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NOW Supplements Niacin
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.3
USERS' SCORE
Good
Based on 3 Reviews
8.3
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Niacin (Vitamin B-3)(from 640 mg of Inositol Hexanicotinate)
500 mg
3125%
Inositol(from 640 mg of Inositol Hexanicotinate)
135 mg

Top Medical Research Studies

9
Myo-inositol affects prostate cancer cells
Proteomic Analysis of Anticancer Effect of Myo-inositol in Human Prostate Cancer (DU-145) Cell Line.
Direct investigation of Myo-inositol
We investigated the potential benefits of Myo-inositol, a naturally occurring sugar alcohol, on DU-145 prostate cancer cells. By treating these cancer cells with various doses of Myo-inositol, we determined its half-maximal inhibitory concentration (IC50) using a simple method that measures cell viability.

Our findings revealed that Myo-inositol significantly decreased the viability of DU-145 cells, showing an IC50 of 0.06 mg/ml. This suggests that Myo-inositol may effectively inhibit cancer cell growth.

Furthermore, we performed a detailed proteomic analysis using advanced techniques to explore how Myo-inositol changes protein expression. We found notable differences in protein levels between treated and untreated cells, particularly in areas linked to key cellular functions like cytoskeletal regulation, apoptosis (cell death), and stress responses. For instance, certain proteins tied to tumor suppression were upregulated in response to Myo-inositol treatment.

Overall, these observations highlight Myo-inositol's potential as a therapeutic option. However, further studies are necessary to unravel the underlying mechanisms and assess its effectiveness in combination with other treatments for managing prostate cancer, especially castration-resistant prostate cancer (CRPC).
Read More
9
Isogarcinol suppresses breast cancer growth
Isogarcinol Reduces MARS Levels and Deactivates the PI3K/AKT Pathway to Suppress the Malignant Properties of Breast Cancer Cells.
Highly relevant to cancer treatments
We investigated how isogarcinol (ISO) influences breast cancer cells and what mechanisms are at play. Through lab tests, we found that ISO at 13 μM effectively lowered cell growth and movement. In living subjects, doses of 5 to 15 mg/kg showed a significant reduction in tumor activity.

We observed that ISO achieves its tumor-suppressing effects by lowering the levels of a protein called methionyl-tRNA synthetase (MARS) and deactivating key pathways involved in cancer progression. These findings suggest ISO could be a valuable addition to breast cancer treatment strategies.
Read More
7
Vitamin E Succinate enhances autophagy
[The role of endoplasmic reticulum IP(3)R calcium channel in vitamin E succinate induced autophagy of human gastric cancer cell].
High relevance to gastric cancer treatment
We examined how vitamin E succinate (VES) affects autophagy in human gastric cancer cells by activating a calcium signaling pathway. Our study involved cultured gastric cancer cell lines treated with various doses of VES. We noted that VES significantly reduced cell proliferation and enhanced the formation of autophagosomes, indicating increased autophagy.

However, when we inhibited the calcium channel involved, the positive effects of VES diminished, suggesting the importance of this pathway in its action. Overall, while VES shows promise in promoting autophagy, further research is needed to understand its full potential in cancer treatment.
Read More

Most Useful Reviews

8.8
Significant effects
Flushing-Free Niacin B3 contains quality ingredients that benefit joints, dilate blood vessels, lower blood pressure, improve skin spots, reduce skin cancer, increase cell energy, and alleviate eczema. The effects are significant.
Read More
7.5
Improves energy
This product is beneficial for joints, helps dilate blood vessels, lowers blood pressure, improves skin spots, reduces skin cancer, and increases cell energy. It also reduces eczema and has significant effects.
Read More
6.8
Supports sleep
Although I didn't consume much of it, my fiancée found it helpful, feeling more relaxed and sleeping well. I tried this product on the recommendation of my mentor, who claimed it could help remove cancer and assist those lacking B3 and feeling fatigued.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.3
  • All Researches
9
Myo-inositol affects prostate cancer cells
Proteomic Analysis of Anticancer Effect of Myo-inositol in Human Prostate Cancer (DU-145) Cell Line.
Direct investigation of Myo-inositol
We investigated the potential benefits of Myo-inositol, a naturally occurring sugar alcohol, on DU-145 prostate cancer cells. By treating these cancer cells with various doses of Myo-inositol, we determined its half-maximal inhibitory concentration (IC50) using a simple method that measures cell viability.

Our findings revealed that Myo-inositol significantly decreased the viability of DU-145 cells, showing an IC50 of 0.06 mg/ml. This suggests that Myo-inositol may effectively inhibit cancer cell growth.

Furthermore, we performed a detailed proteomic analysis using advanced techniques to explore how Myo-inositol changes protein expression. We found notable differences in protein levels between treated and untreated cells, particularly in areas linked to key cellular functions like cytoskeletal regulation, apoptosis (cell death), and stress responses. For instance, certain proteins tied to tumor suppression were upregulated in response to Myo-inositol treatment.

Overall, these observations highlight Myo-inositol's potential as a therapeutic option. However, further studies are necessary to unravel the underlying mechanisms and assess its effectiveness in combination with other treatments for managing prostate cancer, especially castration-resistant prostate cancer (CRPC).
Read More
9
Isogarcinol suppresses breast cancer growth
Isogarcinol Reduces MARS Levels and Deactivates the PI3K/AKT Pathway to Suppress the Malignant Properties of Breast Cancer Cells.
Highly relevant to cancer treatments
We investigated how isogarcinol (ISO) influences breast cancer cells and what mechanisms are at play. Through lab tests, we found that ISO at 13 μM effectively lowered cell growth and movement. In living subjects, doses of 5 to 15 mg/kg showed a significant reduction in tumor activity.

We observed that ISO achieves its tumor-suppressing effects by lowering the levels of a protein called methionyl-tRNA synthetase (MARS) and deactivating key pathways involved in cancer progression. These findings suggest ISO could be a valuable addition to breast cancer treatment strategies.
Read More
8
Niacin aids in leukemia treatment
Rapamycin and Niacin combination induces apoptosis and cell cycle arrest through autophagy activation on acute myeloid leukemia cells.
Combination effects, limited isolation
We investigated how the combination of Niacin and Rapamycin affects the growth of acute myeloid leukemia (AML) cells. By conducting a series of experiments on two AML cell lines, THP-1 and NB4, we aimed to see if this duo could meaningfully target cancer cells.

Our findings showed that when used together, Rapamycin and Niacin significantly lowered the viability of the leukemia cells. Specifically, we observed notable increases in cell death, with THP-1 cells experiencing nearly five times more apoptosis, and NB4 cells showing a 7.3-fold increase. The combination treatment also caused a distinct halt in the cell cycle, meaning the cancer cells were not able to continue growing.

Additionally, we noted changes in various proteins linked to autophagy, a process that can help cells maintain balance. While there’s much to be understood, our results suggest that this combination of Niacin and Rapamycin may enhance the fight against AML by promoting cell death and disrupting the cell cycle.

Ultimately, this study highlights the potential of using a natural product like Niacin in a blend with traditional treatments like Rapamycin to combat cancer. However, further research is needed to fully understand the implications of these findings.
Read More
7
Vitamin E Succinate enhances autophagy
[The role of endoplasmic reticulum IP(3)R calcium channel in vitamin E succinate induced autophagy of human gastric cancer cell].
High relevance to gastric cancer treatment
We examined how vitamin E succinate (VES) affects autophagy in human gastric cancer cells by activating a calcium signaling pathway. Our study involved cultured gastric cancer cell lines treated with various doses of VES. We noted that VES significantly reduced cell proliferation and enhanced the formation of autophagosomes, indicating increased autophagy.

However, when we inhibited the calcium channel involved, the positive effects of VES diminished, suggesting the importance of this pathway in its action. Overall, while VES shows promise in promoting autophagy, further research is needed to understand its full potential in cancer treatment.
Read More

User Reviews

USERS' SCORE
Good
Based on 3 Reviews
8.3
  • All Reviews
  • Positive Reviews
  • Negative Reviews
8.8
Significant effects
Flushing-Free Niacin B3 contains quality ingredients that benefit joints, dilate blood vessels, lower blood pressure, improve skin spots, reduce skin cancer, increase cell energy, and alleviate eczema. The effects are significant.
7.5
Improves energy
This product is beneficial for joints, helps dilate blood vessels, lowers blood pressure, improves skin spots, reduces skin cancer, and increases cell energy. It also reduces eczema and has significant effects.
6.8
Supports sleep
Although I didn't consume much of it, my fiancée found it helpful, feeling more relaxed and sleeping well. I tried this product on the recommendation of my mentor, who claimed it could help remove cancer and assist those lacking B3 and feeling fatigued.
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