducted a thorough assessment of motor-related behaviors and anxiety levels, it appears that MI holds potential as an adjunct treatment option. These findings indicate that MI may benefit not only physical symptoms but also emotional well-being, particularly in reducing anxiety-related behaviors in this genetically modified model, which helps us understand its role more clearly. The results could point to new avenues for managing anxiety, especially in conditions like classic galactosemia where traditional treatment methods fall short.
Read More
User Reviews
USERS' SCORE
Good
Based on 8 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
8
Helpful for anxiety
11 people found this helpful
Great product! I found this niacin very helpful for anxiety. Thank you.
Read More
9
Easy to take
4 people found this helpful
My daughter’s anxiety was resolved with niacinamide, but my son, who has ADHD, found the taste unpleasant, so we switched to this. I open the capsule and give him the powder, which is nearly tasteless, making it much easier for him to take than niacinamide.
Read More
9
Boosts energy
Niacin is beneficial for anxiety and mental health. It supports adrenal function and provides energy without causing any flushing.
Read More
7.5
Eased anxiety significantly
7 people found this helpful
I have allergies, hay fever, insomnia, anxiety, and high cholesterol. This autumn, my allergies have been mild, and my anxiety has lessened significantly. Insomnia is also improving, making this treatment effective for the various issues I faced. I initially bought Flash Free to avoid niacin flush, which didn’t occur. There’s no notable taste, and it’s easy to consume. I recommend it for similar symptoms.
Read More
7.5
Promotes calmness
1 people found this helpful
It’s noted that niacin flush may occur, but I did not experience it with this flash-free version. Taking it gives me peace of mind and I recommend it for those with significant stress and anxiety, as it contains vitamin B3, which supports the happy hormone.
Read More
Frequently Asked Questions
7.5
Eased anxiety significantly
7 people found this helpful
I have allergies, hay fever, insomnia, anxiety, and high cholesterol. This autumn, my allergies have been mild, and my anxiety has lessened significantly. Insomnia is also improving, making this treatment effective for the various issues I faced. I initially bought Flash Free to avoid niacin flush, which didn’t occur. There’s no notable taste, and it’s easy to consume. I recommend it for similar symptoms.
0
Needed higher dose
I began taking niacin for sleep issues linked to anxiety. One tablet before bed wasn't effective, so I ended up increasing my dose to four tablets. I am now transitioning to a 500mg niacin with flash.
9
Boosts energy
Niacin is beneficial for anxiety and mental health. It supports adrenal function and provides energy without causing any flushing.
7.5
Promotes calmness
1 people found this helpful
It’s noted that niacin flush may occur, but I did not experience it with this flash-free version. Taking it gives me peace of mind and I recommend it for those with significant stress and anxiety, as it contains vitamin B3, which supports the happy hormone.
9
Easy to take
4 people found this helpful
My daughter’s anxiety was resolved with niacinamide, but my son, who has ADHD, found the taste unpleasant, so we switched to this. I open the capsule and give him the powder, which is nearly tasteless, making it much easier for him to take than niacinamide.
7
Improved morning mood
1 people found this helpful
I started with niacinamide for poor blood circulation and fatigue. Now, I feel better in the mornings, and my anxiety has improved compared to before. I intend to gradually increase my dosage. The size of the tablets is acceptable, not as large as I expected.
8
We evaluated the impact of niacin on anxiety and memory loss by examining its effects in male rats exposed to D-galactose, a chemical known to induce behavioral deficits. In our study, we divided the animals into six groups, with some receiving niacin at different doses (25 mg/kg and 50 mg/kg) and others being treated with D-galactose.
Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.
Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.
Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
8
We explored how d-pinitol, a natural compound found in various fruits and legumes, could impact anxiety and related conditions. In our evaluation, we focused on its effects on mice to understand its potential as an anxiolytic agent.
During our study, we observed that when mice were given d-pinitol at doses ranging from 1 to 100 mg/kg, there was notable evidence of anxiolytic-like actions. In particular, at a dose of 70 mg/kg, d-pinitol showed significant effectiveness in reducing anxiety as assessed in specific behavioral tests.
We also investigated the possible mechanisms behind these effects. Our findings suggest that the GABAergic system may play a key role in mediating the anxiolytic benefits of d-pinitol, which indicates a promising direction for further research. It’s important to remember that while our results are encouraging, d-pinitol did not exhibit diuretic effects, which was a secondary focus of the study.
All in all, our study positions d-pinitol as a compelling candidate for alleviating anxiety, with mechanisms worth exploring further for therapeutic applications.
During our study, we observed that when mice were given d-pinitol at doses ranging from 1 to 100 mg/kg, there was notable evidence of anxiolytic-like actions. In particular, at a dose of 70 mg/kg, d-pinitol showed significant effectiveness in reducing anxiety as assessed in specific behavioral tests.
We also investigated the possible mechanisms behind these effects. Our findings suggest that the GABAergic system may play a key role in mediating the anxiolytic benefits of d-pinitol, which indicates a promising direction for further research. It’s important to remember that while our results are encouraging, d-pinitol did not exhibit diuretic effects, which was a secondary focus of the study.
All in all, our study positions d-pinitol as a compelling candidate for alleviating anxiety, with mechanisms worth exploring further for therapeutic applications.
4
We sought to understand the effects of inositol, a type of mitochondrial modulator, on anxiety as part of a broader examination of its role in treating obsessive-compulsive and related disorders. In this systematic review, we analyzed results from 17 double-blind, randomized, placebo-controlled trials involving 629 participants.
Our findings indicated that while inositol is included among several other treatments, its specific impact on anxiety-related scores did not surpass that of the placebo. Though overall symptoms improved with inositol and other mitochondrial modulators like N-acetylcysteine, the evidence for inositol alone does not demonstrate a significant advantage for anxiety relief.
Overall, while we enjoyed exploring the various treatments and their potential benefits, it is essential to note that inositol's effectiveness on its own concerning anxiety remains unproven when compared directly to placebo.
Our findings indicated that while inositol is included among several other treatments, its specific impact on anxiety-related scores did not surpass that of the placebo. Though overall symptoms improved with inositol and other mitochondrial modulators like N-acetylcysteine, the evidence for inositol alone does not demonstrate a significant advantage for anxiety relief.
Overall, while we enjoyed exploring the various treatments and their potential benefits, it is essential to note that inositol's effectiveness on its own concerning anxiety remains unproven when compared directly to placebo.
7
Inositol as potential anxiety treatment
We examined the potential of inositol as a treatment for anxiety disorders. While several treatments are currently available, many patients still struggle with symptoms, leading us to seek out alternatives like inositol.
Our findings suggest that inositol may have anti-panic effects, indicating it is worth considering for those who haven’t found success with other medications. We noted that it was generally well tolerated, which is essential for anyone looking for anxiety relief without unpleasant side effects.
While inositol shows promise, further research is necessary to firmly establish its efficacy. In this case, it's important to keep expectations grounded and recognize that individual responses may vary.
Overall, inositol presents itself as a intriguing option, especially for patients facing treatment-resistant conditions, highlighting the ongoing need for fresh approaches to managing anxiety.
Our findings suggest that inositol may have anti-panic effects, indicating it is worth considering for those who haven’t found success with other medications. We noted that it was generally well tolerated, which is essential for anyone looking for anxiety relief without unpleasant side effects.
While inositol shows promise, further research is necessary to firmly establish its efficacy. In this case, it's important to keep expectations grounded and recognize that individual responses may vary.
Overall, inositol presents itself as a intriguing option, especially for patients facing treatment-resistant conditions, highlighting the ongoing need for fresh approaches to managing anxiety.
4
Myo-inositol shows no significant anxiety effects
Our study examined the effects of a combined supplement of myo-inositol, probiotics, and micronutrients on the mental wellbeing of women from preconception through pregnancy and into the post-delivery period. We designed a double-blind randomized trial to compare this specific supplement with a standard micronutrient supplement. Our goal was to see if the intervention could lead to reduced anxiety and improved mood in participants.
Throughout various stages of pregnancy and after delivery, we measured mood and anxiety levels using established scales. We found that while there were no significant differences between the supplement group and the control group in terms of anxiety and mood symptoms, there was a modest improvement in overall mental health functioning for those taking the combined supplement. Specifically, women in the intervention group experienced a slight uptick in their mental health scores by 1.21 points compared to the control group by six months post-delivery.
Ultimately, while our findings did not indicate a meaningful impact on anxiety levels, they do suggest that taking myo-inositol along with other nutrients could support overall mental health during the perinatal period, offering some benefits beyond mood and anxiety symptoms alone.
Throughout various stages of pregnancy and after delivery, we measured mood and anxiety levels using established scales. We found that while there were no significant differences between the supplement group and the control group in terms of anxiety and mood symptoms, there was a modest improvement in overall mental health functioning for those taking the combined supplement. Specifically, women in the intervention group experienced a slight uptick in their mental health scores by 1.21 points compared to the control group by six months post-delivery.
Ultimately, while our findings did not indicate a meaningful impact on anxiety levels, they do suggest that taking myo-inositol along with other nutrients could support overall mental health during the perinatal period, offering some benefits beyond mood and anxiety symptoms alone.
References
- Samad N, Hameed A, Manzoor N, Shoukat S, Irfan A, et al. Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment. Exp Gerontol. 2024;198:112624. 10.1016/j.exger.2024.112624
- Bellagamba O, Guo AJ, Senthilkumar S, Lillevik SH, De Biase D, et al. Assessment of Long-Term Safety and Efficacy of Purple Sweet Potato Color (PSPC) and Myo-Inositol (MI) Treatment for Motor Related and Behavioral Phenotypes in a Mouse Model of Classic Galactosemia. J Inherit Metab Dis. 2025;48:e70002. 10.1002/jimd.70002
- El-Heis S, Barton SJ, Chang HF, Nield H, Cox V, et al. Maternal mood, anxiety and mental health functioning after combined myo-inositol, probiotics, micronutrient supplementation from preconception: Findings from the NiPPeR RCT. Psychiatry Res. 2024;334:115813. 10.1016/j.psychres.2024.115813
- Kishi T, Sakuma K, Iwata N. Mitochondrial modulators for obsessive-compulsive and related disorders: a systematic review and meta-analysis. Transl Psychiatry. 2022;12:263. 10.1038/s41398-022-02026-5
- Herwig E, Classen HL, Walk CL, Bedford M, Schwean-Lardner K. Dietary Inositol Reduces Fearfulness and Avoidance in Laying Hens. Animals (Basel). 2019;9. 10.3390/ani9110938
- Alonso-Castro AJ, Alba-Betancourt C, Rocha-González E, Ruiz-Arredondo A, Zapata-Morales JR, et al. Neuropharmacological effects of d-pinitol and its possible mechanisms of action. J Food Biochem. 2019;43:e13070. 10.1111/jfbc.13070
- Zulfarina MS, Syarifah-Noratiqah SB, Nazrun SA, Sharif R, Naina-Mohamed I. Pharmacological Therapy in Panic Disorder: Current Guidelines and Novel Drugs Discovery for Treatment-resistant Patient. Clin Psychopharmacol Neurosci. 2019;17:145. 10.9758/cpn.2019.17.2.145
- Emanuel RHK, Docherty PD, Lunt H, Campbell RE. What do users in a polycystic ovary syndrome (PCOS) forum think about the treatments they tried: Analysing treatment sentiment using machine learning. Phys Eng Sci Med. 2025. 10.1007/s13246-025-01539-9
