Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.8
USERS' SCORE
Good
Based on 3 Reviews
8.2
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Nattokinase (2,000 FU) (enzyme from Natto Extract) (Non-GMO soy derived)
100 mg
**
Top Medical Research Studies
9
We assessed the impact of nattokinase crude extract (NCE) on liver cancer, specifically hepatocellular carcinoma (HCC), using mouse models.
Mice receiving NCE exhibited a 31% survival rate improvement and reduced tumor sizes, as indicated by imaging and pathology evaluations.
Additionally, NCE led to decreased levels of several cancer markers.
Overall, these findings suggest that nattokinase may positively influence liver cancer outcomes in this model.
Mice receiving NCE exhibited a 31% survival rate improvement and reduced tumor sizes, as indicated by imaging and pathology evaluations.
Additionally, NCE led to decreased levels of several cancer markers.
Overall, these findings suggest that nattokinase may positively influence liver cancer outcomes in this model.
Read More
9
We looked into the role of nattokinase, a health supplement known for its ability to dissolve blood clots, in improving treatments for solid tumors. The research focused on how nattokinase can modify the tumor's physical environment to boost the effectiveness of various cancer therapies, including chemotherapy, radiotherapy, and CAR-T cell therapy.
Through intratumoral injections of nattokinase, we found that it breaks down fibronectin, a key component of the tumor's dense extracellular matrix. This process reduces the tumor's stiffness, improves blood flow, and helps alleviate hypoxia—essentially allowing more oxygen and therapeutic agents to reach the tumor. As a result, chemotherapy becomes more effective without causing additional side effects.
Furthermore, we saw that when nattokinase was administered before radiotherapy, it increased the oxygen levels within the tumor, enhancing the responsiveness to radiation. In experiments with a human breast cancer model, the use of nattokinase also fostered better infiltration of CAR-T cells, which are designed to target and kill cancer cells.
These findings suggest that nattokinase is not just a passive health supplement but an active player in transforming the tumor environment to make cancer treatments more successful. Overall, our exploration shows great promise for nattokinase in optimizing cancer therapies, showcasing its potential for widespread application in fighting solid tumors.
Through intratumoral injections of nattokinase, we found that it breaks down fibronectin, a key component of the tumor's dense extracellular matrix. This process reduces the tumor's stiffness, improves blood flow, and helps alleviate hypoxia—essentially allowing more oxygen and therapeutic agents to reach the tumor. As a result, chemotherapy becomes more effective without causing additional side effects.
Furthermore, we saw that when nattokinase was administered before radiotherapy, it increased the oxygen levels within the tumor, enhancing the responsiveness to radiation. In experiments with a human breast cancer model, the use of nattokinase also fostered better infiltration of CAR-T cells, which are designed to target and kill cancer cells.
These findings suggest that nattokinase is not just a passive health supplement but an active player in transforming the tumor environment to make cancer treatments more successful. Overall, our exploration shows great promise for nattokinase in optimizing cancer therapies, showcasing its potential for widespread application in fighting solid tumors.
Read More
8
Nattokinase-heparin benefits cancer therapy
We set out to explore how combining nattokinase, a powerful enzyme known for its ability to dissolve blood clots, with heparin, a well-known anticoagulant, could improve treatment for patients with advanced tumors suffering from cancer-related thrombosis (CAT). CAT often leads to severe complications that negatively impact patients’ quality of life and their chances of survival, which is why finding effective solutions is crucial.
In our investigation, we constructed electrostatic complexes of nattokinase and heparin to minimize the risks associated with intravenous use of nattokinase. We conducted a series of tests, including guinea pig allergy tests and both in vivo and in vitro thrombolysis experiments, to confirm that our new solution was safe and effective in breaking down clots. Then, we evaluated its impact on advanced tumors using a modified doxorubicin treatment to see if this combination could enhance anti-tumor effects while managing thrombosis.
Our findings were promising: the nattokinase-heparin combination not only prevented the formation of clots but also enhanced the effects of doxorubicin therapy in tumor tissue by decreasing fibrin levels. This leads us to believe that this innovative approach could pave the way for improved treatment options for patients with advanced cancer and CAT, ultimately yielding better outcomes using enhanced nano-formulations.
In our investigation, we constructed electrostatic complexes of nattokinase and heparin to minimize the risks associated with intravenous use of nattokinase. We conducted a series of tests, including guinea pig allergy tests and both in vivo and in vitro thrombolysis experiments, to confirm that our new solution was safe and effective in breaking down clots. Then, we evaluated its impact on advanced tumors using a modified doxorubicin treatment to see if this combination could enhance anti-tumor effects while managing thrombosis.
Our findings were promising: the nattokinase-heparin combination not only prevented the formation of clots but also enhanced the effects of doxorubicin therapy in tumor tissue by decreasing fibrin levels. This leads us to believe that this innovative approach could pave the way for improved treatment options for patients with advanced cancer and CAT, ultimately yielding better outcomes using enhanced nano-formulations.
Read More
Most Useful Reviews
7.5
Helps blood cancer
12 people found this helpful
Wonderful! We use this instead of aspirin. My husband has a blood cancer that increases the viscosity of his blood, making it thicker, and this is certainly helping.
Read More
7.5
Excellent support
1 people found this helpful
Its quality is excellent. The bottle and capsule sizes are small and tasteless. It serves as great support for issues like anaemia and for cancer treatments, with medical studies backing its effectiveness.
Read More
6
Destroys cancer cells
It favourably affects the body. I hope it will destroy cancer cells. We will write more about this later.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 4 Researches
8.8
- All Researches
9
We explored the role of a unique engineered strain of Salmonella, which secretes a substance called nattokinase, in improving cancer treatment—specifically radio-immunotherapy for colon tumors. This inventive approach aims to address an important challenge in cancer therapy: the physical barriers in the tumor microenvironment that often prevent immune cells from effectively targeting cancer cells.
The engineered bacteria, which we refer to as VNP, is designed to accumulate at tumor sites after being introduced into the body. Once there, these bacteria produce large amounts of nattokinase, a compound that helps break down a protein called fibronectin, clear out the surrounding tissue structure, and reduce the presence of cells that typically support tumor growth—known as cancer-associated fibroblasts.
By breaking down these barriers, VNP allows vital immune cells, specifically dendritic cells, to enter the tumor more easily. After treatment with radiotherapy, this infiltration leads to an enhanced immune response, recruiting CD8 T cells that work to eliminate tumor cells. We noticed that treating tumors with VNP before radiotherapy not only amplified the targeted effect but also established lasting immune memory, which may help prevent tumor recurrence and metastasis.
Our findings suggest that using engineered bacteria like VNP to breach physical barriers within tumors could significantly enhance the effectiveness of radio-immunotherapy, offering promising insights for future cancer treatments.
The engineered bacteria, which we refer to as VNP, is designed to accumulate at tumor sites after being introduced into the body. Once there, these bacteria produce large amounts of nattokinase, a compound that helps break down a protein called fibronectin, clear out the surrounding tissue structure, and reduce the presence of cells that typically support tumor growth—known as cancer-associated fibroblasts.
By breaking down these barriers, VNP allows vital immune cells, specifically dendritic cells, to enter the tumor more easily. After treatment with radiotherapy, this infiltration leads to an enhanced immune response, recruiting CD8 T cells that work to eliminate tumor cells. We noticed that treating tumors with VNP before radiotherapy not only amplified the targeted effect but also established lasting immune memory, which may help prevent tumor recurrence and metastasis.
Our findings suggest that using engineered bacteria like VNP to breach physical barriers within tumors could significantly enhance the effectiveness of radio-immunotherapy, offering promising insights for future cancer treatments.
Read More
9
We looked into the role of nattokinase, a health supplement known for its ability to dissolve blood clots, in improving treatments for solid tumors. The research focused on how nattokinase can modify the tumor's physical environment to boost the effectiveness of various cancer therapies, including chemotherapy, radiotherapy, and CAR-T cell therapy.
Through intratumoral injections of nattokinase, we found that it breaks down fibronectin, a key component of the tumor's dense extracellular matrix. This process reduces the tumor's stiffness, improves blood flow, and helps alleviate hypoxia—essentially allowing more oxygen and therapeutic agents to reach the tumor. As a result, chemotherapy becomes more effective without causing additional side effects.
Furthermore, we saw that when nattokinase was administered before radiotherapy, it increased the oxygen levels within the tumor, enhancing the responsiveness to radiation. In experiments with a human breast cancer model, the use of nattokinase also fostered better infiltration of CAR-T cells, which are designed to target and kill cancer cells.
These findings suggest that nattokinase is not just a passive health supplement but an active player in transforming the tumor environment to make cancer treatments more successful. Overall, our exploration shows great promise for nattokinase in optimizing cancer therapies, showcasing its potential for widespread application in fighting solid tumors.
Through intratumoral injections of nattokinase, we found that it breaks down fibronectin, a key component of the tumor's dense extracellular matrix. This process reduces the tumor's stiffness, improves blood flow, and helps alleviate hypoxia—essentially allowing more oxygen and therapeutic agents to reach the tumor. As a result, chemotherapy becomes more effective without causing additional side effects.
Furthermore, we saw that when nattokinase was administered before radiotherapy, it increased the oxygen levels within the tumor, enhancing the responsiveness to radiation. In experiments with a human breast cancer model, the use of nattokinase also fostered better infiltration of CAR-T cells, which are designed to target and kill cancer cells.
These findings suggest that nattokinase is not just a passive health supplement but an active player in transforming the tumor environment to make cancer treatments more successful. Overall, our exploration shows great promise for nattokinase in optimizing cancer therapies, showcasing its potential for widespread application in fighting solid tumors.
Read More
9
We assessed the impact of nattokinase crude extract (NCE) on liver cancer, specifically hepatocellular carcinoma (HCC), using mouse models.
Mice receiving NCE exhibited a 31% survival rate improvement and reduced tumor sizes, as indicated by imaging and pathology evaluations.
Additionally, NCE led to decreased levels of several cancer markers.
Overall, these findings suggest that nattokinase may positively influence liver cancer outcomes in this model.
Mice receiving NCE exhibited a 31% survival rate improvement and reduced tumor sizes, as indicated by imaging and pathology evaluations.
Additionally, NCE led to decreased levels of several cancer markers.
Overall, these findings suggest that nattokinase may positively influence liver cancer outcomes in this model.
Read More
8
Nattokinase-heparin benefits cancer therapy
We set out to explore how combining nattokinase, a powerful enzyme known for its ability to dissolve blood clots, with heparin, a well-known anticoagulant, could improve treatment for patients with advanced tumors suffering from cancer-related thrombosis (CAT). CAT often leads to severe complications that negatively impact patients’ quality of life and their chances of survival, which is why finding effective solutions is crucial.
In our investigation, we constructed electrostatic complexes of nattokinase and heparin to minimize the risks associated with intravenous use of nattokinase. We conducted a series of tests, including guinea pig allergy tests and both in vivo and in vitro thrombolysis experiments, to confirm that our new solution was safe and effective in breaking down clots. Then, we evaluated its impact on advanced tumors using a modified doxorubicin treatment to see if this combination could enhance anti-tumor effects while managing thrombosis.
Our findings were promising: the nattokinase-heparin combination not only prevented the formation of clots but also enhanced the effects of doxorubicin therapy in tumor tissue by decreasing fibrin levels. This leads us to believe that this innovative approach could pave the way for improved treatment options for patients with advanced cancer and CAT, ultimately yielding better outcomes using enhanced nano-formulations.
In our investigation, we constructed electrostatic complexes of nattokinase and heparin to minimize the risks associated with intravenous use of nattokinase. We conducted a series of tests, including guinea pig allergy tests and both in vivo and in vitro thrombolysis experiments, to confirm that our new solution was safe and effective in breaking down clots. Then, we evaluated its impact on advanced tumors using a modified doxorubicin treatment to see if this combination could enhance anti-tumor effects while managing thrombosis.
Our findings were promising: the nattokinase-heparin combination not only prevented the formation of clots but also enhanced the effects of doxorubicin therapy in tumor tissue by decreasing fibrin levels. This leads us to believe that this innovative approach could pave the way for improved treatment options for patients with advanced cancer and CAT, ultimately yielding better outcomes using enhanced nano-formulations.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Helps blood cancer
12 people found this helpful
Wonderful! We use this instead of aspirin. My husband has a blood cancer that increases the viscosity of his blood, making it thicker, and this is certainly helping.
Read More
7.5
Excellent support
1 people found this helpful
Its quality is excellent. The bottle and capsule sizes are small and tasteless. It serves as great support for issues like anaemia and for cancer treatments, with medical studies backing its effectiveness.
Read More
6
Destroys cancer cells
It favourably affects the body. I hope it will destroy cancer cells. We will write more about this later.
Read More
Frequently Asked Questions
7.5
Helps blood cancer
12 people found this helpful
Wonderful! We use this instead of aspirin. My husband has a blood cancer that increases the viscosity of his blood, making it thicker, and this is certainly helping.
7.5
Excellent support
1 people found this helpful
Its quality is excellent. The bottle and capsule sizes are small and tasteless. It serves as great support for issues like anaemia and for cancer treatments, with medical studies backing its effectiveness.
6
Destroys cancer cells
It favourably affects the body. I hope it will destroy cancer cells. We will write more about this later.
9
We looked into the role of nattokinase, a health supplement known for its ability to dissolve blood clots, in improving treatments for solid tumors. The research focused on how nattokinase can modify the tumor's physical environment to boost the effectiveness of various cancer therapies, including chemotherapy, radiotherapy, and CAR-T cell therapy.
Through intratumoral injections of nattokinase, we found that it breaks down fibronectin, a key component of the tumor's dense extracellular matrix. This process reduces the tumor's stiffness, improves blood flow, and helps alleviate hypoxia—essentially allowing more oxygen and therapeutic agents to reach the tumor. As a result, chemotherapy becomes more effective without causing additional side effects.
Furthermore, we saw that when nattokinase was administered before radiotherapy, it increased the oxygen levels within the tumor, enhancing the responsiveness to radiation. In experiments with a human breast cancer model, the use of nattokinase also fostered better infiltration of CAR-T cells, which are designed to target and kill cancer cells.
These findings suggest that nattokinase is not just a passive health supplement but an active player in transforming the tumor environment to make cancer treatments more successful. Overall, our exploration shows great promise for nattokinase in optimizing cancer therapies, showcasing its potential for widespread application in fighting solid tumors.
Through intratumoral injections of nattokinase, we found that it breaks down fibronectin, a key component of the tumor's dense extracellular matrix. This process reduces the tumor's stiffness, improves blood flow, and helps alleviate hypoxia—essentially allowing more oxygen and therapeutic agents to reach the tumor. As a result, chemotherapy becomes more effective without causing additional side effects.
Furthermore, we saw that when nattokinase was administered before radiotherapy, it increased the oxygen levels within the tumor, enhancing the responsiveness to radiation. In experiments with a human breast cancer model, the use of nattokinase also fostered better infiltration of CAR-T cells, which are designed to target and kill cancer cells.
These findings suggest that nattokinase is not just a passive health supplement but an active player in transforming the tumor environment to make cancer treatments more successful. Overall, our exploration shows great promise for nattokinase in optimizing cancer therapies, showcasing its potential for widespread application in fighting solid tumors.
8
Nattokinase-heparin benefits cancer therapy
We set out to explore how combining nattokinase, a powerful enzyme known for its ability to dissolve blood clots, with heparin, a well-known anticoagulant, could improve treatment for patients with advanced tumors suffering from cancer-related thrombosis (CAT). CAT often leads to severe complications that negatively impact patients’ quality of life and their chances of survival, which is why finding effective solutions is crucial.
In our investigation, we constructed electrostatic complexes of nattokinase and heparin to minimize the risks associated with intravenous use of nattokinase. We conducted a series of tests, including guinea pig allergy tests and both in vivo and in vitro thrombolysis experiments, to confirm that our new solution was safe and effective in breaking down clots. Then, we evaluated its impact on advanced tumors using a modified doxorubicin treatment to see if this combination could enhance anti-tumor effects while managing thrombosis.
Our findings were promising: the nattokinase-heparin combination not only prevented the formation of clots but also enhanced the effects of doxorubicin therapy in tumor tissue by decreasing fibrin levels. This leads us to believe that this innovative approach could pave the way for improved treatment options for patients with advanced cancer and CAT, ultimately yielding better outcomes using enhanced nano-formulations.
In our investigation, we constructed electrostatic complexes of nattokinase and heparin to minimize the risks associated with intravenous use of nattokinase. We conducted a series of tests, including guinea pig allergy tests and both in vivo and in vitro thrombolysis experiments, to confirm that our new solution was safe and effective in breaking down clots. Then, we evaluated its impact on advanced tumors using a modified doxorubicin treatment to see if this combination could enhance anti-tumor effects while managing thrombosis.
Our findings were promising: the nattokinase-heparin combination not only prevented the formation of clots but also enhanced the effects of doxorubicin therapy in tumor tissue by decreasing fibrin levels. This leads us to believe that this innovative approach could pave the way for improved treatment options for patients with advanced cancer and CAT, ultimately yielding better outcomes using enhanced nano-formulations.
9
We assessed the impact of nattokinase crude extract (NCE) on liver cancer, specifically hepatocellular carcinoma (HCC), using mouse models.
Mice receiving NCE exhibited a 31% survival rate improvement and reduced tumor sizes, as indicated by imaging and pathology evaluations.
Additionally, NCE led to decreased levels of several cancer markers.
Overall, these findings suggest that nattokinase may positively influence liver cancer outcomes in this model.
Mice receiving NCE exhibited a 31% survival rate improvement and reduced tumor sizes, as indicated by imaging and pathology evaluations.
Additionally, NCE led to decreased levels of several cancer markers.
Overall, these findings suggest that nattokinase may positively influence liver cancer outcomes in this model.
9
We explored the role of a unique engineered strain of Salmonella, which secretes a substance called nattokinase, in improving cancer treatment—specifically radio-immunotherapy for colon tumors. This inventive approach aims to address an important challenge in cancer therapy: the physical barriers in the tumor microenvironment that often prevent immune cells from effectively targeting cancer cells.
The engineered bacteria, which we refer to as VNP, is designed to accumulate at tumor sites after being introduced into the body. Once there, these bacteria produce large amounts of nattokinase, a compound that helps break down a protein called fibronectin, clear out the surrounding tissue structure, and reduce the presence of cells that typically support tumor growth—known as cancer-associated fibroblasts.
By breaking down these barriers, VNP allows vital immune cells, specifically dendritic cells, to enter the tumor more easily. After treatment with radiotherapy, this infiltration leads to an enhanced immune response, recruiting CD8 T cells that work to eliminate tumor cells. We noticed that treating tumors with VNP before radiotherapy not only amplified the targeted effect but also established lasting immune memory, which may help prevent tumor recurrence and metastasis.
Our findings suggest that using engineered bacteria like VNP to breach physical barriers within tumors could significantly enhance the effectiveness of radio-immunotherapy, offering promising insights for future cancer treatments.
The engineered bacteria, which we refer to as VNP, is designed to accumulate at tumor sites after being introduced into the body. Once there, these bacteria produce large amounts of nattokinase, a compound that helps break down a protein called fibronectin, clear out the surrounding tissue structure, and reduce the presence of cells that typically support tumor growth—known as cancer-associated fibroblasts.
By breaking down these barriers, VNP allows vital immune cells, specifically dendritic cells, to enter the tumor more easily. After treatment with radiotherapy, this infiltration leads to an enhanced immune response, recruiting CD8 T cells that work to eliminate tumor cells. We noticed that treating tumors with VNP before radiotherapy not only amplified the targeted effect but also established lasting immune memory, which may help prevent tumor recurrence and metastasis.
Our findings suggest that using engineered bacteria like VNP to breach physical barriers within tumors could significantly enhance the effectiveness of radio-immunotherapy, offering promising insights for future cancer treatments.
References
- Zhang Y, Liu Y, Li T, Yang X, Lang S, et al. Engineered bacteria breach tumor physical barriers to enhance radio-immunotherapy. J Control Release. 2024;373:867. doi:10.1016/j.jconrel.2024.07.076
- Wang D, Kou Y, Guo T, Duan L, Chen J, et al. Intravenous injection of nattokinase-heparin electrostatic complex improves the therapeutic effect of advanced tumors by dissolving cancer-related thrombosis. Life Sci. 2024;355:122935. doi:10.1016/j.lfs.2024.122935
- Zhang Y, Pei P, Zhou H, Xie Y, Yang S, et al. Nattokinase-Mediated Regulation of Tumor Physical Microenvironment to Enhance Chemotherapy, Radiotherapy, and CAR-T Therapy of Solid Tumor. ACS Nano. 2023;17:7475. doi:10.1021/acsnano.2c12463
- Yan Y, Wang Y, Qian J, Wu S, Ji Y, et al. Nattokinase Crude Extract Inhibits Hepatocellular Carcinoma Growth in Mice. J Microbiol Biotechnol. 2019;29:1281. doi:10.4014/jmb.1812.12058
