We explored the relationship between neudesin, a protein linked to brain health and energy regulation, and congenital hypothyroidism (CH). In a study involving 52 patients—32 with CH and 20 healthy controls—we examined the neudesin levels before and after treatment with l-thyroxine, a common medication for hypothyroidism.
Initially, we found that the neudesin levels in patients with CH were not significantly different from those in the control group, with averages of 6.77 ng/mL compared to 7.93 ng/mL. However, after one month of l-thyroxine treatment, neudesin levels showed a notable increase in the CH group, reaching an average of 12.85 ng/mL. This change was statistically significant, providing some insight into how protein levels can respond to thyroid hormone treatment.
While neudesin levels rose with therapy, more research is needed to fully understand the role of this protein in brain development and its implications for patients with congenital hypothyroidism. Our findings suggest that while neudesin itself may not differ at baseline, it could play a part in the recovery process, warranting further exploration.
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