Last update
3/6/2026
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.3
USERS' SCORE
Good
Based on 155 Reviews
8.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
L-Theanine
200 mg
*
Inositol
100 mg
*
Top Medical Research Studies
9
This study evaluated the impact of four weeks of L-theanine on stress and cognitive function in 30 healthy adults. Participants received either 200 mg of L-theanine or a placebo in a double-blind setup. We observed significant reductions in anxiety and stress symptoms, as indicated by improved scores on various measures, including sleep quality. Additionally, cognitive functions, such as verbal fluency, showed notable enhancement after L-theanine use. These findings suggest that L-theanine may be beneficial for managing stress-related issues and boosting mental performance.
Read More
8
We conducted a study to understand how inositol, a naturally occurring sugar alcohol, influences anxiety levels in laying hens. Our focus was on the behavior of Lohmann LSL lite hens, which were fed two different diets—one rich and one deficient in protein—while receiving either pure inositol or high levels of phytase.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Throughout the experimental period from 19 to 59 weeks of age, we gathered data through multiple behavior assessments, which included observing their reactions to new objects and monitoring their overall health indicators like feather condition and mortality rates.
Interestingly, inositol appeared to help reduce fearfulness in these hens, which we observed through a decrease in the time it took for them to approach and peck at new objects. However, it's worth noting that while inositol also led to a drop in vent feather cover and was associated with a slight increase in mortality, its primary benefit was tied to its ability to lessen anxiety.
Phytase, on the other hand, did not yield similar effects on behavior or health. These findings point towards the potential of inositol as a useful dietary addition for improving the well-being of laying hens by reducing anxiety levels.
Read More
8
We explored the effects of L-theanine on cognitive anxiety among 18 female archery athletes during a national competition. The research measured anxiety levels using a simple scale, alongside saliva samples to assess markers like salivary alpha-amylase and cortisol.
Results showed that L-theanine significantly reduced cognitive anxiety just before the competition, as well as lowering other stress indicators in comparison to a placebo. Thus, we conclude that L-theanine can be a beneficial aid for athletes looking to manage competition-related anxiety effectively.
Results showed that L-theanine significantly reduced cognitive anxiety just before the competition, as well as lowering other stress indicators in comparison to a placebo. Thus, we conclude that L-theanine can be a beneficial aid for athletes looking to manage competition-related anxiety effectively.
Read More
Most Useful Reviews
10
Life-changing supplement
613 people found this helpful
This product has saved me! I experienced varying degrees of anxiety, depression, emotional eating, and brain fog. I didn't know myself anymore, but this supplement has changed everything. I never took prescription drugs due to fear of side effects. My doctor suggested this, and it's like finding a golden ticket – instead of craziness, it led me out of my struggles! I feel energy to finish tasks, calm during stress, and more like my old self. My anxiety and mood swings have significantly improved, and I've even started losing weight. I now sleep well and feel refreshed. I've told everyone about this – I truly believe everyone should take it to reclaim their happiness!
Read More
9
Natural relaxation
222 people found this helpful
L-theanine helps me relax and unwind naturally. I’ve been using it for a few weeks and feel more relaxed with no negative side effects. It effectively reduces stress and anxiety.
Read More
9
Sleeping better now
133 people found this helpful
L-Theanine for sleep and anxiety – 5 stars. I discovered L-Theanine a few months ago, and it has been remarkable. After cutting back on Ambien due to concerns about long-term effects, I tried this over a weekend. Initially, I was sceptical, but after about 90 minutes, I finally felt sleepy for the first time in years. I now sleep soundly each night. I shared it with my wife, who also found it helpful for her sleep issues and even managed to sleep through a thunderstorm. Several friends undergoing stress have similarly benefited from L-Theanine.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 23 Researches
7.3
- All Researches
9
We investigated the effects of l-theanine, an amino acid found in green tea, on the negative side effects of adolescent THC exposure. Our research used a preclinical model with male rats to see if l-theanine could prevent long-term behavioral and cognitive issues linked to THC exposure.
Findings showed that l-theanine effectively blocked these adverse effects, protecting brain function and regulating important neurotransmitter pathways. As cannabis use grows among adolescents, our study highlights l-theanine's potential as a protective treatment to minimize THC-induced risks.
Findings showed that l-theanine effectively blocked these adverse effects, protecting brain function and regulating important neurotransmitter pathways. As cannabis use grows among adolescents, our study highlights l-theanine's potential as a protective treatment to minimize THC-induced risks.
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9
We examined the role of targeted amino acid therapy, including l-theanine, in addressing mood disorders like anxiety and depression. Our case study focused on a 26-year-old woman with complex mental health challenges who, after struggling with conventional treatments, engaged in a personalized nutrition intervention. Over 12 weeks, she followed a tailored program that emphasized amino acids and specific nutrients.
The results were promising, showing significant improvement in her anxiety, depression, and other related symptoms. This suggests that integrating nutritional therapies may offer new hope for those affected by mood disorders.
The results were promising, showing significant improvement in her anxiety, depression, and other related symptoms. This suggests that integrating nutritional therapies may offer new hope for those affected by mood disorders.
Read More
9
This study evaluated the impact of four weeks of L-theanine on stress and cognitive function in 30 healthy adults. Participants received either 200 mg of L-theanine or a placebo in a double-blind setup. We observed significant reductions in anxiety and stress symptoms, as indicated by improved scores on various measures, including sleep quality. Additionally, cognitive functions, such as verbal fluency, showed notable enhancement after L-theanine use. These findings suggest that L-theanine may be beneficial for managing stress-related issues and boosting mental performance.
Read More
8
L-theanine reduces anxiety effectively
We explored the impact of L-theanine and GABA on anxiety levels in preoperative surgical patients. In a randomized controlled study involving 168 participants, we compared the effects of these amino acids with that of a common sedative, alprazolam.
Our findings showed that both L-theanine and GABA effectively reduced preoperative anxiety while causing minimal sedation and even enhancing cognitive performance. This suggests that L-theanine might be a safe alternative to traditional anxiolytics for managing anxiety before surgery.
Our findings showed that both L-theanine and GABA effectively reduced preoperative anxiety while causing minimal sedation and even enhancing cognitive performance. This suggests that L-theanine might be a safe alternative to traditional anxiolytics for managing anxiety before surgery.
Read More
8
We explored the effects of L-theanine on cognitive anxiety among 18 female archery athletes during a national competition. The research measured anxiety levels using a simple scale, alongside saliva samples to assess markers like salivary alpha-amylase and cortisol.
Results showed that L-theanine significantly reduced cognitive anxiety just before the competition, as well as lowering other stress indicators in comparison to a placebo. Thus, we conclude that L-theanine can be a beneficial aid for athletes looking to manage competition-related anxiety effectively.
Results showed that L-theanine significantly reduced cognitive anxiety just before the competition, as well as lowering other stress indicators in comparison to a placebo. Thus, we conclude that L-theanine can be a beneficial aid for athletes looking to manage competition-related anxiety effectively.
Read More
User Reviews
USERS' SCORE
Good
Based on 155 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
10
Life-changing supplement
613 people found this helpful
This product has saved me! I experienced varying degrees of anxiety, depression, emotional eating, and brain fog. I didn't know myself anymore, but this supplement has changed everything. I never took prescription drugs due to fear of side effects. My doctor suggested this, and it's like finding a golden ticket – instead of craziness, it led me out of my struggles! I feel energy to finish tasks, calm during stress, and more like my old self. My anxiety and mood swings have significantly improved, and I've even started losing weight. I now sleep well and feel refreshed. I've told everyone about this – I truly believe everyone should take it to reclaim their happiness!
Read More
9
Natural relaxation
222 people found this helpful
L-theanine helps me relax and unwind naturally. I’ve been using it for a few weeks and feel more relaxed with no negative side effects. It effectively reduces stress and anxiety.
Read More
9
Sleeping better now
133 people found this helpful
L-Theanine for sleep and anxiety – 5 stars. I discovered L-Theanine a few months ago, and it has been remarkable. After cutting back on Ambien due to concerns about long-term effects, I tried this over a weekend. Initially, I was sceptical, but after about 90 minutes, I finally felt sleepy for the first time in years. I now sleep soundly each night. I shared it with my wife, who also found it helpful for her sleep issues and even managed to sleep through a thunderstorm. Several friends undergoing stress have similarly benefited from L-Theanine.
Read More
10
Prescription alternative
131 people found this helpful
This simple green tea extract has completely replaced my prescription medications for anxiety and panic attacks. I've faced numerous personal challenges, including a house fire and losing family members, increasing my anxiety. After being dissatisfied with Alprazolam and Lexapro, I transitioned to L-Theanine, taking one 200 mg capsule twice daily. The difference was remarkable! My anxiety is under control, and I easily manage potential panic attacks with extra capsules without the fog or side effects of prescriptions. I highly recommend this as an alternative to medication.
Read More
10
Life-changing effect
105 people found this helpful
These capsules have dramatically changed my life. Living with chronic anxiety since childhood, I was in a difficult place when I discovered this product. It has helped me reclaim my freedom in stressful situations that previously caused overwhelming anxiety. I take a capsule each morning and frequently forget I've taken it, only to feel clear-headed within 20 minutes. My brother now uses it too and is very pleased. This product is genuinely amazing.
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Frequently Asked Questions
9
Enhances focus and calmness
14 people found this helpful
This supplement has helped me control my anxiety while boosting my focus and productivity. I felt the positive effects within two days.
9
Easier coping
32 people found this helpful
I take 400 mg of L-theanine in the morning, and it significantly reduces my anxiety. It teaches me how to behave in stressful situations, contributing to my well-being.
7.5
Enhanced productivity
7 people found this helpful
I’ve tried other brands of L-Theanine, but this is the only one that made a difference. Combining it with coffee helps me be more productive during the day while eliminating the jitteriness and anxiety coffee often causes. The quality is always great. I seldom write reviews, but this product significantly impacted my productivity and anxiety, and I hope others experience the same benefits.
8
L-theanine reduces anxiety effectively
We explored the impact of L-theanine and GABA on anxiety levels in preoperative surgical patients. In a randomized controlled study involving 168 participants, we compared the effects of these amino acids with that of a common sedative, alprazolam.
Our findings showed that both L-theanine and GABA effectively reduced preoperative anxiety while causing minimal sedation and even enhancing cognitive performance. This suggests that L-theanine might be a safe alternative to traditional anxiolytics for managing anxiety before surgery.
Our findings showed that both L-theanine and GABA effectively reduced preoperative anxiety while causing minimal sedation and even enhancing cognitive performance. This suggests that L-theanine might be a safe alternative to traditional anxiolytics for managing anxiety before surgery.
7
L-Theanine's potential for anxiety relief
We evaluated how the amino acid L-theanine, commonly found in green tea, affects stress and anxiety through a systematic review of nine clinical trials. These studies compared L-theanine supplements to control groups and suggested that taking 200-400 mg daily may help reduce symptoms of stress and anxiety.
However, the evidence is not yet definitive, as we need more extensive, long-term studies to firmly establish L-theanine’s effectiveness as a treatment for anxiety-related issues.
However, the evidence is not yet definitive, as we need more extensive, long-term studies to firmly establish L-theanine’s effectiveness as a treatment for anxiety-related issues.
8
We explored the effects of L-theanine on cognitive anxiety among 18 female archery athletes during a national competition. The research measured anxiety levels using a simple scale, alongside saliva samples to assess markers like salivary alpha-amylase and cortisol.
Results showed that L-theanine significantly reduced cognitive anxiety just before the competition, as well as lowering other stress indicators in comparison to a placebo. Thus, we conclude that L-theanine can be a beneficial aid for athletes looking to manage competition-related anxiety effectively.
Results showed that L-theanine significantly reduced cognitive anxiety just before the competition, as well as lowering other stress indicators in comparison to a placebo. Thus, we conclude that L-theanine can be a beneficial aid for athletes looking to manage competition-related anxiety effectively.
8
We conducted a thorough look at how L-theanine supplementation might help those dealing with anxiety and other mental health issues. By reviewing multiple controlled trials, we discovered that L-theanine significantly reduced symptoms in individuals with schizophrenia, anxiety disorders, and ADHD compared to control groups.
While these results are promising, we also recognize the need for more research to confirm these findings and better understand how L-theanine works in the body.
While these results are promising, we also recognize the need for more research to confirm these findings and better understand how L-theanine works in the body.
7
L-theanine's potential for anxiety
We reviewed the impact of L-theanine, a natural amino acid found in green tea, on anxiety disorders and psychological stress. This review highlighted that daily doses between 200 to 400 mg for up to eight weeks appear to be safe and may help reduce anxiety and stress.
However, while initial studies indicate potential benefits, more rigorous randomized double-blind placebo-controlled trials are needed to confirm these findings and explore its long-term effects.
Additionally, research into higher doses and various combinations with other treatments is encouraged for a comprehensive understanding.
However, while initial studies indicate potential benefits, more rigorous randomized double-blind placebo-controlled trials are needed to confirm these findings and explore its long-term effects.
Additionally, research into higher doses and various combinations with other treatments is encouraged for a comprehensive understanding.
References
- Deshpande SS, Kurdi M, Baiju A, Athira AS, Sarasamma AG, et al. Comparison of the effects of two amino acids, Gamma-aminobutyric acid (GABA) and L-theanine, on sedation, anxiety, and cognition in preoperative surgical patients - A randomized controlled study. J Anaesthesiol Clin Pharmacol. 2025;41:112. 10.4103/joacp.joacp_417_23
- Lim IS. Effects of supplement L-theanine on cognitive anxiety, salivary alpha-amylase, and cortisol in archery competition. Phys Act Nutr. 2024;28:70. 10.20463/pan.2024.0034
- Moshfeghinia R, Sanaei E, Mostafavi S, Assadian K, Sanaei A, et al. The effects of L-theanine supplementation on the outcomes of patients with mental disorders: a systematic review. BMC Psychiatry. 2024;24:886. 10.1186/s12888-024-06285-y
- Moulin M, Crowley DC, Xiong L, Guthrie N, Lewis ED. Safety and Efficacy of AlphaWave L-Theanine Supplementation for 28 Days in Healthy Adults with Moderate Stress: A Randomized, Double-Blind, Placebo-Controlled Trial. Neurol Ther. 2024;13:1135. 10.1007/s40120-024-00624-7
- Pilipenko VI, Isakov VA, Morozov SV, Sasunova AN, Goncharov AA. [Clinical evaluation of the efficacy of innovative spread of a given fatty acid composition enriched by adaptogens]. Vopr Pitan. 2023;92:104. 10.33029/0042-8833-2023-92-4-104-113
- Ma X, Shin YJ, Park HS, Jeong JW, Kim JY, et al. and Its Supplement Alleviate Stress-Induced Depression and Anxiety in Mice by the Regulation of BDNF Expression and NF-κB Activation. Nutrients. 2023;15. 10.3390/nu15112488
- Rizzo R, Prato A, Scerbo M, Saia F, Barone R, et al. Use of Nutritional Supplements Based on L-Theanine and Vitamin B6 in Children with Tourette Syndrome, with Anxiety Disorders: A Pilot Study. Nutrients. 2022;14. 10.3390/nu14040852
- Evans M, McDonald AC, Xiong L, Crowley DC, Guthrie N. A Randomized, Triple-Blind, Placebo-Controlled, Crossover Study to Investigate the Efficacy of a Single Dose of AlphaWave L-Theanine on Stress in a Healthy Adult Population. Neurol Ther. 2021;10:1061. 10.1007/s40120-021-00284-x
- De Felice M, Renard J, Hudson R, Szkudlarek HJ, Pereira BJ, et al. l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry. J Neurosci. 2021;41:739. 10.1523/JNEUROSCI.1050-20.2020
- Ross K, VanNortwick M, Dragone D. Innovative therapies for mood disorders: A case report. Explore (NY). 2021;17:208. 10.1016/j.explore.2020.03.011
- Williams JL, Everett JM, D'Cunha NM, Sergi D, Georgousopoulou EN, et al. The Effects of Green Tea Amino Acid L-Theanine Consumption on the Ability to Manage Stress and Anxiety Levels: a Systematic Review. Plant Foods Hum Nutr. 2020;75:12. 10.1007/s11130-019-00771-5
- Hidese S, Ogawa S, Ota M, Ishida I, Yasukawa Z, et al. Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial. Nutrients. 2019;11. 10.3390/nu11102362
- Lopes Sakamoto F, Metzker Pereira Ribeiro R, Amador Bueno A, Oliveira Santos H. Psychotropic effects of -theanine and its clinical properties: From the management of anxiety and stress to a potential use in schizophrenia. Pharmacol Res. 2019;147:104395. 10.1016/j.phrs.2019.104395
- Hannant P, Cassidy S, Renshaw D, Joyce A. A double-blind, placebo-controlled, randomised-designed GABA tea study in children diagnosed with autism spectrum conditions: a feasibility study clinical trial registration: ISRCTN 72571312. Nutr Neurosci. 2021;24:45. 10.1080/1028415X.2019.1588486
- Ogawa S, Ota M, Ogura J, Kato K, Kunugi H. Effects of L-theanine on anxiety-like behavior, cerebrospinal fluid amino acid profile, and hippocampal activity in Wistar Kyoto rats. Psychopharmacology (Berl). 2018;235:37. 10.1007/s00213-017-4743-1
- Hidese S, Ota M, Wakabayashi C, Noda T, Ozawa H, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr. 2017;29:72. 10.1017/neu.2016.33
- Bellagamba O, Guo AJ, Senthilkumar S, Lillevik SH, De Biase D, et al. Assessment of Long-Term Safety and Efficacy of Purple Sweet Potato Color (PSPC) and Myo-Inositol (MI) Treatment for Motor Related and Behavioral Phenotypes in a Mouse Model of Classic Galactosemia. J Inherit Metab Dis. 2025;48:e70002. 10.1002/jimd.70002
- El-Heis S, Barton SJ, Chang HF, Nield H, Cox V, et al. Maternal mood, anxiety and mental health functioning after combined myo-inositol, probiotics, micronutrient supplementation from preconception: Findings from the NiPPeR RCT. Psychiatry Res. 2024;334:115813. 10.1016/j.psychres.2024.115813
- Kishi T, Sakuma K, Iwata N. Mitochondrial modulators for obsessive-compulsive and related disorders: a systematic review and meta-analysis. Transl Psychiatry. 2022;12:263. 10.1038/s41398-022-02026-5
- Herwig E, Classen HL, Walk CL, Bedford M, Schwean-Lardner K. Dietary Inositol Reduces Fearfulness and Avoidance in Laying Hens. Animals (Basel). 2019;9. 10.3390/ani9110938
- Alonso-Castro AJ, Alba-Betancourt C, Rocha-González E, Ruiz-Arredondo A, Zapata-Morales JR, et al. Neuropharmacological effects of d-pinitol and its possible mechanisms of action. J Food Biochem. 2019;43:e13070. 10.1111/jfbc.13070
- Zulfarina MS, Syarifah-Noratiqah SB, Nazrun SA, Sharif R, Naina-Mohamed I. Pharmacological Therapy in Panic Disorder: Current Guidelines and Novel Drugs Discovery for Treatment-resistant Patient. Clin Psychopharmacol Neurosci. 2019;17:145. 10.9758/cpn.2019.17.2.145
- Emanuel RHK, Docherty PD, Lunt H, Campbell RE. What do users in a polycystic ovary syndrome (PCOS) forum think about the treatments they tried: Analysing treatment sentiment using machine learning. Phys Eng Sci Med. 2025. 10.1007/s13246-025-01539-9
Data last updated:
