Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
USERS' SCORE
Good
Based on 194 Reviews
8.3
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
5-HTP (5-hydroxytryptophan) (from Griffonia simplicifolia Extract) (Seed)
100 mg
*
Top Medical Research Studies
8
This study explored how the strain WHH2078 can affect anxiety and depression in mice impacted by chronic stress. By administering WHH2078, researchers observed a significant reduction in anxiety-like behaviors over five weeks.
The analysis revealed improved serotonin levels and a healthier gut microbiome, which may have played a role in alleviating these symptoms. While results are promising, it's important to note that these findings are preliminary and primarily observed in animal models.
The analysis revealed improved serotonin levels and a healthier gut microbiome, which may have played a role in alleviating these symptoms. While results are promising, it's important to note that these findings are preliminary and primarily observed in animal models.
Read More
7
5-HTP boosts social exploration in mice
We focused on how 5-hydroxytryptophan (5-HTP) affects anxiety and social behavior in juvenile BALB/c mice, known for their anxiety traits. After testing different treatment combinations, we found that 5-HTP improved social approach behavior and led to more exploration, suggesting a potential decrease in anxiety.
However, we didn’t see any activation of serotonergic neurons in the dorsal raphe nucleus, indicating that other mechanisms might be responsible for these behavioral changes. This means while 5-HTP shows promise, its exact role in anxiety isn't fully clear yet.
However, we didn’t see any activation of serotonergic neurons in the dorsal raphe nucleus, indicating that other mechanisms might be responsible for these behavioral changes. This means while 5-HTP shows promise, its exact role in anxiety isn't fully clear yet.
Read More
8
We examined the effects of YL-0919, a novel medication that functions as both a selective serotonin reuptake inhibitor and a partial serotonin agonist. Through a variety of tests, including models for anxiety and depression, we observed that YL-0919 boosts serotonin levels more effectively than traditional SSRIs.
Our findings indicated significant antidepressant and anxiolytic effects, suggesting that YL-0919 could be a fast-acting treatment with minimal side effects for those struggling with anxiety.
Our findings indicated significant antidepressant and anxiolytic effects, suggesting that YL-0919 could be a fast-acting treatment with minimal side effects for those struggling with anxiety.
Read More
Most Useful Reviews
9
Life-changing supplements
499 people found this helpful
Life changer! I started this in November 2017 with GABA and L-Phenylalanine for mental wellness. I can't pinpoint one specific supplement, but 5-HTP has helped a lot! I take one at night for sleep and another in the morning for energy and mood. These supplements transformed my life. After weeks of use, I felt significant changes, leading me to even take a second job on weekends that aids my mental health.
Read More
9
Restored well-being
465 people found this helpful
I've been taking this nightly for over two years and love it. I have insomnia and take 1 or 2 at bedtime. I'm out within minutes, and it manages my anxiety for the following day. Previously, prescribed medications made me feel numb and abnormal. This makes me feel like myself again. I love it.
Read More
9
Calmness achieved
113 people found this helpful
I am truly grateful for this product! 5-HTP has been invaluable in helping me feel calmer and more balanced, significantly aiding my struggle with anxiety and mood swings.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
- All Researches
8
This study explored how the strain WHH2078 can affect anxiety and depression in mice impacted by chronic stress. By administering WHH2078, researchers observed a significant reduction in anxiety-like behaviors over five weeks.
The analysis revealed improved serotonin levels and a healthier gut microbiome, which may have played a role in alleviating these symptoms. While results are promising, it's important to note that these findings are preliminary and primarily observed in animal models.
The analysis revealed improved serotonin levels and a healthier gut microbiome, which may have played a role in alleviating these symptoms. While results are promising, it's important to note that these findings are preliminary and primarily observed in animal models.
Read More
8
We examined the effects of YL-0919, a novel medication that functions as both a selective serotonin reuptake inhibitor and a partial serotonin agonist. Through a variety of tests, including models for anxiety and depression, we observed that YL-0919 boosts serotonin levels more effectively than traditional SSRIs.
Our findings indicated significant antidepressant and anxiolytic effects, suggesting that YL-0919 could be a fast-acting treatment with minimal side effects for those struggling with anxiety.
Our findings indicated significant antidepressant and anxiolytic effects, suggesting that YL-0919 could be a fast-acting treatment with minimal side effects for those struggling with anxiety.
Read More
7
We investigated how inulin, a prebiotic, could help alleviate anxiety and depression-like behaviors, particularly in the context of alcohol withdrawal. Using a specialized mouse model, we found that inulin enhanced beneficial gut bacteria, increased short-chain fatty acids, and improved serotonin metabolism.
This led to a noticeable improvement in anxiety-related behaviors among the mice. These results suggest that inulin might be a viable nutritional strategy to support mental health in individuals with alcohol dependence by targeting the gut-brain connection.
This led to a noticeable improvement in anxiety-related behaviors among the mice. These results suggest that inulin might be a viable nutritional strategy to support mental health in individuals with alcohol dependence by targeting the gut-brain connection.
Read More
7
5-HTP boosts social exploration in mice
We focused on how 5-hydroxytryptophan (5-HTP) affects anxiety and social behavior in juvenile BALB/c mice, known for their anxiety traits. After testing different treatment combinations, we found that 5-HTP improved social approach behavior and led to more exploration, suggesting a potential decrease in anxiety.
However, we didn’t see any activation of serotonergic neurons in the dorsal raphe nucleus, indicating that other mechanisms might be responsible for these behavioral changes. This means while 5-HTP shows promise, its exact role in anxiety isn't fully clear yet.
However, we didn’t see any activation of serotonergic neurons in the dorsal raphe nucleus, indicating that other mechanisms might be responsible for these behavioral changes. This means while 5-HTP shows promise, its exact role in anxiety isn't fully clear yet.
Read More
User Reviews
USERS' SCORE
Good
Based on 194 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Life-changing supplements
499 people found this helpful
Life changer! I started this in November 2017 with GABA and L-Phenylalanine for mental wellness. I can't pinpoint one specific supplement, but 5-HTP has helped a lot! I take one at night for sleep and another in the morning for energy and mood. These supplements transformed my life. After weeks of use, I felt significant changes, leading me to even take a second job on weekends that aids my mental health.
Read More
9
Restored well-being
465 people found this helpful
I've been taking this nightly for over two years and love it. I have insomnia and take 1 or 2 at bedtime. I'm out within minutes, and it manages my anxiety for the following day. Previously, prescribed medications made me feel numb and abnormal. This makes me feel like myself again. I love it.
Read More
9
Calmness achieved
113 people found this helpful
I am truly grateful for this product! 5-HTP has been invaluable in helping me feel calmer and more balanced, significantly aiding my struggle with anxiety and mood swings.
Read More
10
Calm after therapy
106 people found this helpful
Prescribed by a psychotherapist, it made me calmer, and my anxiety disappeared.
Read More
9
Social anxiety relief
93 people found this helpful
This product helped me conquer social anxiety and depression remarkably. After a month, I felt a renewed perspective on life, noticing less worry and an overall uplift in mood. It truly has transformed my outlook and reduced emotional heaviness.
Read More
Frequently Asked Questions
9
Immediate calmness found
51 people found this helpful
I was pleasantly surprised by how quickly this drug worked! I've always had anxiety issues, but after starting 5-HTP, I experienced calmness and good performance the very next day. No lethargy, just appreciation for the quality product from the manufacturer!
9
Life restored
7 people found this helpful
This has been a genuine lifesaver. Combined with St John's Wort, it’s the best natural solution for anxiety and depression. I struggled greatly with medications that worsened my condition, but moving to this combination allowed me to reclaim my life. Within just three days, I felt transformed, and I haven’t had a relapse in over two years. I still take this occasionally when I feel off.
9
Social anxiety relief
93 people found this helpful
This product helped me conquer social anxiety and depression remarkably. After a month, I felt a renewed perspective on life, noticing less worry and an overall uplift in mood. It truly has transformed my outlook and reduced emotional heaviness.
9
Calmness achieved
113 people found this helpful
I am truly grateful for this product! 5-HTP has been invaluable in helping me feel calmer and more balanced, significantly aiding my struggle with anxiety and mood swings.
9
Boosted social interactions
69 people found this helpful
I've experienced significant anxiety in social situations. After starting this supplement, I immediately felt its positive effects and haven’t stopped since, even pausing during pregnancy. Now, I feel brighter and can navigate social interactions without stress. I no longer scrutinise others’ expressions or withdraw; instead, I can communicate easily and confidently.
10
Calms mind
49 people found this helpful
This product excellently improves mood and boosts the happiness hormone. From the second day, I noticed increased comfort and calmness, with anxiety and depression vanishing. I combined it with L-Theanine and essential vitamins. Depending on the individual, results may vary, but I found it very effective.
10
Serotonin boost
7 people found this helpful
Excellent! I urge everyone suffering from depression and anxiety to consider 5-HTP. After struggling with medication side effects, I switched to this supplement, which naturally leads to serotonin production, helping me regain control over my life. I recommend a gradual reduction of prescription medications for a smoother transition; the temporary discomfort is worth it.
8
Effective calming agent
10 people found this helpful
Initially, I took 2 capsules, which made me feel ill. Now, I take 1 capsule in the morning, and it effectively removes anxiety while balancing my mood. I find that calming comes much faster than it used to.
7.5
Positive experience
4 people found this helpful
Helped I drank a jar. There was a stressful situation after which I felt anxiety and an increased heart rate. I didn't really hope for this supplement, but since I bought it, I tried it. I took 1 capsule daily, as recommended, before bedtime. About 10 days later, my unwanted symptoms began to dissipate. I feel better. During the course, I noted that my dreams became more vivid and my mood improved. For me, this has been a positive experience with this supplement.
9
Improved mood
4 people found this helpful
I purchased this product on my doctor’s advice: it enhances my mood, alleviates anxiety throughout the day, and improves my sleep. I take it in the evenings with magnesium, and I trust this brand for high-quality additives.
7
We investigated how inulin, a prebiotic, could help alleviate anxiety and depression-like behaviors, particularly in the context of alcohol withdrawal. Using a specialized mouse model, we found that inulin enhanced beneficial gut bacteria, increased short-chain fatty acids, and improved serotonin metabolism.
This led to a noticeable improvement in anxiety-related behaviors among the mice. These results suggest that inulin might be a viable nutritional strategy to support mental health in individuals with alcohol dependence by targeting the gut-brain connection.
This led to a noticeable improvement in anxiety-related behaviors among the mice. These results suggest that inulin might be a viable nutritional strategy to support mental health in individuals with alcohol dependence by targeting the gut-brain connection.
7
5-HTP boosts social exploration in mice
We focused on how 5-hydroxytryptophan (5-HTP) affects anxiety and social behavior in juvenile BALB/c mice, known for their anxiety traits. After testing different treatment combinations, we found that 5-HTP improved social approach behavior and led to more exploration, suggesting a potential decrease in anxiety.
However, we didn’t see any activation of serotonergic neurons in the dorsal raphe nucleus, indicating that other mechanisms might be responsible for these behavioral changes. This means while 5-HTP shows promise, its exact role in anxiety isn't fully clear yet.
However, we didn’t see any activation of serotonergic neurons in the dorsal raphe nucleus, indicating that other mechanisms might be responsible for these behavioral changes. This means while 5-HTP shows promise, its exact role in anxiety isn't fully clear yet.
8
We examined the effects of YL-0919, a novel medication that functions as both a selective serotonin reuptake inhibitor and a partial serotonin agonist. Through a variety of tests, including models for anxiety and depression, we observed that YL-0919 boosts serotonin levels more effectively than traditional SSRIs.
Our findings indicated significant antidepressant and anxiolytic effects, suggesting that YL-0919 could be a fast-acting treatment with minimal side effects for those struggling with anxiety.
Our findings indicated significant antidepressant and anxiolytic effects, suggesting that YL-0919 could be a fast-acting treatment with minimal side effects for those struggling with anxiety.
References
- Li K, Wei W, Xu C, Lian X, Bao J, et al. Prebiotic inulin alleviates anxiety and depression-like behavior in alcohol withdrawal mice by modulating the gut microbiota and 5-HT metabolism. Phytomedicine. 2024;135:156181. doi:10.1016/j.phymed.2024.156181
- Russo AM, Payet JM, Kent S, Lesku JA, Lowry CA, et al. Acute treatment with 5-hydroxytryptophan increases social approach behaviour but does not activate serotonergic neurons in the dorsal raphe nucleus in juvenile male BALB/c mice: A model of human disorders with deficits of sociability. J Psychopharmacol. 2022;36:806. doi:10.1177/02698811221089039
- Gao K, Farzi A, Ke X, Yu Y, Chen C, et al. Oral administration of WHH2078 alleviates depressive and anxiety symptoms in mice with induced chronic stress. Food Funct. 2022;13:957. doi:10.1039/d1fo03723d
- Zhang LM, Wang XY, Zhao N, Wang YL, Hu XX, et al. Neurochemical and behavioural effects of hypidone hydrochloride (YL-0919): a novel combined selective 5-HT reuptake inhibitor and partial 5-HT agonist. Br J Pharmacol. 2017;174:769. doi:10.1111/bph.13675
