Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.5
USERS' SCORE
Good
Based on 17 Reviews
8.6
Supplement Facts
Serving Size: 2 Veg Capsules
Amount Per Serving
%DV
Saccharomyces boulardii (10 Billion CFU)(Saccharomyces cerevisiae var. boulardii I-3799)
1,000 mg
**
Top Medical Research Studies
9.5
We explored the effectiveness of a specially engineered probiotic yeast, Saccharomyces boulardii, aimed at treating colitis. By cleverly binding this probiotic to proteins in the gut, we managed to significantly extend its stay in the gastrointestinal tract. This allowed us to observe a noteworthy increase in probiotic levels in the colon.
Importantly, our findings showed improvements in critical health markers, such as colon length and inflammation scores. This innovative approach suggests that targeted probiotics could be a game changer in managing inflammatory bowel diseases.
Importantly, our findings showed improvements in critical health markers, such as colon length and inflammation scores. This innovative approach suggests that targeted probiotics could be a game changer in managing inflammatory bowel diseases.
Read More
9
Saccharomyces boulardii reduces colitis cancer
We examined how Saccharomyces boulardii impacts ulcerative colitis and its related cancer development in mice. In this study, mice underwent a specific treatment to create a model of ulcerative colitis, followed by 12 weeks of S. boulardii treatment.
The results showed a significant reduction in tumor development as well as lower levels of inflammatory markers, TNF-α and IL-6. Additionally, S. boulardii positively influenced the composition of intestinal bacteria. Overall, the findings suggest that saccharomyces boulardii may have protective effects against colitis-related cancer.
The results showed a significant reduction in tumor development as well as lower levels of inflammatory markers, TNF-α and IL-6. Additionally, S. boulardii positively influenced the composition of intestinal bacteria. Overall, the findings suggest that saccharomyces boulardii may have protective effects against colitis-related cancer.
Read More
9
We investigated whether Saccharomyces boulardii could protect mice from experimental colitis. Over three weeks, treated mice showed less weight loss, reduced colon damage, and improved gut barrier function compared to untreated ones.
By promoting beneficial bacteria and reducing harmful ones, it enhanced microbial diversity and transformed the gut's metabolite profile. These beneficial changes correlated with lower inflammation, suggesting that S. boulardii might be a promising treatment option for colitis based on its effects on gut health.
By promoting beneficial bacteria and reducing harmful ones, it enhanced microbial diversity and transformed the gut's metabolite profile. These beneficial changes correlated with lower inflammation, suggesting that S. boulardii might be a promising treatment option for colitis based on its effects on gut health.
Read More
Most Useful Reviews
9
Frequent flare-ups eased
156 people found this helpful
I have suffered from ulcerative colitis for 25 years, experiencing frequent flare-ups that typically required steroids for relief. In recent years, flare-ups have grown more common, but I found that avoiding gluten and dairy helped. Eventually, they returned almost weekly. However, since starting this once a day, there has been significant improvement; I've remained flare-up free for two months now. I can enjoy all the vegetables I like without worrying about soft stools. I've reduced my colitis medication dosage and use this as daily maintenance alongside it. I have never felt so liberated from the bonds of colitis; this stuff truly works.
Read More
9
Effective for colitis
53 people found this helpful
Boulardii was crucial for managing my activated ulcerative colitis, which Gr8-Dophilus alone couldn't handle. Two years ago, a combination of Boulardii, a gluten-free diet, and other products saved my colon from surgery. Unfortunately, my colon deteriorated again, preventing adequate good bacteria growth. Thankfully, Boulardii worked its magic once again.
Read More
9
Colitis relief found
2 people found this helpful
Fast delivery, thank you! These saccharomycetes saved me when I developed pseudomembranous colitis after several antibiotic courses. Nothing helped me, except for Saccharomyces Boulardii, which was a lifesaver.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 16 Researches
8.5
- All Researches
9.5
We explored the effectiveness of a specially engineered probiotic yeast, Saccharomyces boulardii, aimed at treating colitis. By cleverly binding this probiotic to proteins in the gut, we managed to significantly extend its stay in the gastrointestinal tract. This allowed us to observe a noteworthy increase in probiotic levels in the colon.
Importantly, our findings showed improvements in critical health markers, such as colon length and inflammation scores. This innovative approach suggests that targeted probiotics could be a game changer in managing inflammatory bowel diseases.
Importantly, our findings showed improvements in critical health markers, such as colon length and inflammation scores. This innovative approach suggests that targeted probiotics could be a game changer in managing inflammatory bowel diseases.
Read More
9
Probiotic shows anti-inflammatory efficacy
We explored the potential of Saccharomyces boulardii, a probiotic, to ease gut inflammation. This study developed a unique system that displayed specific anti-inflammatory proteins on the probiotic. By optimizing these proteins' expression, the engineered S. boulardii samples were tested on a colitis mouse model.
The results indicated a notably lower disease activity and a reduction in inflammation markers, suggesting that this innovative approach could be effective in improving intestinal health. Overall, our findings highlight the probiotic's promise in managing inflammatory conditions.
The results indicated a notably lower disease activity and a reduction in inflammation markers, suggesting that this innovative approach could be effective in improving intestinal health. Overall, our findings highlight the probiotic's promise in managing inflammatory conditions.
Read More
9
Saccharomyces boulardii as a postbiotic
We explored the impact of Saccharomyces boulardii on colitis, aiming to understand its potential benefits for gut health. Our findings revealed that an oral dose of S. boulardii supernatant helped ease intestinal inflammation and reinforced the gut barrier.
A key player in this process is thioredoxin (Trx), a protein that activated important pathways to reduce inflammation and oxidative stress. By promoting the activation of the epidermal growth factor receptor, Trx showed promise as a new postbiotic treatment for colitis.
However, while these results are encouraging, more research is needed to fully comprehend its long-term effects.
A key player in this process is thioredoxin (Trx), a protein that activated important pathways to reduce inflammation and oxidative stress. By promoting the activation of the epidermal growth factor receptor, Trx showed promise as a new postbiotic treatment for colitis.
However, while these results are encouraging, more research is needed to fully comprehend its long-term effects.
Read More
9
This study delved into the effects of heat-killed Saccharomyces boulardii on ulcerative colitis, aiming to uncover its potential as a treatment option. We observed that this treatment significantly restored body weight, reduced inflammation, and improved gut barrier function in mice with colitis. It also effectively modulated gut microbiota, outperforming other treatments like β-glucan.
Overall, heat-killed Saccharomyces boulardii presents a promising new approach for those suffering from ulcerative colitis, enhancing their quality of life.
Overall, heat-killed Saccharomyces boulardii presents a promising new approach for those suffering from ulcerative colitis, enhancing their quality of life.
Read More
9
We investigated whether Saccharomyces boulardii could protect mice from experimental colitis. Over three weeks, treated mice showed less weight loss, reduced colon damage, and improved gut barrier function compared to untreated ones.
By promoting beneficial bacteria and reducing harmful ones, it enhanced microbial diversity and transformed the gut's metabolite profile. These beneficial changes correlated with lower inflammation, suggesting that S. boulardii might be a promising treatment option for colitis based on its effects on gut health.
By promoting beneficial bacteria and reducing harmful ones, it enhanced microbial diversity and transformed the gut's metabolite profile. These beneficial changes correlated with lower inflammation, suggesting that S. boulardii might be a promising treatment option for colitis based on its effects on gut health.
Read More
User Reviews
USERS' SCORE
Good
Based on 17 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Frequent flare-ups eased
156 people found this helpful
I have suffered from ulcerative colitis for 25 years, experiencing frequent flare-ups that typically required steroids for relief. In recent years, flare-ups have grown more common, but I found that avoiding gluten and dairy helped. Eventually, they returned almost weekly. However, since starting this once a day, there has been significant improvement; I've remained flare-up free for two months now. I can enjoy all the vegetables I like without worrying about soft stools. I've reduced my colitis medication dosage and use this as daily maintenance alongside it. I have never felt so liberated from the bonds of colitis; this stuff truly works.
Read More
9
Effective for colitis
53 people found this helpful
Boulardii was crucial for managing my activated ulcerative colitis, which Gr8-Dophilus alone couldn't handle. Two years ago, a combination of Boulardii, a gluten-free diet, and other products saved my colon from surgery. Unfortunately, my colon deteriorated again, preventing adequate good bacteria growth. Thankfully, Boulardii worked its magic once again.
Read More
9
Colitis relief found
2 people found this helpful
Fast delivery, thank you! These saccharomycetes saved me when I developed pseudomembranous colitis after several antibiotic courses. Nothing helped me, except for Saccharomyces Boulardii, which was a lifesaver.
Read More
7.5
Notable difference experienced
1 people found this helpful
Great for sufferers of colitis, made a noticeable difference!
Read More
9
Tremendous symptom relief
Brilliant! Along with probiotics, my Ulcerative Colitis symptoms have improved tremendously, and I haven’t needed any prescription medication for a while now. I will keep using these as they have been amazing for me.
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Frequently Asked Questions
7.5
Improved condition noted
I purchased these for my husband's Ulcerative Colitis, together with myrrh, slippery elm and golden seal. He has been taking them for 10 days and already noticed improvements.
9
Impressive results
6 people found this helpful
I suffered from ulcerative colitis and took this product twice daily to balance yeast levels in my gut. Along with dietary changes, its effects have been substantial, making it highly recommended.
6
Temporary effectiveness
I take Saccharomyces in courses, three capsules a day. They used to help shape the stool with colitis quite well, but the effect has become less pronounced. If you take a break and then reintroduce it, the effect returns. It should, of course, be taken alongside a restrictive diet.
9
Effective for colitis
53 people found this helpful
Boulardii was crucial for managing my activated ulcerative colitis, which Gr8-Dophilus alone couldn't handle. Two years ago, a combination of Boulardii, a gluten-free diet, and other products saved my colon from surgery. Unfortunately, my colon deteriorated again, preventing adequate good bacteria growth. Thankfully, Boulardii worked its magic once again.
9
Tremendous symptom relief
Brilliant! Along with probiotics, my Ulcerative Colitis symptoms have improved tremendously, and I haven’t needed any prescription medication for a while now. I will keep using these as they have been amazing for me.
7.5
Pain relief achieved
Good for my stomach! I have Ulcerative Colitis and dealt with severe stomach pain and diarrhoea. After starting this supplement one evening, the stomach rumbling and unpleasant odour during toilet visits disappeared.
6
Reduced gas and fatigue
7 people found this helpful
I bought this for my husband, who has ulcerative colitis. Though I'm in remission, I experience fatigue, bleeding, and gas. Recently, I've noticed a decrease in gas buildup. The ingredient quality is excellent, and these high-quality lactic acid bacteria are easy to consume.
7.5
Helps chronic diarrhea
Recently diagnosed with microscopic colitis, I've been taking this along with Sodium Butyrate to manage my chronic diarrhoea effectively. It's proving to be a beneficial addition to my treatment.
9
Highly recommended IBD product
This is an excellent product for IBD; it works wonderfully for Ulcerative Colitis. I take about six per day and adopt a carnivore diet once a month to reset my colon.
8
Saccharomyces boulardii aids colitis treatment
We investigated how Saccharomyces boulardii supernatant (SbS) could help alleviate ulcerative colitis (UC) using a murine model. By examining the FXR-NLRP3 signaling pathway, we found that SbS activates FXR and suppresses the NLRP3 inflammasome, reducing macrophage pyroptosis.
Our results indicated that SbS significantly improved symptoms of colitis, making it a promising treatment approach.
Our results indicated that SbS significantly improved symptoms of colitis, making it a promising treatment approach.
9
We explored how the probiotic yeast, Saccharomyces boulardii, helps treat ulcerative colitis in mice. After administering it for three weeks, we observed that it protected the mice from weight loss, diarrhea, and intestinal damage caused by a substance that simulates the condition.
Saccharomyces boulardii helped strengthen the intestinal barrier, reduced inflammation, and boosted antioxidant levels. The study suggests that it works by blocking inflammatory pathways while encouraging protective mechanisms in the gut. Overall, it shows promising potential in managing ulcerative colitis symptoms in this animal model.
Saccharomyces boulardii helped strengthen the intestinal barrier, reduced inflammation, and boosted antioxidant levels. The study suggests that it works by blocking inflammatory pathways while encouraging protective mechanisms in the gut. Overall, it shows promising potential in managing ulcerative colitis symptoms in this animal model.
9.5
We explored the effectiveness of a specially engineered probiotic yeast, Saccharomyces boulardii, aimed at treating colitis. By cleverly binding this probiotic to proteins in the gut, we managed to significantly extend its stay in the gastrointestinal tract. This allowed us to observe a noteworthy increase in probiotic levels in the colon.
Importantly, our findings showed improvements in critical health markers, such as colon length and inflammation scores. This innovative approach suggests that targeted probiotics could be a game changer in managing inflammatory bowel diseases.
Importantly, our findings showed improvements in critical health markers, such as colon length and inflammation scores. This innovative approach suggests that targeted probiotics could be a game changer in managing inflammatory bowel diseases.
9
We investigated whether Saccharomyces boulardii could protect mice from experimental colitis. Over three weeks, treated mice showed less weight loss, reduced colon damage, and improved gut barrier function compared to untreated ones.
By promoting beneficial bacteria and reducing harmful ones, it enhanced microbial diversity and transformed the gut's metabolite profile. These beneficial changes correlated with lower inflammation, suggesting that S. boulardii might be a promising treatment option for colitis based on its effects on gut health.
By promoting beneficial bacteria and reducing harmful ones, it enhanced microbial diversity and transformed the gut's metabolite profile. These beneficial changes correlated with lower inflammation, suggesting that S. boulardii might be a promising treatment option for colitis based on its effects on gut health.
References
- Culpepper T, Senthil K, Vlcek J, Hazelton A, Heavey MK, et al. Engineered Probiotic Saccharomyces boulardii Reduces Colitis-Associated Colorectal Cancer Burden in Mice. Dig Dis Sci. 2025. 10.1007/s10620-025-09008-9
- Yang L, Li W, Zhao Q, Mo Q, Liu T, et al. Alleviates Colitis by Regulating FXR-NLRP3 Mediated Macrophage Pyroptosis. J Inflamm Res. 2025;18:3161. 10.2147/JIR.S504957
- Han K, Park JS, Kim YW, Lee W, Park K, et al. Efficient surface display of single-chain variable fragments against tumor necrosis factor α on engineered probiotic Saccharomyces boulardii and its application in alleviating intestinal inflammation in vivo. N Biotechnol. 2025;86:107. 10.1016/j.nbt.2025.02.003
- Qin X, Zhao Q, Zhao Q, Yang L, Li W, et al. A Saccharomyces boulardii-derived antioxidant protein, thioredoxin, ameliorates intestinal inflammation through transactivating epidermal growth factor receptor. Pharmacol Res. 2024;208:107372. 10.1016/j.phrs.2024.107372
- Heavey MK, Hazelton A, Wang Y, Garner M, Anselmo AC, et al. Targeted delivery of the probiotic Saccharomyces boulardii to the extracellular matrix enhances gut residence time and recovery in murine colitis. Nat Commun. 2024;15:3784. 10.1038/s41467-024-48128-0
- Jin Y, Wu J, Huang K, Liang Z. Heat-Killed Alleviates Dextran Sulfate Sodium-Induced Ulcerative Colitis by Restoring the Intestinal Barrier, Reducing Inflammation, and Modulating the Gut Microbiota. Nutrients. 2024;16. 10.3390/nu16050702
- Gao H, Li Y, Xu J, Zuo X, Yue T, et al. protects against murine experimental colitis by reshaping the gut microbiome and its metabolic profile. Front Microbiol. 2023;14:1204122. 10.3389/fmicb.2023.1204122
- Hu Q, Yu L, Zhai Q, Zhao J, Tian F. Anti-Inflammatory, Barrier Maintenance, and Gut Microbiome Modulation Effects of QHNLD8L1 on DSS-Induced Ulcerative Colitis in Mice. Int J Mol Sci. 2023;24. 10.3390/ijms24076721
- Xu X, Wu J, Jin Y, Huang K, Zhang Y, et al. Both and Its Postbiotics Alleviate Dextran Sulfate Sodium-Induced Colitis in Mice, Association with Modulating Inflammation and Intestinal Microbiota. Nutrients. 2023;15. 10.3390/nu15061484
- Lee JE, Lee E. The Probiotic Effects of the 28-7 Strain Isolated from Nuruk in a DSS-Induced Colitis Mouse Model. J Microbiol Biotechnol. 2022;32:877. 10.4014/jmb.2206.06035
- Gao H, Li Y, Sun J, Xu H, Wang M, et al. Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice by Regulating NF-B and Nrf2 Signaling Pathways. Oxid Med Cell Longev. 2021;2021:1622375. 10.1155/2021/1622375
- Mu Z, Yang Y, Xia Y, Wang F, Sun Y, et al. Probiotic yeast BR14 ameliorates DSS-induced colitis by restoring the gut barrier and adjusting the intestinal microbiota. Food Funct. 2021;12:8386. 10.1039/d1fo01314a
- Liu CH, Chang JH, Chang YC, Mou KY. Treatment of murine colitis by Saccharomyces boulardii secreting atrial natriuretic peptide. J Mol Med (Berl). 2020;98:1675. 10.1007/s00109-020-01987-8
- Wang C, Li W, Wang H, Ma Y, Zhao X, et al. Saccharomyces boulardii alleviates ulcerative colitis carcinogenesis in mice by reducing TNF-α and IL-6 levels and functions and by rebalancing intestinal microbiota. BMC Microbiol. 2019;19:246. 10.1186/s12866-019-1610-8
- Lam S, Zuo T, Ho M, Chan FKL, Chan PKS, et al. Review article: fungal alterations in inflammatory bowel diseases. Aliment Pharmacol Ther. 2019;50:1159. 10.1111/apt.15523
- Dong JP, Zheng Y, Wu T, He Q, Teng GG, et al. Protective effect of Saccharomyces boulardii on intestinal mucosal barrier of dextran sodium sulfate-induced colitis in mice. Chin Med J (Engl). 2019;132:1951. 10.1097/CM9.0000000000000364
