We delved into how elderberry, specifically from the black elderberry fruit, impacts the flu virus, H1N1. Using an innovative technique called Direct Analysis in Real Time Mass Spectrometry (DART TOF-MS), we were able to identify the powerful anti-viral properties of elderberry extract without the need for complicated processes like separation or derivatization.
Our findings revealed that elderberry extract does indeed inhibit H1N1 infection in a lab setting, with an effective concentration (IC50) of 252 micrograms per milliliter. Interestingly, we discovered that flavonoids present in the elderberry bind to H1N1 virions—essentially blocking their ability to infect host cells.
Among the compounds, two key flavonoids emerged: the 5,7,3',4'-tetra-O-methylquercetin and dihydromyricetin. These compounds not only bound to the virus but also effectively prevented infection. Notably, the tetra-O-methylquercetin demonstrated an impressive IC50 of just 0.13 micrograms per milliliter, which is comparable to well-known antiviral medications like Oseltamivir and Amantadine.
In summary, elderberry shows promising potential as a natural remedy against the H1N1 flu, offering a fascinating area for further research and utilization in flu prevention strategies.
Read More
8
Elderberry effective against flu pathogens
Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses.
We aimed to investigate the effectiveness of a standardized elderberry extract against influenza viruses and respiratory bacterial pathogens. The study utilized liquid cultures to examine how various concentrations of the elderberry extract—specifically 5%, 10%, 15%, and 20%—inhibited bacterial growth.
Our findings revealed that the elderberry extract is not just a potential ally against flu viruses, but also demonstrates activity against several harmful bacteria. We specifically tested its effects on both H5N1-type influenza A and influenza B viruses using reputable laboratory methods.
The results suggest that elderberry could offer additional strategies for combating infections, particularly during the flu season when complications often arise from bacterial super-infections following viral illnesses. These findings encourage the exploration of natural products like elderberry as a supportive treatment for respiratory infections.
Read More
7
Elderberry juice boosts immunity
Anti-influenza virus effects of elderberry juice and its fractions.
We evaluated the effectiveness of elderberry juice, specifically concentrated juice (CJ-E), in combating the human influenza A virus (IFV). Our experiments involved administering CJ-E to mice infected with IFV to observe any potential antiviral effects. While we found that CJ-E had a strong impact on the mice, its antiviral action was less impressive when tested in a controlled cell culture environment.
To further assess its effects, we separated CJ-E into different fractions using ultrafiltration and anion-exchange chromatography. We concentrated on the high-molecular-weight fractions of CJ-E, which appeared to significantly suppress viral replication in the mice's bronchoalveolar lavage fluids (BALFs). Moreover, these fractions seemed to boost the production of IFV-specific neutralizing antibodies in the serum, along with increasing secretory IgA levels in BALFs and feces.
Particularly, one fraction, Fr. II from the high-molecular-weight group, which contained acidic polysaccharides, showed notable strength in defending against the flu infection. In conclusion, our findings suggest that CJ-E can stimulate the immune response and may play a preventative role against the influenza virus infection.
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Most Useful Reviews
9
Instant relief noted
26 people found this helpful
This product is incredible! When our family got a cold, I administered two tablespoons immediately, and the coughing stopped instantly. The symptoms became incredibly mild, allowing me to sleep well at night.
Read More
9
Fast flu recovery
15 people found this helpful
I purchased this for its benefits for colds and flu. When I felt flu symptoms coming on, I took a teaspoon every two hours. By the third dose, I was completely better, without any more stuffy nose or fever.
Read More
7.5
Supports immune health
7 people found this helpful
Black elderberry extract in liquid form provides strong support for the immune system, helping my family to stay healthy throughout the year. It offers robust protection and has been recognised for its healing properties in Europe for centuries. Modern studies have proven its efficacy in strengthening the immune system during seasonal illnesses and alleviating symptoms of colds and flu. The high dose in each portion ensures effectiveness, even during acute illness.
We explored how European black elderberry affects the immune response, particularly regarding flu infections. Through comparing its water extract and polysaccharide fractions to a traditional alcoholic extract, we focused on the role of dendritic cells (DCs), which are crucial for triggering strong T cell responses.
Our findings showed that the water extract and its polysaccharide components effectively matured DCs, enhancing their ability to stimulate T cells significantly. In contrast, the traditional alcoholic extract did not demonstrate any capacity to induce T cell stimulation.
We also observed that the water extracts promoted the production of key inflammatory cytokines like IL-6, TNF-α, and IFN-γ, contributing to a robust immune response, which may be beneficial in fighting off viruses like influenza. Thus, it appears that the polysaccharides from elderberry extracts can play a significant role in modulating the immune system, potentially equipping us to better combat viral threats.
Read More
9
Elderberry shows promise for flu relief
Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials.
We assessed the effectiveness of black elderberry (Sambucus nigra) in treating upper respiratory symptoms, particularly those associated with the flu. The study included 180 participants and examined various factors, such as vaccination status and the underlying causes of symptoms.
Our findings indicated that elderberry supplementation significantly reduced upper respiratory symptoms, offering a promising alternative for those seeking relief without relying on over-the-counter medications or antibiotics. The analysis revealed a strong positive impact, suggesting that elderberry could be particularly beneficial for treating symptoms arising from viral infections.
Overall, this research indicates that elderberry can serve as a safer, effective option for managing flu symptoms and common colds. This could help address concerns about antibiotic misuse and provide a more natural remedy during flu season.
Read More
9
Elderberry inhibits H1N1 flu infection
Elderberry flavonoids bind to and prevent H1N1 infection in vitro.
We delved into how elderberry, specifically from the black elderberry fruit, impacts the flu virus, H1N1. Using an innovative technique called Direct Analysis in Real Time Mass Spectrometry (DART TOF-MS), we were able to identify the powerful anti-viral properties of elderberry extract without the need for complicated processes like separation or derivatization.
Our findings revealed that elderberry extract does indeed inhibit H1N1 infection in a lab setting, with an effective concentration (IC50) of 252 micrograms per milliliter. Interestingly, we discovered that flavonoids present in the elderberry bind to H1N1 virions—essentially blocking their ability to infect host cells.
Among the compounds, two key flavonoids emerged: the 5,7,3',4'-tetra-O-methylquercetin and dihydromyricetin. These compounds not only bound to the virus but also effectively prevented infection. Notably, the tetra-O-methylquercetin demonstrated an impressive IC50 of just 0.13 micrograms per milliliter, which is comparable to well-known antiviral medications like Oseltamivir and Amantadine.
In summary, elderberry shows promising potential as a natural remedy against the H1N1 flu, offering a fascinating area for further research and utilization in flu prevention strategies.
Read More
8
Elderberry shows limited flu benefits
Echinacea and elderberry-should they be used against upper respiratory tract infections during pregnancy?
We examined how elderberry might impact flu treatment based on several studies. From 1995 to 2013, three clinical trials looked specifically at different elderberry preparations, and all concluded that elderberry could be effective against influenza. However, it's important to note that these studies involved only 77 people, which is quite small for drawing definitive conclusions.
While the potential for elderberry's effectiveness seems promising, the limited sample size means we should be cautious in making broad claims about its benefits. There were no human or animal studies mentioned that specifically researched the safety of elderberry during pregnancy, presenting a gap in knowledge that is concerning for pregnant women considering herbal treatments for flu.
Overall, while elderberry appears effective against the flu based on the small trials, we need much more comprehensive research to better understand its efficacy and safety, particularly for vulnerable populations like pregnant women.
Read More
8
Elderberry effective against flu pathogens
Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses.
We aimed to investigate the effectiveness of a standardized elderberry extract against influenza viruses and respiratory bacterial pathogens. The study utilized liquid cultures to examine how various concentrations of the elderberry extract—specifically 5%, 10%, 15%, and 20%—inhibited bacterial growth.
Our findings revealed that the elderberry extract is not just a potential ally against flu viruses, but also demonstrates activity against several harmful bacteria. We specifically tested its effects on both H5N1-type influenza A and influenza B viruses using reputable laboratory methods.
The results suggest that elderberry could offer additional strategies for combating infections, particularly during the flu season when complications often arise from bacterial super-infections following viral illnesses. These findings encourage the exploration of natural products like elderberry as a supportive treatment for respiratory infections.
This product is incredible! When our family got a cold, I administered two tablespoons immediately, and the coughing stopped instantly. The symptoms became incredibly mild, allowing me to sleep well at night.
Read More
9
Fast flu recovery
15 people found this helpful
I purchased this for its benefits for colds and flu. When I felt flu symptoms coming on, I took a teaspoon every two hours. By the third dose, I was completely better, without any more stuffy nose or fever.
Read More
7.5
Supports immune health
7 people found this helpful
Black elderberry extract in liquid form provides strong support for the immune system, helping my family to stay healthy throughout the year. It offers robust protection and has been recognised for its healing properties in Europe for centuries. Modern studies have proven its efficacy in strengthening the immune system during seasonal illnesses and alleviating symptoms of colds and flu. The high dose in each portion ensures effectiveness, even during acute illness.
Read More
10
Effective for recovery
6 people found this helpful
This is the best remedy for colds and flu! My 12-year-old had a viral infection with a high temperature. Following the doctor's advice, I gave him a teaspoon three times a day. After two days, his temperature dropped and within four days he was fully recovered. I’m thrilled as we usually avoid antibiotics. Thank you, Iherb! I will definitely order again!
Read More
9
Immunity success
4 people found this helpful
This is the best elderberry syrup I've tried! We all take a half teaspoon daily and a tablespoon if anyone around us is sick. We’ve been free from cold, flu, and other bugs for over four years!
The flu, short for influenza, is a contagious respiratory illness caused by influenza viruses. It affects the nose, throat, and sometimes the lungs, leading to a range of symptoms that can vary in severity. Common symptoms include fever, chills, muscle aches, cough, congestion, runny nose, headaches, and fatigue. The flu can lead to serious complications, particularly in vulnerable populations such as young children, the elderly, pregnant women, and those with underlying health conditions.
The flu virus spreads primarily through respiratory droplets when an infected person coughs, sneezes, or talks. It can also be transmitted by touching surfaces contaminated with the virus and then touching one's face. Vaccination is the most effective way to prevent the flu, and the vaccine is typically updated annually to provide protection against the most common circulating strains. In addition to vaccination, practicing good hygiene, such as frequent handwashing and respiratory etiquette, can help minimize the risk of infection.
Elderberry (Sambucus) refers to a genus of flowering plants in the family Adoxaceae, comprising several species known for their small berries and traditional medicinal uses. The most commonly recognized species is the European elder, Sambucus nigra, which has been utilized in folk medicine for centuries due to its rich nutrient profile, including antioxidants, vitamins A and C, and dietary fiber. Elderberries are typically fragrant clusters of small, dark purple to black berries that are used in a variety of culinary applications, such as jams, syrups, and wine.
In recent years, elderberry has gained popularity for its potential health benefits, particularly for supporting immune health. Many people consume elderberry supplements or syrups to help alleviate symptoms of colds and flu, with some studies suggesting they may reduce the duration and severity of viral infections. However, it’s important to note that raw elderberries, as well as other parts of the elderberry plant, can be toxic if consumed in large amounts. Therefore, it's recommended to use elderberry products that are properly processed and prepared to ensure safety and efficacy.
Sambucus elderberry is often touted as a natural remedy for flu and cold symptoms. Some studies suggest that elderberry extract may help reduce the duration and severity of flu symptoms by enhancing immune response and inhibiting the replication of certain strains of the influenza virus. The compounds in elderberry, such as flavonoids and phenolic acids, are believed to have anti-inflammatory and antioxidant properties, which can support your immune system during bouts of illness.
However, while elderberry may offer some benefits, it should not be relied upon as a substitute for medical treatment or preventive measures such as vaccinations. It's essential to consult with a healthcare professional for appropriate advice, particularly for managing flu symptoms or for individuals with underlying health conditions. Always choose a high-quality elderberry product and follow the recommended dosages for safety and efficacy.
Based on user reviews, those taking this elderberry supplement for flu symptoms generally report noticeable improvements within a few days. For instance, one user noted that after giving their child the supplement for two days, their temperature dropped and they were fully recovered after four days Read Review. Another user shared their experience with a 7-year-old, stating that after starting the supplement on the second day of illness, their child was back to normal within four days Read Review.
Others have highlighted the importance of early administration, reporting that taking the supplement at the first signs of illness significantly contributed to quicker recovery times. A user emphasized that when they started taking the product at the earliest signs of sickness, they felt better in just a few days Read Review. Overall, while individual results may vary, many users suggest that starting the supplement quickly can lead to faster recovery from the flu.
The use of elderberry as a supplement for flu prevention and treatment has garnered attention in recent scientific studies. Research indicates that elderberry can potentially enhance the immune response against influenza viruses. For instance, a study demonstrated that the water extract and polysaccharides from elderberry significantly matured dendritic cells, improving their ability to stimulate T cell responses, which is crucial for fighting off infections like influenza [1]. Another comprehensive review of existing clinical trials concluded that elderberry supplementation could reduce the duration and severity of flu symptoms, providing a promising alternative for symptom management without relying solely on over-the-counter medications [2].
Further investigations have revealed that elderberry exhibits antiviral effects by inhibiting viral replication, particularly against strains such as H1N1 and others in laboratory settings [8]. These findings suggest that elderberry could not only serve as a supportive treatment for flu symptoms but may also play a preventative role by enhancing immune responses. While the overall evidence seems promising, researchers emphasize the need for larger studies to solidify these benefits and better understand the optimal dosages for effective use during flu season.
Based on user reviews, many individuals report significant improvements in their symptoms when using elderberry liquid, particularly for colds and flu. For example, one user shared that their child's high fever dropped after taking the supplement for just two days, leading to a full recovery within four days Read Review. Another parent found similar results, stating that starting the supplement at the first signs of illness was key, with their child returning to normal in a similarly short period Read Review.
Furthermore, several users emphasized the importance of early administration, noting that taking the elderberry syrup at the onset of cold or flu symptoms consistently resulted in quicker recovery times. One user remarked that they had not gotten sick while using the product regularly, attributing their immune boost to its use Read Review. Others reported feelings of improvement within days, suggesting the product effectively supports the immune system and reduces the severity of symptoms when they do occur Read Review. Overall, while experiences can differ from person to person, the strong anecdotal evidence highlights the potential benefits of elderberry syrup in managing seasonal illnesses.
Based on user reviews, many individuals combine this elderberry supplement with other complementary supplements to enhance their effectiveness against colds and flu. For instance, one user reported taking elderberry alongside vitamin C and echinacea right at the onset of symptoms, which resulted in impressive recovery without any fever or complications, indicating a strong synergistic effect Read Review. Another user mentioned using elderberry in conjunction with a high-protein drink, noting that this combination kept them healthy and possibly avoided illnesses entirely Read Review.
Additionally, some users also reported on the overall boosting effects of taking the elderberry liquid daily to maintain health during flu season, further supporting its role in a preventative regimen Read Review. These accounts suggest that many see this elderberry supplement as an integral part of a holistic approach to managing flu and sniffles, often pairing it with other immune-supporting products to maximize benefits during peak illness periods.
The optimal dosage of Elderberry sambucus for treating influenza is not definitively established due to variations in study methodologies, but research indicates that higher concentrations show more significant antiviral effects. A study highlighted that concentrations of 40 to 80 μg/mL of elderberry extract significantly reduced viral activity and the production of viral proteins, suggesting that it interferes with the influenza virus's ability to infect cells [4]. Another study found that elderberry extract displayed effectiveness in lab conditions at an IC50 of 252 micrograms per milliliter against the H1N1 virus, illustrating its potential in combating flu infections [8].
While elderberry is recognized for its immune-boosting properties, studies frequently point out the need for further research to ascertain precise and effective dosing guidelines. Current findings suggest that while elderberry extracts can alleviate flu symptoms and may shorten illness duration, specific optimal dosages are still under investigation to offer clearer recommendations [2]. For individuals considering elderberry for flu treatment, aiming for concentrated extracts, and following product-specific guidelines is advisable until comprehensive dosing standards are established.
10
Effective for recovery
6 people found this helpful
This is the best remedy for colds and flu! My 12-year-old had a viral infection with a high temperature. Following the doctor's advice, I gave him a teaspoon three times a day. After two days, his temperature dropped and within four days he was fully recovered. I’m thrilled as we usually avoid antibiotics. Thank you, Iherb! I will definitely order again!
10
Rapid flu recovery
1 people found this helpful
This is the best cold and flu remedy of its kind! A 7-year-old child fell ill with a temperature of 39 degrees for 2 days. The doctor diagnosed a viral infection. I followed the instructions and gave a teaspoon three times a day from the second day. The temperature dropped first to 37.5, and after 2 days she was back to normal. She didn’t take anything else! On the fourth day, my son fully recovered with no signs of a cold. I am delighted and a bit shocked! Usually, we couldn’t do without antibiotics in such cases. I will definitely order again!
7.5
Rapid chest recovery
Over the years, this brand has helped me immensely whenever I felt something settling in my chest from a cold or flu. In just days, I felt so much better.
9
Increased resistance
1 people found this helpful
I love this product! I have been using Elderberry for quite a while, and I’ve never felt better. I have not had any illnesses. I take it with a high-protein drink, and they work well together. My daughters use it too. I'm so glad to have discovered it; it has been a blessing for me. While everyone around me caught the flu, I thankfully did not, and I believe it has built up my resistance to illnesses.
9
Accelerates recovery
I drink it myself and give it to the children at the first sign of the flu; it certainly helps them recover faster.
9
Effective for children
I give it to children as soon as the first symptoms appear, along with vitamin C and echinacea. The result is impressive. A couple of days of snot, and we’re back on track. No fever or complications at all! 👍
7.5
Avoided seasonal illnesses
1 people found this helpful
When everyone was sold out, iHerb came through! I started using Now's elderberry liquid at the beginning of cold and flu season, and it has become a staple in my wellness toolkit. When I went to repurchase it from the Now website, it was sold out everywhere. Fortunately, iHerb had a few bottles left, so I was able to get it when I needed it. Though I can't say for certain, I believe that drinking about a teaspoon of this syrup (mixed in water) daily has helped me avoid seasonal illnesses completely and has sped up my recovery from those I have contracted. A great product!
9
Elderberry enhances immune response
Polysaccharides from European Black Elderberry Extract Enhance Dendritic Cell Mediated T Cell Immune Responses.
We explored how European black elderberry affects the immune response, particularly regarding flu infections. Through comparing its water extract and polysaccharide fractions to a traditional alcoholic extract, we focused on the role of dendritic cells (DCs), which are crucial for triggering strong T cell responses.
Our findings showed that the water extract and its polysaccharide components effectively matured DCs, enhancing their ability to stimulate T cells significantly. In contrast, the traditional alcoholic extract did not demonstrate any capacity to induce T cell stimulation.
We also observed that the water extracts promoted the production of key inflammatory cytokines like IL-6, TNF-α, and IFN-γ, contributing to a robust immune response, which may be beneficial in fighting off viruses like influenza. Thus, it appears that the polysaccharides from elderberry extracts can play a significant role in modulating the immune system, potentially equipping us to better combat viral threats.
5
Elderberry’s uncertain flu benefits
Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review.
We explored the effectiveness of elderberry in treating and potentially preventing flu-related illness. This involved a systematic review of five randomized trials, which helped us examine whether elderberry could play a beneficial role in combatting viruses like the flu.
The findings suggest that while elderberry might not lower the risk of catching the common cold, it could potentially reduce the duration and severity of cold symptoms. We learned that elderberry may also shorten the duration of influenza, but the certainty of these benefits is still uncertain.
Interestingly, when comparing elderberry to oseltamivir, a common antiviral medication, elderberry appeared linked to a lower risk of influenza complications and side effects. However, we found no substantial evidence connecting elderberry to significant inflammatory outcomes. Some studies hinted that elderberry might influence certain inflammatory markers, but this effect may lessen with prolonged use.
Overall, we did not find strong, clear-cut benefits from elderberry in treating flu, stressing the need for more research to confirm these findings. Though it seems to be a safe option without overstimulating the immune system, the evidence remains inconclusive, and more studies are essential to draw firmer conclusions.
9
Elderberry inhibits H1N1 flu infection
Elderberry flavonoids bind to and prevent H1N1 infection in vitro.
We delved into how elderberry, specifically from the black elderberry fruit, impacts the flu virus, H1N1. Using an innovative technique called Direct Analysis in Real Time Mass Spectrometry (DART TOF-MS), we were able to identify the powerful anti-viral properties of elderberry extract without the need for complicated processes like separation or derivatization.
Our findings revealed that elderberry extract does indeed inhibit H1N1 infection in a lab setting, with an effective concentration (IC50) of 252 micrograms per milliliter. Interestingly, we discovered that flavonoids present in the elderberry bind to H1N1 virions—essentially blocking their ability to infect host cells.
Among the compounds, two key flavonoids emerged: the 5,7,3',4'-tetra-O-methylquercetin and dihydromyricetin. These compounds not only bound to the virus but also effectively prevented infection. Notably, the tetra-O-methylquercetin demonstrated an impressive IC50 of just 0.13 micrograms per milliliter, which is comparable to well-known antiviral medications like Oseltamivir and Amantadine.
In summary, elderberry shows promising potential as a natural remedy against the H1N1 flu, offering a fascinating area for further research and utilization in flu prevention strategies.
7
Elderberry's variable effectiveness against influenza
Interfering With Lipid Raft Association: A Mechanism to Control Influenza Virus Infection By .
We investigated the effects of elderberry fruit on flu viruses, specifically how it interacts with the H9N2 influenza strain in human epithelial cell cultures. Our approach involved treating the virus and cells with various concentrations of elderberry extract before and after infection to see its influence on virus replication.
During our experiments, we noticed that at lower doses of elderberry extract, the viral activity actually increased. This indicated that the herb didn’t stop the virus from replicating. However, when we applied higher concentrations—specifically 40 and 80 μg/mL—we observed a significant reduction in both the amount of virus present and the production of viral proteins. This suggests elderberry may interfere with how viruses enter cells or how they release from them.
Importantly, the results hint that elderberry's effectiveness might stem from its interaction with lipid rafts in cell membranes. These rafts are crucial for the viruses' fusion and budding processes. Our findings underscore the importance of dosage and timing when using elderberry for treating influenza, highlighting the complexity of herbal treatments.
References
Stich L, Plattner S, McDougall G, Austin C, Steinkasserer A. Polysaccharides from European Black Elderberry Extract Enhance Dendritic Cell Mediated T Cell Immune Responses. Int J Mol Sci. 2022;23. doi:10.3390/ijms23073949
Wieland LS, Piechotta V, Feinberg T, Ludeman E, Hutton B, et al. Elderberry for prevention and treatment of viral respiratory illnesses: a systematic review. BMC Complement Med Ther. 2021;21:112. doi:10.1186/s12906-021-03283-5
Hawkins J, Baker C, Cherry L, Dunne E. Black elderberry (Sambucus nigra) supplementation effectively treats upper respiratory symptoms: A meta-analysis of randomized, controlled clinical trials. Complement Ther Med. 2019;42:361. doi:10.1016/j.ctim.2018.12.004
Shahsavandi S, Ebrahimi MM, Hasaninejad Farahani A. Interfering With Lipid Raft Association: A Mechanism to Control Influenza Virus Infection By . Iran J Pharm Res. 2017;16:1147.
Holst L, Havnen GC, Nordeng H. Echinacea and elderberry-should they be used against upper respiratory tract infections during pregnancy?. Front Pharmacol. 2014;5:31. doi:10.3389/fphar.2014.00031
Kinoshita E, Hayashi K, Katayama H, Hayashi T, Obata A. Anti-influenza virus effects of elderberry juice and its fractions. Biosci Biotechnol Biochem. 2012;76:1633.
Krawitz C, Mraheil MA, Stein M, Imirzalioglu C, Domann E, et al. Inhibitory activity of a standardized elderberry liquid extract against clinically-relevant human respiratory bacterial pathogens and influenza A and B viruses. BMC Complement Altern Med. 2011;11:16. doi:10.1186/1472-6882-11-16
Roschek B, Fink RC, McMichael MD, Li D, Alberte RS. Elderberry flavonoids bind to and prevent H1N1 infection in vitro. Phytochemistry. 2009;70:1255. doi:10.1016/j.phytochem.2009.06.003