Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.8
USERS' SCORE
Moderately Good
Based on 27 Reviews
7.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Niacin (Vitamin B-3)(from 640 mg of Inositol Hexanicotinate)
500 mg
3125%
Inositol (from 640 mg of Inositol Hexanicotinate)
135 mg
†
Top Medical Research Studies
8
We conducted a study to understand how inositol, a naturally occurring sugar alcohol, influences anxiety levels in laying hens. Our focus was on the behavior of Lohmann LSL lite hens, which were fed two different diets—one rich and one deficient in protein—while receiving either pure inositol or high levels of phytase.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Read More
8
We evaluated the impact of niacin on anxiety and memory loss by examining its effects in male rats exposed to D-galactose, a chemical known to induce behavioral deficits. In our study, we divided the animals into six groups, with some receiving niacin at different doses (25 mg/kg and 50 mg/kg) and others being treated with D-galactose.
Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.
Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.
Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
Read More
8
We examined user sentiments surrounding treatments for Polycystic Ovary Syndrome (PCOS) through data collected from an extensive subreddit.
Our analysis revealed that lifestyle changes and supplements were viewed positively, while contraceptives often received negative feedback. Notably, inositol was associated with significant improvements in mental health, including reductions in anxiety.
This study highlights the potential of machine learning to analyze patient experiences, offering valuable insights that might complement traditional clinical research.
Our analysis revealed that lifestyle changes and supplements were viewed positively, while contraceptives often received negative feedback. Notably, inositol was associated with significant improvements in mental health, including reductions in anxiety.
This study highlights the potential of machine learning to analyze patient experiences, offering valuable insights that might complement traditional clinical research.
Read More
Most Useful Reviews
9
Decreased anxiety
29 people found this helpful
I purchased this for a teenager with anxiety. Initially, I was on medication, but I tried niacinamide to reduce my dosage. After three months, I started taking 100mg of niacin, two tablets after meals. I’ve adapted to it, and my anxiety has significantly decreased, allowing me to stop my hospital medication. The niacin seems to work well; I’ll soon try niacin 500mg for future prevention. I’m smiling more and feeling brighter, all without side effects, so I’ll keep using it.
Read More
7.5
Natural treatment for OCD
24 people found this helpful
This product is excellent for OCD challenges. I weigh about 195lbs and take 2x3 of these daily. I've become more relaxed and experience significantly less anxiety about minor issues. It began to work in less than a week without any flushing.
Read More
9
Increased happiness
2 people found this helpful
I bought it to address my anxiety disorders and take six tablets daily. It feels safe and flash-free, and I’ve started to feel vaguely happy. I can sleep well and intend to continue using it.
Read More
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 8 Researches
6.8
- All Researches
8
We evaluated the impact of niacin on anxiety and memory loss by examining its effects in male rats exposed to D-galactose, a chemical known to induce behavioral deficits. In our study, we divided the animals into six groups, with some receiving niacin at different doses (25 mg/kg and 50 mg/kg) and others being treated with D-galactose.
Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.
Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.
Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
Read More
8
We conducted a study to understand how inositol, a naturally occurring sugar alcohol, influences anxiety levels in laying hens. Our focus was on the behavior of Lohmann LSL lite hens, which were fed two different diets—one rich and one deficient in protein—while receiving either pure inositol or high levels of phytase.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Read More
8
We explored how d-pinitol, a natural compound found in various fruits and legumes, could impact anxiety and related conditions. In our evaluation, we focused on its effects on mice to understand its potential as an anxiolytic agent.
During our study, we observed that when mice were given d-pinitol at doses ranging from 1 to 100 mg/kg, there was notable evidence of anxiolytic-like actions. In particular, at a dose of 70 mg/kg, d-pinitol showed significant effectiveness in reducing anxiety as assessed in specific behavioral tests.
We also investigated the possible mechanisms behind these effects. Our findings suggest that the GABAergic system may play a key role in mediating the anxiolytic benefits of d-pinitol, which indicates a promising direction for further research. It’s important to remember that while our results are encouraging, d-pinitol did not exhibit diuretic effects, which was a secondary focus of the study.
All in all, our study positions d-pinitol as a compelling candidate for alleviating anxiety, with mechanisms worth exploring further for therapeutic applications.
During our study, we observed that when mice were given d-pinitol at doses ranging from 1 to 100 mg/kg, there was notable evidence of anxiolytic-like actions. In particular, at a dose of 70 mg/kg, d-pinitol showed significant effectiveness in reducing anxiety as assessed in specific behavioral tests.
We also investigated the possible mechanisms behind these effects. Our findings suggest that the GABAergic system may play a key role in mediating the anxiolytic benefits of d-pinitol, which indicates a promising direction for further research. It’s important to remember that while our results are encouraging, d-pinitol did not exhibit diuretic effects, which was a secondary focus of the study.
All in all, our study positions d-pinitol as a compelling candidate for alleviating anxiety, with mechanisms worth exploring further for therapeutic applications.
Read More
8
We examined user sentiments surrounding treatments for Polycystic Ovary Syndrome (PCOS) through data collected from an extensive subreddit.
Our analysis revealed that lifestyle changes and supplements were viewed positively, while contraceptives often received negative feedback. Notably, inositol was associated with significant improvements in mental health, including reductions in anxiety.
This study highlights the potential of machine learning to analyze patient experiences, offering valuable insights that might complement traditional clinical research.
Our analysis revealed that lifestyle changes and supplements were viewed positively, while contraceptives often received negative feedback. Notably, inositol was associated with significant improvements in mental health, including reductions in anxiety.
This study highlights the potential of machine learning to analyze patient experiences, offering valuable insights that might complement traditional clinical research.
Read More
7
Myo-Inositol improves anxiety behavior
We aimed to explore the impact of myo-inositol (MI) on anxiety in a mouse model of classic galactosemia. Our research involved a combination of acute and chronic evaluations of MI, particularly looking at its effects over a long-term treatment period. We observed that lower doses of MI suggested notable improvements in motor deficits and anxiety-driven hyperactivity among the GalT-KO mice, which are affected by this condition.
While we conducted a thorough assessment of motor-related behaviors and anxiety levels, it appears that MI holds potential as an adjunct treatment option. These findings indicate that MI may benefit not only physical symptoms but also emotional well-being, particularly in reducing anxiety-related behaviors in this genetically modified model, which helps us understand its role more clearly. The results could point to new avenues for managing anxiety, especially in conditions like classic galactosemia where traditional treatment methods fall short.
While we conducted a thorough assessment of motor-related behaviors and anxiety levels, it appears that MI holds potential as an adjunct treatment option. These findings indicate that MI may benefit not only physical symptoms but also emotional well-being, particularly in reducing anxiety-related behaviors in this genetically modified model, which helps us understand its role more clearly. The results could point to new avenues for managing anxiety, especially in conditions like classic galactosemia where traditional treatment methods fall short.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 27 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Decreased anxiety
29 people found this helpful
I purchased this for a teenager with anxiety. Initially, I was on medication, but I tried niacinamide to reduce my dosage. After three months, I started taking 100mg of niacin, two tablets after meals. I’ve adapted to it, and my anxiety has significantly decreased, allowing me to stop my hospital medication. The niacin seems to work well; I’ll soon try niacin 500mg for future prevention. I’m smiling more and feeling brighter, all without side effects, so I’ll keep using it.
Read More
7.5
Natural treatment for OCD
24 people found this helpful
This product is excellent for OCD challenges. I weigh about 195lbs and take 2x3 of these daily. I've become more relaxed and experience significantly less anxiety about minor issues. It began to work in less than a week without any flushing.
Read More
9
Increased happiness
2 people found this helpful
I bought it to address my anxiety disorders and take six tablets daily. It feels safe and flash-free, and I’ve started to feel vaguely happy. I can sleep well and intend to continue using it.
Read More
9
Problem-solving aid
1 people found this helpful
This has been very helpful in addressing many of my issues, including anxiety and unclear thinking.
Read More
7.5
Reduced anxiety
1 people found this helpful
I began with Niacinamide and now use Flashfree for my child with hearing loss. I suffered from severe anxiety and hyperacusis in my youth, but it improved with niacin, lecithin, and PS. I believe niacin was particularly effective for my anxiety.
Read More
Frequently Asked Questions
7.5
Lessened anxiety
After starting niacin and gradually increasing my dosage over two weeks, I've noticed a reduction in my depression and anxiety.
7.5
Clearer mind
3 people found this helpful
I take it for my anxiety disorder and have just started with 2 tablets each in the morning and evening. I’ve noticed my sudden anxiety has diminished, and I feel mentally clearer. I hope this improvement continues.
7.5
Anxiety relief
I take this for my anxiety disorder. It doesn't work miracles, but I feel a sense of relief after taking it. I plan to continue for six months to see more benefits.
7.5
Eased anxiety
2 people found this helpful
Since starting this a year ago, I have felt a significant decrease in anxiety and distress, making life much easier to manage.
9
Decreased anxiety
29 people found this helpful
I purchased this for a teenager with anxiety. Initially, I was on medication, but I tried niacinamide to reduce my dosage. After three months, I started taking 100mg of niacin, two tablets after meals. I’ve adapted to it, and my anxiety has significantly decreased, allowing me to stop my hospital medication. The niacin seems to work well; I’ll soon try niacin 500mg for future prevention. I’m smiling more and feeling brighter, all without side effects, so I’ll keep using it.
7.5
Mood stabilisation
5 people found this helpful
I use vitamin B3 not only to enhance tryptophan assimilation but also to improve digestion and sleep. It's beneficial in combating stress hormones and stabilising mood. It has sedative effects that aid in reducing anxiety and promoting sleep. I take it with L-tryptophan before bed.
7.5
Stability improvement
1 people found this helpful
I bought this intending to enhance my mental stability and sleep. I believe it has reduced my irritability and anxiety; however, I'm combining it with other supplements and will adjust my dosage based on results.
6
Improved sleep
To combat my long-standing anxiety and insomnia, I started exercising and eating properly, and after taking this after dinner, I finally managed to fall asleep.
9
Increased happiness
2 people found this helpful
I bought it to address my anxiety disorders and take six tablets daily. It feels safe and flash-free, and I’ve started to feel vaguely happy. I can sleep well and intend to continue using it.
9
Effective anxiety relief
I purchased this after my psychiatrist introduced it to me, and I've been taking it ever since. It truly alleviates my anxiety, and I adjust the dosage depending on how I feel. I will continue using it.
8
We evaluated the impact of niacin on anxiety and memory loss by examining its effects in male rats exposed to D-galactose, a chemical known to induce behavioral deficits. In our study, we divided the animals into six groups, with some receiving niacin at different doses (25 mg/kg and 50 mg/kg) and others being treated with D-galactose.
Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.
Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
Over a two-week period, we observed how niacin influenced their behavior in various tests designed to measure anxiety and depression. After administering niacin, we found that it significantly reduced the anxiety and depressive symptoms that had developed due to D-galactose. This was particularly encouraging as niacin also appeared to support memory function in the rats, showing promise for addressing cognitive decline.
Biochemically, niacin treatment helped restore levels of antioxidant enzymes and neurotransmitters affected by D-galactose, demonstrating its potential to combat oxidative stress and inflammation. Our findings suggest that niacin can act as both an antioxidant and a neuromodulator, offering a valuable approach for treating anxiety and associated cognitive impairments in aging.
4
We sought to understand the effects of inositol, a type of mitochondrial modulator, on anxiety as part of a broader examination of its role in treating obsessive-compulsive and related disorders. In this systematic review, we analyzed results from 17 double-blind, randomized, placebo-controlled trials involving 629 participants.
Our findings indicated that while inositol is included among several other treatments, its specific impact on anxiety-related scores did not surpass that of the placebo. Though overall symptoms improved with inositol and other mitochondrial modulators like N-acetylcysteine, the evidence for inositol alone does not demonstrate a significant advantage for anxiety relief.
Overall, while we enjoyed exploring the various treatments and their potential benefits, it is essential to note that inositol's effectiveness on its own concerning anxiety remains unproven when compared directly to placebo.
Our findings indicated that while inositol is included among several other treatments, its specific impact on anxiety-related scores did not surpass that of the placebo. Though overall symptoms improved with inositol and other mitochondrial modulators like N-acetylcysteine, the evidence for inositol alone does not demonstrate a significant advantage for anxiety relief.
Overall, while we enjoyed exploring the various treatments and their potential benefits, it is essential to note that inositol's effectiveness on its own concerning anxiety remains unproven when compared directly to placebo.
8
We explored how d-pinitol, a natural compound found in various fruits and legumes, could impact anxiety and related conditions. In our evaluation, we focused on its effects on mice to understand its potential as an anxiolytic agent.
During our study, we observed that when mice were given d-pinitol at doses ranging from 1 to 100 mg/kg, there was notable evidence of anxiolytic-like actions. In particular, at a dose of 70 mg/kg, d-pinitol showed significant effectiveness in reducing anxiety as assessed in specific behavioral tests.
We also investigated the possible mechanisms behind these effects. Our findings suggest that the GABAergic system may play a key role in mediating the anxiolytic benefits of d-pinitol, which indicates a promising direction for further research. It’s important to remember that while our results are encouraging, d-pinitol did not exhibit diuretic effects, which was a secondary focus of the study.
All in all, our study positions d-pinitol as a compelling candidate for alleviating anxiety, with mechanisms worth exploring further for therapeutic applications.
During our study, we observed that when mice were given d-pinitol at doses ranging from 1 to 100 mg/kg, there was notable evidence of anxiolytic-like actions. In particular, at a dose of 70 mg/kg, d-pinitol showed significant effectiveness in reducing anxiety as assessed in specific behavioral tests.
We also investigated the possible mechanisms behind these effects. Our findings suggest that the GABAergic system may play a key role in mediating the anxiolytic benefits of d-pinitol, which indicates a promising direction for further research. It’s important to remember that while our results are encouraging, d-pinitol did not exhibit diuretic effects, which was a secondary focus of the study.
All in all, our study positions d-pinitol as a compelling candidate for alleviating anxiety, with mechanisms worth exploring further for therapeutic applications.
8
We examined user sentiments surrounding treatments for Polycystic Ovary Syndrome (PCOS) through data collected from an extensive subreddit.
Our analysis revealed that lifestyle changes and supplements were viewed positively, while contraceptives often received negative feedback. Notably, inositol was associated with significant improvements in mental health, including reductions in anxiety.
This study highlights the potential of machine learning to analyze patient experiences, offering valuable insights that might complement traditional clinical research.
Our analysis revealed that lifestyle changes and supplements were viewed positively, while contraceptives often received negative feedback. Notably, inositol was associated with significant improvements in mental health, including reductions in anxiety.
This study highlights the potential of machine learning to analyze patient experiences, offering valuable insights that might complement traditional clinical research.
References
- Samad N, Hameed A, Manzoor N, Shoukat S, Irfan A, et al. Antioxidant and neuro-modulatory effects of niacin prevent D-galactose-induced behavioral deficits and memory impairment. Exp Gerontol. 2024;198:112624. 10.1016/j.exger.2024.112624
- Bellagamba O, Guo AJ, Senthilkumar S, Lillevik SH, De Biase D, et al. Assessment of Long-Term Safety and Efficacy of Purple Sweet Potato Color (PSPC) and Myo-Inositol (MI) Treatment for Motor Related and Behavioral Phenotypes in a Mouse Model of Classic Galactosemia. J Inherit Metab Dis. 2025;48:e70002. 10.1002/jimd.70002
- El-Heis S, Barton SJ, Chang HF, Nield H, Cox V, et al. Maternal mood, anxiety and mental health functioning after combined myo-inositol, probiotics, micronutrient supplementation from preconception: Findings from the NiPPeR RCT. Psychiatry Res. 2024;334:115813. 10.1016/j.psychres.2024.115813
- Kishi T, Sakuma K, Iwata N. Mitochondrial modulators for obsessive-compulsive and related disorders: a systematic review and meta-analysis. Transl Psychiatry. 2022;12:263. 10.1038/s41398-022-02026-5
- Herwig E, Classen HL, Walk CL, Bedford M, Schwean-Lardner K. Dietary Inositol Reduces Fearfulness and Avoidance in Laying Hens. Animals (Basel). 2019;9. 10.3390/ani9110938
- Alonso-Castro AJ, Alba-Betancourt C, Rocha-González E, Ruiz-Arredondo A, Zapata-Morales JR, et al. Neuropharmacological effects of d-pinitol and its possible mechanisms of action. J Food Biochem. 2019;43:e13070. 10.1111/jfbc.13070
- Zulfarina MS, Syarifah-Noratiqah SB, Nazrun SA, Sharif R, Naina-Mohamed I. Pharmacological Therapy in Panic Disorder: Current Guidelines and Novel Drugs Discovery for Treatment-resistant Patient. Clin Psychopharmacol Neurosci. 2019;17:145. 10.9758/cpn.2019.17.2.145
- Emanuel RHK, Docherty PD, Lunt H, Campbell RE. What do users in a polycystic ovary syndrome (PCOS) forum think about the treatments they tried: Analysing treatment sentiment using machine learning. Phys Eng Sci Med. 2025. 10.1007/s13246-025-01539-9
