Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
USERS' SCORE
Moderately Good
Based on 75 Reviews
7.5
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
5-HTP (5-hydroxytryptophan) (from Griffonia simplicifolia Extract) (seed)
50 mg
*
Top Medical Research Studies
8
This study explored how the strain WHH2078 can affect anxiety and depression in mice impacted by chronic stress. By administering WHH2078, researchers observed a significant reduction in anxiety-like behaviors over five weeks.
The analysis revealed improved serotonin levels and a healthier gut microbiome, which may have played a role in alleviating these symptoms. While results are promising, it's important to note that these findings are preliminary and primarily observed in animal models.
The analysis revealed improved serotonin levels and a healthier gut microbiome, which may have played a role in alleviating these symptoms. While results are promising, it's important to note that these findings are preliminary and primarily observed in animal models.
Read More
7
5-HTP boosts social exploration in mice
We focused on how 5-hydroxytryptophan (5-HTP) affects anxiety and social behavior in juvenile BALB/c mice, known for their anxiety traits. After testing different treatment combinations, we found that 5-HTP improved social approach behavior and led to more exploration, suggesting a potential decrease in anxiety.
However, we didn’t see any activation of serotonergic neurons in the dorsal raphe nucleus, indicating that other mechanisms might be responsible for these behavioral changes. This means while 5-HTP shows promise, its exact role in anxiety isn't fully clear yet.
However, we didn’t see any activation of serotonergic neurons in the dorsal raphe nucleus, indicating that other mechanisms might be responsible for these behavioral changes. This means while 5-HTP shows promise, its exact role in anxiety isn't fully clear yet.
Read More
8
We examined the effects of YL-0919, a novel medication that functions as both a selective serotonin reuptake inhibitor and a partial serotonin agonist. Through a variety of tests, including models for anxiety and depression, we observed that YL-0919 boosts serotonin levels more effectively than traditional SSRIs.
Our findings indicated significant antidepressant and anxiolytic effects, suggesting that YL-0919 could be a fast-acting treatment with minimal side effects for those struggling with anxiety.
Our findings indicated significant antidepressant and anxiolytic effects, suggesting that YL-0919 could be a fast-acting treatment with minimal side effects for those struggling with anxiety.
Read More
Most Useful Reviews
9
Child's life improved
34 people found this helpful
These pills have been excellent for my daughter’s anxiety. They help her manage her worries remarkably. I see a significant difference when she misses a dose. I highly recommend this product for those struggling with anxiety. The seller is efficient too.
Read More
9
Essential for anxiety
34 people found this helpful
10 stars. I've been using NOW products for over a decade; they're incredibly reliable. I couldn't manage a day without 5-HTP in my system. It's dreadful to have an anxiety disorder; feeling out of control is a nightmare. That's how I felt before discovering these.
Read More
9
Breaking habits
29 people found this helpful
This supplement aids in moving away from addictions smoothly. While it provides a brief euphoria, it helps eliminate anxiety, improve mood, calm nerves, and tackle insomnia. I used to rely on alcohol and sweets but now, after using this remedy, I feel energetic and free from apathy. I wholeheartedly recommend it for anyone with similar problems.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 4 Researches
7.5
- All Researches
8
This study explored how the strain WHH2078 can affect anxiety and depression in mice impacted by chronic stress. By administering WHH2078, researchers observed a significant reduction in anxiety-like behaviors over five weeks.
The analysis revealed improved serotonin levels and a healthier gut microbiome, which may have played a role in alleviating these symptoms. While results are promising, it's important to note that these findings are preliminary and primarily observed in animal models.
The analysis revealed improved serotonin levels and a healthier gut microbiome, which may have played a role in alleviating these symptoms. While results are promising, it's important to note that these findings are preliminary and primarily observed in animal models.
Read More
8
We examined the effects of YL-0919, a novel medication that functions as both a selective serotonin reuptake inhibitor and a partial serotonin agonist. Through a variety of tests, including models for anxiety and depression, we observed that YL-0919 boosts serotonin levels more effectively than traditional SSRIs.
Our findings indicated significant antidepressant and anxiolytic effects, suggesting that YL-0919 could be a fast-acting treatment with minimal side effects for those struggling with anxiety.
Our findings indicated significant antidepressant and anxiolytic effects, suggesting that YL-0919 could be a fast-acting treatment with minimal side effects for those struggling with anxiety.
Read More
7
We investigated how inulin, a prebiotic, could help alleviate anxiety and depression-like behaviors, particularly in the context of alcohol withdrawal. Using a specialized mouse model, we found that inulin enhanced beneficial gut bacteria, increased short-chain fatty acids, and improved serotonin metabolism.
This led to a noticeable improvement in anxiety-related behaviors among the mice. These results suggest that inulin might be a viable nutritional strategy to support mental health in individuals with alcohol dependence by targeting the gut-brain connection.
This led to a noticeable improvement in anxiety-related behaviors among the mice. These results suggest that inulin might be a viable nutritional strategy to support mental health in individuals with alcohol dependence by targeting the gut-brain connection.
Read More
7
5-HTP boosts social exploration in mice
We focused on how 5-hydroxytryptophan (5-HTP) affects anxiety and social behavior in juvenile BALB/c mice, known for their anxiety traits. After testing different treatment combinations, we found that 5-HTP improved social approach behavior and led to more exploration, suggesting a potential decrease in anxiety.
However, we didn’t see any activation of serotonergic neurons in the dorsal raphe nucleus, indicating that other mechanisms might be responsible for these behavioral changes. This means while 5-HTP shows promise, its exact role in anxiety isn't fully clear yet.
However, we didn’t see any activation of serotonergic neurons in the dorsal raphe nucleus, indicating that other mechanisms might be responsible for these behavioral changes. This means while 5-HTP shows promise, its exact role in anxiety isn't fully clear yet.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 75 Reviews
7.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Child's life improved
34 people found this helpful
These pills have been excellent for my daughter’s anxiety. They help her manage her worries remarkably. I see a significant difference when she misses a dose. I highly recommend this product for those struggling with anxiety. The seller is efficient too.
Read More
9
Essential for anxiety
34 people found this helpful
10 stars. I've been using NOW products for over a decade; they're incredibly reliable. I couldn't manage a day without 5-HTP in my system. It's dreadful to have an anxiety disorder; feeling out of control is a nightmare. That's how I felt before discovering these.
Read More
9
Breaking habits
29 people found this helpful
This supplement aids in moving away from addictions smoothly. While it provides a brief euphoria, it helps eliminate anxiety, improve mood, calm nerves, and tackle insomnia. I used to rely on alcohol and sweets but now, after using this remedy, I feel energetic and free from apathy. I wholeheartedly recommend it for anyone with similar problems.
Read More
9
Tremendous help
16 people found this helpful
After discontinuing Lexapro, my anxiety and depression returned. I tried 5HTP based on research and it has helped both. While not as effective as my prescription medication, it has been almost equally beneficial. I recommend 300mg daily, as it has significantly alleviated my anxiety.
Read More
9
Almost symptom-free
15 people found this helpful
Struggling with anxiety and depression since childhood, I was wary of anti-depressants. My doctor recommended 5HTP 150mg twice daily. Alongside psychotherapy, it has almost eliminated my symptoms and improved my overall outlook on life. Following professional advice on dosage is crucial for safety.
Read More
Frequently Asked Questions
9
Improved mood
2 people found this helpful
My mood improved significantly! I noticed tangible results after a week, with an aligned psychological state and a lack of anxiety. I highly recommend it.
9
Joyful mood
8 people found this helpful
I dealt with severe anxiety and depression a few months ago but was reluctant to try SSRIs due to horror stories about side effects. I decided to try 5-HTP as a last resort before SSRIs, and I'm so glad I did. The only side effect I experienced initially was some sleepiness, which I managed by reducing my dose. I took two capsules daily, one in the morning and one before bed. Initially, I felt no difference for about four weeks, but then it was as if the sun came out. I feel energetic, optimistic, and relaxed, which is remarkable given I usually experience mild SAD-like symptoms during December.
9
Calming effect
3 people found this helpful
I take this supplement for anxiety, and it has helped me tremendously. I feel much calmer and more in control when I take it. My purchases from iHerb arrive quickly and well-packaged. I’d appreciate a like if my comment was helpful. 👍🏻🥰
9
Improved mood
1 people found this helpful
This helps with restful sleep. I bought it for my husband, and he drinks it an hour before bed. It aids in reducing anxiety and excessive excitability. The small capsules are easy to take, resulting in improved sleep and mood.
8.5
Helps reduce stress
14 people found this helpful
This is my third purchase of this supplement, which I highly recommend. It aids in calming my mood, reducing stress and anxiety significantly. It also helps me sleep well, especially before and after social events. The ingredient 5-HTP is important as it converts to serotonin, enhancing my overall quality of life. If my review helps you, please show your support!
9
Anxiety control
1 people found this helpful
Excellent product. I have managed to control my anxiety and depression by taking a capsule before bed, which has improved my sleep. I also take L-Tyrosine in the morning after breakfast. This has helped me far more than prescription antidepressants like venlafaxine.
7.5
Energising support
1 people found this helpful
The calming effect is noticeable without inducing sleepiness. Instead, it makes me more energetic in a positive way, reducing my anxiety at work. It also aids my stress levels and mood while curbing cravings. The pills are an ideal size and have no taste or smell, making them easy to take.
9
Significant difference
7 people found this helpful
More people need to know about this product; it works wonders. I take 4 capsules at night, and I definitely notice a difference in my moods and anxiety levels. I was close to needing anti-anxiety medication, but after trying this product, I noticed improvement the very next morning.
0
Severe reaction
7 people found this helpful
I bought this to address my anxiety but ended up experiencing serotonin syndrome: rapid heart rate and heavy sweating. I had to discontinue use.
7
We investigated how inulin, a prebiotic, could help alleviate anxiety and depression-like behaviors, particularly in the context of alcohol withdrawal. Using a specialized mouse model, we found that inulin enhanced beneficial gut bacteria, increased short-chain fatty acids, and improved serotonin metabolism.
This led to a noticeable improvement in anxiety-related behaviors among the mice. These results suggest that inulin might be a viable nutritional strategy to support mental health in individuals with alcohol dependence by targeting the gut-brain connection.
This led to a noticeable improvement in anxiety-related behaviors among the mice. These results suggest that inulin might be a viable nutritional strategy to support mental health in individuals with alcohol dependence by targeting the gut-brain connection.
7
5-HTP boosts social exploration in mice
We focused on how 5-hydroxytryptophan (5-HTP) affects anxiety and social behavior in juvenile BALB/c mice, known for their anxiety traits. After testing different treatment combinations, we found that 5-HTP improved social approach behavior and led to more exploration, suggesting a potential decrease in anxiety.
However, we didn’t see any activation of serotonergic neurons in the dorsal raphe nucleus, indicating that other mechanisms might be responsible for these behavioral changes. This means while 5-HTP shows promise, its exact role in anxiety isn't fully clear yet.
However, we didn’t see any activation of serotonergic neurons in the dorsal raphe nucleus, indicating that other mechanisms might be responsible for these behavioral changes. This means while 5-HTP shows promise, its exact role in anxiety isn't fully clear yet.
8
This study explored how the strain WHH2078 can affect anxiety and depression in mice impacted by chronic stress. By administering WHH2078, researchers observed a significant reduction in anxiety-like behaviors over five weeks.
The analysis revealed improved serotonin levels and a healthier gut microbiome, which may have played a role in alleviating these symptoms. While results are promising, it's important to note that these findings are preliminary and primarily observed in animal models.
The analysis revealed improved serotonin levels and a healthier gut microbiome, which may have played a role in alleviating these symptoms. While results are promising, it's important to note that these findings are preliminary and primarily observed in animal models.
8
We examined the effects of YL-0919, a novel medication that functions as both a selective serotonin reuptake inhibitor and a partial serotonin agonist. Through a variety of tests, including models for anxiety and depression, we observed that YL-0919 boosts serotonin levels more effectively than traditional SSRIs.
Our findings indicated significant antidepressant and anxiolytic effects, suggesting that YL-0919 could be a fast-acting treatment with minimal side effects for those struggling with anxiety.
Our findings indicated significant antidepressant and anxiolytic effects, suggesting that YL-0919 could be a fast-acting treatment with minimal side effects for those struggling with anxiety.
References
- Li K, Wei W, Xu C, Lian X, Bao J, et al. Prebiotic inulin alleviates anxiety and depression-like behavior in alcohol withdrawal mice by modulating the gut microbiota and 5-HT metabolism. Phytomedicine. 2024;135:156181. 10.1016/j.phymed.2024.156181
- Russo AM, Payet JM, Kent S, Lesku JA, Lowry CA, et al. Acute treatment with 5-hydroxytryptophan increases social approach behaviour but does not activate serotonergic neurons in the dorsal raphe nucleus in juvenile male BALB/c mice: A model of human disorders with deficits of sociability. J Psychopharmacol. 2022;36:806. 10.1177/02698811221089039
- Gao K, Farzi A, Ke X, Yu Y, Chen C, et al. Oral administration of WHH2078 alleviates depressive and anxiety symptoms in mice with induced chronic stress. Food Funct. 2022;13:957. 10.1039/d1fo03723d
- Zhang LM, Wang XY, Zhao N, Wang YL, Hu XX, et al. Neurochemical and behavioural effects of hypidone hydrochloride (YL-0919): a novel combined selective 5-HT reuptake inhibitor and partial 5-HT agonist. Br J Pharmacol. 2017;174:769. 10.1111/bph.13675
