Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.1
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Oregano Oil (Origanum vulgare) min. 55% Carvacrol)
0.2 ml / 181 mg
**
Ginger Oil (Zingiber officinale)
0.02 ml / 17.6 mg
**
Fennel Oil (Foeniculum vulgare)
0.02 ml / 19.3 mg
**
Top Medical Research Studies
9
We investigated the potential of oregano essential oil, specifically Origanum majorana Essential Oil (OMEO), as a treatment for non-small cell lung cancer (NSCLC). In our pre-clinical study, we utilized two well-known human NSCLC cell lines, A549 and LNM35, to see how OMEO affected their growth and viability. To our satisfaction, we found that OMEO significantly reduced the viability of these cancer cells and inhibited the growth of their colonies in a concentration-dependent manner.
The oil worked partly by inducing a specific type of cell death, which is crucial for combatting cancer, and it reduced levels of a protein linked to cancer survival. We also observed that OMEO slowed down tumor growth in live models, including those implanted with A549 and LNM35 cells. Excitingly, it hindered the migration and invasion of these cancer cells and decreased the occurrence and growth of metastasis in the lymph nodes when tested in mice.
Remarkably, despite some three months of treatment with OMEO, the mice showed no adverse effects on critical body functions like blood or liver health. This suggests that OMEO not only offers a robust anticancer effect but also does so safely.
The oil worked partly by inducing a specific type of cell death, which is crucial for combatting cancer, and it reduced levels of a protein linked to cancer survival. We also observed that OMEO slowed down tumor growth in live models, including those implanted with A549 and LNM35 cells. Excitingly, it hindered the migration and invasion of these cancer cells and decreased the occurrence and growth of metastasis in the lymph nodes when tested in mice.
Remarkably, despite some three months of treatment with OMEO, the mice showed no adverse effects on critical body functions like blood or liver health. This suggests that OMEO not only offers a robust anticancer effect but also does so safely.
Read More
8
Oregano depsides show anti-cancer potential
We isolated four specific compounds, known as depsides, from the medicinal plants Origanum dictamnus and Satureja pilosa to examine their effects on cancer cells. Using advanced techniques such as nuclear magnetic resonance and mass spectrometry, we identified these compounds and assessed their potency against human carbonic anhydrases, which are enzymes often associated with tumor growth.
In our tests, we found that these compounds preferentially inhibited tumor-associated carbonic anhydrases over the normal forms, suggesting a targeted approach in blocking cancer pathways. Furthermore, we employed X-ray crystallography to better understand how one of these compounds, salvianolic acid P, binds to the enzymes involved.
Importantly, we also observed significant cytotoxic effects on a particular type of breast cancer cell line known as MDA-MB-231. This finding indicates that these depsides could be promising candidates for further research in cancer treatment, opening new avenues for using natural compounds from oregano as therapeutic options.
In our tests, we found that these compounds preferentially inhibited tumor-associated carbonic anhydrases over the normal forms, suggesting a targeted approach in blocking cancer pathways. Furthermore, we employed X-ray crystallography to better understand how one of these compounds, salvianolic acid P, binds to the enzymes involved.
Importantly, we also observed significant cytotoxic effects on a particular type of breast cancer cell line known as MDA-MB-231. This finding indicates that these depsides could be promising candidates for further research in cancer treatment, opening new avenues for using natural compounds from oregano as therapeutic options.
Read More
8
Oregano oil shows cancer treatment potential
We explored the therapeutic potential of oregano essential oil, specifically focusing on its ability to treat prostate cancer. Using a specially prepared form called oregano essential oil-based nanoemulsion (OENE), we aimed to see how it affected prostate cancer cells (PC3). Our methods included synthesizing and characterizing OENE, and then we conducted tests to determine its toxicity and efficacy.
Results revealed that OENE has an inhibitory concentration (IC) of 13.82 g/mL, meaning it can effectively reduce the growth of cancer cells. We observed pronounced changes in the cancer cells, such as shrinkage and decreased density. Additionally, OENE reduced the accumulation of harmful lipid droplets within these cells, pointing to its role in disrupting lipid metabolism.
On a molecular level, the treatment increased the expressions of pro-apoptotic factors like BAX and caspase 3, which help induce cell death. Meanwhile, the levels of the anti-apoptotic factor BCL2 dropped significantly. This combination of effects indicates that OENE can trigger apoptosis—the process of programmed cell death—in prostate cancer cells.
In summary, our findings suggest that oregano essential oil holds promise as a potential treatment for prostate cancer, paving the way for future in vivo studies.
Results revealed that OENE has an inhibitory concentration (IC) of 13.82 g/mL, meaning it can effectively reduce the growth of cancer cells. We observed pronounced changes in the cancer cells, such as shrinkage and decreased density. Additionally, OENE reduced the accumulation of harmful lipid droplets within these cells, pointing to its role in disrupting lipid metabolism.
On a molecular level, the treatment increased the expressions of pro-apoptotic factors like BAX and caspase 3, which help induce cell death. Meanwhile, the levels of the anti-apoptotic factor BCL2 dropped significantly. This combination of effects indicates that OENE can trigger apoptosis—the process of programmed cell death—in prostate cancer cells.
In summary, our findings suggest that oregano essential oil holds promise as a potential treatment for prostate cancer, paving the way for future in vivo studies.
Read More
Most Useful Reviews
9
Positive effects
Family members undergoing cancer chemotherapy have noted that they feel better after taking it! I will repurchase this regularly!
Read More
7.5
Stopped growth
I've used this herb in my battle against cancer, and thankfully, it hasn't progressed.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 15 Researches
8.1
- All Researches
9
Oregano oil shows anticancer potential
We sought to understand how oregano essential oil (EO) affects cancer cells, particularly colorectal cancer (CRC) cells. Our study involved human colon carcinoma cell lines and various essential oils, including oregano.
We discovered that oregano exhibited strong cytotoxic effects, meaning it could potentially kill cancer cells. In fact, among all the oils we tested, oregano showed the highest effectiveness with significant damage to the DNA of the cancer cells and increased levels of reactive oxygen species (ROS).
We found that after just 24 hours of exposure to oregano oil, the cancer cells displayed notable responses, indicating that this natural substance might play a role in combating CRC. While we also explored the antibacterial properties of several essential oils, oregano stood out as particularly effective against harmful bacteria.
However, other oils like peppermint, lemon, and lavender did not show the same effects on cancer cell viability. This highlights oregano's potential as a beneficial ingredient in cancer treatment, distinguishing it from some other essential oils that did not impact lactic acid bacteria survival but had anticancer effects.
We discovered that oregano exhibited strong cytotoxic effects, meaning it could potentially kill cancer cells. In fact, among all the oils we tested, oregano showed the highest effectiveness with significant damage to the DNA of the cancer cells and increased levels of reactive oxygen species (ROS).
We found that after just 24 hours of exposure to oregano oil, the cancer cells displayed notable responses, indicating that this natural substance might play a role in combating CRC. While we also explored the antibacterial properties of several essential oils, oregano stood out as particularly effective against harmful bacteria.
However, other oils like peppermint, lemon, and lavender did not show the same effects on cancer cell viability. This highlights oregano's potential as a beneficial ingredient in cancer treatment, distinguishing it from some other essential oils that did not impact lactic acid bacteria survival but had anticancer effects.
Read More
9
Oregano oil shows promise against infections
Our exploration centered on understanding the potential benefits of oregano, specifically essential oil from Origanum punonense, in combating cancer and infections. The study identified key phytochemical components in the oil, and we applied various tests to assess its effects on cancer cell growth and its ability to fight bacterial infections.
We found that the essential oil contains a wealth of phytochemicals, with carvacrol being the most prominent. When tested at a concentration of 500 µg/mL, the oil demonstrated significant antiproliferative activity across different cancer cell lines. This suggests that oregano oil might help slow down the growth of cancer cells, presenting an intriguing avenue for further research.
Moreover, the oil exhibited strong antimicrobial properties, battling several harmful bacteria and fungi, including those linked with diabetic foot infections. The broad-spectrum activity of oregano oil may hold promise for treating infections, especially in patients with weakened immune systems. However, as we uncovered its remarkable characteristics, it's important to recognize that our findings mainly point toward its effectiveness in managing infections rather than as a standalone cancer treatment.
We found that the essential oil contains a wealth of phytochemicals, with carvacrol being the most prominent. When tested at a concentration of 500 µg/mL, the oil demonstrated significant antiproliferative activity across different cancer cell lines. This suggests that oregano oil might help slow down the growth of cancer cells, presenting an intriguing avenue for further research.
Moreover, the oil exhibited strong antimicrobial properties, battling several harmful bacteria and fungi, including those linked with diabetic foot infections. The broad-spectrum activity of oregano oil may hold promise for treating infections, especially in patients with weakened immune systems. However, as we uncovered its remarkable characteristics, it's important to recognize that our findings mainly point toward its effectiveness in managing infections rather than as a standalone cancer treatment.
Read More
9
We investigated the potential of oregano essential oil, specifically Origanum majorana Essential Oil (OMEO), as a treatment for non-small cell lung cancer (NSCLC). In our pre-clinical study, we utilized two well-known human NSCLC cell lines, A549 and LNM35, to see how OMEO affected their growth and viability. To our satisfaction, we found that OMEO significantly reduced the viability of these cancer cells and inhibited the growth of their colonies in a concentration-dependent manner.
The oil worked partly by inducing a specific type of cell death, which is crucial for combatting cancer, and it reduced levels of a protein linked to cancer survival. We also observed that OMEO slowed down tumor growth in live models, including those implanted with A549 and LNM35 cells. Excitingly, it hindered the migration and invasion of these cancer cells and decreased the occurrence and growth of metastasis in the lymph nodes when tested in mice.
Remarkably, despite some three months of treatment with OMEO, the mice showed no adverse effects on critical body functions like blood or liver health. This suggests that OMEO not only offers a robust anticancer effect but also does so safely.
The oil worked partly by inducing a specific type of cell death, which is crucial for combatting cancer, and it reduced levels of a protein linked to cancer survival. We also observed that OMEO slowed down tumor growth in live models, including those implanted with A549 and LNM35 cells. Excitingly, it hindered the migration and invasion of these cancer cells and decreased the occurrence and growth of metastasis in the lymph nodes when tested in mice.
Remarkably, despite some three months of treatment with OMEO, the mice showed no adverse effects on critical body functions like blood or liver health. This suggests that OMEO not only offers a robust anticancer effect but also does so safely.
Read More
9
Oregano extracts show cancer potential
We explored the potential of extracts from three different oregano species in combating breast cancer. This study examined how these polyphenol-rich extracts interact with breast cancer cell lines, specifically MDA-MB-231 and MCF-7.
The extracts were carefully prepared from dried oregano leaves. We assessed their antioxidant activity, total phenol content, and the types of phenolic acids and flavonoids present using advanced chromatography techniques.
In our tests, one particular oregano extract stood out, demonstrating excellent antioxidant properties. It significantly hindered the growth of both breast cancer cell lines without harming normal fibroblast cells. This non-cytotoxic effect was quite similar to that of cisplatin, a common chemotherapy drug.
These promising results suggest that oregano extracts could be a valuable source for future cancer research, especially regarding their antiproliferative mechanisms. We believe our findings offer fresh insights into natural treatments for breast cancer.
The extracts were carefully prepared from dried oregano leaves. We assessed their antioxidant activity, total phenol content, and the types of phenolic acids and flavonoids present using advanced chromatography techniques.
In our tests, one particular oregano extract stood out, demonstrating excellent antioxidant properties. It significantly hindered the growth of both breast cancer cell lines without harming normal fibroblast cells. This non-cytotoxic effect was quite similar to that of cisplatin, a common chemotherapy drug.
These promising results suggest that oregano extracts could be a valuable source for future cancer research, especially regarding their antiproliferative mechanisms. We believe our findings offer fresh insights into natural treatments for breast cancer.
Read More
9
We explored the effects of oregano extract on MDA-MB-231 cells, a type of aggressive breast cancer known as triple negative breast cancer (TNBC). Our study found that this extraction from oregano, specifically its aqueous form, inhibited the growth of these cancer cells and triggered processes leading to cell death.
We observed that the oregano extract not only curtailed cell viability but also stimulated autophagy, a process that helps cells clean out damaged components. Additionally, it spurred apoptosis, which is the programmed death that can prevent the spread of cancer.
Notably, we found that the extract increased the ability of the cells to adhere to one another, which could inhibit their migration and spread. Furthermore, there was a reduction in key proteins that usually promote cancer cell invasion and inflammation. Our results also showed that oregano extract prevented new blood vessel formation, further indicating a potential to hamper cancer progression.
Overall, our findings suggest that oregano extract could be a promising approach in managing aggressive breast cancer, especially given the limitations of current treatment options for TNBC.
We observed that the oregano extract not only curtailed cell viability but also stimulated autophagy, a process that helps cells clean out damaged components. Additionally, it spurred apoptosis, which is the programmed death that can prevent the spread of cancer.
Notably, we found that the extract increased the ability of the cells to adhere to one another, which could inhibit their migration and spread. Furthermore, there was a reduction in key proteins that usually promote cancer cell invasion and inflammation. Our results also showed that oregano extract prevented new blood vessel formation, further indicating a potential to hamper cancer progression.
Overall, our findings suggest that oregano extract could be a promising approach in managing aggressive breast cancer, especially given the limitations of current treatment options for TNBC.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Positive effects
Family members undergoing cancer chemotherapy have noted that they feel better after taking it! I will repurchase this regularly!
Read More
7.5
Stopped growth
I've used this herb in my battle against cancer, and thankfully, it hasn't progressed.
Read More
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Kozics K, Mesárošová M, Šramková M, Bučková M, Puškárová A, et al. Evaluation of Bioactivity of Essential Oils: Cytotoxic/Genotoxic Effects on Colorectal Cancer Cell Lines, Antibacterial Activity, and Survival of Lactic Acid Bacteria. Molecules. 2025;30. doi:10.3390/molecules30040890
- Yumrutaş Ö, Yumrutaş P, Pehlivan M, Korkmaz M, Kahraman D. Origanum syriacum Induces Apoptosis in Lung Cancer Cells by Altering the Ratio of Bax/Bcl2. Anticancer Agents Med Chem. 2025. doi:10.2174/0118715206333509241112060647
- Paloukopoulou C, Ntagli OS, Gherardi L, Dourdouni V, Filippou G, et al. Depsides from Origanum dictamnus and Satureja pilosa as selective inhibitors of carbonic anhydrases: Isolation, structure elucidation, X-ray crystallography. Arch Pharm (Weinheim). 2025;358:e2400823. doi:10.1002/ardp.202400823
- Tomsuk Ö, Kuete V, Sivas H, Kürkçüoğlu M. Effects of essential oil of Origanum onites and its major component carvacrol on the expression of toxicity pathway genes in HepG2 cells. BMC Complement Med Ther. 2024;24:265. doi:10.1186/s12906-024-04571-6
- Ahmed S, Zengin G, Di Simone SC, Acquaviva A, Libero ML, et al. Combining the Pharmaceutical and Toxicological Properties of Selected Essential Oils with their Chemical Components by GC-MS Analysis. Chem Biodivers. 2024;21:e202400738. doi:10.1002/cbdv.202400738
- Issa K, Bakhatan A, Khaled MA, Jaradat N, Hawash M, et al. Exploring the phytoconstituents, antimicrobial potency, and cytotoxic effects of essential oil from Origanum punonense from Palestine. BMC Complement Med Ther. 2024;24:106. doi:10.1186/s12906-024-04395-4
- Vârban D, Zăhan M, Crișan I, Pop CR, Gál E, et al. Unraveling the Potential of Organic Oregano and Tarragon Essential Oils: Profiling Composition, FT-IR and Bioactivities. Plants (Basel). 2023;12. doi:10.3390/plants12234017
- Di Liberto D, Iacuzzi N, Pratelli G, Porrello A, Maggio A, et al. Cytotoxic Effect Induced by Sicilian Oregano Essential Oil in Human Breast Cancer Cells. Cells. 2023;12. doi:10.3390/cells12232733
- Georgantopoulos A, Vougioukas A, Kalousi FD, Tsialtas I, Psarra AG. Comparative Studies on the Anti-Inflammatory and Apoptotic Activities of Four Greek Essential Oils: Involvement in the Regulation of NF-κΒ and Steroid Receptor Signaling. Life (Basel). 2023;13. doi:10.3390/life13071534
- Kakalis A, Tsekouras V, Mavrikou S, Moschopoulou G, Kintzios S, et al. Farm or Lab? A Comparative Study of Oregano's Leaf and Callus Volatile Isolates Chemistry and Cytotoxicity. Plants (Basel). 2023;12. doi:10.3390/plants12071472
- Bringas-Burgos BF, Martínez-Robinson KG, Toledano-Magaña Y, García-Ramos JC, Ovando-Martínez M, et al. Antiproliferative Effect of Essential Oil Obtained from Oregano (Lippia palmeri S. Watson) Leaves Grown in Hydroponics and LED Light. Chem Biodivers. 2023;20:e202201076. doi:10.1002/cbdv.202201076
- Arafat K, Sulaiman S, Al-Azawi AM, Yasin J, Sugathan S, et al. Origanum majorana essential oil decreases lung tumor growth and metastasis in vitro and in vivo. Biomed Pharmacother. 2022;155:113762. doi:10.1016/j.biopha.2022.113762
- Criollo-Mendoza MS, Ramos-Payán R, Contreras-Angulo LA, Gutiérrez-Grijalva EP, León-Félix J, et al. Cytotoxic Activity of Polyphenol Extracts from Three Oregano Species: , and and Antiproliferative Potential of against Two Types of Breast Cancer Cell Lines (MDA-MB-231 and MCF-7). Molecules. 2022;27. doi:10.3390/molecules27165240
- AlKahlout A, Fardoun M, Mesmar J, Abdallah R, Badran A, et al. L. Attenuates the Malignant Phenotype of MDA-MB231 Breast Cancer Cells. Front Oncol. 2022;12:922196. doi:10.3389/fonc.2022.922196
- Perumalsamy H, Shanmugam R, Kim JR, Anandapadmanaban G, Huq MA, et al. Nanoemulsion and Encapsulation Strategy of Hydrophobic Oregano Essential Oil Increased Human Prostate Cancer Cell Death via Apoptosis by Attenuating Lipid Metabolism. Bioinorg Chem Appl. 2022;2022:9569226. doi:10.1155/2022/9569226
