Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.3
USERS' SCORE
Good
Based on 4 Reviews
8.2
Supplement Facts
Serving Size: 1 Lozenge
Amount Per Serving
%DV
Folate
167 mcg DFE(100 mcg folic acid)
42%
Vitamin B-12 (as Cyanocobalamin)
1 mg (1,000 mcg)
41,667%
Top Medical Research Studies
9
Folate protects osteoblasts from homocysteine
We investigated how folate (FA) impacts osteoblasts, particularly under the influence of homocysteine (Hcy), which is linked to osteoporosis. In our study, we treated MC3T3-E1 cells—the classic model for studying bone formation—with different concentrations of FA and observed several key factors.
Our findings revealed that Hcy adversely affects osteoblasts in a dose-dependent manner. This included decreased cell density and reduced proliferation ability, which are crucial for healthy bone development. However, when we introduced FA, it not only helped protect the osteoblasts from undergoing apoptosis (or cell death) but also displayed a direct bone-forming effect.
Furthermore, we noticed that the beneficial effects of FA were associated with the inhibition of a stress pathway in the cells known as the PERK/ATF-4/CHOP pathway. By reducing stress within the endoplasmic reticulum—a critical site for proper protein folding and cell function—FA aids in maintaining the health and function of osteoblasts when faced with Hcy.
Overall, our research sheds light on how folate can serve as a promising factor in ameliorating the negative effects of homocysteine on bone cells, suggesting a potential avenue for preventing osteoporosis.
Our findings revealed that Hcy adversely affects osteoblasts in a dose-dependent manner. This included decreased cell density and reduced proliferation ability, which are crucial for healthy bone development. However, when we introduced FA, it not only helped protect the osteoblasts from undergoing apoptosis (or cell death) but also displayed a direct bone-forming effect.
Furthermore, we noticed that the beneficial effects of FA were associated with the inhibition of a stress pathway in the cells known as the PERK/ATF-4/CHOP pathway. By reducing stress within the endoplasmic reticulum—a critical site for proper protein folding and cell function—FA aids in maintaining the health and function of osteoblasts when faced with Hcy.
Overall, our research sheds light on how folate can serve as a promising factor in ameliorating the negative effects of homocysteine on bone cells, suggesting a potential avenue for preventing osteoporosis.
Read More
9
We explored the impact of folate, or folic acid, on osteoporosis that develops from a high-fat diet (HFD). In our investigation, we fed mice a normal diet, an HFD, or an HFD with added folic acid for 16 weeks. Throughout this period, we monitored weight and examined various metabolic health markers.
Our findings revealed that folic acid significantly reduced body fat and alleviated metabolic issues such as insulin resistance, high lipid levels, and systemic inflammation in the mice. Alongside these benefits, we also observed improvements in bone health. The folic acid-treated mice showed less bone loss and better bone structure, including a decrease in the number of harmful cells that contribute to bone erosion.
A key mechanism behind these benefits appears to involve the activation of the AMPK signaling pathway. By promoting this pathway, folic acid helps enhance lipid metabolism and reduce oxidative stress, which are crucial for maintaining bone health. Overall, our study suggests that folic acid plays an important role in combating osteoporosis linked to high-fat diets.
Our findings revealed that folic acid significantly reduced body fat and alleviated metabolic issues such as insulin resistance, high lipid levels, and systemic inflammation in the mice. Alongside these benefits, we also observed improvements in bone health. The folic acid-treated mice showed less bone loss and better bone structure, including a decrease in the number of harmful cells that contribute to bone erosion.
A key mechanism behind these benefits appears to involve the activation of the AMPK signaling pathway. By promoting this pathway, folic acid helps enhance lipid metabolism and reduce oxidative stress, which are crucial for maintaining bone health. Overall, our study suggests that folic acid plays an important role in combating osteoporosis linked to high-fat diets.
Read More
7
We set out to explore the relationship between dietary folate intake and the risk of osteoporosis in the general U.S. population. Using data from the National Health and Nutrition Examination Survey conducted between 2017 and 2020, we analyzed the bone mineral density of 2,297 participants to identify any connections.
Our findings revealed that higher dietary folate intake is significantly linked to a lower risk of osteoporosis. This trend was particularly strong among participants over the age of 60, especially women, where the results were even more pronounced. The dose-response curve indicated a non-linear relationship, suggesting that as folate intake increases, the protective effect against osteoporosis enhances.
While our study offers important insights into how folate may play a beneficial role in bone health, it also highlights the need for further research to confirm these associations. This initial evidence is exciting as it opens the door to considering dietary folate as part of a preventive strategy against osteoporosis.
Our findings revealed that higher dietary folate intake is significantly linked to a lower risk of osteoporosis. This trend was particularly strong among participants over the age of 60, especially women, where the results were even more pronounced. The dose-response curve indicated a non-linear relationship, suggesting that as folate intake increases, the protective effect against osteoporosis enhances.
While our study offers important insights into how folate may play a beneficial role in bone health, it also highlights the need for further research to confirm these associations. This initial evidence is exciting as it opens the door to considering dietary folate as part of a preventive strategy against osteoporosis.
Read More
Most Useful Reviews
9
Memory and skincare
Vitamin B12 is not only delicious but also beneficial. It strengthens memory, prevents osteoporosis, and promotes healthy hair and skin. The large quantity and excellent quality make it a standout supplement. Ingredients like folic acid and niacin are energising and effective, providing support for metabolism, the nervous system, and overall health.
Read More
7.5
Improved bone density
I can't go a day without this essential vitamin. It's crucial for my brain health, especially after my brain tumours, and for my bones; I had osteoporosis but have managed to reduce it to osteopenia. The benefits of B12 are vital to my well-being.
Read More
6
Supports bone health
Vitamin B12 is vital for daily health, especially in forming red blood cells and maintaining nerve cell health. A deficiency results in noticeable symptoms. Key benefits include mood regulation and mental health; nutritionist Samantha Cassetti highlights its importance for the nervous system and blood cell formation. It aids neurotransmitter production, influencing mood, making it potentially beneficial for people prone to depression. Additionally, it supports healthy fetal growth and bone growth while preventing osteoporosis. Good absorption is crucial, requiring adequate stomach acid and pectin.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 12 Researches
7.3
- All Researches
9
We explored the connection between folic acid intake and bone health, particularly in relation to body fat levels. By analyzing data from the NHANES database, we found a significant link between folic acid consumption and bone mineral density (BMD) in individuals aged 20 to 60.
To further investigate, we conducted an experiment using male C57Bl/6 mice, some of which were given a high-fat diet while others ate a normal diet. We supplemented the mice with folic acid through their drinking water. The results were quite revealing; mice with higher body fat exhibited signs of bone microstructure damage and marked bone loss. In contrast, those receiving folic acid showed improved bone quality.
We also noted that the high body fat in mice led to various metabolic issues, including abnormal blood lipids and dysregulation of intestinal flora. However, with folic acid supplementation, those adverse effects were mitigated. Our findings suggest that folic acid may influence certain metabolic pathways, promoting beneficial factors like LCA and TGR5 in the body.
Overall, our findings indicate that folic acid intake is related to BMD and may play a protective role against bone loss caused by high body fat. This study opens up new avenues for preventing osteoporosis and improving bone health through dietary adjustments.
To further investigate, we conducted an experiment using male C57Bl/6 mice, some of which were given a high-fat diet while others ate a normal diet. We supplemented the mice with folic acid through their drinking water. The results were quite revealing; mice with higher body fat exhibited signs of bone microstructure damage and marked bone loss. In contrast, those receiving folic acid showed improved bone quality.
We also noted that the high body fat in mice led to various metabolic issues, including abnormal blood lipids and dysregulation of intestinal flora. However, with folic acid supplementation, those adverse effects were mitigated. Our findings suggest that folic acid may influence certain metabolic pathways, promoting beneficial factors like LCA and TGR5 in the body.
Overall, our findings indicate that folic acid intake is related to BMD and may play a protective role against bone loss caused by high body fat. This study opens up new avenues for preventing osteoporosis and improving bone health through dietary adjustments.
Read More
9
Folate protects osteoblasts from homocysteine
We investigated how folate (FA) impacts osteoblasts, particularly under the influence of homocysteine (Hcy), which is linked to osteoporosis. In our study, we treated MC3T3-E1 cells—the classic model for studying bone formation—with different concentrations of FA and observed several key factors.
Our findings revealed that Hcy adversely affects osteoblasts in a dose-dependent manner. This included decreased cell density and reduced proliferation ability, which are crucial for healthy bone development. However, when we introduced FA, it not only helped protect the osteoblasts from undergoing apoptosis (or cell death) but also displayed a direct bone-forming effect.
Furthermore, we noticed that the beneficial effects of FA were associated with the inhibition of a stress pathway in the cells known as the PERK/ATF-4/CHOP pathway. By reducing stress within the endoplasmic reticulum—a critical site for proper protein folding and cell function—FA aids in maintaining the health and function of osteoblasts when faced with Hcy.
Overall, our research sheds light on how folate can serve as a promising factor in ameliorating the negative effects of homocysteine on bone cells, suggesting a potential avenue for preventing osteoporosis.
Our findings revealed that Hcy adversely affects osteoblasts in a dose-dependent manner. This included decreased cell density and reduced proliferation ability, which are crucial for healthy bone development. However, when we introduced FA, it not only helped protect the osteoblasts from undergoing apoptosis (or cell death) but also displayed a direct bone-forming effect.
Furthermore, we noticed that the beneficial effects of FA were associated with the inhibition of a stress pathway in the cells known as the PERK/ATF-4/CHOP pathway. By reducing stress within the endoplasmic reticulum—a critical site for proper protein folding and cell function—FA aids in maintaining the health and function of osteoblasts when faced with Hcy.
Overall, our research sheds light on how folate can serve as a promising factor in ameliorating the negative effects of homocysteine on bone cells, suggesting a potential avenue for preventing osteoporosis.
Read More
9
We explored the impact of folate, or folic acid, on osteoporosis that develops from a high-fat diet (HFD). In our investigation, we fed mice a normal diet, an HFD, or an HFD with added folic acid for 16 weeks. Throughout this period, we monitored weight and examined various metabolic health markers.
Our findings revealed that folic acid significantly reduced body fat and alleviated metabolic issues such as insulin resistance, high lipid levels, and systemic inflammation in the mice. Alongside these benefits, we also observed improvements in bone health. The folic acid-treated mice showed less bone loss and better bone structure, including a decrease in the number of harmful cells that contribute to bone erosion.
A key mechanism behind these benefits appears to involve the activation of the AMPK signaling pathway. By promoting this pathway, folic acid helps enhance lipid metabolism and reduce oxidative stress, which are crucial for maintaining bone health. Overall, our study suggests that folic acid plays an important role in combating osteoporosis linked to high-fat diets.
Our findings revealed that folic acid significantly reduced body fat and alleviated metabolic issues such as insulin resistance, high lipid levels, and systemic inflammation in the mice. Alongside these benefits, we also observed improvements in bone health. The folic acid-treated mice showed less bone loss and better bone structure, including a decrease in the number of harmful cells that contribute to bone erosion.
A key mechanism behind these benefits appears to involve the activation of the AMPK signaling pathway. By promoting this pathway, folic acid helps enhance lipid metabolism and reduce oxidative stress, which are crucial for maintaining bone health. Overall, our study suggests that folic acid plays an important role in combating osteoporosis linked to high-fat diets.
Read More
8
We explored the relationship between dietary folic acid intake and the risk of osteoporosis among middle-aged and older adults. This was a large-scale study involving over 5,000 people aged 45 and older, using data from the National Health and Nutritional Examination Survey conducted between 2007 and 2010.
Our analysis focused on dietary habits and osteoporosis diagnoses, revealing that individuals with osteoporosis tended to have lower dietary folic acid intake compared to those without the condition. Specifically, we found a significant link between higher folic acid intake and lower odds of developing osteoporosis.
Notably, we identified a key threshold for dietary folic acid, pinpointing 475.5 micrograms per day as the optimal amount for reducing osteoporosis risk. This suggests that incorporating more folate-rich foods into our diets could be beneficial for maintaining bone health, especially as we age.
Overall, our findings point to the potential protective effects of daily dietary folic acid against osteoporosis in older adults, highlighting the importance of nutrition in bone health.
Our analysis focused on dietary habits and osteoporosis diagnoses, revealing that individuals with osteoporosis tended to have lower dietary folic acid intake compared to those without the condition. Specifically, we found a significant link between higher folic acid intake and lower odds of developing osteoporosis.
Notably, we identified a key threshold for dietary folic acid, pinpointing 475.5 micrograms per day as the optimal amount for reducing osteoporosis risk. This suggests that incorporating more folate-rich foods into our diets could be beneficial for maintaining bone health, especially as we age.
Overall, our findings point to the potential protective effects of daily dietary folic acid against osteoporosis in older adults, highlighting the importance of nutrition in bone health.
Read More
8
We explored the connection between dietary folate intake and bone mineral density (BMD) in the general population of the USA. Using data from the National Health and Nutrition Examination Survey, we examined the dietary habits of nearly 10,000 participants, collecting information on their folate consumption and BMD measurements through advanced techniques.
Our analysis revealed a significant positive association between higher folate intake and improved BMD, particularly among older individuals and non-Hispanic whites. Specifically, we found that those consuming more folate showed better bone density across several key areas, such as the femoral neck and lumbar spine.
Interestingly, factors like physical activity levels and vitamin D status appeared to influence these results, suggesting a complex interaction at play. For postmenopausal women, a daily folate intake of around 528-569 µg was highlighted as particularly beneficial.
Overall, our findings suggest that increasing dietary folate might be a helpful strategy for supporting bone health, especially for those at risk of osteoporosis. Awareness and screening for low folate intake could be crucial for preventing bone-related issues as we age.
Our analysis revealed a significant positive association between higher folate intake and improved BMD, particularly among older individuals and non-Hispanic whites. Specifically, we found that those consuming more folate showed better bone density across several key areas, such as the femoral neck and lumbar spine.
Interestingly, factors like physical activity levels and vitamin D status appeared to influence these results, suggesting a complex interaction at play. For postmenopausal women, a daily folate intake of around 528-569 µg was highlighted as particularly beneficial.
Overall, our findings suggest that increasing dietary folate might be a helpful strategy for supporting bone health, especially for those at risk of osteoporosis. Awareness and screening for low folate intake could be crucial for preventing bone-related issues as we age.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Memory and skincare
Vitamin B12 is not only delicious but also beneficial. It strengthens memory, prevents osteoporosis, and promotes healthy hair and skin. The large quantity and excellent quality make it a standout supplement. Ingredients like folic acid and niacin are energising and effective, providing support for metabolism, the nervous system, and overall health.
Read More
7.5
Improved bone density
I can't go a day without this essential vitamin. It's crucial for my brain health, especially after my brain tumours, and for my bones; I had osteoporosis but have managed to reduce it to osteopenia. The benefits of B12 are vital to my well-being.
Read More
6
Supports bone health
Vitamin B12 is vital for daily health, especially in forming red blood cells and maintaining nerve cell health. A deficiency results in noticeable symptoms. Key benefits include mood regulation and mental health; nutritionist Samantha Cassetti highlights its importance for the nervous system and blood cell formation. It aids neurotransmitter production, influencing mood, making it potentially beneficial for people prone to depression. Additionally, it supports healthy fetal growth and bone growth while preventing osteoporosis. Good absorption is crucial, requiring adequate stomach acid and pectin.
Read More
7.5
Disease prevention benefits
Vitamin B12 is crucial for daily health, aiding in red blood cell production and reducing osteoporosis risk. It boosts energy, heart health, and the immune system while acting as an anti-inflammatory. Its role in overall well-being cannot be overstated.
Read More
Frequently Asked Questions
7.5
Improved bone density
I can't go a day without this essential vitamin. It's crucial for my brain health, especially after my brain tumours, and for my bones; I had osteoporosis but have managed to reduce it to osteopenia. The benefits of B12 are vital to my well-being.
6
Supports bone health
Vitamin B12 is vital for daily health, especially in forming red blood cells and maintaining nerve cell health. A deficiency results in noticeable symptoms. Key benefits include mood regulation and mental health; nutritionist Samantha Cassetti highlights its importance for the nervous system and blood cell formation. It aids neurotransmitter production, influencing mood, making it potentially beneficial for people prone to depression. Additionally, it supports healthy fetal growth and bone growth while preventing osteoporosis. Good absorption is crucial, requiring adequate stomach acid and pectin.
7.5
Disease prevention benefits
Vitamin B12 is crucial for daily health, aiding in red blood cell production and reducing osteoporosis risk. It boosts energy, heart health, and the immune system while acting as an anti-inflammatory. Its role in overall well-being cannot be overstated.
9
Memory and skincare
Vitamin B12 is not only delicious but also beneficial. It strengthens memory, prevents osteoporosis, and promotes healthy hair and skin. The large quantity and excellent quality make it a standout supplement. Ingredients like folic acid and niacin are energising and effective, providing support for metabolism, the nervous system, and overall health.
8
We explored the relationship between dietary folic acid intake and the risk of osteoporosis among middle-aged and older adults. This was a large-scale study involving over 5,000 people aged 45 and older, using data from the National Health and Nutritional Examination Survey conducted between 2007 and 2010.
Our analysis focused on dietary habits and osteoporosis diagnoses, revealing that individuals with osteoporosis tended to have lower dietary folic acid intake compared to those without the condition. Specifically, we found a significant link between higher folic acid intake and lower odds of developing osteoporosis.
Notably, we identified a key threshold for dietary folic acid, pinpointing 475.5 micrograms per day as the optimal amount for reducing osteoporosis risk. This suggests that incorporating more folate-rich foods into our diets could be beneficial for maintaining bone health, especially as we age.
Overall, our findings point to the potential protective effects of daily dietary folic acid against osteoporosis in older adults, highlighting the importance of nutrition in bone health.
Our analysis focused on dietary habits and osteoporosis diagnoses, revealing that individuals with osteoporosis tended to have lower dietary folic acid intake compared to those without the condition. Specifically, we found a significant link between higher folic acid intake and lower odds of developing osteoporosis.
Notably, we identified a key threshold for dietary folic acid, pinpointing 475.5 micrograms per day as the optimal amount for reducing osteoporosis risk. This suggests that incorporating more folate-rich foods into our diets could be beneficial for maintaining bone health, especially as we age.
Overall, our findings point to the potential protective effects of daily dietary folic acid against osteoporosis in older adults, highlighting the importance of nutrition in bone health.
8
Our exploration focused on the role of folate, a B vitamin, in promoting bone health and preventing osteoporosis. We examined various studies to understand whether adequate folate intake and supplementation could support bone density and reduce fracture risks, particularly in the elderly population.
The review included 29 studies, revealing some interesting insights. We found that low levels of serum folate are often associated with decreased bone mineral density (BMD) and a higher risk of fractures, especially among older women. However, the connection between dietary intake of other B vitamins and bone health wasn't as strong, indicating that folate might hold a unique position in bone maintenance.
When we looked into dietary sources, only two studies were relevant. One showed that higher folate intake could positively affect BMD in women, while another suggested a link between vitamin B6 and reduced hip fracture risk for a specific group of women.
Additionally, folate supplementation, particularly in those with hyperhomocysteinemia or low folate levels, consistently demonstrated a positive effect on BMD across several studies. This makes it clear that for older patients with these specific concerns, folate supplementation can be an essential part of their treatment plan.
In conclusion, monitoring folate and homocysteine levels in elderly individuals with osteopenia or osteoporosis is crucial, and folate supplementation can be a vital strategy for improving bone health.
The review included 29 studies, revealing some interesting insights. We found that low levels of serum folate are often associated with decreased bone mineral density (BMD) and a higher risk of fractures, especially among older women. However, the connection between dietary intake of other B vitamins and bone health wasn't as strong, indicating that folate might hold a unique position in bone maintenance.
When we looked into dietary sources, only two studies were relevant. One showed that higher folate intake could positively affect BMD in women, while another suggested a link between vitamin B6 and reduced hip fracture risk for a specific group of women.
Additionally, folate supplementation, particularly in those with hyperhomocysteinemia or low folate levels, consistently demonstrated a positive effect on BMD across several studies. This makes it clear that for older patients with these specific concerns, folate supplementation can be an essential part of their treatment plan.
In conclusion, monitoring folate and homocysteine levels in elderly individuals with osteopenia or osteoporosis is crucial, and folate supplementation can be a vital strategy for improving bone health.
9
Folate protects osteoblasts from homocysteine
We investigated how folate (FA) impacts osteoblasts, particularly under the influence of homocysteine (Hcy), which is linked to osteoporosis. In our study, we treated MC3T3-E1 cells—the classic model for studying bone formation—with different concentrations of FA and observed several key factors.
Our findings revealed that Hcy adversely affects osteoblasts in a dose-dependent manner. This included decreased cell density and reduced proliferation ability, which are crucial for healthy bone development. However, when we introduced FA, it not only helped protect the osteoblasts from undergoing apoptosis (or cell death) but also displayed a direct bone-forming effect.
Furthermore, we noticed that the beneficial effects of FA were associated with the inhibition of a stress pathway in the cells known as the PERK/ATF-4/CHOP pathway. By reducing stress within the endoplasmic reticulum—a critical site for proper protein folding and cell function—FA aids in maintaining the health and function of osteoblasts when faced with Hcy.
Overall, our research sheds light on how folate can serve as a promising factor in ameliorating the negative effects of homocysteine on bone cells, suggesting a potential avenue for preventing osteoporosis.
Our findings revealed that Hcy adversely affects osteoblasts in a dose-dependent manner. This included decreased cell density and reduced proliferation ability, which are crucial for healthy bone development. However, when we introduced FA, it not only helped protect the osteoblasts from undergoing apoptosis (or cell death) but also displayed a direct bone-forming effect.
Furthermore, we noticed that the beneficial effects of FA were associated with the inhibition of a stress pathway in the cells known as the PERK/ATF-4/CHOP pathway. By reducing stress within the endoplasmic reticulum—a critical site for proper protein folding and cell function—FA aids in maintaining the health and function of osteoblasts when faced with Hcy.
Overall, our research sheds light on how folate can serve as a promising factor in ameliorating the negative effects of homocysteine on bone cells, suggesting a potential avenue for preventing osteoporosis.
9
We explored the impact of folate, or folic acid, on osteoporosis that develops from a high-fat diet (HFD). In our investigation, we fed mice a normal diet, an HFD, or an HFD with added folic acid for 16 weeks. Throughout this period, we monitored weight and examined various metabolic health markers.
Our findings revealed that folic acid significantly reduced body fat and alleviated metabolic issues such as insulin resistance, high lipid levels, and systemic inflammation in the mice. Alongside these benefits, we also observed improvements in bone health. The folic acid-treated mice showed less bone loss and better bone structure, including a decrease in the number of harmful cells that contribute to bone erosion.
A key mechanism behind these benefits appears to involve the activation of the AMPK signaling pathway. By promoting this pathway, folic acid helps enhance lipid metabolism and reduce oxidative stress, which are crucial for maintaining bone health. Overall, our study suggests that folic acid plays an important role in combating osteoporosis linked to high-fat diets.
Our findings revealed that folic acid significantly reduced body fat and alleviated metabolic issues such as insulin resistance, high lipid levels, and systemic inflammation in the mice. Alongside these benefits, we also observed improvements in bone health. The folic acid-treated mice showed less bone loss and better bone structure, including a decrease in the number of harmful cells that contribute to bone erosion.
A key mechanism behind these benefits appears to involve the activation of the AMPK signaling pathway. By promoting this pathway, folic acid helps enhance lipid metabolism and reduce oxidative stress, which are crucial for maintaining bone health. Overall, our study suggests that folic acid plays an important role in combating osteoporosis linked to high-fat diets.
References
- Zhou L, Deng W, Wu Q, Pan Y, Huang H. Association between dietary folate intake and the risk of osteoporosis in adults: a cross-sectional study. BMC Musculoskelet Disord. 2024;25:487. doi:10.1186/s12891-024-07605-9
- Zhang YW, Hu Y, Wang SC, Li ZH, Cai GQ, et al. Linking the relationship between dietary folic acid intake and risk of osteoporosis among middle-aged and older people: A nationwide population-based study. Food Sci Nutr. 2024;12:4110. doi:10.1002/fsn3.4070
- Zhang Y, Wei J, Feng X, Lin Q, Deng J, et al. Folic acid supplementation prevents high body fat-induced bone loss through TGR5 signaling pathways. Food Funct. 2024;15:4193. doi:10.1039/d4fo00404c
- Zheng Z, Luo H, Xu W, Xue Q. Association between dietary folate intake and bone mineral density in a diverse population: a cross-sectional study. J Orthop Surg Res. 2023;18:684. doi:10.1186/s13018-023-04188-4
- Yuan YF, Wang S, Zhou H, Tang BB, Liu Y, et al. Exploratory study of sea buckthorn enhancing QiangGuYin efficacy by inhibiting CKIP-1 and Notum activating the Wnt/β-catenin signaling pathway and analysis of active ingredients by molecular docking. Front Pharmacol. 2022;13:994995. doi:10.3389/fphar.2022.994995
- Clements M, Heffernan M, Ward M, Hoey L, Doherty LC, et al. A 2-Year Randomized Controlled Trial With Low-Dose B-Vitamin Supplementation Shows Benefits on Bone Mineral Density in Adults With Lower B12 Status. J Bone Miner Res. 2022;37:2443. doi:10.1002/jbmr.4709
- Su S, Zhang D, Liu J, Zhao H, Tang X, et al. Folate ameliorates homocysteine-induced osteoblast dysfunction by reducing endoplasmic reticulum stress-activated PERK/ATF-4/CHOP pathway in MC3T3-E1 cells. J Bone Miner Metab. 2022;40:422. doi:10.1007/s00774-022-01313-x
- He H, Zhang Y, Sun Y, Zhang Y, Xu J, et al. Folic Acid Attenuates High-Fat Diet-Induced Osteoporosis Through the AMPK Signaling Pathway. Front Cell Dev Biol. 2021;9:791880. doi:10.3389/fcell.2021.791880
- Rondanelli M, Tartara A, Fossari F, Vecchio V, Faliva MA, et al. Adequate Intake and Supplementation of B Vitamins, in Particular Folic Acid, can Play a Protective Role in Bone Health. Curr Aging Sci. 2022;15:110. doi:10.2174/1874609814666211005101730
- Adhish M, Manjubala I. Integrative in-silico and in-vitro analysis of taurine and vitamin B12 in modulating PPARγ and Wnt signaling in hyperhomocysteinemia-induced osteoporosis. Biol Direct. 2024;19:141. doi:10.1186/s13062-024-00581-z
- Li Z, Zheng R, Xue H, Zhu H. Vitamin B12 as a novel risk biomarker of spinal fractures. Medicine (Baltimore). 2022;101:e30796. doi:10.1097/MD.0000000000030796
- Kalimeri M, Leek F, Wang NX, Koh HR, Roy NC, et al. Folate and Vitamin B-12 Status Is Associated With Bone Mineral Density and Hip Strength of Postmenopausal Chinese-Singaporean Women. JBMR Plus. 2020;4:e10399. doi:10.1002/jbm4.10399
