5/29/2025
Last update
5/29/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
USERS' SCORE
Good
Based on 56 Reviews
8.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
St. John's Wort Extract(Hypericum perforatum) (Herb) (min. 0.3% Hypericin)
300 mg
*
Top Medical Research Studies
8
We examined the effectiveness of Hypericum perforatum, commonly known as St. John's Wort, specifically for anxiety treatment in elderly patients aged 60 and above. This analysis was based on data from randomized, controlled clinical trials, which provided a robust framework for our observations.
In our exploration, we focused on how this herbal remedy compares to placebo treatments. The findings indicated that Hypericum extract demonstrated significant benefits for anxiety, showing better results on established measures of anxiety symptoms.
Importantly, the effects we observed were consistent across the board, matching the outcomes seen in studies that included younger populations as well. This confirms that Hypericum perforatum is a viable option for managing anxiety in older adults.
Overall, this herbal treatment stands out as a well-tolerated and effective alternative to more conventional, synthetic medications, offering hope for those seeking natural solutions to anxiety.
In our exploration, we focused on how this herbal remedy compares to placebo treatments. The findings indicated that Hypericum extract demonstrated significant benefits for anxiety, showing better results on established measures of anxiety symptoms.
Importantly, the effects we observed were consistent across the board, matching the outcomes seen in studies that included younger populations as well. This confirms that Hypericum perforatum is a viable option for managing anxiety in older adults.
Overall, this herbal treatment stands out as a well-tolerated and effective alternative to more conventional, synthetic medications, offering hope for those seeking natural solutions to anxiety.
Read More
8
Hypericum extracts alleviate anxiety symptoms
We set out to evaluate how extracts from Hypericum perforatum (HP), commonly known as St. John’s Wort, along with quercetin (Q), could impact anxiety and overall brain health. In this study, we used a rat model to observe various biological effects, particularly focusing on oxidative stress and inflammation, both of which can influence anxiety levels.
The rats were divided into different groups, receiving either a control treatment, a known anxiety-inducing agent, or our test compounds. Over a period of 21 days, we administered HP and Q and monitored several brain and serum markers associated with anxiety. Our findings revealed that HP and Q showed promising anti-inflammatory and antioxidant properties.
Specifically, we noted reductions in inflammatory cytokines and oxidative stress markers in the brain, which could indicate a protective effect against anxiety. These results suggest that HP may indeed help improve anxiety-like behaviors by modulating key processes in the brain. Overall, the inclusion of Hypericum extracts in a natural compounds-rich diet may offer beneficial effects for mental health.
The rats were divided into different groups, receiving either a control treatment, a known anxiety-inducing agent, or our test compounds. Over a period of 21 days, we administered HP and Q and monitored several brain and serum markers associated with anxiety. Our findings revealed that HP and Q showed promising anti-inflammatory and antioxidant properties.
Specifically, we noted reductions in inflammatory cytokines and oxidative stress markers in the brain, which could indicate a protective effect against anxiety. These results suggest that HP may indeed help improve anxiety-like behaviors by modulating key processes in the brain. Overall, the inclusion of Hypericum extracts in a natural compounds-rich diet may offer beneficial effects for mental health.
Read More
8
Hypericum perforatum alleviates post-MI anxiety
We investigated the effects of Hypericum perforatum, commonly known as St. John's Wort, on anxiety that follows a heart attack. Our research focused on measuring how this herbal treatment could help in not just relieving anxiety, but also improving heart functions after a myocardial infarction (MI).
To enhance the absorption and efficacy of HP, we formulated it into a self-nanoemulsifying self-nanosuspension (HP.SNESNS). In our study, we used a group of rats that had experienced MI and observed that HP.SNESNS significantly reduced anxiety and depressive-like behaviors, alongside cognitive dysfunction.
Notably, it increased levels of essential neurotransmitters like norepinephrine and serotonin in the brain, which are known to play a vital role in mood regulation. Additionally, we found that HP.SNESNS helped protect heart tissues by reducing inflammation markers and restoring heart architecture. Overall, these improvements were comparable to those seen with higher doses of unformulated HP.
In conclusion, our findings indicate that HP.SNESNS not only helps manage anxiety in a post-MI context but also offers cardio-protective benefits, making it a promising candidate for further research.
To enhance the absorption and efficacy of HP, we formulated it into a self-nanoemulsifying self-nanosuspension (HP.SNESNS). In our study, we used a group of rats that had experienced MI and observed that HP.SNESNS significantly reduced anxiety and depressive-like behaviors, alongside cognitive dysfunction.
Notably, it increased levels of essential neurotransmitters like norepinephrine and serotonin in the brain, which are known to play a vital role in mood regulation. Additionally, we found that HP.SNESNS helped protect heart tissues by reducing inflammation markers and restoring heart architecture. Overall, these improvements were comparable to those seen with higher doses of unformulated HP.
In conclusion, our findings indicate that HP.SNESNS not only helps manage anxiety in a post-MI context but also offers cardio-protective benefits, making it a promising candidate for further research.
Read More
Most Useful Reviews
9
No more anxiety
83 people found this helpful
I have a family history of depression and noticed signs in myself at 35. Prescription medications didn't work and caused anxiety. I tried St. John's Wort, discarding my prescriptions. After 15 years, I’m depression-free and quite mellow without anxiety attacks from ineffective drugs. I take two in the morning and one at noon, satisfied with Now Foods' quality and price.
Read More
9
Helps social anxiety
23 people found this helpful
St. John's Wort is the best supplement for my social anxiety disorder and OCD. After avoiding prescription meds, I noticed a significant difference within a month after starting two capsules each morning.
Read More
7.5
Potent anxiety relief
12 people found this helpful
This natural SSRI is incredibly effective for depression and anxiety. I experienced results after three to four weeks. However, consult a doctor before use, as it may interfere with other medications.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8
- All Researches
8
Hypericum perforatum alleviates post-MI anxiety
We investigated the effects of Hypericum perforatum, commonly known as St. John's Wort, on anxiety that follows a heart attack. Our research focused on measuring how this herbal treatment could help in not just relieving anxiety, but also improving heart functions after a myocardial infarction (MI).
To enhance the absorption and efficacy of HP, we formulated it into a self-nanoemulsifying self-nanosuspension (HP.SNESNS). In our study, we used a group of rats that had experienced MI and observed that HP.SNESNS significantly reduced anxiety and depressive-like behaviors, alongside cognitive dysfunction.
Notably, it increased levels of essential neurotransmitters like norepinephrine and serotonin in the brain, which are known to play a vital role in mood regulation. Additionally, we found that HP.SNESNS helped protect heart tissues by reducing inflammation markers and restoring heart architecture. Overall, these improvements were comparable to those seen with higher doses of unformulated HP.
In conclusion, our findings indicate that HP.SNESNS not only helps manage anxiety in a post-MI context but also offers cardio-protective benefits, making it a promising candidate for further research.
To enhance the absorption and efficacy of HP, we formulated it into a self-nanoemulsifying self-nanosuspension (HP.SNESNS). In our study, we used a group of rats that had experienced MI and observed that HP.SNESNS significantly reduced anxiety and depressive-like behaviors, alongside cognitive dysfunction.
Notably, it increased levels of essential neurotransmitters like norepinephrine and serotonin in the brain, which are known to play a vital role in mood regulation. Additionally, we found that HP.SNESNS helped protect heart tissues by reducing inflammation markers and restoring heart architecture. Overall, these improvements were comparable to those seen with higher doses of unformulated HP.
In conclusion, our findings indicate that HP.SNESNS not only helps manage anxiety in a post-MI context but also offers cardio-protective benefits, making it a promising candidate for further research.
Read More
8
Hypericum extracts alleviate anxiety symptoms
We set out to evaluate how extracts from Hypericum perforatum (HP), commonly known as St. John’s Wort, along with quercetin (Q), could impact anxiety and overall brain health. In this study, we used a rat model to observe various biological effects, particularly focusing on oxidative stress and inflammation, both of which can influence anxiety levels.
The rats were divided into different groups, receiving either a control treatment, a known anxiety-inducing agent, or our test compounds. Over a period of 21 days, we administered HP and Q and monitored several brain and serum markers associated with anxiety. Our findings revealed that HP and Q showed promising anti-inflammatory and antioxidant properties.
Specifically, we noted reductions in inflammatory cytokines and oxidative stress markers in the brain, which could indicate a protective effect against anxiety. These results suggest that HP may indeed help improve anxiety-like behaviors by modulating key processes in the brain. Overall, the inclusion of Hypericum extracts in a natural compounds-rich diet may offer beneficial effects for mental health.
The rats were divided into different groups, receiving either a control treatment, a known anxiety-inducing agent, or our test compounds. Over a period of 21 days, we administered HP and Q and monitored several brain and serum markers associated with anxiety. Our findings revealed that HP and Q showed promising anti-inflammatory and antioxidant properties.
Specifically, we noted reductions in inflammatory cytokines and oxidative stress markers in the brain, which could indicate a protective effect against anxiety. These results suggest that HP may indeed help improve anxiety-like behaviors by modulating key processes in the brain. Overall, the inclusion of Hypericum extracts in a natural compounds-rich diet may offer beneficial effects for mental health.
Read More
8
We explored the effectiveness of a treatment combining lifestyle changes with herbal medicine in managing symptoms of Polycystic Ovary Syndrome (PCOS) in overweight women. In our study, we specifically assessed how a blend of herbal ingredients, including Hypericum perforatum, influenced anxiety levels.
Although we found that women receiving the combination treatment showed significant improvements in various health markers—such as hormonal balance and quality of life—the specific effects of Hypericum perforatum on anxiety couldn't be isolated. It was included in a mixture with other herbs, making it challenging to determine its individual impact.
At the three-month mark, participants taking the combination treatment reported reductions in menstruation irregularities and improved well-being. However, since the results were derived from a combination treatment, we can't definitively state how much Hypericum perforatum itself contributed to anxiety mitigation. This caveat is essential for anyone considering this herbal supplement for anxiety management.
Although we found that women receiving the combination treatment showed significant improvements in various health markers—such as hormonal balance and quality of life—the specific effects of Hypericum perforatum on anxiety couldn't be isolated. It was included in a mixture with other herbs, making it challenging to determine its individual impact.
At the three-month mark, participants taking the combination treatment reported reductions in menstruation irregularities and improved well-being. However, since the results were derived from a combination treatment, we can't definitively state how much Hypericum perforatum itself contributed to anxiety mitigation. This caveat is essential for anyone considering this herbal supplement for anxiety management.
Read More
8
We explored how an extract from Hypericum scabrum, known for its antioxidant properties, affects anxiety levels in rats subjected to a long-term high-fat diet (HFD). Our study involved sixty male Wistar rats, which we divided into six groups—some fed a standard diet while others received a high-fat diet, with certain groups supplemented with varying doses of the extract. Over three months, we assessed anxiety levels using the elevated plus-maze test, a common method for studying anxious behaviors in animals.
Our findings indicated that the rats on the high-fat diet showed increased anxiety behaviors compared to those on the standard diet, evidenced by spending less time in the open arms of the maze. However, the inclusion of H. scabrum extract significantly improved these anxiety measures, suggesting a potential anxiolytic effect. We also observed notable changes in oxidative stress markers: the HFD diet increased harmful compounds in the serum while reducing protective antioxidants, but the extract supplementation helped normalize these levels.
In essence, our study suggests that H. scabrum not only alleviates anxiety behaviors associated with a high-fat diet but also counters oxidative stress. This reinforces the possibility that dietary components and natural extracts like H. scabrum could play important roles in managing anxiety and overall mental health.
Our findings indicated that the rats on the high-fat diet showed increased anxiety behaviors compared to those on the standard diet, evidenced by spending less time in the open arms of the maze. However, the inclusion of H. scabrum extract significantly improved these anxiety measures, suggesting a potential anxiolytic effect. We also observed notable changes in oxidative stress markers: the HFD diet increased harmful compounds in the serum while reducing protective antioxidants, but the extract supplementation helped normalize these levels.
In essence, our study suggests that H. scabrum not only alleviates anxiety behaviors associated with a high-fat diet but also counters oxidative stress. This reinforces the possibility that dietary components and natural extracts like H. scabrum could play important roles in managing anxiety and overall mental health.
Read More
8
We examined the effectiveness of Hypericum perforatum, commonly known as St. John's Wort, specifically for anxiety treatment in elderly patients aged 60 and above. This analysis was based on data from randomized, controlled clinical trials, which provided a robust framework for our observations.
In our exploration, we focused on how this herbal remedy compares to placebo treatments. The findings indicated that Hypericum extract demonstrated significant benefits for anxiety, showing better results on established measures of anxiety symptoms.
Importantly, the effects we observed were consistent across the board, matching the outcomes seen in studies that included younger populations as well. This confirms that Hypericum perforatum is a viable option for managing anxiety in older adults.
Overall, this herbal treatment stands out as a well-tolerated and effective alternative to more conventional, synthetic medications, offering hope for those seeking natural solutions to anxiety.
In our exploration, we focused on how this herbal remedy compares to placebo treatments. The findings indicated that Hypericum extract demonstrated significant benefits for anxiety, showing better results on established measures of anxiety symptoms.
Importantly, the effects we observed were consistent across the board, matching the outcomes seen in studies that included younger populations as well. This confirms that Hypericum perforatum is a viable option for managing anxiety in older adults.
Overall, this herbal treatment stands out as a well-tolerated and effective alternative to more conventional, synthetic medications, offering hope for those seeking natural solutions to anxiety.
Read More
User Reviews
USERS' SCORE
Good
Based on 56 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
No more anxiety
83 people found this helpful
I have a family history of depression and noticed signs in myself at 35. Prescription medications didn't work and caused anxiety. I tried St. John's Wort, discarding my prescriptions. After 15 years, I’m depression-free and quite mellow without anxiety attacks from ineffective drugs. I take two in the morning and one at noon, satisfied with Now Foods' quality and price.
Read More
9
Helps social anxiety
23 people found this helpful
St. John's Wort is the best supplement for my social anxiety disorder and OCD. After avoiding prescription meds, I noticed a significant difference within a month after starting two capsules each morning.
Read More
7.5
Potent anxiety relief
12 people found this helpful
This natural SSRI is incredibly effective for depression and anxiety. I experienced results after three to four weeks. However, consult a doctor before use, as it may interfere with other medications.
Read More
9
Natural anxiety aid
11 people found this helpful
After struggling with antidepressants, I found that St. John’s Wort effectively eased my panic and anxiety. I take 900 to 1800 mg per day and appreciate this affordable product.
Read More
9
Anxiety under control
11 people found this helpful
My anxiety runs in my family, and despite trying numerous prescription medications with side effects, St. John's Wort was my last resort. It helps control my anxiety, and I have no side effects. It started working on day one.
Read More
Frequently Asked Questions
9
Helps social anxiety
23 people found this helpful
St. John's Wort is the best supplement for my social anxiety disorder and OCD. After avoiding prescription meds, I noticed a significant difference within a month after starting two capsules each morning.
9
Anxiety under control
11 people found this helpful
My anxiety runs in my family, and despite trying numerous prescription medications with side effects, St. John's Wort was my last resort. It helps control my anxiety, and I have no side effects. It started working on day one.
7.5
Potent anxiety relief
12 people found this helpful
This natural SSRI is incredibly effective for depression and anxiety. I experienced results after three to four weeks. However, consult a doctor before use, as it may interfere with other medications.
9
Natural anxiety aid
11 people found this helpful
After struggling with antidepressants, I found that St. John’s Wort effectively eased my panic and anxiety. I take 900 to 1800 mg per day and appreciate this affordable product.
9
Natural alternative
1 people found this helpful
I transitioned from prescription anti-anxiety medication to this product, taking two daily, and it works just as effectively.
9
Mood improvement
8 people found this helpful
St. John’s Wort helped during a tough time as a new parent. I had anxiety and irritation but found relief with this herb, which improved my mood and sleep, taking it in the morning and evening.
9
Effective alternative
4 people found this helpful
St. John's Wort has been as effective for my anxiety and depression as prescribed medications, without side effects. After experimentation, I found the ideal dosage, particularly when combined with L-theanine. It greatly enhances my mood and mental clarity.
9
Calmness achieved
3 people found this helpful
This product has greatly reduced my anxiety, especially at work. I also take L-theanine, but adding St. John's Wort has made me feel significantly calmer and more positive.
9
Mood improvement
5 people found this helpful
St. John's Wort is a well-known medicinal herb that aids mild to moderate anxiety and depression. It contains 300 mg of Standardised extract per capsule. After a gradual effect, I noticed my mood stabilised, anxiety decreased, and I regained energy by the fourth week. However, it's crucial to read the warnings as it interacts with various medications and alcohol.
9
No more anxiety
83 people found this helpful
I have a family history of depression and noticed signs in myself at 35. Prescription medications didn't work and caused anxiety. I tried St. John's Wort, discarding my prescriptions. After 15 years, I’m depression-free and quite mellow without anxiety attacks from ineffective drugs. I take two in the morning and one at noon, satisfied with Now Foods' quality and price.
8
We examined the effectiveness of Hypericum perforatum, commonly known as St. John's Wort, specifically for anxiety treatment in elderly patients aged 60 and above. This analysis was based on data from randomized, controlled clinical trials, which provided a robust framework for our observations.
In our exploration, we focused on how this herbal remedy compares to placebo treatments. The findings indicated that Hypericum extract demonstrated significant benefits for anxiety, showing better results on established measures of anxiety symptoms.
Importantly, the effects we observed were consistent across the board, matching the outcomes seen in studies that included younger populations as well. This confirms that Hypericum perforatum is a viable option for managing anxiety in older adults.
Overall, this herbal treatment stands out as a well-tolerated and effective alternative to more conventional, synthetic medications, offering hope for those seeking natural solutions to anxiety.
In our exploration, we focused on how this herbal remedy compares to placebo treatments. The findings indicated that Hypericum extract demonstrated significant benefits for anxiety, showing better results on established measures of anxiety symptoms.
Importantly, the effects we observed were consistent across the board, matching the outcomes seen in studies that included younger populations as well. This confirms that Hypericum perforatum is a viable option for managing anxiety in older adults.
Overall, this herbal treatment stands out as a well-tolerated and effective alternative to more conventional, synthetic medications, offering hope for those seeking natural solutions to anxiety.
8
Hypericum extracts alleviate anxiety symptoms
We set out to evaluate how extracts from Hypericum perforatum (HP), commonly known as St. John’s Wort, along with quercetin (Q), could impact anxiety and overall brain health. In this study, we used a rat model to observe various biological effects, particularly focusing on oxidative stress and inflammation, both of which can influence anxiety levels.
The rats were divided into different groups, receiving either a control treatment, a known anxiety-inducing agent, or our test compounds. Over a period of 21 days, we administered HP and Q and monitored several brain and serum markers associated with anxiety. Our findings revealed that HP and Q showed promising anti-inflammatory and antioxidant properties.
Specifically, we noted reductions in inflammatory cytokines and oxidative stress markers in the brain, which could indicate a protective effect against anxiety. These results suggest that HP may indeed help improve anxiety-like behaviors by modulating key processes in the brain. Overall, the inclusion of Hypericum extracts in a natural compounds-rich diet may offer beneficial effects for mental health.
The rats were divided into different groups, receiving either a control treatment, a known anxiety-inducing agent, or our test compounds. Over a period of 21 days, we administered HP and Q and monitored several brain and serum markers associated with anxiety. Our findings revealed that HP and Q showed promising anti-inflammatory and antioxidant properties.
Specifically, we noted reductions in inflammatory cytokines and oxidative stress markers in the brain, which could indicate a protective effect against anxiety. These results suggest that HP may indeed help improve anxiety-like behaviors by modulating key processes in the brain. Overall, the inclusion of Hypericum extracts in a natural compounds-rich diet may offer beneficial effects for mental health.
8
Hypericum perforatum alleviates post-MI anxiety
We investigated the effects of Hypericum perforatum, commonly known as St. John's Wort, on anxiety that follows a heart attack. Our research focused on measuring how this herbal treatment could help in not just relieving anxiety, but also improving heart functions after a myocardial infarction (MI).
To enhance the absorption and efficacy of HP, we formulated it into a self-nanoemulsifying self-nanosuspension (HP.SNESNS). In our study, we used a group of rats that had experienced MI and observed that HP.SNESNS significantly reduced anxiety and depressive-like behaviors, alongside cognitive dysfunction.
Notably, it increased levels of essential neurotransmitters like norepinephrine and serotonin in the brain, which are known to play a vital role in mood regulation. Additionally, we found that HP.SNESNS helped protect heart tissues by reducing inflammation markers and restoring heart architecture. Overall, these improvements were comparable to those seen with higher doses of unformulated HP.
In conclusion, our findings indicate that HP.SNESNS not only helps manage anxiety in a post-MI context but also offers cardio-protective benefits, making it a promising candidate for further research.
To enhance the absorption and efficacy of HP, we formulated it into a self-nanoemulsifying self-nanosuspension (HP.SNESNS). In our study, we used a group of rats that had experienced MI and observed that HP.SNESNS significantly reduced anxiety and depressive-like behaviors, alongside cognitive dysfunction.
Notably, it increased levels of essential neurotransmitters like norepinephrine and serotonin in the brain, which are known to play a vital role in mood regulation. Additionally, we found that HP.SNESNS helped protect heart tissues by reducing inflammation markers and restoring heart architecture. Overall, these improvements were comparable to those seen with higher doses of unformulated HP.
In conclusion, our findings indicate that HP.SNESNS not only helps manage anxiety in a post-MI context but also offers cardio-protective benefits, making it a promising candidate for further research.
References
- Khalil HMA, Mahmoud DB, El-Shiekh RA, Bakr AF, Boseila AA, et al. Antidepressant and Cardioprotective Effects of Self-Nanoemulsifying Self-Nanosuspension Loaded with Hypericum perforatum on Post-Myocardial Infarction Depression in Rats. AAPS PharmSciTech. 2022;23:243. 10.1208/s12249-022-02387-6
- Sevastre-Berghian AC, Toma VA, Sevastre B, Hanganu D, Vlase L, et al. Characterization and biological effects of Hypericum extracts on experimentally-induced - anxiety, oxidative stress and inflammation in rats. J Physiol Pharmacol. 2018;69. 10.26402/jpp.2018.5.13
- Arentz S, Smith CA, Abbott J, Fahey P, Cheema BS, et al. Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial. Phytother Res. 2017;31:1330. 10.1002/ptr.5858
- Ganji A, Salehi I, Sarihi A, Shahidi S, Komaki A. Effects of Hypericum Scabrum extract on anxiety and oxidative stress biomarkers in rats fed a long-term high-fat diet. Metab Brain Dis. 2017;32:503. 10.1007/s11011-016-9940-9
- Kasper S. Phytopharmaceutical treatment of anxiety, depression, and dementia in the elderly: evidence from randomized, controlled clinical trials. Wien Med Wochenschr. 2015;165:217. 10.1007/s10354-015-0360-y
