Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7
USERS' SCORE
Good
Based on 4 Reviews
8.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Glutathione (Reduced Form)
500 mg
**
Milk Thistle Extract (Silybum marianum) (Fruit/Seeds) (Standardized to 80 mg Silymarin Flavonoids - equivalent 80%)
100 mg
**
Alpha Lipoic Acid
50 mg
**
Top Medical Research Studies
8
Silibinin shows promise for anxiety
We explored how silibinin, a compound from the Silybum marianum plant, might alleviate anxiety and depression in a mouse model of Parkinson's disease. Using various behavioral tests, we found that silibinin treatment significantly reduced anxiety-like behaviors while also improving the condition of hippocampal neurons.
Additionally, it restored levels of key mood-regulating neurotransmitters. By lowering markers of neuroinflammation, silibinin showed promise as a potential treatment for anxiety and depression associated with Parkinson's disease.
Additionally, it restored levels of key mood-regulating neurotransmitters. By lowering markers of neuroinflammation, silibinin showed promise as a potential treatment for anxiety and depression associated with Parkinson's disease.
Read More
8
We investigated the effects of silibinin, a compound from milk thistle, on anxiety and depression-like behavior in rats exposed to amyloid beta. The findings were promising, showing that silibinin significantly reduced anxiety and depression symptoms in various behavioral tests.
Additionally, it was effective in minimizing brain damage associated with these conditions. The treatment appears to work by enhancing the BDNF/TrkB pathway and reducing autophagy in the hippocampus, suggesting a multifaceted role in improving mental health.
Additionally, it was effective in minimizing brain damage associated with these conditions. The treatment appears to work by enhancing the BDNF/TrkB pathway and reducing autophagy in the hippocampus, suggesting a multifaceted role in improving mental health.
Read More
8
Our study aimed to determine whether silibinin and naringenin, two flavonoids, could reduce anxiety caused by acute stress using a zebrafish model.
We assessed their effects through behavioral tests, noting that the treated zebrafish showed increased exploration in the upper and well-lit areas of their tanks compared to the control group.
The results suggest that these flavonoids may have potential as therapeutic agents for anxiety with their significant anxiolytic properties.
We assessed their effects through behavioral tests, noting that the treated zebrafish showed increased exploration in the upper and well-lit areas of their tanks compared to the control group.
The results suggest that these flavonoids may have potential as therapeutic agents for anxiety with their significant anxiolytic properties.
Read More
Most Useful Reviews
9
Reduced anxiety symptoms
4 people found this helpful
This DIM product combined with vitex is incredible for premenstrual syndrome. Just 13 days into this cycle, I've observed a marked decrease in mood swings and anxiety. I take 2 DIM capsules and 3 VITEX capsules, plus glutathione to detox my kidneys and eliminate hormones. IT HAS CHANGED MY LIFE.
Read More
9
Effective for anxiety
The anti-anxiety glutathione is a lifesaver for me; it effectively reduces my anxiety and provides stress relief. I always pair it with vitamin C, and it works wonders, benefiting both my skin and mental health. I continue to buy more and recommend it to my friends. 🥰
Read More
7.5
Life-changing improvement
101 people found this helpful
I began taking this vitamin about a month ago and have noticed a significant improvement in my overall health. I've experienced considerably less stress, increased energy, and an uplift in my mood. As someone who has suffered from mild depression and anxiety for many years, these changes have been transformative for me.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7
- All Researches
8
Our study aimed to determine whether silibinin and naringenin, two flavonoids, could reduce anxiety caused by acute stress using a zebrafish model.
We assessed their effects through behavioral tests, noting that the treated zebrafish showed increased exploration in the upper and well-lit areas of their tanks compared to the control group.
The results suggest that these flavonoids may have potential as therapeutic agents for anxiety with their significant anxiolytic properties.
We assessed their effects through behavioral tests, noting that the treated zebrafish showed increased exploration in the upper and well-lit areas of their tanks compared to the control group.
The results suggest that these flavonoids may have potential as therapeutic agents for anxiety with their significant anxiolytic properties.
Read More
8
Silibinin shows promise for anxiety
We explored how silibinin, a compound from the Silybum marianum plant, might alleviate anxiety and depression in a mouse model of Parkinson's disease. Using various behavioral tests, we found that silibinin treatment significantly reduced anxiety-like behaviors while also improving the condition of hippocampal neurons.
Additionally, it restored levels of key mood-regulating neurotransmitters. By lowering markers of neuroinflammation, silibinin showed promise as a potential treatment for anxiety and depression associated with Parkinson's disease.
Additionally, it restored levels of key mood-regulating neurotransmitters. By lowering markers of neuroinflammation, silibinin showed promise as a potential treatment for anxiety and depression associated with Parkinson's disease.
Read More
8
We investigated the effects of silibinin, a compound from milk thistle, on anxiety and depression-like behavior in rats exposed to amyloid beta. The findings were promising, showing that silibinin significantly reduced anxiety and depression symptoms in various behavioral tests.
Additionally, it was effective in minimizing brain damage associated with these conditions. The treatment appears to work by enhancing the BDNF/TrkB pathway and reducing autophagy in the hippocampus, suggesting a multifaceted role in improving mental health.
Additionally, it was effective in minimizing brain damage associated with these conditions. The treatment appears to work by enhancing the BDNF/TrkB pathway and reducing autophagy in the hippocampus, suggesting a multifaceted role in improving mental health.
Read More
4
We delved into the effects of silybum marianum, among other herbs, on anxiety disorders based on a thorough review of clinical studies.
Our findings suggest that silybum marianum, along with several other plant-based remedies, has shown potential for alleviating anxiety when used over extended periods.
However, we must note that conclusions should be taken cautiously due to some study limitations, including small sample sizes and short treatment durations.
Overall, while there is some support for silybum marianum's effectiveness, further rigorous research is necessary to confirm its benefits for anxiety.
Our findings suggest that silybum marianum, along with several other plant-based remedies, has shown potential for alleviating anxiety when used over extended periods.
However, we must note that conclusions should be taken cautiously due to some study limitations, including small sample sizes and short treatment durations.
Overall, while there is some support for silybum marianum's effectiveness, further rigorous research is necessary to confirm its benefits for anxiety.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced anxiety symptoms
4 people found this helpful
This DIM product combined with vitex is incredible for premenstrual syndrome. Just 13 days into this cycle, I've observed a marked decrease in mood swings and anxiety. I take 2 DIM capsules and 3 VITEX capsules, plus glutathione to detox my kidneys and eliminate hormones. IT HAS CHANGED MY LIFE.
Read More
9
Effective for anxiety
The anti-anxiety glutathione is a lifesaver for me; it effectively reduces my anxiety and provides stress relief. I always pair it with vitamin C, and it works wonders, benefiting both my skin and mental health. I continue to buy more and recommend it to my friends. 🥰
Read More
7.5
Life-changing improvement
101 people found this helpful
I began taking this vitamin about a month ago and have noticed a significant improvement in my overall health. I've experienced considerably less stress, increased energy, and an uplift in my mood. As someone who has suffered from mild depression and anxiety for many years, these changes have been transformative for me.
Read More
7.5
Helps with anxiety
I love how this product aids my anxiety and boosts my energy.
Read More
Frequently Asked Questions
9
Reduced anxiety symptoms
4 people found this helpful
This DIM product combined with vitex is incredible for premenstrual syndrome. Just 13 days into this cycle, I've observed a marked decrease in mood swings and anxiety. I take 2 DIM capsules and 3 VITEX capsules, plus glutathione to detox my kidneys and eliminate hormones. IT HAS CHANGED MY LIFE.
7.5
Life-changing improvement
101 people found this helpful
I began taking this vitamin about a month ago and have noticed a significant improvement in my overall health. I've experienced considerably less stress, increased energy, and an uplift in my mood. As someone who has suffered from mild depression and anxiety for many years, these changes have been transformative for me.
9
Effective for anxiety
The anti-anxiety glutathione is a lifesaver for me; it effectively reduces my anxiety and provides stress relief. I always pair it with vitamin C, and it works wonders, benefiting both my skin and mental health. I continue to buy more and recommend it to my friends. 🥰
7.5
Helps with anxiety
I love how this product aids my anxiety and boosts my energy.
8
Silibinin shows promise for anxiety
We explored how silibinin, a compound from the Silybum marianum plant, might alleviate anxiety and depression in a mouse model of Parkinson's disease. Using various behavioral tests, we found that silibinin treatment significantly reduced anxiety-like behaviors while also improving the condition of hippocampal neurons.
Additionally, it restored levels of key mood-regulating neurotransmitters. By lowering markers of neuroinflammation, silibinin showed promise as a potential treatment for anxiety and depression associated with Parkinson's disease.
Additionally, it restored levels of key mood-regulating neurotransmitters. By lowering markers of neuroinflammation, silibinin showed promise as a potential treatment for anxiety and depression associated with Parkinson's disease.
8
We investigated the effects of silibinin, a compound from milk thistle, on anxiety and depression-like behavior in rats exposed to amyloid beta. The findings were promising, showing that silibinin significantly reduced anxiety and depression symptoms in various behavioral tests.
Additionally, it was effective in minimizing brain damage associated with these conditions. The treatment appears to work by enhancing the BDNF/TrkB pathway and reducing autophagy in the hippocampus, suggesting a multifaceted role in improving mental health.
Additionally, it was effective in minimizing brain damage associated with these conditions. The treatment appears to work by enhancing the BDNF/TrkB pathway and reducing autophagy in the hippocampus, suggesting a multifaceted role in improving mental health.
4
We delved into the effects of silybum marianum, among other herbs, on anxiety disorders based on a thorough review of clinical studies.
Our findings suggest that silybum marianum, along with several other plant-based remedies, has shown potential for alleviating anxiety when used over extended periods.
However, we must note that conclusions should be taken cautiously due to some study limitations, including small sample sizes and short treatment durations.
Overall, while there is some support for silybum marianum's effectiveness, further rigorous research is necessary to confirm its benefits for anxiety.
Our findings suggest that silybum marianum, along with several other plant-based remedies, has shown potential for alleviating anxiety when used over extended periods.
However, we must note that conclusions should be taken cautiously due to some study limitations, including small sample sizes and short treatment durations.
Overall, while there is some support for silybum marianum's effectiveness, further rigorous research is necessary to confirm its benefits for anxiety.
References
- Nachammai V, Jeyabalan S, Muthusamy S. Anxiolytic effects of silibinin and naringenin on zebrafish model: A preclinical study. Indian J Pharmacol. 2021;53:457. doi:10.4103/ijp.IJP_18_20
- Liu X, Chen W, Wang C, Liu W, Hayashi T, et al. Silibinin ameliorates depression/anxiety-like behaviors of Parkinson's disease mouse model and is associated with attenuated STING-IRF3-IFN-β pathway activation and neuroinflammation. Physiol Behav. 2021;241:113593. doi:10.1016/j.physbeh.2021.113593
- Song X, Liu B, Cui L, Zhou B, Liu W, et al. Silibinin ameliorates anxiety/depression-like behaviors in amyloid β-treated rats by upregulating BDNF/TrkB pathway and attenuating autophagy in hippocampus. Physiol Behav. 2017;179:487. doi:10.1016/j.physbeh.2017.07.023
- Sarris J, McIntyre E, Camfield DA. Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence. CNS Drugs. 2013;27:301. doi:10.1007/s40263-013-0059-9
