5/2/2025
Last update
5/2/2025
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
USERS' SCORE
Good
Based on 5 Reviews
8.3
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calcium (elemental) (from 2,775 mg complex of Calcium Carbonate, Calcium Citrate, Calcium Ascorbate)
1 g (1,000 mg)
77%
Magnesium (elemental) (from 928 mg complex of Magnesium Oxide, Magnesium Citrate, Magnesium Ascorbate)
500 mg
119%
Top Medical Research Studies
8
Magnesium alloy inhibits cancer growth
We explored how magnesium alloy, particularly a variant containing 1% calcium, impacts cervical cancer cells. Our investigation revealed that this alloy has promising antitumor properties which could pave the way for new treatments.
In our experiments, we tested the effects of the Mg-1%Ca alloy both in laboratory settings and in living organisms. This alloy was found to release magnesium ions and hydroxide ions more slowly than expected. We observed that it effectively inhibited the growth of cervical cancer cells, specifically SiHa and HeLa cell lines.
Additionally, the presence of the alloy induced apoptosis, or programmed cell death, in the cancer cells, disrupted their structural integrity, and hindered their ability to migrate and invade other tissues. Importantly, the Mg-1%Ca alloy was seen to influence key molecular pathways, specifically the MAPK/ERK signaling pathway, which plays a role in cancer cell proliferation.
With these results, it's evident that magnesium alloy could serve as a useful adjunct to current cervical cancer therapies, potentially helping to prevent both cancer growth and metastasis.
In our experiments, we tested the effects of the Mg-1%Ca alloy both in laboratory settings and in living organisms. This alloy was found to release magnesium ions and hydroxide ions more slowly than expected. We observed that it effectively inhibited the growth of cervical cancer cells, specifically SiHa and HeLa cell lines.
Additionally, the presence of the alloy induced apoptosis, or programmed cell death, in the cancer cells, disrupted their structural integrity, and hindered their ability to migrate and invade other tissues. Importantly, the Mg-1%Ca alloy was seen to influence key molecular pathways, specifically the MAPK/ERK signaling pathway, which plays a role in cancer cell proliferation.
With these results, it's evident that magnesium alloy could serve as a useful adjunct to current cervical cancer therapies, potentially helping to prevent both cancer growth and metastasis.
Read More
8
We observed intriguing connections between magnesium levels and cancer treatment outcomes. Our focus was on how elevated serum magnesium might influence the effectiveness of immune checkpoint blockers, a promising class of cancer therapy.
While our findings suggest a potential benefit of higher magnesium levels in conjunction with these treatments, it’s important to note that isolating the effects of magnesium alone was challenging. We found that patients who had elevated magnesium levels experienced more favorable outcomes, yet we must remain cautious in interpreting these results as definitive proof of magnesium's standalone effectiveness.
Overall, the investigation into magnesium's impact on cancer treatment highlights an interesting avenue for future research. Understanding how our bodies' minerals interact with innovative therapies like immune checkpoint blockers could open new doors in the fight against cancer.
While our findings suggest a potential benefit of higher magnesium levels in conjunction with these treatments, it’s important to note that isolating the effects of magnesium alone was challenging. We found that patients who had elevated magnesium levels experienced more favorable outcomes, yet we must remain cautious in interpreting these results as definitive proof of magnesium's standalone effectiveness.
Overall, the investigation into magnesium's impact on cancer treatment highlights an interesting avenue for future research. Understanding how our bodies' minerals interact with innovative therapies like immune checkpoint blockers could open new doors in the fight against cancer.
Read More
9
We looked into the question of how magnesium levels might affect cancer treatment outcomes, especially for patients receiving immune checkpoint blockers. The study pointed out that elevated serum magnesium levels corresponded with more favorable results in these patients, suggesting that magnesium could play a positive role in their treatment journey.
However, the findings did not specifically isolate the effects of magnesium from those of other treatments. This means that while we observed a correlation between high magnesium levels and improved outcomes, we can't definitively say that magnesium alone caused these results. It’s important to note that further research is needed to clarify this relationship and understand how magnesium interacts with cancer therapies.
Overall, while the presence of sufficient magnesium appears to be beneficial, the intricate connection between magnesium levels and cancer treatment success is still not fully understood.
However, the findings did not specifically isolate the effects of magnesium from those of other treatments. This means that while we observed a correlation between high magnesium levels and improved outcomes, we can't definitively say that magnesium alone caused these results. It’s important to note that further research is needed to clarify this relationship and understand how magnesium interacts with cancer therapies.
Overall, while the presence of sufficient magnesium appears to be beneficial, the intricate connection between magnesium levels and cancer treatment success is still not fully understood.
Read More
Most Useful Reviews
7.5
Normal health indicators
1 people found this helpful
For a friend, 60+ After cancer, a woman constantly takes some medications, the side effect of which is a decrease in bone density. The doctor recommended taking calcium in addition, along with magnesium and vitamin D3+K2 for better absorption. On control examinations, all her indicators are normal, as well as her well-being. ❤️
Read More
9
Balanced bone density
My bones are happier! Since dealing with breast cancer last year, my bones have been under a lot of stress due to my medication. My doctor recommended a good calcium supplement to help balance my bone density. I trust NOW so much that I wouldn't consider anything else. Our body needs magnesium to absorb calcium, so this combination is just perfect for my requirements.
Read More
9
Excellent product help
After breast cancer surgery, I started taking anti-hormone drugs. To avoid osteoporosis, the doctor suggested I must supplement enough calcium. "NOW Foods, Calcium and Magnesium, 250 Tablets," with a calcium to magnesium ratio of 2:1, is very good for my sleep aid. Taking it with the D3 I purchased earlier, it is an excellent product that meets my needs.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 8 Researches
7.8
- All Researches
9
We looked into the question of how magnesium levels might affect cancer treatment outcomes, especially for patients receiving immune checkpoint blockers. The study pointed out that elevated serum magnesium levels corresponded with more favorable results in these patients, suggesting that magnesium could play a positive role in their treatment journey.
However, the findings did not specifically isolate the effects of magnesium from those of other treatments. This means that while we observed a correlation between high magnesium levels and improved outcomes, we can't definitively say that magnesium alone caused these results. It’s important to note that further research is needed to clarify this relationship and understand how magnesium interacts with cancer therapies.
Overall, while the presence of sufficient magnesium appears to be beneficial, the intricate connection between magnesium levels and cancer treatment success is still not fully understood.
However, the findings did not specifically isolate the effects of magnesium from those of other treatments. This means that while we observed a correlation between high magnesium levels and improved outcomes, we can't definitively say that magnesium alone caused these results. It’s important to note that further research is needed to clarify this relationship and understand how magnesium interacts with cancer therapies.
Overall, while the presence of sufficient magnesium appears to be beneficial, the intricate connection between magnesium levels and cancer treatment success is still not fully understood.
Read More
9
We examined how magnesium plays a role in enhancing T cell-mediated cancer immunotherapy. The study focused on a unique magnesium peroxide-based nanoigniter designed to disrupt the tumors' defenses. By combating the challenging immunosuppressive environment surrounding tumors, this innovative treatment aims to allow T cells to attack more effectively.
The nanoigniter is loaded with doxorubicin and metformin, and it works doubly by breaking down the tough extracellular matrix (ECM) that makes it difficult for T cells to infiltrate tumors. We observed that this approach not only promotes stronger responses from CD8 T cells — a critical type of immune cell in our bodies — but also boosts their effectiveness and prevents their fatigue under harsh conditions.
While the study highlights magnesium's supportive role in improving immunotherapy outcomes, it does not isolate the mineral's direct impact on cancer. Therefore, while we see promising interactions, determining magnesium's specific effects remains complex and linked to the overall treatment plan.
The nanoigniter is loaded with doxorubicin and metformin, and it works doubly by breaking down the tough extracellular matrix (ECM) that makes it difficult for T cells to infiltrate tumors. We observed that this approach not only promotes stronger responses from CD8 T cells — a critical type of immune cell in our bodies — but also boosts their effectiveness and prevents their fatigue under harsh conditions.
While the study highlights magnesium's supportive role in improving immunotherapy outcomes, it does not isolate the mineral's direct impact on cancer. Therefore, while we see promising interactions, determining magnesium's specific effects remains complex and linked to the overall treatment plan.
Read More
9
We investigated how magnesium might enhance the effectiveness of cytotoxic T lymphocytes (CTLs) in fighting glioblastoma, a particularly aggressive form of brain cancer. CTLs, although present in glioblastoma, often struggle to infiltrate tumors effectively and are hampered by various inhibitory markers, notably NK1.1.
This study introduced a novel method using a specially designed nanoeditor, named Mg@MK-8931@MPP. This editor combines magnesium with a specific drug that helps empower CTLs and encourages their infiltration into the tumor while addressing the challenges of delivering treatment safely in the brain.
We observed that once the magnesium-based nanoeditor localized within glioblastoma, it enabled the effective release of MK-8931. This release repolarized M2-like macrophages, promoting a more significant CTL presence within the tumor site. Furthermore, magnesium worked to amplify the immune response, boosting the production of crucial antitumor cytokines and proteins.
Additionally, we found that blocking the NK1.1 receptor on CTLs extended their cytotoxic activity, enhancing treatment outcomes. Research on both T-cell-deficient and standard mouse models validated the potential of this magnesium-driven metalloimmunotherapy approach in treating glioblastoma effectively.
Overall, this strategy not only broadens the application of metalloimmunotherapy to glioblastoma but also emphasizes the importance of ensuring the functionality of CTLs in the fight against cancer.
This study introduced a novel method using a specially designed nanoeditor, named Mg@MK-8931@MPP. This editor combines magnesium with a specific drug that helps empower CTLs and encourages their infiltration into the tumor while addressing the challenges of delivering treatment safely in the brain.
We observed that once the magnesium-based nanoeditor localized within glioblastoma, it enabled the effective release of MK-8931. This release repolarized M2-like macrophages, promoting a more significant CTL presence within the tumor site. Furthermore, magnesium worked to amplify the immune response, boosting the production of crucial antitumor cytokines and proteins.
Additionally, we found that blocking the NK1.1 receptor on CTLs extended their cytotoxic activity, enhancing treatment outcomes. Research on both T-cell-deficient and standard mouse models validated the potential of this magnesium-driven metalloimmunotherapy approach in treating glioblastoma effectively.
Overall, this strategy not only broadens the application of metalloimmunotherapy to glioblastoma but also emphasizes the importance of ensuring the functionality of CTLs in the fight against cancer.
Read More
8
We explored the impact of calcium and vitamin D supplementation on bone health in young adults after surgery for differentiated thyroid carcinoma (DTC). This study focused on patients under 50 years who had thyroidectomy and were experiencing vitamin D deficiency or insufficiency.
Over the course of one year, we provided patients with daily calcium and vitamin D supplements, monitoring their bone metabolism along the way. After analyzing results from 458 patients, we found that those receiving the supplements had lower levels of parathyroid hormone (PTH) and a notable increase in bone mineral density (BMD) at both the lumbar spine and hip compared to those who did not receive any supplements.
Our findings suggest that calcium, combined with vitamin D, can play a beneficial role in reducing bone loss in young DTC patients suffering from vitamin D malnutrition after thyroid surgery. This could mean improved bone health and a reduced risk of osteoporosis for these patients in the future.
Over the course of one year, we provided patients with daily calcium and vitamin D supplements, monitoring their bone metabolism along the way. After analyzing results from 458 patients, we found that those receiving the supplements had lower levels of parathyroid hormone (PTH) and a notable increase in bone mineral density (BMD) at both the lumbar spine and hip compared to those who did not receive any supplements.
Our findings suggest that calcium, combined with vitamin D, can play a beneficial role in reducing bone loss in young DTC patients suffering from vitamin D malnutrition after thyroid surgery. This could mean improved bone health and a reduced risk of osteoporosis for these patients in the future.
Read More
8
Magnesium alloy inhibits cancer growth
We explored how magnesium alloy, particularly a variant containing 1% calcium, impacts cervical cancer cells. Our investigation revealed that this alloy has promising antitumor properties which could pave the way for new treatments.
In our experiments, we tested the effects of the Mg-1%Ca alloy both in laboratory settings and in living organisms. This alloy was found to release magnesium ions and hydroxide ions more slowly than expected. We observed that it effectively inhibited the growth of cervical cancer cells, specifically SiHa and HeLa cell lines.
Additionally, the presence of the alloy induced apoptosis, or programmed cell death, in the cancer cells, disrupted their structural integrity, and hindered their ability to migrate and invade other tissues. Importantly, the Mg-1%Ca alloy was seen to influence key molecular pathways, specifically the MAPK/ERK signaling pathway, which plays a role in cancer cell proliferation.
With these results, it's evident that magnesium alloy could serve as a useful adjunct to current cervical cancer therapies, potentially helping to prevent both cancer growth and metastasis.
In our experiments, we tested the effects of the Mg-1%Ca alloy both in laboratory settings and in living organisms. This alloy was found to release magnesium ions and hydroxide ions more slowly than expected. We observed that it effectively inhibited the growth of cervical cancer cells, specifically SiHa and HeLa cell lines.
Additionally, the presence of the alloy induced apoptosis, or programmed cell death, in the cancer cells, disrupted their structural integrity, and hindered their ability to migrate and invade other tissues. Importantly, the Mg-1%Ca alloy was seen to influence key molecular pathways, specifically the MAPK/ERK signaling pathway, which plays a role in cancer cell proliferation.
With these results, it's evident that magnesium alloy could serve as a useful adjunct to current cervical cancer therapies, potentially helping to prevent both cancer growth and metastasis.
Read More
User Reviews
USERS' SCORE
Good
Based on 5 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
7.5
Normal health indicators
1 people found this helpful
For a friend, 60+ After cancer, a woman constantly takes some medications, the side effect of which is a decrease in bone density. The doctor recommended taking calcium in addition, along with magnesium and vitamin D3+K2 for better absorption. On control examinations, all her indicators are normal, as well as her well-being. ❤️
Read More
9
Balanced bone density
My bones are happier! Since dealing with breast cancer last year, my bones have been under a lot of stress due to my medication. My doctor recommended a good calcium supplement to help balance my bone density. I trust NOW so much that I wouldn't consider anything else. Our body needs magnesium to absorb calcium, so this combination is just perfect for my requirements.
Read More
9
Excellent product help
After breast cancer surgery, I started taking anti-hormone drugs. To avoid osteoporosis, the doctor suggested I must supplement enough calcium. "NOW Foods, Calcium and Magnesium, 250 Tablets," with a calcium to magnesium ratio of 2:1, is very good for my sleep aid. Taking it with the D3 I purchased earlier, it is an excellent product that meets my needs.
Read More
7.5
Normal health indicators
Regular purchase for an elderly friend. After cancer, a woman constantly takes some medications, leading to a decrease in bone density. The doctor recommended taking calcium along with magnesium and vitamin D3+K2 for better absorption. On control examinations, all her indicators are normal, as well as her well-being. ❤️
Read More
6
Affordability concern
Good product! I consume large quantities, up to 25g daily. I use it to help my fight against health issues caused by agricultural pesticides/toxins resulting in a terminal cancer prognosis. I'm slowly winning but need you to reduce pricing to ensure continued affordability. Cheers and thanks for the excellent product. Craig McPherson.
Read More
Frequently Asked Questions
9
Excellent product help
After breast cancer surgery, I started taking anti-hormone drugs. To avoid osteoporosis, the doctor suggested I must supplement enough calcium. "NOW Foods, Calcium and Magnesium, 250 Tablets," with a calcium to magnesium ratio of 2:1, is very good for my sleep aid. Taking it with the D3 I purchased earlier, it is an excellent product that meets my needs.
9
Balanced bone density
My bones are happier! Since dealing with breast cancer last year, my bones have been under a lot of stress due to my medication. My doctor recommended a good calcium supplement to help balance my bone density. I trust NOW so much that I wouldn't consider anything else. Our body needs magnesium to absorb calcium, so this combination is just perfect for my requirements.
7.5
Normal health indicators
1 people found this helpful
For a friend, 60+ After cancer, a woman constantly takes some medications, the side effect of which is a decrease in bone density. The doctor recommended taking calcium in addition, along with magnesium and vitamin D3+K2 for better absorption. On control examinations, all her indicators are normal, as well as her well-being. ❤️
6
Affordability concern
Good product! I consume large quantities, up to 25g daily. I use it to help my fight against health issues caused by agricultural pesticides/toxins resulting in a terminal cancer prognosis. I'm slowly winning but need you to reduce pricing to ensure continued affordability. Cheers and thanks for the excellent product. Craig McPherson.
7
We investigated how calcium treatment, in conjunction with various electroporation methods, affects cancer cell viability. In our study, we used 4T1 breast cancer cells and applied different forms of electroporation, such as reversible and irreversible treatments along with calcium electroporation. We were particularly interested in the bystander effect, where treated cells might affect untreated nearby cells.
By transferring conditioned media from the treated to untreated cells, we observed significant impacts on cell viability. The results showed that after applying calcium electroporation and bleomycin treatments, colony formation plummeted to nearly zero, and metabolic activity dipped as low as 11.62%. Additionally, other assessments, including flow cytometry, confirmed a drastic decrease in cell viability in the presence of calcium therapy.
While the study highlighted calcium’s role in enhancing the effects of electroporation, the combined treatments reduced the overall viability of surrounding cells markedly. We also noticed a delay in wound healing with conditioned media, indicating that calcium treatment could significantly impact not just treated but also neighboring cancer cells. Overall, calcium's combined effects were powerful, emphasizing its utility in cancer treatment strategies.
By transferring conditioned media from the treated to untreated cells, we observed significant impacts on cell viability. The results showed that after applying calcium electroporation and bleomycin treatments, colony formation plummeted to nearly zero, and metabolic activity dipped as low as 11.62%. Additionally, other assessments, including flow cytometry, confirmed a drastic decrease in cell viability in the presence of calcium therapy.
While the study highlighted calcium’s role in enhancing the effects of electroporation, the combined treatments reduced the overall viability of surrounding cells markedly. We also noticed a delay in wound healing with conditioned media, indicating that calcium treatment could significantly impact not just treated but also neighboring cancer cells. Overall, calcium's combined effects were powerful, emphasizing its utility in cancer treatment strategies.
4
We examined how calcium levels impact the interactions between platelets and cancer cells, as these interactions are crucial for cancer metastasis. Our focus was on specific platelet receptors called integrins, which play vital roles in these interactions.
Throughout our study, we discovered that calcium significantly affects the functionality of these integrins and the overall behavior of platelets. When we reduced calcium levels, we noticed a change in how platelets interacted with breast cancer cells (specifically MDA-MB-231). On the contrary, environments with high calcium levels did not seem to affect these interactions as significantly.
Interestingly, we observed that hypercalcemia, or elevated calcium levels, appeared to enhance cancer cell invasion in the presence of platelets for both breast and lung cancer cells (MDA-MB-231 and A549, respectively). This suggests that rather than obstructing metastatic processes, high calcium may facilitate cancer spread, offering a new perspective on calcium's role in cancer dynamics.
Overall, this study sheds light on how calcium adjustments could be viewed not only as a potential therapeutic strategy but also as a factor impacting cancer progression, especially through platelet interactions.
Throughout our study, we discovered that calcium significantly affects the functionality of these integrins and the overall behavior of platelets. When we reduced calcium levels, we noticed a change in how platelets interacted with breast cancer cells (specifically MDA-MB-231). On the contrary, environments with high calcium levels did not seem to affect these interactions as significantly.
Interestingly, we observed that hypercalcemia, or elevated calcium levels, appeared to enhance cancer cell invasion in the presence of platelets for both breast and lung cancer cells (MDA-MB-231 and A549, respectively). This suggests that rather than obstructing metastatic processes, high calcium may facilitate cancer spread, offering a new perspective on calcium's role in cancer dynamics.
Overall, this study sheds light on how calcium adjustments could be viewed not only as a potential therapeutic strategy but also as a factor impacting cancer progression, especially through platelet interactions.
References
- Barauskaitė-Šarkinienė N, Novickij V, Šatkauskas S, Ruzgys P. Investigation of the Bystander Effect on Cell Viability After Application of Combined Electroporation-Based Methods. Int J Mol Sci. 2025;26. 10.3390/ijms26052297
- Sun L, Lin X, Li N, Zhang Q, Jiang Y, et al. Effects of vitamin D and calcium supplementation on bone of young adults after thyroidectomy of differentiated thyroid carcinoma. Endocrine. 2025. 10.1007/s12020-025-04195-x
- Morris K, Masri S, Schnoor B, Papa AL. Calcium levels modulate platelet function, platelet-cancer cell interaction, and cancer cell invasion. Sci Rep. 2025;15:7750. 10.1038/s41598-024-79280-8
- Ouyang Y, Cao L, Zhao Q, Yang W, Lin C. Biodegradable Mg-1%Ca alloy inhibits the growth of cervical cancer. Biomed Mater. 2025. 10.1088/1748-605X/adb2cc
- Wang Z, Wang Z. Letter Re: Elevated serum magnesium levels prompt favourable outcomes in cancer patients treated with immune checkpoint blockers. Eur J Cancer. 2025;216:115187. 10.1016/j.ejca.2024.115187
- Kitapli S, Alkan A, Tanriverdi O. Elevated serum magnesium levels prompt favourable outcomes in cancer patients treated with immune checkpoint blockers. Eur J Cancer. 2025;216:115188. 10.1016/j.ejca.2024.115188
- Hao H, Sun S, Fu Y, Wen S, Wen Y, et al. Magnesium peroxide-based biomimetic nanoigniter degrades extracellular matrix to awake T cell-mediated cancer immunotherapy. Biomaterials. 2025;317:123043. 10.1016/j.biomaterials.2024.123043
- Li W, Tian H, Yan Z, Yu X, Li B, et al. Magnesium-Phenolic Nanoeditor Refining Gliomatous T Cells for Metalloimmunotherapy. ACS Nano. 2025;19:1222. 10.1021/acsnano.4c13388
