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SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.7
USERS' SCORE
Good
Based on 1 Review
8.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Potassium (from 310 mg Potassium Citrate)
99 mg
2%
Top Medical Research Studies
8
Potassium chloride influences vertigo symptoms
Rat Model of Ménière's Attack: Intratympanic Injection of Potassium Chloride Produces Direction-Changing Spontaneous Nystagmus and Hearing Fluctuations.
Highly relevant to potassium's effects
We investigated how potassium chloride influences symptoms of vertigo by implementing a controlled study in rats. Through intratympanic injections of various potassium chloride concentrations, we monitored the effects on spontaneous nystagmus and hearing changes in the subjects.
Specifically, we noted that rats receiving higher concentrations of potassium chloride exhibited irritative nystagmus, which is characterized by rapid eye movements towards the affected side, followed by potential paralytic nystagmus towards the opposite side. In contrast, no nystagmus was observed in the rats injected with distilled water.
Our findings revealed significant hearing impairment shortly after the potassium chloride injection, mirroring the symptoms of an acute Ménière's attack. Remarkably, this disruption was reversible, and hearing improved by the following day.
This research not only enhances our understanding of the connection between potassium levels and vertigo symptoms, but also offers a valuable rat model for studying Ménière's disease and its underlying mechanisms.
Specifically, we noted that rats receiving higher concentrations of potassium chloride exhibited irritative nystagmus, which is characterized by rapid eye movements towards the affected side, followed by potential paralytic nystagmus towards the opposite side. In contrast, no nystagmus was observed in the rats injected with distilled water.
Our findings revealed significant hearing impairment shortly after the potassium chloride injection, mirroring the symptoms of an acute Ménière's attack. Remarkably, this disruption was reversible, and hearing improved by the following day.
This research not only enhances our understanding of the connection between potassium levels and vertigo symptoms, but also offers a valuable rat model for studying Ménière's disease and its underlying mechanisms.
Read More
9
SK channels and vertigo treatment
SK Channels Modulation Accelerates Equilibrium Recovery in Unilateral Vestibular Neurectomized Rats.
Moderate relevance to potassium effects
We investigated how potassium channels, specifically small conductance calcium-activated potassium (SK) channels, influence vertigo symptoms following a sudden loss of vestibular function. Our focus was on understanding whether blocking these channels could lessen vertigo, a common and often debilitating condition.
Using a rodent model, we found that blocking SK channels with apamin significantly reduced the severity of vertigo symptoms. This indicates that targeting these channels can help accelerate recovery from the dizziness caused by vestibular disorders.
Interestingly, we also discovered that other SK channel blockers seemed to help improve symptoms, while activating these channels worsened the condition. Notably, apamin outperformed acetyl-DL-leucine—the latter being a treatment option often used in human clinics for similar conditions.
Overall, these results suggest a promising therapeutic role for SK channels in managing vertigo, opening new avenues for treatment strategies in vestibular disorders.
Using a rodent model, we found that blocking SK channels with apamin significantly reduced the severity of vertigo symptoms. This indicates that targeting these channels can help accelerate recovery from the dizziness caused by vestibular disorders.
Interestingly, we also discovered that other SK channel blockers seemed to help improve symptoms, while activating these channels worsened the condition. Notably, apamin outperformed acetyl-DL-leucine—the latter being a treatment option often used in human clinics for similar conditions.
Overall, these results suggest a promising therapeutic role for SK channels in managing vertigo, opening new avenues for treatment strategies in vestibular disorders.
Read More
8
Potassium's role in vestibular function
Impact of 4-aminopyridine on vestibulo-ocular reflex performance.
Explores potassium effect on vertigo
We observed the impact of a potassium channel blocker called 4-aminopyridine (4-AP) on the vestibulo-ocular reflex (VOR), which helps stabilize our vision during head movements. To study this, we recorded the activity of motor neurons in tadpoles, specifically focusing on their response under both resting conditions and during motion.
At various concentrations of 4-AP, we noticed that spontaneous firing rates of neurons increased, leading to bursts of activity. During movement, the drug not only enhanced the firing rate but also delayed its peak, indicating that it alters the timing and intensity of eye movements triggered by head movements.
This suggests that potassium channels like Kv1.1 play a crucial role in how our vestibular system processes motion signals. The observed effects of 4-AP could provide insights into potential treatments for conditions like nystagmus and episodic ataxia, where the balance and stability of vision are affected by irregular vestibular signals.
Overall, our findings highlight the significance of potassium in modulating vertigo-related responses, making it a valuable area for further research and potential clinical applications.
At various concentrations of 4-AP, we noticed that spontaneous firing rates of neurons increased, leading to bursts of activity. During movement, the drug not only enhanced the firing rate but also delayed its peak, indicating that it alters the timing and intensity of eye movements triggered by head movements.
This suggests that potassium channels like Kv1.1 play a crucial role in how our vestibular system processes motion signals. The observed effects of 4-AP could provide insights into potential treatments for conditions like nystagmus and episodic ataxia, where the balance and stability of vision are affected by irregular vestibular signals.
Overall, our findings highlight the significance of potassium in modulating vertigo-related responses, making it a valuable area for further research and potential clinical applications.
Read More
Most Useful Reviews
8.8
Reduced vertigo symptoms
This potassium supplement works well for me, alleviating muscle cramps and significantly helping with vertigo. I initially began taking it after adopting a carnivore diet. The capsules are a good size, and I've come to appreciate this particular brand as one of my favourites.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 6 Researches
7.7
9
SK channels and vertigo treatment
SK Channels Modulation Accelerates Equilibrium Recovery in Unilateral Vestibular Neurectomized Rats.
Moderate relevance to potassium effects
We investigated how potassium channels, specifically small conductance calcium-activated potassium (SK) channels, influence vertigo symptoms following a sudden loss of vestibular function. Our focus was on understanding whether blocking these channels could lessen vertigo, a common and often debilitating condition.
Using a rodent model, we found that blocking SK channels with apamin significantly reduced the severity of vertigo symptoms. This indicates that targeting these channels can help accelerate recovery from the dizziness caused by vestibular disorders.
Interestingly, we also discovered that other SK channel blockers seemed to help improve symptoms, while activating these channels worsened the condition. Notably, apamin outperformed acetyl-DL-leucine—the latter being a treatment option often used in human clinics for similar conditions.
Overall, these results suggest a promising therapeutic role for SK channels in managing vertigo, opening new avenues for treatment strategies in vestibular disorders.
Using a rodent model, we found that blocking SK channels with apamin significantly reduced the severity of vertigo symptoms. This indicates that targeting these channels can help accelerate recovery from the dizziness caused by vestibular disorders.
Interestingly, we also discovered that other SK channel blockers seemed to help improve symptoms, while activating these channels worsened the condition. Notably, apamin outperformed acetyl-DL-leucine—the latter being a treatment option often used in human clinics for similar conditions.
Overall, these results suggest a promising therapeutic role for SK channels in managing vertigo, opening new avenues for treatment strategies in vestibular disorders.
Read More
9
Potassium's role in vertigo treatment
Update on the pharmacotherapy of cerebellar and central vestibular disorders.
Explains potassium's interaction challenges
We observed how potassium-based treatments could potentially influence vertigo symptoms, particularly in the context of central vestibular disorders and forms of nystagmus. The research highlights 4-aminopyridine (4-AP) as a promising option for tackling downbeat nystagmus and upbeat nystagmus, which are forms of acquired persistent fixation nystagmus.
In various studies, 4-AP has shown to enhance the excitability of certain brain cells, leading to improved control over vestibular functions. This is particularly valuable for patients suffering from episodic ataxia type 2, with evidence from both animal models and controlled trials pointing to its efficacy.
We also noted other treatments like chlorzoxazone, which showed some ability to alleviate downbeat nystagmus, and acetyl-DL-leucine, which has demonstrated potential benefits in several case series for cerebellar diseases.
While ongoing trials may offer new perspectives on these treatments, it's crucial to acknowledge the complexities of how potassium interacts with other therapies. The results highlight both the potential benefits and the challenges in isolating the specific effects of potassium on vertigo.
In various studies, 4-AP has shown to enhance the excitability of certain brain cells, leading to improved control over vestibular functions. This is particularly valuable for patients suffering from episodic ataxia type 2, with evidence from both animal models and controlled trials pointing to its efficacy.
We also noted other treatments like chlorzoxazone, which showed some ability to alleviate downbeat nystagmus, and acetyl-DL-leucine, which has demonstrated potential benefits in several case series for cerebellar diseases.
While ongoing trials may offer new perspectives on these treatments, it's crucial to acknowledge the complexities of how potassium interacts with other therapies. The results highlight both the potential benefits and the challenges in isolating the specific effects of potassium on vertigo.
Read More
8
Potassium chloride influences vertigo symptoms
Rat Model of Ménière's Attack: Intratympanic Injection of Potassium Chloride Produces Direction-Changing Spontaneous Nystagmus and Hearing Fluctuations.
Highly relevant to potassium's effects
We investigated how potassium chloride influences symptoms of vertigo by implementing a controlled study in rats. Through intratympanic injections of various potassium chloride concentrations, we monitored the effects on spontaneous nystagmus and hearing changes in the subjects.
Specifically, we noted that rats receiving higher concentrations of potassium chloride exhibited irritative nystagmus, which is characterized by rapid eye movements towards the affected side, followed by potential paralytic nystagmus towards the opposite side. In contrast, no nystagmus was observed in the rats injected with distilled water.
Our findings revealed significant hearing impairment shortly after the potassium chloride injection, mirroring the symptoms of an acute Ménière's attack. Remarkably, this disruption was reversible, and hearing improved by the following day.
This research not only enhances our understanding of the connection between potassium levels and vertigo symptoms, but also offers a valuable rat model for studying Ménière's disease and its underlying mechanisms.
Specifically, we noted that rats receiving higher concentrations of potassium chloride exhibited irritative nystagmus, which is characterized by rapid eye movements towards the affected side, followed by potential paralytic nystagmus towards the opposite side. In contrast, no nystagmus was observed in the rats injected with distilled water.
Our findings revealed significant hearing impairment shortly after the potassium chloride injection, mirroring the symptoms of an acute Ménière's attack. Remarkably, this disruption was reversible, and hearing improved by the following day.
This research not only enhances our understanding of the connection between potassium levels and vertigo symptoms, but also offers a valuable rat model for studying Ménière's disease and its underlying mechanisms.
Read More
8
Potassium's role in vestibular function
Impact of 4-aminopyridine on vestibulo-ocular reflex performance.
Explores potassium effect on vertigo
We observed the impact of a potassium channel blocker called 4-aminopyridine (4-AP) on the vestibulo-ocular reflex (VOR), which helps stabilize our vision during head movements. To study this, we recorded the activity of motor neurons in tadpoles, specifically focusing on their response under both resting conditions and during motion.
At various concentrations of 4-AP, we noticed that spontaneous firing rates of neurons increased, leading to bursts of activity. During movement, the drug not only enhanced the firing rate but also delayed its peak, indicating that it alters the timing and intensity of eye movements triggered by head movements.
This suggests that potassium channels like Kv1.1 play a crucial role in how our vestibular system processes motion signals. The observed effects of 4-AP could provide insights into potential treatments for conditions like nystagmus and episodic ataxia, where the balance and stability of vision are affected by irregular vestibular signals.
Overall, our findings highlight the significance of potassium in modulating vertigo-related responses, making it a valuable area for further research and potential clinical applications.
At various concentrations of 4-AP, we noticed that spontaneous firing rates of neurons increased, leading to bursts of activity. During movement, the drug not only enhanced the firing rate but also delayed its peak, indicating that it alters the timing and intensity of eye movements triggered by head movements.
This suggests that potassium channels like Kv1.1 play a crucial role in how our vestibular system processes motion signals. The observed effects of 4-AP could provide insights into potential treatments for conditions like nystagmus and episodic ataxia, where the balance and stability of vision are affected by irregular vestibular signals.
Overall, our findings highlight the significance of potassium in modulating vertigo-related responses, making it a valuable area for further research and potential clinical applications.
Read More
7
Potassium's Role in Vertigo Treatment
A novel gene variant in the voltage-dependent Kv3.3 channel in an atypical form of SCA13 with dominant central vertigo.
Study explores potassium and vertigo
We examined a rare case of spinocerebellar ataxia (SCA13), focusing on a patient who primarily experienced episodes of central vertigo. This individual's symptoms were quite different from typical cases, showing only mild progressive cerebellar issues coupled with cognitive impairment.
During our research, we discovered a specific genetic variant in the patient's Kv3.3 potassium channel, which is known to be linked to SCA13. By conducting electrical recordings in frog oocytes, we found that this variant affected the potassium currents. While most mutations in Kv3.3 disrupt its function significantly, this particular variant seemed to reduce current amplitude and led to increased inactivation rather than causing a complete loss of function.
An interesting aspect was our treatment approach. We utilized riluzole, a drug that helps activate potassium channels, which led to partial improvement of symptoms in our patient. Notably, we observed that elevating potassium levels in the patient’s blood also countered the inactivation effects of the Kv3.3 channel. Our findings suggest that maintaining potassium levels within a normal range or perhaps using specific new medications could offer innovative therapies for patients dealing with SCA13 and related conditions.
Overall, these insights not only enhance our understanding of how potassium channels can influence vertigo symptoms but also broaden the scope of potential treatments available for atypical neurological disorders.
During our research, we discovered a specific genetic variant in the patient's Kv3.3 potassium channel, which is known to be linked to SCA13. By conducting electrical recordings in frog oocytes, we found that this variant affected the potassium currents. While most mutations in Kv3.3 disrupt its function significantly, this particular variant seemed to reduce current amplitude and led to increased inactivation rather than causing a complete loss of function.
An interesting aspect was our treatment approach. We utilized riluzole, a drug that helps activate potassium channels, which led to partial improvement of symptoms in our patient. Notably, we observed that elevating potassium levels in the patient’s blood also countered the inactivation effects of the Kv3.3 channel. Our findings suggest that maintaining potassium levels within a normal range or perhaps using specific new medications could offer innovative therapies for patients dealing with SCA13 and related conditions.
Overall, these insights not only enhance our understanding of how potassium channels can influence vertigo symptoms but also broaden the scope of potential treatments available for atypical neurological disorders.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Review
8.5
8.8
Reduced vertigo symptoms
This potassium supplement works well for me, alleviating muscle cramps and significantly helping with vertigo. I initially began taking it after adopting a carnivore diet. The capsules are a good size, and I've come to appreciate this particular brand as one of my favourites.
