SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.8
USERS' SCORE
Good
Based on 8 Reviews
8.4
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Niacin (Vitamin B-3)(from 640 mg of Inositol Hexanicotinate)
500 mg
3125%
Inositol(from 640 mg of Inositol Hexanicotinate)
135 mg

Top Medical Research Studies

8
Inositol reduces anxiety in hens
Dietary Inositol Reduces Fearfulness and Avoidance in Laying Hens.
Highlights study's focused results
We conducted a study to understand how inositol, a naturally occurring sugar alcohol, influences anxiety levels in laying hens. Our focus was on the behavior of Lohmann LSL lite hens, which were fed two different diets—one rich and one deficient in protein—while receiving either pure inositol or high levels of phytase.

Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.

Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.

Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Read More
8
Niacin helps reduce anxiety symptoms
Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment.
Direct focus on niacin's effects
We evaluated the impact of niacin on anxiety and memory loss by examining its effects in male rats exposed to D-galactose, a chemical known to induce behavioral deficits. In our study, we divided the animals into six groups, with some receiving niacin at different doses (25 mg/kg and 50 mg/kg) and others being treated with D-galactose.

Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.

Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
Read More
8
PCOS treatment insights from users
What do users in a polycystic ovary syndrome (PCOS) forum think about the treatments they tried: Analysing treatment sentiment using machine learning.
Effective AI analysis in healthcare
We examined user sentiments surrounding treatments for Polycystic Ovary Syndrome (PCOS) through data collected from an extensive subreddit.

Our analysis revealed that lifestyle changes and supplements were viewed positively, while contraceptives often received negative feedback. Notably, inositol was associated with significant improvements in mental health, including reductions in anxiety.

This study highlights the potential of machine learning to analyze patient experiences, offering valuable insights that might complement traditional clinical research.
Read More

Most Useful Reviews

9
Helpful for anxiety
Great product! I found this niacin very helpful for anxiety. Thank you.
Read More
9.5
Easy to take
My daughter’s anxiety was resolved with niacinamide, but my son, who has ADHD, found the taste unpleasant, so we switched to this. I open the capsule and give him the powder, which is nearly tasteless, making it much easier for him to take than niacinamide.
Read More
7
Boosts energy
Niacin is beneficial for anxiety and mental health. It supports adrenal function and provides energy without causing any flushing.
Read More

Medical Researches

SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.8
  • All Researches
8
Niacin helps reduce anxiety symptoms
Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment.
Direct focus on niacin's effects
We evaluated the impact of niacin on anxiety and memory loss by examining its effects in male rats exposed to D-galactose, a chemical known to induce behavioral deficits. In our study, we divided the animals into six groups, with some receiving niacin at different doses (25 mg/kg and 50 mg/kg) and others being treated with D-galactose.

Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.

Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
Read More
8
Inositol reduces anxiety in hens
Dietary Inositol Reduces Fearfulness and Avoidance in Laying Hens.
Highlights study's focused results
We conducted a study to understand how inositol, a naturally occurring sugar alcohol, influences anxiety levels in laying hens. Our focus was on the behavior of Lohmann LSL lite hens, which were fed two different diets—one rich and one deficient in protein—while receiving either pure inositol or high levels of phytase.

Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.

Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.

Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Read More
8
d-Pinitol shows potential for anxiety
Neuropharmacological effects of d-pinitol and its possible mechanisms of action.
Focused on anxiolytic effects
We explored how d-pinitol, a natural compound found in various fruits and legumes, could impact anxiety and related conditions. In our evaluation, we focused on its effects on mice to understand its potential as an anxiolytic agent.

During our study, we observed that when mice were given d-pinitol at doses ranging from 1 to 100 mg/kg, there was notable evidence of anxiolytic-like actions. In particular, at a dose of 70 mg/kg, d-pinitol showed significant effectiveness in reducing anxiety as assessed in specific behavioral tests.

We also investigated the possible mechanisms behind these effects. Our findings suggest that the GABAergic system may play a key role in mediating the anxiolytic benefits of d-pinitol, which indicates a promising direction for further research. It’s important to remember that while our results are encouraging, d-pinitol did not exhibit diuretic effects, which was a secondary focus of the study.

All in all, our study positions d-pinitol as a compelling candidate for alleviating anxiety, with mechanisms worth exploring further for therapeutic applications.
Read More
8
PCOS treatment insights from users
What do users in a polycystic ovary syndrome (PCOS) forum think about the treatments they tried: Analysing treatment sentiment using machine learning.
Effective AI analysis in healthcare
We examined user sentiments surrounding treatments for Polycystic Ovary Syndrome (PCOS) through data collected from an extensive subreddit.

Our analysis revealed that lifestyle changes and supplements were viewed positively, while contraceptives often received negative feedback. Notably, inositol was associated with significant improvements in mental health, including reductions in anxiety.

This study highlights the potential of machine learning to analyze patient experiences, offering valuable insights that might complement traditional clinical research.
Read More
7
Myo-Inositol improves anxiety behavior
Assessment of Long-Term Safety and Efficacy of Purple Sweet Potato Color (PSPC) and Myo-Inositol (MI) Treatment for Motor Related and Behavioral Phenotypes in a Mouse Model of Classic Galactosemia.
Relevant focus on anxiety treatment
We aimed to explore the impact of myo-inositol (MI) on anxiety in a mouse model of classic galactosemia. Our research involved a combination of acute and chronic evaluations of MI, particularly looking at its effects over a long-term treatment period. We observed that lower doses of MI suggested notable improvements in motor deficits and anxiety-driven hyperactivity among the GalT-KO mice, which are affected by this condition.

While we conducted a thorough assessment of motor-related behaviors and anxiety levels, it appears that MI holds potential as an adjunct treatment option. These findings indicate that MI may benefit not only physical symptoms but also emotional well-being, particularly in reducing anxiety-related behaviors in this genetically modified model, which helps us understand its role more clearly. The results could point to new avenues for managing anxiety, especially in conditions like classic galactosemia where traditional treatment methods fall short.
Read More

User Reviews

USERS' SCORE
Good
Based on 8 Reviews
8.4
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9
Helpful for anxiety
Great product! I found this niacin very helpful for anxiety. Thank you.
9.5
Easy to take
My daughter’s anxiety was resolved with niacinamide, but my son, who has ADHD, found the taste unpleasant, so we switched to this. I open the capsule and give him the powder, which is nearly tasteless, making it much easier for him to take than niacinamide.
7
Boosts energy
Niacin is beneficial for anxiety and mental health. It supports adrenal function and provides energy without causing any flushing.
8.8
Eased anxiety significantly
I have allergies, hay fever, insomnia, anxiety, and high cholesterol. This autumn, my allergies have been mild, and my anxiety has lessened significantly. Insomnia is also improving, making this treatment effective for the various issues I faced. I initially bought Flash Free to avoid niacin flush, which didn’t occur. There’s no notable taste, and it’s easy to consume. I recommend it for similar symptoms.
Read More
8.8
Promotes calmness
It’s noted that niacin flush may occur, but I did not experience it with this flash-free version. Taking it gives me peace of mind and I recommend it for those with significant stress and anxiety, as it contains vitamin B3, which supports the happy hormone.

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