Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
L-Carnosine (B-alanyl-L-histidine)
500 mg
*
Top Medical Research Studies
9
We explored the neuroprotective effects of carnosine in mice exposed to a Parkinson's-like condition using MPTP. By adding varying doses of carnosine to their drinking water over four weeks, we noticed that it effectively reduced damaging oxidative stress and inflammatory responses.
Notably, carnosine preserved essential dopamine levels and improved glutathione activity, indicating its potential to protect against neurodegeneration. Overall, our findings suggest that carnosine may offer a beneficial strategy in mitigating the effects of Parkinson's disease.
Notably, carnosine preserved essential dopamine levels and improved glutathione activity, indicating its potential to protect against neurodegeneration. Overall, our findings suggest that carnosine may offer a beneficial strategy in mitigating the effects of Parkinson's disease.
8
We evaluated the effects of intranasal (IN) carnosine treatment on motor dysfunction and α-synuclein aggregation in a specific mouse model of Parkinson's disease. Over eight weeks, we treated Thy1-aSyn mice with varying doses of carnosine.
Our findings showed that higher doses resulted in improved motor function and a notable reduction in α-synuclein-positive cell bodies in the substantia nigra. However, carnosine didn’t impact α-synuclein levels in the olfactory bulb.
Overall, intranasal carnosine appears to reduce α-synuclein accumulation, potentially easing motor deficits in this model.
Our findings showed that higher doses resulted in improved motor function and a notable reduction in α-synuclein-positive cell bodies in the substantia nigra. However, carnosine didn’t impact α-synuclein levels in the olfactory bulb.
Overall, intranasal carnosine appears to reduce α-synuclein accumulation, potentially easing motor deficits in this model.
8
We investigated how carnosine could help protect against the damaging effects of a neurotoxin related to Parkinson's disease in a rat model. After administering carnosine before the neurotoxin exposure, we noted significant improvements, including reduced abnormal movements and less neuron apoptosis. While carnosine did not significantly impact all measured oxidative stress markers, it showed promise in enhancing certain cellular functions. Overall, our findings suggest that administering carnosine may benefit individuals in the early stages of Parkinson's by providing neuroprotection from toxic agents.
Most Useful Reviews
8.5
Significant improvement noted
46 people found this helpful
Carnosine is truly remarkable. We have given it to our child twice, and there has been a noticeable breakthrough in their speech development, with no other changes made to their diet or medications. For an elderly relative with Parkinson's, the results are similarly impressive. They reported, "the fog in the head is gone, and there are fewer goosebumps," while continuing their standard therapy. I highly recommend trying Carnosine, as it appears quite safe unless one has serious low blood pressure or is scheduled for surgery soon. The Now Foods capsules are easy to take, being large yet manageable. I wish everyone good health!
7.5
Supportive results noted
5 people found this helpful
I am purchasing Carnosine for both myself and my brother for the second time. At 59 years old, I feel rejuvenated after taking it. My brother, who has Parkinson's disease, seems to benefit as well. In conjunction with his medications, Carnosine provides a supportive effect that is truly valuable. Thank you.
6
Minor improvements seen
I buy this for my mother who has Parkinson's. The effect is small, but it does exist. We've noticed a reduction in her tremors and an improvement in her cognitive function.
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 10 Researches
7.6
- All Researches
9
We explored the neuroprotective effects of carnosine in mice exposed to a Parkinson's-like condition using MPTP. By adding varying doses of carnosine to their drinking water over four weeks, we noticed that it effectively reduced damaging oxidative stress and inflammatory responses.
Notably, carnosine preserved essential dopamine levels and improved glutathione activity, indicating its potential to protect against neurodegeneration. Overall, our findings suggest that carnosine may offer a beneficial strategy in mitigating the effects of Parkinson's disease.
Notably, carnosine preserved essential dopamine levels and improved glutathione activity, indicating its potential to protect against neurodegeneration. Overall, our findings suggest that carnosine may offer a beneficial strategy in mitigating the effects of Parkinson's disease.
8
We evaluated the effects of intranasal (IN) carnosine treatment on motor dysfunction and α-synuclein aggregation in a specific mouse model of Parkinson's disease. Over eight weeks, we treated Thy1-aSyn mice with varying doses of carnosine.
Our findings showed that higher doses resulted in improved motor function and a notable reduction in α-synuclein-positive cell bodies in the substantia nigra. However, carnosine didn’t impact α-synuclein levels in the olfactory bulb.
Overall, intranasal carnosine appears to reduce α-synuclein accumulation, potentially easing motor deficits in this model.
Our findings showed that higher doses resulted in improved motor function and a notable reduction in α-synuclein-positive cell bodies in the substantia nigra. However, carnosine didn’t impact α-synuclein levels in the olfactory bulb.
Overall, intranasal carnosine appears to reduce α-synuclein accumulation, potentially easing motor deficits in this model.
8
We observed that carnosine shows potential in combating the effects of Parkinson's disease in a study involving GT1-7 neurons. The results indicated that carnosine significantly reduced cell death caused by a toxic substance, 6-hydroxydopamine, suggesting its protective effects.
Additionally, it helped lower the levels of inflammatory markers and oxidative stress, which are often problematic in Parkinson's. These findings lead us to believe carnosine might be beneficial in delaying or preventing the progression of Parkinson's disease, although further research is necessary for concrete conclusions.
Additionally, it helped lower the levels of inflammatory markers and oxidative stress, which are often problematic in Parkinson's. These findings lead us to believe carnosine might be beneficial in delaying or preventing the progression of Parkinson's disease, although further research is necessary for concrete conclusions.
8
C/LA complex improves dopamine levels
We explored the protective effects of a new carnosine and α-lipoic acid complex on early-stage Parkinson’s disease in rats. Following a chemical treatment to induce the disease, we administered the complex and observed significant benefits.
This combination effectively restored critical neurotransmitter levels, particularly dopamine, which is crucial for motor control and coordination. The C/LA complex produced measurable improvements in brain metabolism and antioxidant activity that its individual components did not achieve alone.
Overall, our findings suggest that the C/LA complex shows promise as a potential treatment for Parkinson’s.
This combination effectively restored critical neurotransmitter levels, particularly dopamine, which is crucial for motor control and coordination. The C/LA complex produced measurable improvements in brain metabolism and antioxidant activity that its individual components did not achieve alone.
Overall, our findings suggest that the C/LA complex shows promise as a potential treatment for Parkinson’s.
8
We investigated how carnosine could help protect against the damaging effects of a neurotoxin related to Parkinson's disease in a rat model. After administering carnosine before the neurotoxin exposure, we noted significant improvements, including reduced abnormal movements and less neuron apoptosis. While carnosine did not significantly impact all measured oxidative stress markers, it showed promise in enhancing certain cellular functions. Overall, our findings suggest that administering carnosine may benefit individuals in the early stages of Parkinson's by providing neuroprotection from toxic agents.
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
8.5
Significant improvement noted
46 people found this helpful
Carnosine is truly remarkable. We have given it to our child twice, and there has been a noticeable breakthrough in their speech development, with no other changes made to their diet or medications. For an elderly relative with Parkinson's, the results are similarly impressive. They reported, "the fog in the head is gone, and there are fewer goosebumps," while continuing their standard therapy. I highly recommend trying Carnosine, as it appears quite safe unless one has serious low blood pressure or is scheduled for surgery soon. The Now Foods capsules are easy to take, being large yet manageable. I wish everyone good health!
7.5
Supportive results noted
5 people found this helpful
I am purchasing Carnosine for both myself and my brother for the second time. At 59 years old, I feel rejuvenated after taking it. My brother, who has Parkinson's disease, seems to benefit as well. In conjunction with his medications, Carnosine provides a supportive effect that is truly valuable. Thank you.
6
Minor improvements seen
I buy this for my mother who has Parkinson's. The effect is small, but it does exist. We've noticed a reduction in her tremors and an improvement in her cognitive function.
Frequently Asked Questions
8.5
Significant improvement noted
46 people found this helpful
Carnosine is truly remarkable. We have given it to our child twice, and there has been a noticeable breakthrough in their speech development, with no other changes made to their diet or medications. For an elderly relative with Parkinson's, the results are similarly impressive. They reported, "the fog in the head is gone, and there are fewer goosebumps," while continuing their standard therapy. I highly recommend trying Carnosine, as it appears quite safe unless one has serious low blood pressure or is scheduled for surgery soon. The Now Foods capsules are easy to take, being large yet manageable. I wish everyone good health!
7.5
Supportive results noted
5 people found this helpful
I am purchasing Carnosine for both myself and my brother for the second time. At 59 years old, I feel rejuvenated after taking it. My brother, who has Parkinson's disease, seems to benefit as well. In conjunction with his medications, Carnosine provides a supportive effect that is truly valuable. Thank you.
6
Minor improvements seen
I buy this for my mother who has Parkinson's. The effect is small, but it does exist. We've noticed a reduction in her tremors and an improvement in her cognitive function.
References
- Brown JM, Baker LS, Seroogy KB, Genter MB. Intranasal Carnosine Mitigates α-Synuclein Pathology and Motor Dysfunction in the Thy1-aSyn Mouse Model of Parkinson's Disease. ACS Chem Neurosci. 2021;12:2347. doi:10.1021/acschemneuro.1c00096
- Kubota M, Kobayashi N, Sugizaki T, Shimoda M, Kawahara M, et al. Carnosine suppresses neuronal cell death and inflammation induced by 6-hydroxydopamine in an in vitro model of Parkinson's disease. PLoS One. 2020;15:e0240448. doi:10.1371/journal.pone.0240448
- Bermúdez ML, Seroogy KB, Genter MB. Evaluation of Carnosine Intervention in the Thy1-aSyn Mouse Model of Parkinson's Disease. Neuroscience. 2019;411:270. doi:10.1016/j.neuroscience.2019.05.026
- Bermúdez ML, Skelton MR, Genter MB. Intranasal carnosine attenuates transcriptomic alterations and improves mitochondrial function in the Thy1-aSyn mouse model of Parkinson's disease. Mol Genet Metab. 2018;125:305. doi:10.1016/j.ymgme.2018.08.002
- Kulikova OI, Berezhnoy DS, Stvolinsky SL, Lopachev AV, Orlova VS, et al. Neuroprotective effect of the carnosine - α-lipoic acid nanomicellar complex in a model of early-stage Parkinson's disease. Regul Toxicol Pharmacol. 2018;95:254. doi:10.1016/j.yrtph.2018.03.025
- Makletsova MG, Rikhireva GT, Poleshuk VV, Grjakalov KV, Timerbaeva SL, et al. [The effect of antioxidants on in vivo and in vitro methemoglobin formation in erytrocytes of patients with Parkinson`s disease]. Biomed Khim. 2016;62:193. doi:10.18097/PBMC20166202193
- Afshin-Majd S, Khalili M, Roghani M, Mehranmehr N, Baluchnejadmojarad T. Carnosine exerts neuroprotective effect against 6-hydroxydopamine toxicity in hemiparkinsonian rat. Mol Neurobiol. 2015;51:1064. doi:10.1007/s12035-014-8771-0
- Hipkiss AR. Aging risk factors and Parkinson's disease: contrasting roles of common dietary constituents. Neurobiol Aging. 2014;35:1469. doi:10.1016/j.neurobiolaging.2013.11.032
- Tsai SJ, Kuo WW, Liu WH, Yin MC. Antioxidative and anti-inflammatory protection from carnosine in the striatum of MPTP-treated mice. J Agric Food Chem. 2010;58:11510. doi:10.1021/jf103258p
- Boldyrev A, Fedorova T, Stepanova M, Dobrotvorskaya I, Kozlova E, et al. Carnosine [corrected] increases efficiency of DOPA therapy of Parkinson's disease: a pilot study. Rejuvenation Res. 2008;11:821. doi:10.1089/rej.2008.0716
