SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
15
Total Fat
1.5 g
2%**
Fish Oil Concentrate
1.3 g (1,300 mg)
†
Docosahexaenoic Acid (DHA)
1 g (1,000 mg)
†
Top Medical Research Studies
8
DHA shows potential for depression
The Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.
Direct assessment of DHA's effects
We conducted a study to find out whether docosahexaenoic acid (DHA), a type of omega-3 fatty acid, could effectively help those dealing with major depressive disorder (MDD). Over the course of 12 weeks, 60 participants were involved in a double-blind, placebo-controlled trial. They were divided into two groups: one received 3.2 grams of DHA daily, while the other group was given an equivalent amount of soybean oil as a placebo.
Throughout the study, we measured depression levels using the Hamilton Rating Scale for Depression (HRSD). Our results were intriguing—those taking the DHA showed significant improvements in their depression scores compared to the placebo group by weeks 4, 6, 8, and 12. While we noted that 26.7% of participants receiving DHA achieved remission by week 12, this was not statistically significant in comparison to the placebo group.
Overall, our findings support the idea that DHA may serve as a promising alternative treatment for individuals suffering from MDD. Although the results are encouraging, we recognize the need for further research to confirm these benefits conclusively.
Throughout the study, we measured depression levels using the Hamilton Rating Scale for Depression (HRSD). Our results were intriguing—those taking the DHA showed significant improvements in their depression scores compared to the placebo group by weeks 4, 6, 8, and 12. While we noted that 26.7% of participants receiving DHA achieved remission by week 12, this was not statistically significant in comparison to the placebo group.
Overall, our findings support the idea that DHA may serve as a promising alternative treatment for individuals suffering from MDD. Although the results are encouraging, we recognize the need for further research to confirm these benefits conclusively.
Read More
4
DHA may prevent depression recurrence
The N-3 polyunsaturated fatty acids supplementation to prevent depression recurrence in patients with late-life depression: A 52-week double-blind, placebo-controlled trial.
Highly relevant to depression research
We conducted a thorough 52-week study to explore the potential benefits of docosahexaenoic acid (DHA), an omega-3 fatty acid, in preventing depression from returning in elderly patients who are currently stable. In our research, we gathered 39 elderly participants who were in a good mental state and divided them into two groups: one received a specific dose of DHA, while the other group received a placebo.
Throughout the year, we carefully monitored changes in their depressive symptoms and overall mental health at various points, including at the start and every few months afterward. Our analysis revealed a noteworthy finding: those taking DHA experienced a significant reduction in the risk of depression coming back compared to those who did not receive the supplement.
However, when it came to alleviating existing depressive or anxiety symptoms, DHA didn’t show a considerable impact over the placebo. Despite the positive results regarding preventing recurrence, we should keep in mind the study’s limited size, as this could influence the broader applicability of our findings.
Throughout the year, we carefully monitored changes in their depressive symptoms and overall mental health at various points, including at the start and every few months afterward. Our analysis revealed a noteworthy finding: those taking DHA experienced a significant reduction in the risk of depression coming back compared to those who did not receive the supplement.
However, when it came to alleviating existing depressive or anxiety symptoms, DHA didn’t show a considerable impact over the placebo. Despite the positive results regarding preventing recurrence, we should keep in mind the study’s limited size, as this could influence the broader applicability of our findings.
Read More
9
DHA beneficial for depression
Plasma Polyunsaturated Fatty Acid Levels and Mental Health in Middle-Aged and Elderly Adults.
Moderate relevance to DHA effects
We explored the intriguing relationship between docosahexaenoic acid (DHA), a type of omega-3 polyunsaturated fatty acid, and its potential effects on depression among middle-aged and elderly adults. Our research pulled from a substantial sample size of over 102,000 residents from the UK Biobank, enabling us to thoroughly investigate how varying levels of PUFAs, particularly DHA, are associated with depressive and anxiety disorders.
The findings revealed that higher plasma levels of DHA were linked to a lower risk of developing depressive disorders compared to those with lower levels. Specifically, we observed a hazard ratio of 0.80 for individuals with the highest DHA levels, indicating a significant protective effect. This trend extended to anxiety disorders as well, suggesting that increasing our intake of omega-3 PUFAs might be a reachable goal for enhancing mental health.
Additionally, we noted that higher levels of DHA were also related to a decrease in adverse psychological symptoms. Encompassing the impact on brain health, we incorporated neuroimaging data from nearly 8,800 participants to investigate white matter microstructures, further supporting the link between omega-3 PUFAs like DHA and overall mental well-being.
The evidence we gathered underscores the importance of considering omega-3 PUFAs, particularly DHA, as a promising nutritional approach for helping to prevent and manage depression in older adults.
The findings revealed that higher plasma levels of DHA were linked to a lower risk of developing depressive disorders compared to those with lower levels. Specifically, we observed a hazard ratio of 0.80 for individuals with the highest DHA levels, indicating a significant protective effect. This trend extended to anxiety disorders as well, suggesting that increasing our intake of omega-3 PUFAs might be a reachable goal for enhancing mental health.
Additionally, we noted that higher levels of DHA were also related to a decrease in adverse psychological symptoms. Encompassing the impact on brain health, we incorporated neuroimaging data from nearly 8,800 participants to investigate white matter microstructures, further supporting the link between omega-3 PUFAs like DHA and overall mental well-being.
The evidence we gathered underscores the importance of considering omega-3 PUFAs, particularly DHA, as a promising nutritional approach for helping to prevent and manage depression in older adults.
Read More
Most Useful Reviews
8.3
Mind balanced
Replying to @serenity: Girls, this is amazing. I swear, for my soul and anyone who has depression, taking vitamin D is essential. It has made my mind balanced and alert.
Read More
8.8
Improved mood
My senior dog and I have been taking high doses of DHA for our inflammation, and I've noticed a significant improvement in our quality of life. We've seen benefits in our skin, nails, hair, and mobility. As someone who has depression, I unexpectedly noticed a better mood with fewer episodes over the past three months.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7
- All Researches
9
DHA beneficial for depression
Plasma Polyunsaturated Fatty Acid Levels and Mental Health in Middle-Aged and Elderly Adults.
Moderate relevance to DHA effects
We explored the intriguing relationship between docosahexaenoic acid (DHA), a type of omega-3 polyunsaturated fatty acid, and its potential effects on depression among middle-aged and elderly adults. Our research pulled from a substantial sample size of over 102,000 residents from the UK Biobank, enabling us to thoroughly investigate how varying levels of PUFAs, particularly DHA, are associated with depressive and anxiety disorders.
The findings revealed that higher plasma levels of DHA were linked to a lower risk of developing depressive disorders compared to those with lower levels. Specifically, we observed a hazard ratio of 0.80 for individuals with the highest DHA levels, indicating a significant protective effect. This trend extended to anxiety disorders as well, suggesting that increasing our intake of omega-3 PUFAs might be a reachable goal for enhancing mental health.
Additionally, we noted that higher levels of DHA were also related to a decrease in adverse psychological symptoms. Encompassing the impact on brain health, we incorporated neuroimaging data from nearly 8,800 participants to investigate white matter microstructures, further supporting the link between omega-3 PUFAs like DHA and overall mental well-being.
The evidence we gathered underscores the importance of considering omega-3 PUFAs, particularly DHA, as a promising nutritional approach for helping to prevent and manage depression in older adults.
The findings revealed that higher plasma levels of DHA were linked to a lower risk of developing depressive disorders compared to those with lower levels. Specifically, we observed a hazard ratio of 0.80 for individuals with the highest DHA levels, indicating a significant protective effect. This trend extended to anxiety disorders as well, suggesting that increasing our intake of omega-3 PUFAs might be a reachable goal for enhancing mental health.
Additionally, we noted that higher levels of DHA were also related to a decrease in adverse psychological symptoms. Encompassing the impact on brain health, we incorporated neuroimaging data from nearly 8,800 participants to investigate white matter microstructures, further supporting the link between omega-3 PUFAs like DHA and overall mental well-being.
The evidence we gathered underscores the importance of considering omega-3 PUFAs, particularly DHA, as a promising nutritional approach for helping to prevent and manage depression in older adults.
Read More
9
Omega-3 helps juvenile depression
Omega-3 alleviates behavioral and molecular changes in a mouse model of stress-induced juvenile depression.
Validates omega-3's effectiveness in depression
We used a unique model to explore how docosahexaenoic acid, an omega-3 fatty acid, may help alleviate symptoms of depression in young mice. By exposing juvenile mice to alternating ultrasound stress frequencies known to induce depressive-like behaviors, we aimed to mimic conditions of juvenile depression.
Throughout the study, these mice received either a supplement containing both DHA and eicosapentaenoic acid (EPA) or a placebo. The results were quite promising! Mice treated with the omega-3 supplement showed significantly fewer signs of depression and anxiety compared to those that received the placebo. This included a noticeable improvement in behaviors related to pleasure and reduced anxiety.
Additionally, the omega-3 treatment seemed to have a positive effect on hormone levels and inflammatory markers in the brain, indicating that the anti-inflammatory properties of DHA could be part of its effectiveness. Overall, our findings suggest that omega-3 fatty acids might hold potential as a therapeutic option for addressing juvenile depression.
Throughout the study, these mice received either a supplement containing both DHA and eicosapentaenoic acid (EPA) or a placebo. The results were quite promising! Mice treated with the omega-3 supplement showed significantly fewer signs of depression and anxiety compared to those that received the placebo. This included a noticeable improvement in behaviors related to pleasure and reduced anxiety.
Additionally, the omega-3 treatment seemed to have a positive effect on hormone levels and inflammatory markers in the brain, indicating that the anti-inflammatory properties of DHA could be part of its effectiveness. Overall, our findings suggest that omega-3 fatty acids might hold potential as a therapeutic option for addressing juvenile depression.
Read More
9
DHA alleviates epilepsy-related depression
DHA and EPA Alleviate Epileptic Depression in PTZ-Treated Young Mice Model by Inhibiting Neuroinflammation through Regulating Microglial M2 Polarization and Improving Mitochondrial Metabolism.
Focus on DHA's isolated effects
We explored the impact of docosahexaenoic acid (DHA) on depressive symptoms associated with epilepsy in a young mouse model. Through our investigation, we fed mice a diet enriched with DHA and administered pentylenetetrazole (PTZ) to induce epilepsy. Notably, our findings indicated that both DHA and eicosapentaenoic acid (EPA) significantly reduced depressive symptoms in this model, with EPA showing even greater effectiveness.
Analyzing the underlying mechanisms revealed that DHA and EPA helped repair neuronal damage and improve myelin structure in the hippocampus—the brain region vital for mood regulation. Furthermore, they tackled neuroinflammation by encouraging the polarizing of microglial cells toward a protective state and suppressing harmful inflammatory responses.
Additionally, we observed that both fatty acids decreased oxidative stress and improved mitochondrial function, which are crucial aspects of brain health. These results suggest that integrating DHA (and EPA) into dietary interventions could offer a promising strategy to alleviate depression in children with epilepsy, providing a potential pathway to enhance their quality of life.
Analyzing the underlying mechanisms revealed that DHA and EPA helped repair neuronal damage and improve myelin structure in the hippocampus—the brain region vital for mood regulation. Furthermore, they tackled neuroinflammation by encouraging the polarizing of microglial cells toward a protective state and suppressing harmful inflammatory responses.
Additionally, we observed that both fatty acids decreased oxidative stress and improved mitochondrial function, which are crucial aspects of brain health. These results suggest that integrating DHA (and EPA) into dietary interventions could offer a promising strategy to alleviate depression in children with epilepsy, providing a potential pathway to enhance their quality of life.
Read More
8
DHA shows potential for depression
The Efficacy of Omega-3 Fatty Acids as the Monotherapy for Depression: A Randomized, Double-Blind, Placebo-Controlled Pilot Study.
Direct assessment of DHA's effects
We conducted a study to find out whether docosahexaenoic acid (DHA), a type of omega-3 fatty acid, could effectively help those dealing with major depressive disorder (MDD). Over the course of 12 weeks, 60 participants were involved in a double-blind, placebo-controlled trial. They were divided into two groups: one received 3.2 grams of DHA daily, while the other group was given an equivalent amount of soybean oil as a placebo.
Throughout the study, we measured depression levels using the Hamilton Rating Scale for Depression (HRSD). Our results were intriguing—those taking the DHA showed significant improvements in their depression scores compared to the placebo group by weeks 4, 6, 8, and 12. While we noted that 26.7% of participants receiving DHA achieved remission by week 12, this was not statistically significant in comparison to the placebo group.
Overall, our findings support the idea that DHA may serve as a promising alternative treatment for individuals suffering from MDD. Although the results are encouraging, we recognize the need for further research to confirm these benefits conclusively.
Throughout the study, we measured depression levels using the Hamilton Rating Scale for Depression (HRSD). Our results were intriguing—those taking the DHA showed significant improvements in their depression scores compared to the placebo group by weeks 4, 6, 8, and 12. While we noted that 26.7% of participants receiving DHA achieved remission by week 12, this was not statistically significant in comparison to the placebo group.
Overall, our findings support the idea that DHA may serve as a promising alternative treatment for individuals suffering from MDD. Although the results are encouraging, we recognize the need for further research to confirm these benefits conclusively.
Read More
8
Omega-3s' role in depression
Omega-3 fatty acids and major depression: a Mendelian randomization study.
Moderate relevance with slight limitations.
We examined the role of omega-3 fatty acids, particularly focusing on eicosapentaenoic acid (EPA) rather than docosahexaenoic acid (DHA), in depression. A large two-sample Mendelian randomization approach was used, leveraging data from UK Biobank and the Psychiatric Genomics Consortium.
While our findings showed that higher levels of omega-3 fatty acids can lower the odds of major depressive disorder (MDD), the specific effects of DHA were not thoroughly analyzed. Instead, EPA was highlighted as having a notable impact on reducing depression risk.
Despite these insights, it’s important to note that we did not find distinct evidence linking DHA directly to improvements in depression outcomes. This indicates that while omega-3 fatty acids are relevant to depression, caution is warranted when interpreting the effects of individual components like DHA.
Therefore, while there seems to be a connection with omega-3 intake and depression risk, the exact benefits of DHA remain unclear. This raises important questions about how different omega-3s influence mental health and stresses the need for further targeted research to clarify these effects.
While our findings showed that higher levels of omega-3 fatty acids can lower the odds of major depressive disorder (MDD), the specific effects of DHA were not thoroughly analyzed. Instead, EPA was highlighted as having a notable impact on reducing depression risk.
Despite these insights, it’s important to note that we did not find distinct evidence linking DHA directly to improvements in depression outcomes. This indicates that while omega-3 fatty acids are relevant to depression, caution is warranted when interpreting the effects of individual components like DHA.
Therefore, while there seems to be a connection with omega-3 intake and depression risk, the exact benefits of DHA remain unclear. This raises important questions about how different omega-3s influence mental health and stresses the need for further targeted research to clarify these effects.
Read More
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
8.3
Mind balanced
Replying to @serenity: Girls, this is amazing. I swear, for my soul and anyone who has depression, taking vitamin D is essential. It has made my mind balanced and alert.
8.8
Improved mood
My senior dog and I have been taking high doses of DHA for our inflammation, and I've noticed a significant improvement in our quality of life. We've seen benefits in our skin, nails, hair, and mobility. As someone who has depression, I unexpectedly noticed a better mood with fewer episodes over the past three months.
Read More
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