' 
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.6
USERS' SCORE
Good
Based on 27 Reviews
8.4
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Niacin (Vitamin B-3)(from 640 mg of Inositol Hexanicotinate)
500 mg
3125%
Inositol (from 640 mg of Inositol Hexanicotinate)
135 mg
†
Top Medical Research Studies
8
Inositol reduces anxiety in hens
Dietary Inositol Reduces Fearfulness and Avoidance in Laying Hens.
Highlights study's focused results
We conducted a study to understand how inositol, a naturally occurring sugar alcohol, influences anxiety levels in laying hens. Our focus was on the behavior of Lohmann LSL lite hens, which were fed two different diets—one rich and one deficient in protein—while receiving either pure inositol or high levels of phytase.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Read More
8
Niacin helps reduce anxiety symptoms
Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment.
Direct focus on niacin's effects
We evaluated the impact of niacin on anxiety and memory loss by examining its effects in male rats exposed to D-galactose, a chemical known to induce behavioral deficits. In our study, we divided the animals into six groups, with some receiving niacin at different doses (25 mg/kg and 50 mg/kg) and others being treated with D-galactose.
Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.
Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.
Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
Read More
8
d-Pinitol shows potential for anxiety
Neuropharmacological effects of d-pinitol and its possible mechanisms of action.
Focused on anxiolytic effects
We explored how d-pinitol, a natural compound found in various fruits and legumes, could impact anxiety and related conditions. In our evaluation, we focused on its effects on mice to understand its potential as an anxiolytic agent.
During our study, we observed that when mice were given d-pinitol at doses ranging from 1 to 100 mg/kg, there was notable evidence of anxiolytic-like actions. In particular, at a dose of 70 mg/kg, d-pinitol showed significant effectiveness in reducing anxiety as assessed in specific behavioral tests.
We also investigated the possible mechanisms behind these effects. Our findings suggest that the GABAergic system may play a key role in mediating the anxiolytic benefits of d-pinitol, which indicates a promising direction for further research. It’s important to remember that while our results are encouraging, d-pinitol did not exhibit diuretic effects, which was a secondary focus of the study.
All in all, our study positions d-pinitol as a compelling candidate for alleviating anxiety, with mechanisms worth exploring further for therapeutic applications.
During our study, we observed that when mice were given d-pinitol at doses ranging from 1 to 100 mg/kg, there was notable evidence of anxiolytic-like actions. In particular, at a dose of 70 mg/kg, d-pinitol showed significant effectiveness in reducing anxiety as assessed in specific behavioral tests.
We also investigated the possible mechanisms behind these effects. Our findings suggest that the GABAergic system may play a key role in mediating the anxiolytic benefits of d-pinitol, which indicates a promising direction for further research. It’s important to remember that while our results are encouraging, d-pinitol did not exhibit diuretic effects, which was a secondary focus of the study.
All in all, our study positions d-pinitol as a compelling candidate for alleviating anxiety, with mechanisms worth exploring further for therapeutic applications.
Read More
Most Useful Reviews
9.5
Decreased anxiety
I purchased this for a teenager with anxiety. Initially, I was on medication, but I tried niacinamide to reduce my dosage. After three months, I started taking 100mg of niacin, two tablets after meals. I’ve adapted to it, and my anxiety has significantly decreased, allowing me to stop my hospital medication. The niacin seems to work well; I’ll soon try niacin 500mg for future prevention. I’m smiling more and feeling brighter, all without side effects, so I’ll keep using it.
Read More
7.5
Natural treatment for OCD
This product is excellent for OCD challenges. I weigh about 195lbs and take 2x3 of these daily. I've become more relaxed and experience significantly less anxiety about minor issues. It began to work in less than a week without any flushing.
Read More
9.5
Increased happiness
I bought it to address my anxiety disorders and take six tablets daily. It feels safe and flash-free, and I’ve started to feel vaguely happy. I can sleep well and intend to continue using it.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 7 Researches
6.6
- All Researches
8
Niacin helps reduce anxiety symptoms
Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment.
Direct focus on niacin's effects
We evaluated the impact of niacin on anxiety and memory loss by examining its effects in male rats exposed to D-galactose, a chemical known to induce behavioral deficits. In our study, we divided the animals into six groups, with some receiving niacin at different doses (25 mg/kg and 50 mg/kg) and others being treated with D-galactose.
Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.
Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.
Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
Read More
8
Inositol reduces anxiety in hens
Dietary Inositol Reduces Fearfulness and Avoidance in Laying Hens.
Highlights study's focused results
We conducted a study to understand how inositol, a naturally occurring sugar alcohol, influences anxiety levels in laying hens. Our focus was on the behavior of Lohmann LSL lite hens, which were fed two different diets—one rich and one deficient in protein—while receiving either pure inositol or high levels of phytase.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Read More
8
d-Pinitol shows potential for anxiety
Neuropharmacological effects of d-pinitol and its possible mechanisms of action.
Focused on anxiolytic effects
We explored how d-pinitol, a natural compound found in various fruits and legumes, could impact anxiety and related conditions. In our evaluation, we focused on its effects on mice to understand its potential as an anxiolytic agent.
During our study, we observed that when mice were given d-pinitol at doses ranging from 1 to 100 mg/kg, there was notable evidence of anxiolytic-like actions. In particular, at a dose of 70 mg/kg, d-pinitol showed significant effectiveness in reducing anxiety as assessed in specific behavioral tests.
We also investigated the possible mechanisms behind these effects. Our findings suggest that the GABAergic system may play a key role in mediating the anxiolytic benefits of d-pinitol, which indicates a promising direction for further research. It’s important to remember that while our results are encouraging, d-pinitol did not exhibit diuretic effects, which was a secondary focus of the study.
All in all, our study positions d-pinitol as a compelling candidate for alleviating anxiety, with mechanisms worth exploring further for therapeutic applications.
During our study, we observed that when mice were given d-pinitol at doses ranging from 1 to 100 mg/kg, there was notable evidence of anxiolytic-like actions. In particular, at a dose of 70 mg/kg, d-pinitol showed significant effectiveness in reducing anxiety as assessed in specific behavioral tests.
We also investigated the possible mechanisms behind these effects. Our findings suggest that the GABAergic system may play a key role in mediating the anxiolytic benefits of d-pinitol, which indicates a promising direction for further research. It’s important to remember that while our results are encouraging, d-pinitol did not exhibit diuretic effects, which was a secondary focus of the study.
All in all, our study positions d-pinitol as a compelling candidate for alleviating anxiety, with mechanisms worth exploring further for therapeutic applications.
Read More
7
Myo-Inositol improves anxiety behavior
Assessment of Long-Term Safety and Efficacy of Purple Sweet Potato Color (PSPC) and Myo-Inositol (MI) Treatment for Motor Related and Behavioral Phenotypes in a Mouse Model of Classic Galactosemia.
Relevant focus on anxiety treatment
We aimed to explore the impact of myo-inositol (MI) on anxiety in a mouse model of classic galactosemia. Our research involved a combination of acute and chronic evaluations of MI, particularly looking at its effects over a long-term treatment period. We observed that lower doses of MI suggested notable improvements in motor deficits and anxiety-driven hyperactivity among the GalT-KO mice, which are affected by this condition.
While we conducted a thorough assessment of motor-related behaviors and anxiety levels, it appears that MI holds potential as an adjunct treatment option. These findings indicate that MI may benefit not only physical symptoms but also emotional well-being, particularly in reducing anxiety-related behaviors in this genetically modified model, which helps us understand its role more clearly. The results could point to new avenues for managing anxiety, especially in conditions like classic galactosemia where traditional treatment methods fall short.
While we conducted a thorough assessment of motor-related behaviors and anxiety levels, it appears that MI holds potential as an adjunct treatment option. These findings indicate that MI may benefit not only physical symptoms but also emotional well-being, particularly in reducing anxiety-related behaviors in this genetically modified model, which helps us understand its role more clearly. The results could point to new avenues for managing anxiety, especially in conditions like classic galactosemia where traditional treatment methods fall short.
Read More
7
Inositol as potential anxiety treatment
Pharmacological Therapy in Panic Disorder: Current Guidelines and Novel Drugs Discovery for Treatment-resistant Patient.
Relevant effectiveness of inositol
We examined the potential of inositol as a treatment for anxiety disorders. While several treatments are currently available, many patients still struggle with symptoms, leading us to seek out alternatives like inositol.
Our findings suggest that inositol may have anti-panic effects, indicating it is worth considering for those who haven’t found success with other medications. We noted that it was generally well tolerated, which is essential for anyone looking for anxiety relief without unpleasant side effects.
While inositol shows promise, further research is necessary to firmly establish its efficacy. In this case, it's important to keep expectations grounded and recognize that individual responses may vary.
Overall, inositol presents itself as a intriguing option, especially for patients facing treatment-resistant conditions, highlighting the ongoing need for fresh approaches to managing anxiety.
Our findings suggest that inositol may have anti-panic effects, indicating it is worth considering for those who haven’t found success with other medications. We noted that it was generally well tolerated, which is essential for anyone looking for anxiety relief without unpleasant side effects.
While inositol shows promise, further research is necessary to firmly establish its efficacy. In this case, it's important to keep expectations grounded and recognize that individual responses may vary.
Overall, inositol presents itself as a intriguing option, especially for patients facing treatment-resistant conditions, highlighting the ongoing need for fresh approaches to managing anxiety.
Read More
User Reviews
USERS' SCORE
Good
Based on 27 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Decreased anxiety
I purchased this for a teenager with anxiety. Initially, I was on medication, but I tried niacinamide to reduce my dosage. After three months, I started taking 100mg of niacin, two tablets after meals. I’ve adapted to it, and my anxiety has significantly decreased, allowing me to stop my hospital medication. The niacin seems to work well; I’ll soon try niacin 500mg for future prevention. I’m smiling more and feeling brighter, all without side effects, so I’ll keep using it.
Read More
7.5
Natural treatment for OCD
This product is excellent for OCD challenges. I weigh about 195lbs and take 2x3 of these daily. I've become more relaxed and experience significantly less anxiety about minor issues. It began to work in less than a week without any flushing.
9.5
Increased happiness
I bought it to address my anxiety disorders and take six tablets daily. It feels safe and flash-free, and I’ve started to feel vaguely happy. I can sleep well and intend to continue using it.
9.5
Problem-solving aid
This has been very helpful in addressing many of my issues, including anxiety and unclear thinking.
8.8
Reduced anxiety
I began with Niacinamide and now use Flashfree for my child with hearing loss. I suffered from severe anxiety and hyperacusis in my youth, but it improved with niacin, lecithin, and PS. I believe niacin was particularly effective for my anxiety.
