Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.8
USERS' SCORE
Good
Based on 12 Reviews
8.1
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Glutathione (Reduced Form)
500 mg
**
Milk Thistle Extract (Silybum marianum) (Fruit/Seeds) (Standardized to 80 mg Silymarin Flavonoids - equivalent 80%)
100 mg
**
Alpha Lipoic Acid
50 mg
**
Top Medical Research Studies
9
We aimed to uncover how silibinin, a compound from milk thistle, impacts cancer, specifically in adenoid cystic carcinoma cells and Balb/c nude mice. The study identified 75 key targets linked to tumor growth and showcased that silibinin significantly reduced cell viability, proliferation, and migration.
Additionally, it induced cancer cell death and inhibited tumor growth in live subjects. Our findings highlighted how silibinin acts on specific proteins affecting cancer pathways, offering valuable insights into its potential as an anti-tumor treatment.
Additionally, it induced cancer cell death and inhibited tumor growth in live subjects. Our findings highlighted how silibinin acts on specific proteins affecting cancer pathways, offering valuable insights into its potential as an anti-tumor treatment.
Read More
8
We explored the impact of silymarin, a compound from Silybum marianum, on SPC212 human mesothelioma cells. Through a series of laboratory tests, we observed that silymarin exhibits a dose-dependent cytotoxic effect, with notable markers of apoptosis like cell shrinkage and nuclear changes. Although silymarin shows promise in inducing cell death in cancer cells, further research is needed to fully understand its potential as a cancer treatment.
Read More
7
We explored the effects of Silybum marianum on nerve damage caused by the chemotherapy drug cisplatin in cancer patients. In a double-blind study involving 60 participants, we divided them into two groups: one receiving Silybum and the other a placebo.
Our findings revealed that those treated with Silybum experienced a significant reduction in symptoms of peripheral neuropathy compared to those who received the placebo. This suggests that Silybum marianum may offer relief for patients dealing with the harsh side effects of chemotherapy.
Our findings revealed that those treated with Silybum experienced a significant reduction in symptoms of peripheral neuropathy compared to those who received the placebo. This suggests that Silybum marianum may offer relief for patients dealing with the harsh side effects of chemotherapy.
Read More
Most Useful Reviews
9
Aid after chemotherapy
This powerful antioxidant is found naturally in fruits and vegetables and produced by the body. As a cancer patient, I use this product following my chemotherapy and radiation treatments to facilitate quicker recovery and detox.
Read More
7.5
Body detoxification
8 people found this helpful
Glutathione is a naturally occurring substance in our bodies, composed of amino acids. It detoxifies the liver of harmful chemicals, pollutants, toxins, and drugs. If overburdened with toxins, glutathione processing becomes insufficient, leading to increased disease susceptibility, including cancer and Parkinson's. Thus, nourishing the body from the outside is vital; this supplement performs excellently.
Read More
9
Health protection
2 people found this helpful
A magic supplement for health! Glutathione, made up of amino acids, combats oxidative stress, slows ageing, protects against cancer, reduces inflammation, and maintains liver and kidney health. Thanks to IHerb for this wonderful health supplement!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 19 Researches
7.8
- All Researches
9.5
We explored how nitric oxide gas donors can boost radiotherapy effectiveness in lung cancer patients resistant to treatment. These donors, specifically designed into SAB-NO nanoparticles, help counteract the protective mechanisms like PD-L1 and COX-2 that allow tumors to evade damage from radiation.
By generating more DNA damage and reversing tumor hypoxia, this innovative approach transforms resistant tumors into more vulnerable targets for treatment. Overall, we found that this combination therapy could significantly suppress lung tumor growth, demonstrating a promising new strategy for overcoming resistance in cancer treatment.
By generating more DNA damage and reversing tumor hypoxia, this innovative approach transforms resistant tumors into more vulnerable targets for treatment. Overall, we found that this combination therapy could significantly suppress lung tumor growth, demonstrating a promising new strategy for overcoming resistance in cancer treatment.
Read More
9
We aimed to uncover how silibinin, a compound from milk thistle, impacts cancer, specifically in adenoid cystic carcinoma cells and Balb/c nude mice. The study identified 75 key targets linked to tumor growth and showcased that silibinin significantly reduced cell viability, proliferation, and migration.
Additionally, it induced cancer cell death and inhibited tumor growth in live subjects. Our findings highlighted how silibinin acts on specific proteins affecting cancer pathways, offering valuable insights into its potential as an anti-tumor treatment.
Additionally, it induced cancer cell death and inhibited tumor growth in live subjects. Our findings highlighted how silibinin acts on specific proteins affecting cancer pathways, offering valuable insights into its potential as an anti-tumor treatment.
Read More
9
We investigated how grape seed procyanidin extract (GSE) and milk thistle silymarin extract (MTE) work together to combat lung cancer. Our study involved cell line experiments, along with testing on mice to see how these extracts affect tumor growth.
The results showed that GSE and MTE not only slowed down cancer cell growth but also worked better together. They boosted the levels of specific tumor suppressors, which play a key role in their effectiveness. Overall, this combination appears promising for lung cancer treatment.
The results showed that GSE and MTE not only slowed down cancer cell growth but also worked better together. They boosted the levels of specific tumor suppressors, which play a key role in their effectiveness. Overall, this combination appears promising for lung cancer treatment.
Read More
9
We conducted a thorough analysis to determine how alpha-lipoic acid, in combination with other supplements, affects early complications like edema and seroma following breast-conserving surgery (BCS). Our study was structured as a double-blind, randomized, placebo-controlled trial involving 114 participants over a span of three years.
Participants were divided into three groups, with one group receiving a mix of Casperome™-Boswellia Phytosome and bromelain along with alpha-lipoic acid, while the other groups received either bromelain with a placebo or just a placebo. Over a period of 30 days, we gathered data on the effectiveness of these treatments.
Our findings revealed that the combination of bromelain and alpha-lipoic acid significantly reduced the incidence of edema and seroma compared to the placebo. Specifically, after one month, we observed marked improvements in patients who received the active treatment. This research highlights the potential therapeutic benefits of alpha-lipoic acid, especially when used with other agents, in managing early complications that can follow breast surgery. Although it’s important to note that the specific isolating effects of alpha-lipoic acid on its own were challenging to determine, the results offer a promising glimpse into its use in surgical recovery.
Participants were divided into three groups, with one group receiving a mix of Casperome™-Boswellia Phytosome and bromelain along with alpha-lipoic acid, while the other groups received either bromelain with a placebo or just a placebo. Over a period of 30 days, we gathered data on the effectiveness of these treatments.
Our findings revealed that the combination of bromelain and alpha-lipoic acid significantly reduced the incidence of edema and seroma compared to the placebo. Specifically, after one month, we observed marked improvements in patients who received the active treatment. This research highlights the potential therapeutic benefits of alpha-lipoic acid, especially when used with other agents, in managing early complications that can follow breast surgery. Although it’s important to note that the specific isolating effects of alpha-lipoic acid on its own were challenging to determine, the results offer a promising glimpse into its use in surgical recovery.
Read More
8
We explored a novel approach to enhance cuproptosis, a new kind of cancer cell death driven by copper ions. By using an engineered nanoplatform that delivers copper in conjunction with elesclomol and glucose oxidase, we found significant improvements in targeting cancer cells.
This strategy increases copper influx while reducing its efflux, leading to effective tumor suppression in mice without harmful side effects. Overall, our findings suggest a promising route for developing better cancer therapies through copper metabolism regulation.
This strategy increases copper influx while reducing its efflux, leading to effective tumor suppression in mice without harmful side effects. Overall, our findings suggest a promising route for developing better cancer therapies through copper metabolism regulation.
Read More
User Reviews
USERS' SCORE
Good
Based on 12 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
9
Aid after chemotherapy
This powerful antioxidant is found naturally in fruits and vegetables and produced by the body. As a cancer patient, I use this product following my chemotherapy and radiation treatments to facilitate quicker recovery and detox.
Read More
7.5
Body detoxification
8 people found this helpful
Glutathione is a naturally occurring substance in our bodies, composed of amino acids. It detoxifies the liver of harmful chemicals, pollutants, toxins, and drugs. If overburdened with toxins, glutathione processing becomes insufficient, leading to increased disease susceptibility, including cancer and Parkinson's. Thus, nourishing the body from the outside is vital; this supplement performs excellently.
Read More
9
Health protection
2 people found this helpful
A magic supplement for health! Glutathione, made up of amino acids, combats oxidative stress, slows ageing, protects against cancer, reduces inflammation, and maintains liver and kidney health. Thanks to IHerb for this wonderful health supplement!
Read More
9
Cancer prevention
1 people found this helpful
500mg is best! The cost-performance is not great at 750mg, while 100mg offers minimal effect; hence, 500mg is ideal. My husband and I take it for cancer prevention and to strengthen our throat's mucous membrane due to susceptibility to colds. I prefer it for its cost-effectiveness over other brands.
Read More
9
Master antioxidant details
Glutathione is known as the "master antioxidant" and serves as an excellent protective agent against cancer and other illnesses. I include it in my comprehensive treatment and take it at night, appreciating its effectiveness. Highly recommend.
Read More
Frequently Asked Questions
9
Aid after chemotherapy
This powerful antioxidant is found naturally in fruits and vegetables and produced by the body. As a cancer patient, I use this product following my chemotherapy and radiation treatments to facilitate quicker recovery and detox.
9
Master antioxidant details
Glutathione is known as the "master antioxidant" and serves as an excellent protective agent against cancer and other illnesses. I include it in my comprehensive treatment and take it at night, appreciating its effectiveness. Highly recommend.
9
Health protection
2 people found this helpful
A magic supplement for health! Glutathione, made up of amino acids, combats oxidative stress, slows ageing, protects against cancer, reduces inflammation, and maintains liver and kidney health. Thanks to IHerb for this wonderful health supplement!
6
Supports liver health
A nutritional supplement beneficial for liver health, acting as an antioxidant and anticancer agent. It eliminates free radicals that harm body cells and promotes skin elasticity.
7.5
Prevents cancer effectively
8 people found this helpful
Excellent glutathione supplement with milk thistle extract and alpha-lipoic acid. It comprises three essential amino acids, acting as one of the most significant antioxidants that combat free radicals, helping to maintain skin health and improve heart and blood vessel health. It is beneficial for individuals with autism, immune disorders, and colon infections. Additionally, it prevents cancer and aids memory preservation. Suitable for adults, its high quality is vegetarian and non-GMO, providing a two-month supply, and its taste does not induce acidity.
7.5
Body detoxification
8 people found this helpful
Glutathione is a naturally occurring substance in our bodies, composed of amino acids. It detoxifies the liver of harmful chemicals, pollutants, toxins, and drugs. If overburdened with toxins, glutathione processing becomes insufficient, leading to increased disease susceptibility, including cancer and Parkinson's. Thus, nourishing the body from the outside is vital; this supplement performs excellently.
9
Cancer prevention
1 people found this helpful
500mg is best! The cost-performance is not great at 750mg, while 100mg offers minimal effect; hence, 500mg is ideal. My husband and I take it for cancer prevention and to strengthen our throat's mucous membrane due to susceptibility to colds. I prefer it for its cost-effectiveness over other brands.
8
We explored the effects of Silybum marianum, commonly known for its active compound silymarin, on cancer treatment. Studies indicate that silymarin may help trigger cell death, impede cancer growth, and induce cell cycle arrest across various cancers, including skin, liver, and breast cancer.
While promising, it's important to note that these results stem from laboratory studies rather than extensive clinical trials. We observed that Silybum marianum shows potential as part of a broader medicinal approach, given its diverse health benefits and protective effects on the liver.
While promising, it's important to note that these results stem from laboratory studies rather than extensive clinical trials. We observed that Silybum marianum shows potential as part of a broader medicinal approach, given its diverse health benefits and protective effects on the liver.
8
We aimed to understand how the combination of silymarin, derived from the milk thistle plant, and cisplatin, a well-known chemotherapy drug, affects ovarian cancer cells. Our study involved treating A2780 cells with these substances, both separately and together.
The results were promising: the combination treatment significantly reduced cell proliferation and promoted cancer cell death more effectively than either treatment alone. Additionally, it was found that this co-treatment altered the expression of certain cancer-related genes.
Overall, we believe this combination therapy could represent a valuable approach for future ovarian cancer treatments.
The results were promising: the combination treatment significantly reduced cell proliferation and promoted cancer cell death more effectively than either treatment alone. Additionally, it was found that this co-treatment altered the expression of certain cancer-related genes.
Overall, we believe this combination therapy could represent a valuable approach for future ovarian cancer treatments.
7
Nano-silymarin shows potential benefits
We conducted a triple-blinded, randomized clinical trial involving 60 patients to explore if nano-silymarin could reduce neuropathy and hand-foot syndrome caused by popular chemotherapy regimens used for metastatic colorectal cancer.
Patients received nano-silymarin during their treatment, and we assessed the severity of any side effects after three and six chemotherapy cycles.
While the study suggests that nano-silymarin might help prevent these adverse reactions, more extensive research is needed to confirm these findings and examine different doses.
Patients received nano-silymarin during their treatment, and we assessed the severity of any side effects after three and six chemotherapy cycles.
While the study suggests that nano-silymarin might help prevent these adverse reactions, more extensive research is needed to confirm these findings and examine different doses.
7
Silymarin shows potential for hepatoprotection
This study focused on whether oral silymarin could prevent liver damage in breast cancer patients undergoing treatment with doxorubicin.
We observed 50 patients in a triple-blind, placebo-controlled trial where they took either silymarin or a placebo for over two months. Interestingly, while silymarin showed significant results in protecting liver health based on imaging, it didn’t reflect in the lab tests.
Overall, while promising, further research is needed to optimize the benefits of silymarin in cancer care.
We observed 50 patients in a triple-blind, placebo-controlled trial where they took either silymarin or a placebo for over two months. Interestingly, while silymarin showed significant results in protecting liver health based on imaging, it didn’t reflect in the lab tests.
Overall, while promising, further research is needed to optimize the benefits of silymarin in cancer care.
9
We aimed to uncover how silibinin, a compound from milk thistle, impacts cancer, specifically in adenoid cystic carcinoma cells and Balb/c nude mice. The study identified 75 key targets linked to tumor growth and showcased that silibinin significantly reduced cell viability, proliferation, and migration.
Additionally, it induced cancer cell death and inhibited tumor growth in live subjects. Our findings highlighted how silibinin acts on specific proteins affecting cancer pathways, offering valuable insights into its potential as an anti-tumor treatment.
Additionally, it induced cancer cell death and inhibited tumor growth in live subjects. Our findings highlighted how silibinin acts on specific proteins affecting cancer pathways, offering valuable insights into its potential as an anti-tumor treatment.
7
We explored how silibinin, a compound from milk thistle, affects a protein called ID3, which promotes cancer spread in lung cancer cells. Through various methods, including lab testing and patient data analysis, we found that silibinin can effectively reduce ID3 activity.
Although ID3 is considered challenging to target with drugs, our study suggests that silibinin could be a promising treatment avenue to combat metastasis in non-small cell lung cancer. Further research could confirm its potential as a therapeutic option.
Although ID3 is considered challenging to target with drugs, our study suggests that silibinin could be a promising treatment avenue to combat metastasis in non-small cell lung cancer. Further research could confirm its potential as a therapeutic option.
9
We investigated how grape seed procyanidin extract (GSE) and milk thistle silymarin extract (MTE) work together to combat lung cancer. Our study involved cell line experiments, along with testing on mice to see how these extracts affect tumor growth.
The results showed that GSE and MTE not only slowed down cancer cell growth but also worked better together. They boosted the levels of specific tumor suppressors, which play a key role in their effectiveness. Overall, this combination appears promising for lung cancer treatment.
The results showed that GSE and MTE not only slowed down cancer cell growth but also worked better together. They boosted the levels of specific tumor suppressors, which play a key role in their effectiveness. Overall, this combination appears promising for lung cancer treatment.
References
- Hu R, Jiang X, Zhu L, Meng R, Yang R, et al. Overcoming radiation-induced PD-L1 and COX-2 upregulation by nitric oxide gas nanogenerator to sensitize radiotherapy of lung cancer. Biomaterials. 2025;321:123335. doi:10.1016/j.biomaterials.2025.123335
- Gao Y, Han R, Guo Z, Zhuang Z, Fu J, et al. Multi-pathway copper metabolisms regulation based on an engineered copper/ferrous nanoplatform for enhanced tumor cuproptosis therapy. Colloids Surf B Biointerfaces. 2025;252:114682. doi:10.1016/j.colsurfb.2025.114682
- Karbasforooshan H, Rahimi H, Arasteh O, Allahyari A, Varmaghani M, et al. Evaluation of Oral Nano-Silymarin Formulation Efficacy in the Prevention of Hand-Foot Syndrome and Neuropathy Induced by XELOX or m-FOLFOX6 Regimens in Metastatic Colorectal Cancer: A Triple-Blinded, Randomized Clinical Trial. Iran J Pharm Res. 2024;23:e152364. doi:10.5812/ijpr-152364
- Tomsuk Ö, Kaçar S. Mechanistic Insights into Silymarin-Induced Apoptosis and Growth Inhibition in SPC212 Human Mesothelioma Cells. Cell Biochem Biophys. 2025. doi:10.1007/s12013-024-01650-w
- Fatemi Shandiz A, Karimi G, Dayyani M, Hosseini S, Elyasi S. Evaluation of oral silymarin formulation efficacy in prevention of doxorubicin induced hepatotoxicity in patients with non-metastatic breast cancer. J Oncol Pharm Pract. 2024. doi:10.1177/10781552241268778
- Gholami AH, Ansari H, Dadkhah A. Effect of Silybum Marianum on Reduction of Chemotherapy-Induced Peripheral Neurotoxicity with Cisplatin. Adv Biomed Res. 2024;13:21. doi:10.4103/abr.abr_365_21
- Li P, Wang D, Yang X, Liu C, Li X, et al. Anti-Tumor Activity and Mechanism of Silibinin Based on Network Pharmacology and Experimental Verification. Molecules. 2024;29. doi:10.3390/molecules29081901
- Verdura S, Encinar JA, Gratchev A, Llop-Hernández À, López J, et al. Silibinin is a suppressor of the metastasis-promoting transcription factor ID3. Phytomedicine. 2024;128:155493. doi:10.1016/j.phymed.2024.155493
- Karimzadeh MR, Masoudi Chelegahi A, Shahbazi S, Reiisi S. Co-treatment of silymarin and cisplatin inhibited cell proliferation, induced apoptosis in ovarian cancer. Mol Biol Rep. 2024;51:118. doi:10.1007/s11033-023-09026-8
- Zhang X, Jiang Y, Guo N, Ding Y, Feng J, et al. Application of SNAP-tag-EGFR cell membrane chromatography model in screening antitumor active components of Silybum marianum (L.) Gaertn. J Pharm Biomed Anal. 2024;238:115816. doi:10.1016/j.jpba.2023.115816
- Rahnama S, Tehrankhah ZM, Mohajerani F, Mohammadi FS, Yeganeh ZY, et al. Milk thistle nano-micelle formulation promotes cell cycle arrest and apoptosis in hepatocellular carcinoma cells through modulating miR-155-3p /SOCS2 /PHLDA1 signaling axis. BMC Complement Med Ther. 2023;23:337. doi:10.1186/s12906-023-04168-5
- Gheybi F, Rajabian F, Tayarani-Najaran Z, Adibi AR, Alavizadeh SH, et al. Liposomal silymarin anti-oxidative and anti-apoptotic features in lung cells: An implication in cadmium toxicity. J Trace Elem Med Biol. 2023;80:127291. doi:10.1016/j.jtemb.2023.127291
- Wu S, Chen G, Chen EY, Farshidpour LS, Zhang Q, et al. Core Structure-Activity Relationship Studies of 5,7,20--Trimethylsilybins in Prostate Cancer Cell Models. Pharmaceuticals (Basel). 2023;16. doi:10.3390/ph16040531
- Parsa L, Motafakkerazad R, Soheyli ST, Haratian A, Kosari-Nasab M, et al. Silymarin in combination with ATRA enhances apoptosis induction in human acute promyelocytic NB4 cells. Toxicon. 2023;228:107127. doi:10.1016/j.toxicon.2023.107127
- Nawaz A, Zaib S, Khan I, Ahmed A, Shahzadi K, et al. : An Overview of its Phytochemistry and Pharmacological Activities with Emphasis on Potential Anticancer Properties. Anticancer Agents Med Chem. 2023;23:1519. doi:10.2174/1871520623666230412111152
- Faixová D, Ratvaj M, Maruščáková IC, Hrčková G, Karaffová V, et al. Silybin Showed Higher Cytotoxic, Antiproliferative, and Anti-Inflammatory Activities in the CaCo Cancer Cell Line while Retaining Viability and Proliferation in Normal Intestinal IPEC-1 Cells. Life (Basel). 2023;13. doi:10.3390/life13020492
- Mao JT, Xue B, Lu QY, Lundmark L, Burns W, et al. Combinations of grape seed procyanidin extract and milk thistle silymarin extract against lung cancer - The role of MiR-663a and FHIT. Life Sci. 2023;318:121492. doi:10.1016/j.lfs.2023.121492
- Ghodousi M, Karbasforooshan H, Arabi L, Elyasi S. Silymarin as a preventive or therapeutic measure for chemotherapy and radiotherapy-induced adverse reactions: a comprehensive review of preclinical and clinical data. Eur J Clin Pharmacol. 2023;79:15. doi:10.1007/s00228-022-03434-8
- Sgaramella LI, Pasculli A, Moschetta M, Puntillo F, Dicillo P, et al. Randomized controlled trial of bromelain and alpha-lipoic acid in breast conservative surgery. Sci Rep. 2025;15:4899. doi:10.1038/s41598-025-86651-2
