We explored the case of a 23-month-old boy suffering from severe pancytopenia linked to Imerslund-Gräsbeck syndrome, a rare condition caused by an inability to absorb vitamin B12. Upon diagnosis, the boy received vitamin B12 replacement therapy, which effectively addressed his symptoms and improved his health.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
Read More
9.5
Oral B12 significantly improves anemia
Oral vitamin B12 supplementation in pernicious anemia: a prospective cohort study.
We focused on how oral vitamin B12 could help those with pernicious anemia, where absorption is usually impaired. Participants diagnosed with vitamin B12 deficiency due to this condition took a daily dose of 1000 μg of oral cyanocobalamin.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Read More
9
B12 treatment improves anemia outcomes
Transcobalamin deficiency - a rare genetic defect in transportation of cobalamin; case report.
We explored a rare condition called Transcobalamin deficiency, which hinders vitamin B12 transport in the body. This case involved a 2-year-old boy suffering from severe anemia and frequent infections.
After genetic tests revealed a specific mutation, we administered high doses of methylcobalamin. Remarkably, the child's health significantly improved, highlighting the importance of diagnosing and treating this deficiency early to avoid serious complications.
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Most Useful Reviews
9
Significant improvement
3 people found this helpful
For years, I suffered from anemia with a haemoglobin level around 90. I learned that vitamin B12, not found in plant-based foods, is vital for iron absorption. After taking this vitamin alongside iron for three months, my haemoglobin rose from 90 to 135! This is an excellent result, and I’ll continue taking B12 as I don’t plan to eat meat again.
Read More
9
Increased energy
2 people found this helpful
I never realised how effective vitamin B12 could be. The quality impressed me after tests revealed my anaemia was affected by vitamin B12 rather than low iron levels. I noticed a significant boost in my energy and improved metabolism.
Read More
9
Convenient to take
1 people found this helpful
I use vitamin B12 as recommended by my doctor for my elderly parents with anaemia. This product is convenient to take, combined with folic acid, making it simpler for their treatment. We appreciate the quality and availability.
We explored the case of a 23-month-old boy suffering from severe pancytopenia linked to Imerslund-Gräsbeck syndrome, a rare condition caused by an inability to absorb vitamin B12. Upon diagnosis, the boy received vitamin B12 replacement therapy, which effectively addressed his symptoms and improved his health.
This case highlights the significance of early detection and treatment of IGS to avoid potential neurological damage. It's crucial to recognize this condition, even when neurological symptoms are absent, to provide timely care.
Read More
9.5
Oral B12 significantly improves anemia
Oral vitamin B12 supplementation in pernicious anemia: a prospective cohort study.
We focused on how oral vitamin B12 could help those with pernicious anemia, where absorption is usually impaired. Participants diagnosed with vitamin B12 deficiency due to this condition took a daily dose of 1000 μg of oral cyanocobalamin.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
Read More
9.5
Nutrition education reduces anemia
Effect of nutrition education and iron-folic acid supplementation on anemia among pregnant women in Ethiopia: a quasi-experimental study.
We observed the influence of nutrition education and iron-folic acid (IFA) supplementation on the levels of anemia among pregnant women in Butajira, Ethiopia. Through a quasi-experimental design over three months, we provided pregnant women with health education based on the Health Belief Model, alongside IFA supplements over a six-week period.
At the end of the study, we noticed a remarkable improvement. The proportion of anemia in women receiving the intervention dropped significantly from 27.8% to just 7.2%. Additionally, the knowledge about IFA supplementation improved notably in the intervention group compared to those who did not receive the same level of education, showing a clear connection between education, adherence to supplementation, and overall hemoglobin levels.
We found that participants who engaged in the educational interventions were more likely to adhere to their IFA supplement regimen—2.26 times more so than those who did not participate. This highlights the vital role that combining community-based education and supplementation can play in tackling anemia during pregnancy and improving maternal health outcomes effectively.
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9.5
Folate's limited role in anemia
An Unusual Case of Hemolytic Anemia: A Case Report.
Our exploration centered on how folate impacts anemia, specifically in cases of vitamin B12 deficiency. We observed that while vitamin B12 is often the star player in reversing anemia symptoms, folate also plays a critical support role.
Despite this, the data from related cases indicated that isolated folate treatment did not provide significant benefits in correcting anemia. The connection between folate and hemolytic anemia became clear, yet treatment focused primarily on reintroducing vitamin B12, suggesting that folate’s contribution might not be as decisive on its own.
This finding emphasizes the importance of comprehensive treatment approaches and the need for health care providers to consider both vitamins in managing anemia. Ultimately, the positive outcomes we identified were closely tied to vitamin B12 administration rather than folate acting independently.
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9.5
Vitamin B12 aids anemia recovery
Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review.
We investigated how vitamin B12 treatment plays a role in addressing anemia in a young adolescent with complex health issues, including severe anemia, joint problems, and neurological symptoms. This individual presented with a deficiency in vitamin B12, alongside other autoimmune conditions, leading to a diagnosis of subacute combined degeneration of the spinal cord.
The patient's treatment regimen included high-dose intravenous methylprednisolone, immunoglobulin therapy, oral naproxen, and vitamin B12 supplementation, among others. We observed that the introduction of vitamin B12 into her treatment plan contributed to combating her anemia effectively. The combination of therapies, especially with vitamin B12, significantly improved her overall health and restored her quality of life.
Our findings highlight the importance of early diagnosis and prompt treatment in patients with complex autoimmune issues. Specifically, vitamin B12 emerges as a critical component in managing anemia related to such conditions. While the study is anecdotal, it reinforces the idea that vitamin B12 can be beneficial in improving anemia outcomes in similarly affected patients.
For years, I suffered from anemia with a haemoglobin level around 90. I learned that vitamin B12, not found in plant-based foods, is vital for iron absorption. After taking this vitamin alongside iron for three months, my haemoglobin rose from 90 to 135! This is an excellent result, and I’ll continue taking B12 as I don’t plan to eat meat again.
Read More
9
Increased energy
2 people found this helpful
I never realised how effective vitamin B12 could be. The quality impressed me after tests revealed my anaemia was affected by vitamin B12 rather than low iron levels. I noticed a significant boost in my energy and improved metabolism.
Read More
9
Convenient to take
1 people found this helpful
I use vitamin B12 as recommended by my doctor for my elderly parents with anaemia. This product is convenient to take, combined with folic acid, making it simpler for their treatment. We appreciate the quality and availability.
Read More
9
Effective absorption
My doctor prescribed Vitamin B12 due to my anaemia. This vitamin is vital for bodily functions, and I've been directed to take it for life. The tablets are sweet and pleasant, making absorption easier.
Read More
7.5
Helps with deficiency
I am pleased with this vitamin B12 supplement. My elderly parents take it as directed by their doctor. My mother, who has diabetes and struggles with absorption due to medication, and my father, who suffers from dementia and anaemia, both benefit significantly from this vitamin.
Anemia is a medical condition characterized by a deficiency of red blood cells or hemoglobin in the blood, which can result in reduced oxygen flow to the body's organs. The most common type of anemia is iron-deficiency anemia, which occurs when the body does not have enough iron to produce adequate hemoglobin. Other types can arise from chronic diseases, genetic conditions, or a lack of certain vitamins such as B12 or folate. Symptoms often include fatigue, weakness, pale skin, and shortness of breath, particularly during physical activity.
Diagnosing anemia typically involves blood tests to measure levels of red blood cells, hemoglobin concentration, and other related factors. Treatment varies depending on the underlying cause but may include dietary changes, supplements, or medications. In some cases, more serious interventions may be necessary, such as blood transfusions or treatments for associated conditions. If you suspect you have anemia, it's essential to consult a healthcare professional for appropriate evaluation and management.
Vitamin B12, also known as cobalamin, is a water-soluble vitamin that plays a crucial role in several vital functions in the human body. It is essential for red blood cell formation, neurological function, and DNA synthesis. Naturally occurring in animal products, the vitamin can be found in high concentrations in meat, fish, eggs, and dairy, making it particularly important for those following a vegetarian or vegan diet, as plant-based sources of B12 are limited and often require supplementation.
A deficiency in vitamin B12 can lead to serious health issues, including anemia, fatigue, memory problems, and nerve damage. Due to its significance, it's crucial for individuals, particularly those at risk of deficiency, to ensure adequate intake through diet or supplementation. For most adults, the recommended daily allowance (RDA) is around 2.4 micrograms, though pregnant or breastfeeding women may require higher amounts. If you're considering B12 supplements, it's advisable to consult with a healthcare provider to determine the best option for your specific needs and health status.
B12 plays a crucial role in the formation of red blood cells, and a deficiency can lead to a specific type of anemia called pernicious anemia. In this condition, the body lacks sufficient vitamin B12, which is essential for producing healthy red blood cells, resulting in a decreased ability to transport oxygen throughout the body. Symptoms of this type of anemia can include fatigue, weakness, and even neurological issues if left untreated.
Supplementing with B12 can alleviate these symptoms and correct the deficiency, making it an effective part of the treatment plan for those diagnosed with pernicious anemia. However, it's essential to consult with a healthcare professional before starting supplementation, as the specific needs can vary significantly between individuals. They may recommend dietary adjustments or injections depending on the severity of the deficiency and the underlying causes. In sum, while B12 can certainly help with certain types of anemia, addressing the root cause with professional guidance is key for effective treatment.
Based on user reviews, the timeline for seeing results from Vitamin B12 supplementation for anemia can vary significantly. Many users report noticeable improvements within a few weeks to several months of consistent use. For instance, one user mentioned that after three months of taking Vitamin B12 alongside iron, their hemoglobin levels rose significantly, indicating substantial progress in managing their anemia (Read Review). Another user simply noted a significant boost in energy, suggesting benefits can manifest relatively quickly (Read Review).
However, the effectiveness may depend on individual circumstances, including existing health conditions and dietary habits. Several users emphasized the importance of consulting a healthcare professional before beginning supplementation to determine the best approach for their specific case (Read Review). Overall, while some experience results soon after starting Vitamin B12, others may encounter varying timelines based on their unique health profiles and needs.
Scientific research supports the use of Vitamin B12 supplementation in addressing anemia, particularly in cases related to deficiencies like pernicious anemia. For instance, in a case study, a patient diagnosed with pernicious anemia showed significant improvement after receiving parenteral B12 treatment, highlighting the critical role of this vitamin in managing anemia symptoms and contributing to neurological health ([3]). Furthermore, systematic investigations have shown that Vitamin B12 therapy can effectively reverse symptoms of anemia caused by deficiencies, underscoring the importance of proper diagnosis and targeted treatment strategies ([1]).
Moreover, studies have explored oral B12 supplementation's efficacy, demonstrating how it can successfully elevate B12 levels and alleviate anemia symptoms, with around 88.5% of participants experiencing improvements within a month ([10]). Another research highlighted the enhanced effectiveness of innovative formulations like Sucrosomial Vitamin B12 for maintaining adequate levels in individuals with absorption challenges, indicating its promising potential for managing vitamin deficiency-related anemia ([33]). Collectively, these findings reinforce the significance of Vitamin B12 in anemia treatment, particularly for those with specific deficiencies and related conditions.
Users report various improvements in symptoms associated with anemia after using Vitamin B12 supplements. For instance, one user experienced a remarkable jump in their hemoglobin levels from 90 to 135 after three months of supplementation combined with iron, highlighting the vitamin's effectiveness in addressing their anemia (Read Review). Another user noted a significant boost in energy and metabolism, indicating a broader impact on their overall vitality and wellbeing (Read Review).
Additionally, several users have observed benefits for elderly individuals who have difficulty with absorption due to various health conditions, indicating that the product is beneficial for a diverse range of users. Reviews suggest that not only does Vitamin B12 help in the treatment of anemia, but it may also alleviate symptoms like muscle spasms and numbness in certain cases (Read Review). However, it's important to note that individual results can vary, and some users have reported less success, emphasizing the need for personalized medical advice before starting any new supplement regimen (Read Review).
Users report positive experiences when combining Vitamin B12 with other supplements to handle anemia, particularly with iron and folic acid. One user noted remarkable progress, with their hemoglobin levels increasing from 90 to 135 after three months of taking Vitamin B12 alongside iron, emphasizing the vitamin's role in iron absorption and overall effectiveness in treating anemia (Read Review). Another user confirmed that their elderly parents benefited from combining B12 with folic acid, applauding the simplicity and convenience of this approach in managing their anemia (Read Review).
Additionally, users reported that Vitamin B12 can have broader health impacts when used in conjunction with other supplements. For example, a user stated the supplement significantly improved their energy levels and overall metabolism, indicating synergistic benefits when paired with other treatments (Read Review). However, some users have advised consulting healthcare professionals before starting any new supplement combinations to ensure the best outcomes tailored to individual health needs and conditions (Read Review).
The optimal dose of vitamin B12 for treating anemia can vary depending on the specific circumstances of the deficiency. Research indicates that for severe deficiencies, higher dosages may be necessary. For instance, doses exceeding 200 µg per day are categorized as drug dosages and are effective in addressing anemia and its associated symptoms. Lower doses, around 50 µg daily, can stabilize abnormal blood markers but may not be sufficient for all individuals with significant deficiencies [28].
Additionally, studies have demonstrated that 1000 µg of oral cyanocobalamin can effectively correct deficiencies over time, revealing that a substantial portion of individuals saw improvements in just a month's time [10]. Intramuscular injections of methylcobalamin also showed significant benefits in cases like pernicious anemia, where absorption issues complicate treatment [3]. Therefore, it is crucial to assess individual needs and severity of deficiency to determine the most effective dose for each patient.
9
Significant improvement
3 people found this helpful
For years, I suffered from anemia with a haemoglobin level around 90. I learned that vitamin B12, not found in plant-based foods, is vital for iron absorption. After taking this vitamin alongside iron for three months, my haemoglobin rose from 90 to 135! This is an excellent result, and I’ll continue taking B12 as I don’t plan to eat meat again.
9
Increased energy
2 people found this helpful
I never realised how effective vitamin B12 could be. The quality impressed me after tests revealed my anaemia was affected by vitamin B12 rather than low iron levels. I noticed a significant boost in my energy and improved metabolism.
7.5
Potential alternative
I believe it may serve as an alternative to folic acid and could be more effective for patients with anaemia. It's important to consult a doctor before use.
7
Muscle spasms relief
1 people found this helpful
I find Vitamin B12 excellent for alleviating muscle spasms and numbness, as well as treating anaemia. The tablets are easy to absorb and seem effective for my needs.
4
Metformin side effects
I’ve been on metformin for years and experienced stomach upset and anaemia. While B12 is essential, this product didn’t work best for me. I switched to a different brand for better results.
9
Convenient to take
1 people found this helpful
I use vitamin B12 as recommended by my doctor for my elderly parents with anaemia. This product is convenient to take, combined with folic acid, making it simpler for their treatment. We appreciate the quality and availability.
8
Pernicious anemia diagnosis and treatment
Rural health challenges in Western Uganda: pernicious anemia masquerading as recurrent lower limb weakness-a case report.
We explored a case involving a 51-year-old Ugandan man who experienced recurring lower limb weakness and was ultimately diagnosed with pernicious anemia. His condition stemmed from vitamin B12 deficiency, confirmed by blood tests showing macrocytic anemia and low cobalamin levels.
With treatment using methylcobalamin injections, he showed significant improvement. This case emphasizes the need for heightened awareness of vitamin B12 deficiency in diagnosing anemia, especially in areas with limited health resources.
8
Pernicious anemia linked to B12
A long-standing undiagnosed case of vitamin B12 deficiency: a case report.
This case explores the journey of a 40-year-old woman who suffered from various nonspecific symptoms, mistakenly attributed to other health issues, for ten years. Her vitamin B12 levels were critically low, ultimately diagnosed as pernicious anemia.
After starting parenteral B12 treatment, we observed significant neurological improvements, underscoring how vital it is to recognize vitamin B12 deficiency as a potential cause of anemia, even when classic symptoms aren't present. This case reminds us to maintain a broad perspective for accurate diagnosis.
9.5
Oral B12 significantly improves anemia
Oral vitamin B12 supplementation in pernicious anemia: a prospective cohort study.
We focused on how oral vitamin B12 could help those with pernicious anemia, where absorption is usually impaired. Participants diagnosed with vitamin B12 deficiency due to this condition took a daily dose of 1000 μg of oral cyanocobalamin.
Over a year, an impressive 88.5% of them no longer showed deficiency after just one month, with significant improvements in vitamin B12 levels and related biological markers. Importantly, these benefits lasted throughout the study period.
9
Effective B12 treatment for anemia
Comparative bioavailability study of supplemental oral Sucrosomial vs. oral conventional vitamin B12 in enhancing circulatory B12 levels in healthy deficient adults: a multicentre, double-blind randomized clinical trial.
We conducted a study to explore how effective different vitamin B12 supplements are at increasing levels of this crucial vitamin in people with a deficiency. This clinical trial involved healthy adults who were found to have low B12 levels.
Our research spanned across three centers in Pakistan, where participants received either a new formulation of Sucrosomial vitamin B12 or conventional B12 supplements. They took a daily dose for seven days, and we measured their serum B12 levels at various points before and after the treatment.
What we found was quite significant: the Sucrosomial vitamin B12 was notably better at elevating and maintaining higher B12 levels in the bloodstream compared to traditional options. This is important because low vitamin B12 can lead to serious health issues, like megaloblastic anemia and neurological problems.
Overall, this innovative supplement could offer a valuable solution for individuals with B12 deficiency, especially those who may have absorption issues. Our findings support the potential of Sucrosomial vitamin B12 in enhancing health through improved nutrient bioavailability.
9
Vitamin B12's role in anemia
A Framework to Guide Defining an Upper Threshold of Crystalline Vitamin B12 in Foods and Food Supplements.
We explored how vitamin B12 affects anemia, specifically through its role in correcting deficiencies. The research analyzes oral B12 intake and its absorption, particularly in individuals showing signs of deficiency.
There’s a clear relationship between the amount of B12 consumed and the body’s response. Supplements offering up to 20 µg of B12 daily are deemed safe and unlikely to trigger side effects.
For those severely affected, higher dosages—like 50 µg—may help stabilize abnormal markers in the blood, while foods designed for medical purposes can contain up to 150 µg.
However, anything beyond 200 µg per day should be treated as a drug, as it can effectively address anemia and related symptoms. Importantly, for individuals diagnosed with deficiency, proper medical treatment remains essential, leaning towards higher doses of B12.
References
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Upadhyay RP, Chowdhury R, Mundra S, Taneja S, Jacob M, et al. Comparative effectiveness of daily therapeutic supplementation with multiple micronutrients and iron-folic acid versus iron-folic acid alone in children with mild-to-moderate anaemia in rural India: an open-label, randomised controlled trial. Lancet Glob Health. 2025;13:e497. 10.1016/S2214-109X(24)00559-X
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Merga RT, Birhane M, Dhinsa M, Muleta B, Jemal J, et al. Determinants of compliance with iron-folic acid supplementation among pregnant mothers in Bule Hora district, Southern Ethiopia: unmatched case-control study. BMC Public Health. 2025;25:832. 10.1186/s12889-025-22005-x
Weeks CJ, Mian M, Stokes M, Gold M, Shah A, et al. The Role of Ferritin and Folate in Determining Stem Cell Collection for Autologous Stem Cell Transplant in Multiple Myeloma. Hematol Rep. 2025;17. 10.3390/hematolrep17010005
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Kant SB, Bashir R, Khan B, Shabbir NA, Nizami AA, et al. A Cross-Sectional Study of the Maternal Health Factors: The Interplay Between Breastfeeding Patterns, Gut Microbiota, Anemia, and Cardiovascular Risk in Lactating Mothers. Cureus. 2024;16:e76316. 10.7759/cureus.76316
Belhaj R, Maaloul I, Kolsi R, Rekik T, Chabchoub I, et al. Study of clinical manifestations and etiologies of megaloblastic anemia in children. Transfus Clin Biol. 2025. 10.1016/j.tracli.2025.01.006
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Kataria S, Kataria S, Chougule D, Bharti B, Rastogi A. Evaluating the Impact of an Iron Supplementation Program for Combating Anemia in School-Age and Adolescent Females by a Grassroots Organization in India. Cureus. 2024;16:e75608. 10.7759/cureus.75608
Bolka A, Bosha T, Gebremedhin S. Effect of School-Based Weekly Iron and Folic Acid Supplementation Program on the Serum Folate Status of Adolescent Girls in Sidama Region, Southern Ethiopia: Comparative Cross-Sectional Study. Food Nutr Bull. 2025. 10.1177/03795721241304475
Chillo SL, Woldesemayat EM, Dangisso MH. Intermittent versus daily oral iron folic acid supplementation and pregnancy outcome in low- and middle-income countries: a systematic review and meta-analysis of experimental studies. Reprod Health. 2025;22:2. 10.1186/s12978-024-01917-8
Kaneko M, Masuda Y, Ishikawa K, Shikata H. Coexistence of Cold Agglutinin and Cryoglobulin in a Patient With Severe Anemia Following COVID-19 Infection. Cureus. 2024;16:e75257. 10.7759/cureus.75257
Contreras R, Méndez GP, Mujica J, Padilla C, Selamé ME, et al. [Paroxysmal Nocturnal Hemoglobinuria: A Rare but Treatable Cause of Acute Kidney Injury. Case Report]. Rev Med Chil. 2024;152:627. 10.4067/s0034-98872024000500627
Singh G, Ranjitha R, Baskaran P, Goel AD, Gupta MK, et al. Family-centered Health Education Intervention for Improving Iron-folic Acid Adherence and Anemia Reduction among Antenatal Mothers in Rural Jodhpur: A Quasi-experimental Study. Indian J Public Health. 2024;68:495. 10.4103/ijph.ijph_844_23
Zhang C, Cha R, Long K, Liu Y, Dong Y, et al. Functionalized Iron Oxide Nanoparticles for Both Dual-Modal Imaging and Erythropoiesis. ACS Appl Mater Interfaces. 2024;16:68905. 10.1021/acsami.4c15206
Sachdeva M, Purohit A, Malik M, Jain L, Pradhan P, et al. Comparison of Efficacy and Safety of Parenteral vs Oral Route of Vitamin B12 Supplementation for the Treatment of Vitamin B12 Deficiency Anemia in Children: A Systematic Review. Nutr Rev. 2025. 10.1093/nutrit/nuae227
Obeid R, Geisel J, Pietrzik K, Andres E. A Framework to Guide Defining an Upper Threshold of Crystalline Vitamin B12 in Foods and Food Supplements. Curr Nutr Rep. 2025;14:32. 10.1007/s13668-025-00622-7
Goncalves H, De Oliveira Simões F, Sá R, Fraga Campos B, Domingues RM, et al. Severe Symptomatic Anemia as a Rare Initial Manifestation of Type 3 Polyglandular Autoimmune Syndrome: A Case Report. Cureus. 2024;16:e75800. 10.7759/cureus.75800
Lang C, Huang P, Gao J, Chen Y, He Z. Co-existence of autoimmune polyglandular syndrome type 3b and undifferentiated connective tissue disease with subacute combined degeneration of spinal cord in children: a case report and literature review. BMC Pediatr. 2024;24:817. 10.1186/s12887-024-05262-4
Tavares Pereira J, Barbosa Barroso J, Azevedo A, Ribeiro A, Tonel C. Pseudo-Thrombotic Microangiopathy Secondary to Vitamin B12 Deficiency. Cureus. 2024;16:e73620. 10.7759/cureus.73620
Jamil M, Nasser Z, Jamil D, Sheqwara JZ. Unmasking Vitamin B12 Deficiency Misdiagnosed as Myelodysplastic Syndrome. Case Rep Hematol. 2024;2024:3258227. 10.1155/2024/3258227
Memon NM, Conti G, Brilli E, Tarantino G, Chaudhry MNA, et al. Comparative bioavailability study of supplemental oral Sucrosomial vs. oral conventional vitamin B12 in enhancing circulatory B12 levels in healthy deficient adults: a multicentre, double-blind randomized clinical trial. Front Nutr. 2024;11:1493593. 10.3389/fnut.2024.1493593