Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.2
USERS' SCORE
Good
Based on 3 Reviews
8.4
Supplement Facts
Serving Size: 2 Softgels
Amount Per Serving
%DV
Calories
20
Total Fat
2 g
3%**
Saturated Fat
0.5 g
3%**
Polyunsaturated Fat
1 g
†
Monounsaturated Fat
0.5 g
†
Fish Oil Concentrate
2 g (2,000 mg)
†
Eicosapentaenoic Acid (EPA)
360 mg
†
Docosahexaenoic Acid (DHA)
240 mg
†
Top Medical Research Studies
8
We aimed to understand how eicosapentaenoic acid (EPA) affects psoriasis, a skin condition known for causing redness, irritation, and thickened skin. By creating skin models that reflect both healthy and psoriatic conditions, we were able to assess the impact of EPA directly on lipid profiles—a key factor in skin health.
Our research revealed that in psoriatic skin models, there was a notable increase in certain fatty acids linked to inflammation, such as arachidonic acid (AA) and linoleic acid (LA). However, when we supplemented the media with EPA, we noticed a significant shift. The levels of beneficial omega-3 fatty acids, including EPA, docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA), rose in both epidermal and dermal tissues.
More importantly, the addition of EPA helped to balance the production of lipid mediators in the skin. We observed increases in several anti-inflammatory molecules, such as prostaglandin E (PGE) and 12-hydroxyeicosapentaenoic acid (12-HEPE), indicating a move toward a more stable and healthier skin environment. These results suggest that EPA could play an important role in managing psoriasis by promoting a healthier lipid balance in the skin, potentially easing symptoms and encouraging skin healing.
Our research revealed that in psoriatic skin models, there was a notable increase in certain fatty acids linked to inflammation, such as arachidonic acid (AA) and linoleic acid (LA). However, when we supplemented the media with EPA, we noticed a significant shift. The levels of beneficial omega-3 fatty acids, including EPA, docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA), rose in both epidermal and dermal tissues.
More importantly, the addition of EPA helped to balance the production of lipid mediators in the skin. We observed increases in several anti-inflammatory molecules, such as prostaglandin E (PGE) and 12-hydroxyeicosapentaenoic acid (12-HEPE), indicating a move toward a more stable and healthier skin environment. These results suggest that EPA could play an important role in managing psoriasis by promoting a healthier lipid balance in the skin, potentially easing symptoms and encouraging skin healing.
Read More
9
Eicosapentaenoic acid benefits psoriasis
We assessed the effects of eicosapentaenoic acid (EPA), an omega-3 fatty acid, on psoriasis through intravenous administration in a series of studies. The investigation aimed to understand whether replacing arachidonic acid, which has pro-inflammatory properties, with EPA could be beneficial for patients suffering from psoriasis.
Participants received daily infusions of either an EPA-based lipid emulsion or a conventional n-6 lipid emulsion. Throughout the studies, we closely monitored the clinical progression of psoriasis, along with specific inflammatory markers in the blood.
Our findings were notable: the group receiving the n-3 fatty acid treatment showed a significantly higher response rate. We observed a remarkable tenfold increase in specific products derived from neutrophils, indicating enhanced benefits from EPA. Additionally, plasma levels of EPA rose swiftly within just a few days of treatment.
In summary, our research suggests that intravenous administration of n-3 fatty acids effectively reduces psoriasis symptoms, likely due to alterations in inflammatory processes. This rapid response contrasts sharply with slower improvements seen with oral supplementation of fatty acids.
Participants received daily infusions of either an EPA-based lipid emulsion or a conventional n-6 lipid emulsion. Throughout the studies, we closely monitored the clinical progression of psoriasis, along with specific inflammatory markers in the blood.
Our findings were notable: the group receiving the n-3 fatty acid treatment showed a significantly higher response rate. We observed a remarkable tenfold increase in specific products derived from neutrophils, indicating enhanced benefits from EPA. Additionally, plasma levels of EPA rose swiftly within just a few days of treatment.
In summary, our research suggests that intravenous administration of n-3 fatty acids effectively reduces psoriasis symptoms, likely due to alterations in inflammatory processes. This rapid response contrasts sharply with slower improvements seen with oral supplementation of fatty acids.
Read More
We explored the effectiveness of a specialized treatment regimen involving docosahexaenoic acid (DHA) as part of an n-3 fatty acid lipid infusion for patients suffering from acute guttate psoriasis. This study included twenty hospitalized individuals with significant skin involvement and was conducted in a randomized, double-blind, placebo-controlled manner to ensure reliable results.
Participants received either a daily infusion of the n-3 fatty acid emulsion, which contained DHA and eicosapentaenoic acid (EPA), or a conventional n-6 lipid emulsion lacking significant benefits from omega-3s. We recorded clinical changes over ten days, assessing factors such as skin redness, swelling, and peeling, along with patients' subjective feelings about their symptoms.
The results were telling: those receiving the n-3 infusion showed a remarkable improvement in their psoriasis symptoms—between 45% and 76%—within just ten days. In contrast, the n-6 group experienced only moderate improvement, around 16-25%. Furthermore, we noted significant changes in the patients' immune response. The n-3 group had an increased production of beneficial leukotriene products, while inflammatory markers decreased, suggesting a positive modulation of the body's inflammatory response by DHA and EPA.
Overall, our investigation highlights a potential rapid benefit of using n-3 fatty acids, particularly DHA, in treating acute psoriasis. This indicates a promising avenue for improving the lives of those affected by this challenging skin condition.
Participants received either a daily infusion of the n-3 fatty acid emulsion, which contained DHA and eicosapentaenoic acid (EPA), or a conventional n-6 lipid emulsion lacking significant benefits from omega-3s. We recorded clinical changes over ten days, assessing factors such as skin redness, swelling, and peeling, along with patients' subjective feelings about their symptoms.
The results were telling: those receiving the n-3 infusion showed a remarkable improvement in their psoriasis symptoms—between 45% and 76%—within just ten days. In contrast, the n-6 group experienced only moderate improvement, around 16-25%. Furthermore, we noted significant changes in the patients' immune response. The n-3 group had an increased production of beneficial leukotriene products, while inflammatory markers decreased, suggesting a positive modulation of the body's inflammatory response by DHA and EPA.
Overall, our investigation highlights a potential rapid benefit of using n-3 fatty acids, particularly DHA, in treating acute psoriasis. This indicates a promising avenue for improving the lives of those affected by this challenging skin condition.
Read More
Most Useful Reviews
9
Smoother skin
I tried this Omega for the first time and noticed results in just ten days. Previously, I used a Russian brand that was ineffective. My psoriasis has improved; the skin on my hands is smoother, and the cracks are healing. I’ve purchased a large jar since the quality is excellent, and my mother, who is hypertensive, found it beneficial too.
Read More
7.5
No side effects
I’m on my second can of Omega. The capsules are quite large, but easy to swallow. My mother experienced some eructation, so we paused for a bit. I ordered it for my husband on his doctor's advice for psoriasis management, and he has had no side effects so far, which is reassuring.
Read More
7.5
Improved skin
I regularly take Omega for my psoriasis, and the skin condition has improved significantly. It also benefits my cardiovascular system and gallbladder function. I’ve found it best to take with a breakfast containing fats for effectiveness.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 26 Researches
7.2
- All Researches
9.5
We evaluated the impact of docosahexaenoic acid (DHA) supplementation, alongside eicosapentaenoic acid (EPA), in patients suffering from chronic, stable psoriasis. This study involved 80 participants, 34 of whom also had psoriatic arthritis, and they were given specific doses of fatty acid ethyl esters for a period of eight weeks.
The results showed a noteworthy decrease in the Psoriasis Area Severity Index (PASI) scores, which went from an average of 3.56 before treatment to 1.24 after eight weeks. This significant reduction illustrates the potential effectiveness of DHA for managing symptoms of psoriasis, such as itching and plaque scaling.
It was particularly encouraging to see that seven patients were completely healed, with many others experiencing significant improvement. The majority of those with psoriatic arthritis reported feeling less joint pain during the study. Through our observations, it became clear that polyunsaturated ethyl ester lipids, like DHA, may serve as a valuable complement to traditional therapies for both psoriasis and psoriatic arthritis.
The results showed a noteworthy decrease in the Psoriasis Area Severity Index (PASI) scores, which went from an average of 3.56 before treatment to 1.24 after eight weeks. This significant reduction illustrates the potential effectiveness of DHA for managing symptoms of psoriasis, such as itching and plaque scaling.
It was particularly encouraging to see that seven patients were completely healed, with many others experiencing significant improvement. The majority of those with psoriatic arthritis reported feeling less joint pain during the study. Through our observations, it became clear that polyunsaturated ethyl ester lipids, like DHA, may serve as a valuable complement to traditional therapies for both psoriasis and psoriatic arthritis.
Read More
9
Eicosapentaenoic acid benefits psoriasis
We assessed the effects of eicosapentaenoic acid (EPA), an omega-3 fatty acid, on psoriasis through intravenous administration in a series of studies. The investigation aimed to understand whether replacing arachidonic acid, which has pro-inflammatory properties, with EPA could be beneficial for patients suffering from psoriasis.
Participants received daily infusions of either an EPA-based lipid emulsion or a conventional n-6 lipid emulsion. Throughout the studies, we closely monitored the clinical progression of psoriasis, along with specific inflammatory markers in the blood.
Our findings were notable: the group receiving the n-3 fatty acid treatment showed a significantly higher response rate. We observed a remarkable tenfold increase in specific products derived from neutrophils, indicating enhanced benefits from EPA. Additionally, plasma levels of EPA rose swiftly within just a few days of treatment.
In summary, our research suggests that intravenous administration of n-3 fatty acids effectively reduces psoriasis symptoms, likely due to alterations in inflammatory processes. This rapid response contrasts sharply with slower improvements seen with oral supplementation of fatty acids.
Participants received daily infusions of either an EPA-based lipid emulsion or a conventional n-6 lipid emulsion. Throughout the studies, we closely monitored the clinical progression of psoriasis, along with specific inflammatory markers in the blood.
Our findings were notable: the group receiving the n-3 fatty acid treatment showed a significantly higher response rate. We observed a remarkable tenfold increase in specific products derived from neutrophils, indicating enhanced benefits from EPA. Additionally, plasma levels of EPA rose swiftly within just a few days of treatment.
In summary, our research suggests that intravenous administration of n-3 fatty acids effectively reduces psoriasis symptoms, likely due to alterations in inflammatory processes. This rapid response contrasts sharply with slower improvements seen with oral supplementation of fatty acids.
Read More
We explored the effectiveness of a specialized treatment regimen involving docosahexaenoic acid (DHA) as part of an n-3 fatty acid lipid infusion for patients suffering from acute guttate psoriasis. This study included twenty hospitalized individuals with significant skin involvement and was conducted in a randomized, double-blind, placebo-controlled manner to ensure reliable results.
Participants received either a daily infusion of the n-3 fatty acid emulsion, which contained DHA and eicosapentaenoic acid (EPA), or a conventional n-6 lipid emulsion lacking significant benefits from omega-3s. We recorded clinical changes over ten days, assessing factors such as skin redness, swelling, and peeling, along with patients' subjective feelings about their symptoms.
The results were telling: those receiving the n-3 infusion showed a remarkable improvement in their psoriasis symptoms—between 45% and 76%—within just ten days. In contrast, the n-6 group experienced only moderate improvement, around 16-25%. Furthermore, we noted significant changes in the patients' immune response. The n-3 group had an increased production of beneficial leukotriene products, while inflammatory markers decreased, suggesting a positive modulation of the body's inflammatory response by DHA and EPA.
Overall, our investigation highlights a potential rapid benefit of using n-3 fatty acids, particularly DHA, in treating acute psoriasis. This indicates a promising avenue for improving the lives of those affected by this challenging skin condition.
Participants received either a daily infusion of the n-3 fatty acid emulsion, which contained DHA and eicosapentaenoic acid (EPA), or a conventional n-6 lipid emulsion lacking significant benefits from omega-3s. We recorded clinical changes over ten days, assessing factors such as skin redness, swelling, and peeling, along with patients' subjective feelings about their symptoms.
The results were telling: those receiving the n-3 infusion showed a remarkable improvement in their psoriasis symptoms—between 45% and 76%—within just ten days. In contrast, the n-6 group experienced only moderate improvement, around 16-25%. Furthermore, we noted significant changes in the patients' immune response. The n-3 group had an increased production of beneficial leukotriene products, while inflammatory markers decreased, suggesting a positive modulation of the body's inflammatory response by DHA and EPA.
Overall, our investigation highlights a potential rapid benefit of using n-3 fatty acids, particularly DHA, in treating acute psoriasis. This indicates a promising avenue for improving the lives of those affected by this challenging skin condition.
Read More
9
We explored how docosahexaenoic acid (DHA)—a key component of fish oil—could have a positive impact on psoriasis, a skin condition known for its inflammation and excessive skin cell growth. The study focused on how DHA is metabolized in guinea pig skin and its potential to influence inflammatory processes associated with this condition.
During our research, we incubated guinea pig skin enzyme preparations with two types of fatty acids from fish oil, namely eicosapentaenoic acid and DHA. We found that these fatty acids get converted into specific metabolites that might help regulate unwanted inflammation. Notably, the metabolites 15-hydroxyeicosapentaenoic acid and 17-hydroxydocosahexaenoic acid emerged from this conversion and showed promise as inhibitors of an enzyme linked to the production of inflammatory compounds.
The findings indicated that these metabolites effectively inhibit the enzyme 5-lipoxygenase, which is responsible for producing LTB4—a molecule linked to the worsening of psoriasis. The inhibitory effects observed give us insight into a possible mechanism through which DHA from fish oil could help alleviate symptoms of this challenging skin disorder. This metabolic pathway opens up avenues for future research into the therapeutic potential of DHA for managing psoriasis and similar inflammatory conditions.
During our research, we incubated guinea pig skin enzyme preparations with two types of fatty acids from fish oil, namely eicosapentaenoic acid and DHA. We found that these fatty acids get converted into specific metabolites that might help regulate unwanted inflammation. Notably, the metabolites 15-hydroxyeicosapentaenoic acid and 17-hydroxydocosahexaenoic acid emerged from this conversion and showed promise as inhibitors of an enzyme linked to the production of inflammatory compounds.
The findings indicated that these metabolites effectively inhibit the enzyme 5-lipoxygenase, which is responsible for producing LTB4—a molecule linked to the worsening of psoriasis. The inhibitory effects observed give us insight into a possible mechanism through which DHA from fish oil could help alleviate symptoms of this challenging skin disorder. This metabolic pathway opens up avenues for future research into the therapeutic potential of DHA for managing psoriasis and similar inflammatory conditions.
Read More
8
We aimed to understand how eicosapentaenoic acid (EPA) affects psoriasis, a skin condition known for causing redness, irritation, and thickened skin. By creating skin models that reflect both healthy and psoriatic conditions, we were able to assess the impact of EPA directly on lipid profiles—a key factor in skin health.
Our research revealed that in psoriatic skin models, there was a notable increase in certain fatty acids linked to inflammation, such as arachidonic acid (AA) and linoleic acid (LA). However, when we supplemented the media with EPA, we noticed a significant shift. The levels of beneficial omega-3 fatty acids, including EPA, docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA), rose in both epidermal and dermal tissues.
More importantly, the addition of EPA helped to balance the production of lipid mediators in the skin. We observed increases in several anti-inflammatory molecules, such as prostaglandin E (PGE) and 12-hydroxyeicosapentaenoic acid (12-HEPE), indicating a move toward a more stable and healthier skin environment. These results suggest that EPA could play an important role in managing psoriasis by promoting a healthier lipid balance in the skin, potentially easing symptoms and encouraging skin healing.
Our research revealed that in psoriatic skin models, there was a notable increase in certain fatty acids linked to inflammation, such as arachidonic acid (AA) and linoleic acid (LA). However, when we supplemented the media with EPA, we noticed a significant shift. The levels of beneficial omega-3 fatty acids, including EPA, docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA), rose in both epidermal and dermal tissues.
More importantly, the addition of EPA helped to balance the production of lipid mediators in the skin. We observed increases in several anti-inflammatory molecules, such as prostaglandin E (PGE) and 12-hydroxyeicosapentaenoic acid (12-HEPE), indicating a move toward a more stable and healthier skin environment. These results suggest that EPA could play an important role in managing psoriasis by promoting a healthier lipid balance in the skin, potentially easing symptoms and encouraging skin healing.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.4
- All Reviews
- Positive Reviews
- Negative Reviews
9
Smoother skin
I tried this Omega for the first time and noticed results in just ten days. Previously, I used a Russian brand that was ineffective. My psoriasis has improved; the skin on my hands is smoother, and the cracks are healing. I’ve purchased a large jar since the quality is excellent, and my mother, who is hypertensive, found it beneficial too.
Read More
7.5
No side effects
I’m on my second can of Omega. The capsules are quite large, but easy to swallow. My mother experienced some eructation, so we paused for a bit. I ordered it for my husband on his doctor's advice for psoriasis management, and he has had no side effects so far, which is reassuring.
Read More
7.5
Improved skin
I regularly take Omega for my psoriasis, and the skin condition has improved significantly. It also benefits my cardiovascular system and gallbladder function. I’ve found it best to take with a breakfast containing fats for effectiveness.
Read More
Frequently Asked Questions
9
Smoother skin
I tried this Omega for the first time and noticed results in just ten days. Previously, I used a Russian brand that was ineffective. My psoriasis has improved; the skin on my hands is smoother, and the cracks are healing. I’ve purchased a large jar since the quality is excellent, and my mother, who is hypertensive, found it beneficial too.
7.5
Improved skin
I regularly take Omega for my psoriasis, and the skin condition has improved significantly. It also benefits my cardiovascular system and gallbladder function. I’ve found it best to take with a breakfast containing fats for effectiveness.
7.5
No side effects
I’m on my second can of Omega. The capsules are quite large, but easy to swallow. My mother experienced some eructation, so we paused for a bit. I ordered it for my husband on his doctor's advice for psoriasis management, and he has had no side effects so far, which is reassuring.
8
We aimed to understand how eicosapentaenoic acid (EPA) affects psoriasis, a skin condition known for causing redness, irritation, and thickened skin. By creating skin models that reflect both healthy and psoriatic conditions, we were able to assess the impact of EPA directly on lipid profiles—a key factor in skin health.
Our research revealed that in psoriatic skin models, there was a notable increase in certain fatty acids linked to inflammation, such as arachidonic acid (AA) and linoleic acid (LA). However, when we supplemented the media with EPA, we noticed a significant shift. The levels of beneficial omega-3 fatty acids, including EPA, docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA), rose in both epidermal and dermal tissues.
More importantly, the addition of EPA helped to balance the production of lipid mediators in the skin. We observed increases in several anti-inflammatory molecules, such as prostaglandin E (PGE) and 12-hydroxyeicosapentaenoic acid (12-HEPE), indicating a move toward a more stable and healthier skin environment. These results suggest that EPA could play an important role in managing psoriasis by promoting a healthier lipid balance in the skin, potentially easing symptoms and encouraging skin healing.
Our research revealed that in psoriatic skin models, there was a notable increase in certain fatty acids linked to inflammation, such as arachidonic acid (AA) and linoleic acid (LA). However, when we supplemented the media with EPA, we noticed a significant shift. The levels of beneficial omega-3 fatty acids, including EPA, docosahexaenoic acid (DHA), and docosapentaenoic acid (DPA), rose in both epidermal and dermal tissues.
More importantly, the addition of EPA helped to balance the production of lipid mediators in the skin. We observed increases in several anti-inflammatory molecules, such as prostaglandin E (PGE) and 12-hydroxyeicosapentaenoic acid (12-HEPE), indicating a move toward a more stable and healthier skin environment. These results suggest that EPA could play an important role in managing psoriasis by promoting a healthier lipid balance in the skin, potentially easing symptoms and encouraging skin healing.
7
We explored the impact of a combination of omega-3 fatty acids, particularly eicosapentaenoic acid (EPA), on individuals suffering from psoriasis. In our study, we focused on patients with mild to moderate forms of the disease, which often requires careful management rather than aggressive treatment due to potential side effects.
Through research involving 58 patients, we looked at how this supplementation influenced immune cells and a network of proteins called cytokines in the bloodstream. We observed changes in cytokine levels, such as a decrease in CCL2 and an increase in IFN-γR1, suggesting that these omega-3 fatty acids might play a role in modulating the immune response.
Additionally, we noted a shift in immune cell profiles, with a transition from naive to effector CD4 T cells and reductions in markers of activation on both CD4 and CD8 T cells. These findings indicate that the inclusion of eicosapentaenoic acid in herring roe oil can be beneficial in enhancing the immune system's balance, which may contribute to better management of psoriasis symptoms.
Overall, our findings provide support for the use of herring roe oil as a supplementary treatment option for individuals with psoriasis, potentially improving their quality of life through improved immune regulation.
Through research involving 58 patients, we looked at how this supplementation influenced immune cells and a network of proteins called cytokines in the bloodstream. We observed changes in cytokine levels, such as a decrease in CCL2 and an increase in IFN-γR1, suggesting that these omega-3 fatty acids might play a role in modulating the immune response.
Additionally, we noted a shift in immune cell profiles, with a transition from naive to effector CD4 T cells and reductions in markers of activation on both CD4 and CD8 T cells. These findings indicate that the inclusion of eicosapentaenoic acid in herring roe oil can be beneficial in enhancing the immune system's balance, which may contribute to better management of psoriasis symptoms.
Overall, our findings provide support for the use of herring roe oil as a supplementary treatment option for individuals with psoriasis, potentially improving their quality of life through improved immune regulation.
4
We conducted a thorough examination of how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, impacts psoriasis-like skin inflammation. Utilizing the K14-Rac1V12 mouse model over a 12-week diet intervention period, we compared the effects of EPA with docosahexaenoic acid (DHA).
Our findings revealed that while both EPA and DHA offer potential benefits, the effects of EPA were less pronounced. We observed notable reductions in circulating pro-inflammatory cytokines and changes in immune cell behavior. However, when we specifically looked at the skin conditions of the mice, DHA outperformed EPA by promoting higher levels of beneficial lipid mediators like resolvin D5, protectin DX, and maresin 2.
On the other hand, EPA did show some positive results, particularly in reducing the skin accumulation of harmful compounds like prostaglandin E and thromboxane B. Overall, while EPA did play a role, our study suggests that DHA may be a more effective treatment option for managing psoriasis.
Our findings revealed that while both EPA and DHA offer potential benefits, the effects of EPA were less pronounced. We observed notable reductions in circulating pro-inflammatory cytokines and changes in immune cell behavior. However, when we specifically looked at the skin conditions of the mice, DHA outperformed EPA by promoting higher levels of beneficial lipid mediators like resolvin D5, protectin DX, and maresin 2.
On the other hand, EPA did show some positive results, particularly in reducing the skin accumulation of harmful compounds like prostaglandin E and thromboxane B. Overall, while EPA did play a role, our study suggests that DHA may be a more effective treatment option for managing psoriasis.
7
Eicosapentaenoic acid and psoriasis
We looked into the effects of eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, specifically focusing on its role in treating psoriasis. The study highlighted that EPA has anti-inflammatory properties, which can be beneficial for chronic inflammatory diseases, including psoriasis.
Our review of the research suggested that dietary supplements containing between 1 to 8 grams of EPA per day could potentially help in managing the symptoms of psoriasis. However, it's notable that the study did not clarify whether the benefits observed were solely due to EPA or if they were part of a broader treatment plan that included other interventions.
Furthermore, the results align with other findings indicating that omega-3 fatty acids can ease inflammation, offering hope for those dealing with psoriasis and similar inflammatory conditions. Overall, while the potential of EPA in this context is promising, more detailed research will be vital to understand its effectiveness more comprehensively.
Our review of the research suggested that dietary supplements containing between 1 to 8 grams of EPA per day could potentially help in managing the symptoms of psoriasis. However, it's notable that the study did not clarify whether the benefits observed were solely due to EPA or if they were part of a broader treatment plan that included other interventions.
Furthermore, the results align with other findings indicating that omega-3 fatty acids can ease inflammation, offering hope for those dealing with psoriasis and similar inflammatory conditions. Overall, while the potential of EPA in this context is promising, more detailed research will be vital to understand its effectiveness more comprehensively.
8
We conducted a study to explore the effects of eicosapentaenoic acid when used alongside low-dose etretinate in the treatment of chronic, stable psoriasis vulgaris. In this randomized open trial, we compared the outcomes of two different treatment approaches in 40 patients: one group received low-dose etretinate alone, while the other group had the treatment in combination with eicosapentaenoic acid.
Over a period of 12 weeks, we observed that the combination therapy led to better and faster improvements in the patients compared to those who only received etretinate. It was particularly encouraging to note that eicosapentaenoic acid showed good safety profiles, with only mild or tolerable adverse reactions reported from the etretinate treatment.
These findings suggest that combining eicosapentaenoic acid with low-dose etretinate might offer a more effective approach to managing psoriasis without causing significant side effects.
Over a period of 12 weeks, we observed that the combination therapy led to better and faster improvements in the patients compared to those who only received etretinate. It was particularly encouraging to note that eicosapentaenoic acid showed good safety profiles, with only mild or tolerable adverse reactions reported from the etretinate treatment.
These findings suggest that combining eicosapentaenoic acid with low-dose etretinate might offer a more effective approach to managing psoriasis without causing significant side effects.
8
We explored how eicosapentaenoic acid (EPA), a type of omega-3 fatty acid, can affect T cells in a model of psoriasis—a chronic skin disease characterized by red, inflamed patches. In our experiment, we used a specialized coculture system with psoriatic keratinocytes and T cells, some of which received a supplement of EPA while others did not. This setup allowed us to observe direct effects of EPA on inflammatory responses associated with psoriasis.
Our findings were promising. We noted that EPA reduced the number of T cells producing the inflammatory marker IL-17A, while increasing the presence of regulatory T cells that help control inflammation. This suggests that EPA might play a role in shifting the immune response in a more favorable direction for those with psoriasis. Moreover, we saw that EPA normalized the excessive growth of keratinocytes and diminished IL-17A levels in our psoriatic skin model.
Additionally, the research revealed that EPA supplementation affected certain signaling pathways in skin cells, potentially contributing to its anti-inflammatory properties. With these results, we believe that EPA has the potential to offer a supportive role in managing psoriasis by modulating T cell responses and reducing inflammation.
Our findings were promising. We noted that EPA reduced the number of T cells producing the inflammatory marker IL-17A, while increasing the presence of regulatory T cells that help control inflammation. This suggests that EPA might play a role in shifting the immune response in a more favorable direction for those with psoriasis. Moreover, we saw that EPA normalized the excessive growth of keratinocytes and diminished IL-17A levels in our psoriatic skin model.
Additionally, the research revealed that EPA supplementation affected certain signaling pathways in skin cells, potentially contributing to its anti-inflammatory properties. With these results, we believe that EPA has the potential to offer a supportive role in managing psoriasis by modulating T cell responses and reducing inflammation.
References
- Morin S, Tremblay A, Dumais E, Julien P, Flamand N, et al. Eicosapentaenoic Acid Influences the Lipid Profile of an In Vitro Psoriatic Skin Model Produced with T Cells. Biomolecules. 2023;13. doi:10.3390/biom13091413
- Petrovic A, Bueide I, Tveit KS, Hallaråker H, Bjørndal B, et al. Herring roe oil in treatment of psoriasis - influence on immune cells and cytokine network. Front Immunol. 2023;14:1128986. doi:10.3389/fimmu.2023.1128986
- Vijayapoopathi S, Ramamoorthy R, Meganathan J, Kalaiyazhagan A, Bhuvarahamurthy S, et al. Nutraceutical combination ameliorates imiquimod-induced psoriasis in mice. Chem Biol Drug Des. 2023;102:1578. doi:10.1111/cbdd.14350
- Morin S, Bélanger S, Cortez Ghio S, Pouliot R. Eicosapentaenoic acid reduces the proportion of IL-17A-producing T cells in a 3D psoriatic skin model. J Lipid Res. 2023;64:100428. doi:10.1016/j.jlr.2023.100428
- Sorokin AV, Arnardottir H, Svirydava M, Ng Q, Baumer Y, et al. Comparison of the dietary omega-3 fatty acids impact on murine psoriasis-like skin inflammation and associated lipid dysfunction. J Nutr Biochem. 2023;117:109348. doi:10.1016/j.jnutbio.2023.109348
- Morin S, Simard M, Rioux G, Julien P, Pouliot R. Alpha-Linolenic Acid Modulates T Cell Incorporation in a 3D Tissue-Engineered Psoriatic Skin Model. Cells. 2022;11. doi:10.3390/cells11091513
- Zhan J, Tang X, Wang F, Han J. Association Between Daily Dietary Eicosatetraenoic Acid Intake and the Lower Risk of Psoriasis in American Adults. Clin Cosmet Investig Dermatol. 2021;14:1541. doi:10.2147/CCID.S333288
- Morin S, Simard M, Flamand N, Pouliot R. Biological action of docosahexaenoic acid in a 3D tissue-engineered psoriatic skin model: Focus on the PPAR signaling pathway. Biochim Biophys Acta Mol Cell Biol Lipids. 2021;1866:159032. doi:10.1016/j.bbalip.2021.159032
- Simard M, Rioux G, Morin S, Martin C, Guérin SL, et al. Investigation of Omega-3 Polyunsaturated Fatty Acid Biological Activity in a Tissue-Engineered Skin Model Involving Psoriatic Cells. J Invest Dermatol. 2021;141:2391. doi:10.1016/j.jid.2021.02.755
- Maruani A, Samimi M, Stembridge N, Abdel Hay R, Tavernier E, et al. Non-antistreptococcal interventions for acute guttate psoriasis or an acute guttate flare of chronic psoriasis. Cochrane Database Syst Rev. 2019;4:CD011541. doi:10.1002/14651858.CD011541.pub2
- Zulfakar MH, Edwards M, Heard CM. Is there a role for topically delivered eicosapentaenoic acid in the treatment of psoriasis?. Eur J Dermatol. 2007;17:284.
- Wolters M. [The significance of diet and associated factors in psoriasis]. Hautarzt. 2006;57:999.
- Gil A. Polyunsaturated fatty acids and inflammatory diseases. Biomed Pharmacother. 2002;56:388.
- Mayser P, Grimm H, Grimminger F. n-3 fatty acids in psoriasis. Br J Nutr. 2002;87 Suppl 1:S77.
- Danno K, Sugie N. Combination therapy with low-dose etretinate and eicosapentaenoic acid for psoriasis vulgaris. J Dermatol. 1998;25:703.
- Mayser P, Mrowietz U, Arenberger P, Bartak P, Buchvald J, et al. Omega-3 fatty acid-based lipid infusion in patients with chronic plaque psoriasis: results of a double-blind, randomized, placebo-controlled, multicenter trial. J Am Acad Dermatol. 1998;38:539.
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