Overview
SCIENTIFIC SCORE
Questionable
Based on 18 Researches
6.8
USERS' SCORE
Good
Based on 7 Reviews
8.7
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Folate
167 mcg DFE(100 mcg folic acid)
42%
Vitamin B-12 (as Cyanocobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
8
We investigated the potential of vitamin B12 to mitigate anxiety in adult zebrafish subjected to chronic alcohol exposure. Our study involved exposing zebrafish to alcohol and then providing them with vitamin B12 to see if it would help reduce anxiety-related behaviors. By using a geotaxis test, we could observe how the fish responded in terms of anxiety in a controlled environment.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
The effects were examined alongside oxidative stress and brain health, letting us delve into the biological changes that might occur due to both alcohol and vitamin treatment. The results indicated that chronic alcohol exposure did indeed affect brain function and behavior in the zebrafish. However, we found promising evidence that vitamin B12 operations as a neuroprotective agent, possibly offering relief from the anxiety associated with long-term alcohol use.
Our findings suggest that there may be valuable implications for using vitamin B12 in addressing anxiety related to chronic alcoholism, albeit further studies would be instrumental to fully understand its capabilities and mechanisms.
9
Vitamin B shows anxiety relief potential
We investigated how vitamin B might alleviate anxiety and depression caused by nicotine withdrawal in adolescent male rats.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
8
We aimed to understand how a daily dose of 1000 mcg of vitamin B12 affects anxiety and overall symptoms in fibromyalgia patients. In a straightforward open-label study, patients took this vitamin for 50 days and completed various health questionnaires before and after the treatment.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
Most Useful Reviews
10
Improved memory
2 people found this helpful
After taking vitamin B12, I noticed an improvement in memory and concentration, and my anxiety diminished.
9
Calmer routines
1 people found this helpful
I regularly order for myself and my family. I appreciate the quality and size, which ensure a good effect. My sleep has improved, daily routines are calmer, and there is less anxiety along with more energy. I genuinely feel that my nervous system is in a more restful state than before, when I was easily irritated by small matters. Additionally, I have noticed a better metabolism and feel lighter. 
9
Highly recommended
1 people found this helpful
Superb product! I have been using it for over a year, and it has significantly helped with my anxiety and nervousness. I recommend it!
Medical Researches
SCIENTIFIC SCORE
Questionable
Based on 18 Researches
6.8
- All Researches
9
Vitamin B shows anxiety relief potential
We investigated how vitamin B might alleviate anxiety and depression caused by nicotine withdrawal in adolescent male rats.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
The study compared the effects of vitamin B with bupropion, revealing that vitamin B was similarly effective in reducing withdrawal symptoms.
Notably, it also demonstrated a positive impact on antioxidant and anti-inflammatory levels, suggesting vitamin B could be a promising treatment not just for nicotine withdrawal but potentially for other conditions linked to oxidative stress.
8
We aimed to understand how a daily dose of 1000 mcg of vitamin B12 affects anxiety and overall symptoms in fibromyalgia patients. In a straightforward open-label study, patients took this vitamin for 50 days and completed various health questionnaires before and after the treatment.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
8
We investigated the potential effects of folic acid on anxiety arising from chronic inflammatory pain. Using a group of adult rats, we induced inflammatory pain by injecting them with complete Freund's adjuvant into their hindpaw. Pain levels and behaviors were measured through paw withdrawal tests to monitor mechanical and thermal sensitivity.
Our findings revealed that the rats experienced heightened pain levels, correlating with increased expression of Matrix metalloproteinase 2 (MMP2) in certain nerve regions. Most importantly, we discovered that long-term treatment with folic acid not only lowered MMP2 levels but also provided significant relief from the chronic pain. Additionally, this treatment helped reduce anxiety related to pain, showing that folic acid could play a protective role in managing both chronic inflammatory pain and the anxiety that often accompanies it.
The results suggest that folic acid could be a valuable therapeutic option for tackling both pain and the psychological distress that can follow chronic inflammation. This dual benefit opens the door for further exploration of folic acid in pain management strategies.
Our findings revealed that the rats experienced heightened pain levels, correlating with increased expression of Matrix metalloproteinase 2 (MMP2) in certain nerve regions. Most importantly, we discovered that long-term treatment with folic acid not only lowered MMP2 levels but also provided significant relief from the chronic pain. Additionally, this treatment helped reduce anxiety related to pain, showing that folic acid could play a protective role in managing both chronic inflammatory pain and the anxiety that often accompanies it.
The results suggest that folic acid could be a valuable therapeutic option for tackling both pain and the psychological distress that can follow chronic inflammation. This dual benefit opens the door for further exploration of folic acid in pain management strategies.
8
A recent study explored how a combination of chlorzoxazone and folic acid can influence anxiety and cognitive functions. The research focused on SCA3-84Q mice, which exhibit anxiety, memory decline, and signs of low mood due to a genetic condition known as spinocerebellar ataxia type 3.
We assessed how long-term injections of chlorzoxazone alone, and in combination with folic acid, affected the brain's Purkinje cells and the overall behavior of these mice. While both treatments seemed to enhance certain motor functions, it was notably the combination of chlorzoxazone and folic acid that significantly reduced anxiety and depressed behavior, alongside improving recognition memory.
Our findings suggest that addressing not just motor symptoms but also mood and cognitive functions is crucial in treating conditions like SCA3. This combination therapy could pave the way for more comprehensive treatment strategies for patients dealing with similar conditions.
We assessed how long-term injections of chlorzoxazone alone, and in combination with folic acid, affected the brain's Purkinje cells and the overall behavior of these mice. While both treatments seemed to enhance certain motor functions, it was notably the combination of chlorzoxazone and folic acid that significantly reduced anxiety and depressed behavior, alongside improving recognition memory.
Our findings suggest that addressing not just motor symptoms but also mood and cognitive functions is crucial in treating conditions like SCA3. This combination therapy could pave the way for more comprehensive treatment strategies for patients dealing with similar conditions.
8
Folic acid eases withdrawal symptoms
We explored the impact of folic acid (FA) on anxiety and depressive-like behaviors in adolescent male rats following nicotine withdrawal. In our study, we divided the rats into groups that received either a nicotine treatment or a vehicle control, then observed their behavior as they experienced withdrawal.
After this period, we introduced various doses of FA and compared their effects on the rats' mood. Our findings indicate that folic acid may help reduce anxiety and depression symptoms linked to nicotine withdrawal.
The study suggested that FA works by inhibiting the activity of an enzyme related to serotonin metabolism, along with balancing oxidative stress and inflammation. While other treatments, like bupropion, were also examined, the potential of FA to improve cognitive issues arising from nicotine withdrawal stands out.
Overall, we observed that folic acid could be a beneficial supplement for addressing anxiety and depression during the challenging withdrawal process from nicotine.
After this period, we introduced various doses of FA and compared their effects on the rats' mood. Our findings indicate that folic acid may help reduce anxiety and depression symptoms linked to nicotine withdrawal.
The study suggested that FA works by inhibiting the activity of an enzyme related to serotonin metabolism, along with balancing oxidative stress and inflammation. While other treatments, like bupropion, were also examined, the potential of FA to improve cognitive issues arising from nicotine withdrawal stands out.
Overall, we observed that folic acid could be a beneficial supplement for addressing anxiety and depression during the challenging withdrawal process from nicotine.
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.7
- All Reviews
- Positive Reviews
- Negative Reviews
10
Improved memory
2 people found this helpful
After taking vitamin B12, I noticed an improvement in memory and concentration, and my anxiety diminished.
9
Calmer routines
1 people found this helpful
I regularly order for myself and my family. I appreciate the quality and size, which ensure a good effect. My sleep has improved, daily routines are calmer, and there is less anxiety along with more energy. I genuinely feel that my nervous system is in a more restful state than before, when I was easily irritated by small matters. Additionally, I have noticed a better metabolism and feel lighter.
9
Highly recommended
1 people found this helpful
Superb product! I have been using it for over a year, and it has significantly helped with my anxiety and nervousness. I recommend it!
10
Anxiety relief
I have overcome anxiety, shaking, and anger after taking this; I wholeheartedly recommend it.
9
Super cocktail
2 people found this helpful
Essential for individuals struggling with alcohol addiction. I take B12 alongside B6. B12 effectively alleviates anxiety, while B6 simply calms. Together, they form a super cocktail. Both vitamins are vital for individuals suffering from alcoholism, as alcohol depletes them, leading to anxiety and instability. It creates a vicious circle. If a relative suffers from this issue, I recommend introducing this cocktail. 
Frequently Asked Questions
10
Improved memory
2 people found this helpful
After taking vitamin B12, I noticed an improvement in memory and concentration, and my anxiety diminished.
9
Calmer routines
1 people found this helpful
I regularly order for myself and my family. I appreciate the quality and size, which ensure a good effect. My sleep has improved, daily routines are calmer, and there is less anxiety along with more energy. I genuinely feel that my nervous system is in a more restful state than before, when I was easily irritated by small matters. Additionally, I have noticed a better metabolism and feel lighter.
9
Highly recommended
1 people found this helpful
Superb product! I have been using it for over a year, and it has significantly helped with my anxiety and nervousness. I recommend it!
9
Super cocktail
2 people found this helpful
Essential for individuals struggling with alcohol addiction. I take B12 alongside B6. B12 effectively alleviates anxiety, while B6 simply calms. Together, they form a super cocktail. Both vitamins are vital for individuals suffering from alcoholism, as alcohol depletes them, leading to anxiety and instability. It creates a vicious circle. If a relative suffers from this issue, I recommend introducing this cocktail.
10
Anxiety relief
I have overcome anxiety, shaking, and anger after taking this; I wholeheartedly recommend it.
7
We set out to understand how Vitamin B affects behavior and brain chemistry in rats experiencing depression due to stress. In our study, 72 rats were divided into three groups: a control group, a group under stress, and a group under stress receiving Vitamin B injections.
Results showed that Vitamin B helped elevate brain chemicals associated with mood and reduced anxiety-like behaviors by improving neurochemical balance. This suggests a beneficial impact of Vitamin B on anxiety, particularly through its influence on essential neurotransmitters and the brain's supporting structures.
Results showed that Vitamin B helped elevate brain chemicals associated with mood and reduced anxiety-like behaviors by improving neurochemical balance. This suggests a beneficial impact of Vitamin B on anxiety, particularly through its influence on essential neurotransmitters and the brain's supporting structures.
4
We explored the impact of high-dose Vitamin B6 and B12 supplementation on anxiety in a double-blind study involving 478 young adults. Participants reported their anxiety and depression levels before and after taking the supplements for a month.
While B6 showed promising results, significantly reducing anxiety and even suggesting lower depression levels, B12 did not produce notable benefits in these areas. Overall, our findings point to B6’s potential in enhancing GABA activity, which may help with emotional regulation.
While B6 showed promising results, significantly reducing anxiety and even suggesting lower depression levels, B12 did not produce notable benefits in these areas. Overall, our findings point to B6’s potential in enhancing GABA activity, which may help with emotional regulation.
8
We aimed to understand how a daily dose of 1000 mcg of vitamin B12 affects anxiety and overall symptoms in fibromyalgia patients. In a straightforward open-label study, patients took this vitamin for 50 days and completed various health questionnaires before and after the treatment.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
The results revealed that vitamin B12 significantly improved both the severity of fibromyalgia symptoms and anxiety scores. This suggests that considering vitamin B12 as an additional therapy for fibromyalgia and related anxiety could be beneficial.
7
We set out to explore the role of serum vitamin B12 levels in relation to anxiety disorders, using a robust methodology that involved genetic data analysis. By pulling information from large-scale genome-wide association studies, we focused on identifying potential causal relationships between vitamin B12 and anxiety symptoms.
Our findings suggest that higher levels of vitamin B12 might be associated with an increased risk of anxiety disorders. Specifically, the analysis revealed that for every unit increase in serum vitamin B12, there's an odds ratio of 1.34 for anxiety disorders. This means that individuals with elevated vitamin B12 levels could be more likely to experience anxiety.
However, it’s essential to note that while there is a suggestive link, the relationship isn't fully straightforward. Other factors could be influencing this association, and we cannot eliminate the possibility that genetic variation might play a role in these findings. Thus, further studies are necessary to validate these results in broader and more diverse populations.
In conclusion, while our study highlights a potential connection between serum vitamin B12 levels and anxiety, it's crucial to approach these observations with caution until more research can provide clearer insights.
Our findings suggest that higher levels of vitamin B12 might be associated with an increased risk of anxiety disorders. Specifically, the analysis revealed that for every unit increase in serum vitamin B12, there's an odds ratio of 1.34 for anxiety disorders. This means that individuals with elevated vitamin B12 levels could be more likely to experience anxiety.
However, it’s essential to note that while there is a suggestive link, the relationship isn't fully straightforward. Other factors could be influencing this association, and we cannot eliminate the possibility that genetic variation might play a role in these findings. Thus, further studies are necessary to validate these results in broader and more diverse populations.
In conclusion, while our study highlights a potential connection between serum vitamin B12 levels and anxiety, it's crucial to approach these observations with caution until more research can provide clearer insights.
We evaluated how a multinutrient formula, including B12, influenced memory, attention, and mood in middle-aged adults over 12 weeks.
While we saw an increase in B vitamin levels with active treatment, the results on cognitive functions were mixed.
Notably, individuals with an "optimal" diet showed improved attention and reduced anxiety, while no benefits were found for those with "sub-optimal" diets.
This suggests that B12's impact on anxiety may rely on dietary quality, indicating the need for more targeted studies in the future.
While we saw an increase in B vitamin levels with active treatment, the results on cognitive functions were mixed.
Notably, individuals with an "optimal" diet showed improved attention and reduced anxiety, while no benefits were found for those with "sub-optimal" diets.
This suggests that B12's impact on anxiety may rely on dietary quality, indicating the need for more targeted studies in the future.
References
- Chen J, Liu J, Zhang P, Zhang S. [Effects of Vitamin B on Behaviors, Brain Monoamine Neurotransmitters, and Brain-Derived Neurotrophic Factor in Depressive Rats]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2025;56:206. 10.12182/20250160608
- Al Jassem O, Kheir K, Ismail A, Abou-Abbas L, Masri A, et al. Vitamin B12 deficiency and neuropsychiatric symptoms in Lebanon: A cross-sectional study of vegans, vegetarians, and omnivores. PLoS One. 2024;19:e0297976. 10.1371/journal.pone.0297976
- Tengelmann C, Joos S, Kaußner Y, Malzahn U, Lunden L, et al. Feasibility, safety and effectiveness of prednisolone and vitamin B1, B6, and B12 in patients with post-COVID-19-syndrome (PreVitaCOV) - protocol of a randomised, double-blind, placebo-controlled multicentre trial in primary care (phase IIIb). BMC Infect Dis. 2024;24:56. 10.1186/s12879-023-08925-2
- Pahlavani H, Masoudi M, Khoshroo N, Kakhki S, Mahdi Rezavanimehr M, et al. Vitamin B reversed anxiety and depression induced by adolescent nicotine withdrawal through alteration the inflammatory, oxidative and serotoninergic profiles in male rats. Biochem Pharmacol. 2023;217:115832. 10.1016/j.bcp.2023.115832
- Pickering G, Noah L, Pereira B, Goubayon J, Leray V, et al. Assessing brain function in stressed healthy individuals following the use of a combination of green tea, Rhodiola, magnesium, and B vitamins: an fMRI study. Front Nutr. 2023;10:1211321. 10.3389/fnut.2023.1211321
- Shemirani F, Titcomb TJ, Saxby SM, Eyck PT, Rubenstein LM, et al. Association of serum homocysteine, folate, and vitamin B and mood following the Swank and Wahls elimination dietary interventions in relapsing-remitting multiple sclerosis: Secondary analysis of the WAVES trial. Mult Scler Relat Disord. 2023;75:104743. 10.1016/j.msard.2023.104743
- Young LM, Gauci S, Arnoldy L, Martin L, Perry N, et al. Investigating the Effects of a Multinutrient Supplement on Cognition, Mood and Biochemical Markers in Middle-Aged Adults with 'Optimal' and 'Sub-Optimal' Diets: A Randomized Double Blind Placebo Controlled Trial. Nutrients. 2022;14. 10.3390/nu14235079
- Gharibpoor F, Ghavidel-Parsa B, Sattari N, Bidari A, Nejatifar F, et al. Effect of vitamin B12 on the symptom severity and psychological profile of fibromyalgia patients; a prospective pre-post study. BMC Rheumatol. 2022;6:51. 10.1186/s41927-022-00282-y
- Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, et al. High-dose Vitamin B6 supplementation reduces anxiety and strengthens visual surround suppression. Hum Psychopharmacol. 2022;37:e2852. 10.1002/hup.2852
- Ni WH, Wang K, Wang Y, Lu J, Lu CT, et al. Long-term folic acid treatment relieves chronic inflammatory pain and pain-induced anxiety by reducing MMP2 expression in rats. Neuropharmacology. 2025;269:110352. 10.1016/j.neuropharm.2025.110352
- Marinina KS, Bezprozvanny IB, Egorova PA. A combination of chlorzoxazone and folic acid improves recognition memory, anxiety and depression in SCA3-84Q mice. Hum Mol Genet. 2024;33:1406. 10.1093/hmg/ddae079
- Rezaei Moghadam M, Khoshrou A, Kakhki S, Hosseini SH, Shirinzadeh Feizabadi A, et al. Folic Acid Ameliorates Anxiety- and Depressive-Like Behavior Induced by Nicotine Withdrawal Through Restoration of Behavioral and Biochemical Alterations in Adolescent Male Rats. Nicotine Tob Res. 2024;26:733. 10.1093/ntr/ntad227
- Marengo L, Barey A, Salguero A, Fabio MC, Cendán CM, et al. Neurobehavioral alterations induced by third-trimester gestation-equivalent ethanol exposure are inhibited by folate administration. Dev Psychobiol. 2023;65:e22426. 10.1002/dev.22426
- de Carvalho J, Lerner A, Feingold D. Management of Hyperhomocysteinemia, Low Vitamin Levels, and Low Cortisol in Cannabis Users: A Report of 2 Cases. J Chiropr Med. 2022;21:322. 10.1016/j.jcm.2022.03.001
- Zhao T, Wu D, Du J, Liu G, Ji G, et al. Folic Acid Attenuates Glial Activation in Neonatal Mice and Improves Adult Mood Disorders Through Epigenetic Regulation. Front Pharmacol. 2022;13:818423. 10.3389/fphar.2022.818423
- Nahar M, Rai R, Jat D. Therapeutic intervention of vitamin B12 in mitigating chronic alcoholism induced alterations in adult zebrafish (): a holistic approach. Int J Neurosci. 2024. 10.1080/00207454.2024.2398564
- Hu Y, Yu M, Wang Y, Wu H, Yang X, et al. Exploring the Association between Serum B Vitamins, Homocysteine and Mental Disorders: Insights from Mendelian Randomization. Nutrients. 2024;16. 10.3390/nu16131986
- Tan Y, Zhou L, Huang J, Chen X, Wu Y, et al. Vitamin B12, Folate, Homocysteine, Inflammatory Mediators (Interleukin-6, Tumor Necrosis Factor-α and C-Reactive Protein) Levels in Adolescents with Anxiety or Depressive Symptoms. Neuropsychiatr Dis Treat. 2023;19:785. 10.2147/NDT.S399378
