5/2/2025
Last update
5/2/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.7
USERS' SCORE
Good
Based on 3 Reviews
8.3
Supplement Facts
Serving Size: 2 Tablets
Amount Per Serving
%DV
Calcium (elemental) (from 2,775 mg complex of Calcium Carbonate, Calcium Citrate, Calcium Ascorbate)
1 g (1,000 mg)
77%
Magnesium (elemental) (from 928 mg complex of Magnesium Oxide, Magnesium Citrate, Magnesium Ascorbate)
500 mg
119%
Top Medical Research Studies
9
We explored the connection between dietary magnesium intake and hypertension along with other health issues in US adults. In our study, we analyzed data from over 24,000 people, taking into account various lifestyle factors.
We found that those with higher magnesium intake had significantly lower rates of hypertension, diabetes, and hyperlipidemia compared to those with the least intake. Notably, participants in the highest quintile of magnesium consumption were less likely to suffer from these conditions.
These results suggest that increasing magnesium-rich foods in our diets could help prevent these prevalent health concerns.
We found that those with higher magnesium intake had significantly lower rates of hypertension, diabetes, and hyperlipidemia compared to those with the least intake. Notably, participants in the highest quintile of magnesium consumption were less likely to suffer from these conditions.
These results suggest that increasing magnesium-rich foods in our diets could help prevent these prevalent health concerns.
Read More
8
Magnesium effectively lowers blood pressure
We explored how magnesium supplementation can affect systolic blood pressure (SBP) in the general population. Through careful analysis of placebo-controlled, randomized clinical trials, we focused on understanding the optimal dosages and treatment durations necessary to achieve significant reductions in SBP. Past findings revealed that magnesium could reduce SBP by an average of 2.79 mm Hg, and our goal was to dive deeper into these results.
Our meta-analysis showed promising outcomes. Specifically, we noticed that magnesium taken at lower doses, particularly ≤360 mg per day, led to a notable decrease in SBP of about 3.03 mm Hg, especially when the treatment duration exceeded three months. This suggests that for those looking to manage their blood pressure, longer-term use of magnesium at these dosages may be beneficial.
While we found encouraging evidence pointing to the effectiveness of magnesium in lowering SBP, we acknowledge the importance of further studies. These future investigations should focus on varied dosages and longer follow-up periods to strengthen our understanding and provide tailored recommendations for individuals seeking to utilize magnesium in their hypertension management strategies.
Our meta-analysis showed promising outcomes. Specifically, we noticed that magnesium taken at lower doses, particularly ≤360 mg per day, led to a notable decrease in SBP of about 3.03 mm Hg, especially when the treatment duration exceeded three months. This suggests that for those looking to manage their blood pressure, longer-term use of magnesium at these dosages may be beneficial.
While we found encouraging evidence pointing to the effectiveness of magnesium in lowering SBP, we acknowledge the importance of further studies. These future investigations should focus on varied dosages and longer follow-up periods to strengthen our understanding and provide tailored recommendations for individuals seeking to utilize magnesium in their hypertension management strategies.
Read More
9.5
We observed the use of clevidipine, a calcium channel blocker, to manage hypertension in a dog undergoing surgery for pheochromocytoma. This treatment was initiated after the dog had been already prepared for surgery with medications like phenoxybenzamine, which was given to help control the underlying condition.
During the surgical procedure, when blood pressure spiked significantly due to adrenal gland manipulation, clevidipine was administered intravenously to help bring the mean arterial pressure down to a safer range. This swift action allowed the dog’s blood pressure and heart rate to stabilize, showcasing how effective clevidipine can be in these stressful situations.
After a successful surgery and recovery, the dog was discharged and showed stable clinical signs for two years afterward. Our findings highlight clevidipine's effectiveness as a fast-acting vasodilator with a strong safety profile, particularly in emergencies involving high blood pressure.
During the surgical procedure, when blood pressure spiked significantly due to adrenal gland manipulation, clevidipine was administered intravenously to help bring the mean arterial pressure down to a safer range. This swift action allowed the dog’s blood pressure and heart rate to stabilize, showcasing how effective clevidipine can be in these stressful situations.
After a successful surgery and recovery, the dog was discharged and showed stable clinical signs for two years afterward. Our findings highlight clevidipine's effectiveness as a fast-acting vasodilator with a strong safety profile, particularly in emergencies involving high blood pressure.
Read More
Most Useful Reviews
9
Reduced headaches
I am very satisfied with this product, and I've even ordered it for my mum as a supplement for her hypertension! Since she started, her headaches have noticeably decreased!
Read More
7.5
Heart protection
These are excellent vitamins for my mother, who suffers from hypertension. I purchased them to accompany her calcium and magnesium, aimed at protecting her heart. I completed my own course as well, ensuring we both benefit from these valuable supplements!
Read More
6
Improved mood
Magnesium is essential for converting food into energy, synthesising DNA and proteins, and conducting nerve impulses. It aids in maintaining a steady heartbeat, muscle contractions, and strong bones. A deficiency can increase the risk of cardiovascular diseases, hypertension, osteoporosis, and even type 2 diabetes. Calcium and Magnesium NOW Foods delivers 119% of the daily value of magnesium and 77% of calcium. I take 2 capsules during breakfast, along with vitamin D and krill oil. I find the taste neutral, as I drink it down with plenty of water. After two months of supplementation, my stress levels decreased and my mood has improved. Overall, I’m pleased and plan to take another course after a break!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 20 Researches
7.7
- All Researches
9.5
We observed the use of clevidipine, a calcium channel blocker, to manage hypertension in a dog undergoing surgery for pheochromocytoma. This treatment was initiated after the dog had been already prepared for surgery with medications like phenoxybenzamine, which was given to help control the underlying condition.
During the surgical procedure, when blood pressure spiked significantly due to adrenal gland manipulation, clevidipine was administered intravenously to help bring the mean arterial pressure down to a safer range. This swift action allowed the dog’s blood pressure and heart rate to stabilize, showcasing how effective clevidipine can be in these stressful situations.
After a successful surgery and recovery, the dog was discharged and showed stable clinical signs for two years afterward. Our findings highlight clevidipine's effectiveness as a fast-acting vasodilator with a strong safety profile, particularly in emergencies involving high blood pressure.
During the surgical procedure, when blood pressure spiked significantly due to adrenal gland manipulation, clevidipine was administered intravenously to help bring the mean arterial pressure down to a safer range. This swift action allowed the dog’s blood pressure and heart rate to stabilize, showcasing how effective clevidipine can be in these stressful situations.
After a successful surgery and recovery, the dog was discharged and showed stable clinical signs for two years afterward. Our findings highlight clevidipine's effectiveness as a fast-acting vasodilator with a strong safety profile, particularly in emergencies involving high blood pressure.
Read More
9
We conducted a retrospective study to investigate how magnesium sulfate paired with labetalol affects vascular health and pregnancy outcomes in women with preeclampsia—a serious condition that can occur during pregnancy characterized by high blood pressure.
Our analysis focused on clinical data from 262 women treated for preeclampsia. The patients were divided into two groups: one group received magnesium sulfate alone, while the other group was treated with both magnesium sulfate and labetalol. By measuring key indicators such as nitric oxide and endothelin-1 levels, along with blood pressure readings, we aimed to determine the effectiveness of these treatments.
The results showed that the combination of magnesium sulfate and labetalol notably improved vascular function and pregnancy outcomes for these women. Not only did this treatment help in better controlling high blood pressure during pregnancy, but it also reduced the chances of adverse outcomes for both mothers and babies. Importantly, the study found this combined treatment to be as safe as using magnesium sulfate alone.
This reinforces the idea that magnesium can play a significant role in treating hypertension during pregnancy, especially when paired with other medications like labetalol.
Our analysis focused on clinical data from 262 women treated for preeclampsia. The patients were divided into two groups: one group received magnesium sulfate alone, while the other group was treated with both magnesium sulfate and labetalol. By measuring key indicators such as nitric oxide and endothelin-1 levels, along with blood pressure readings, we aimed to determine the effectiveness of these treatments.
The results showed that the combination of magnesium sulfate and labetalol notably improved vascular function and pregnancy outcomes for these women. Not only did this treatment help in better controlling high blood pressure during pregnancy, but it also reduced the chances of adverse outcomes for both mothers and babies. Importantly, the study found this combined treatment to be as safe as using magnesium sulfate alone.
This reinforces the idea that magnesium can play a significant role in treating hypertension during pregnancy, especially when paired with other medications like labetalol.
Read More
9
We examined an experimental model of pulmonary arterial hypertension (PAH) induced by monocrotaline in rats. Our research focused on the combined effects of Magnesium sulfate along with Rosuvastatin and Sildenafil, which were administered two weeks after the initial MCT injection.
Using measures like the Fulton Index and various cardiac dimensions, we observed improvements in right ventricular function and markers of oxidative stress. Notably, Magnesium sulfate appeared to work well with Rosuvastatin, which is known for its anti-inflammatory properties, enhancing the overall treatment effectiveness on pulmonary hypertension.
However, since Magnesium was administered in combination with these other treatments, we could not determine its isolated benefits on hypertension specifically. The study did highlight the importance of multi-pronged approaches in tackling such complex conditions, suggesting that further research might clarify Magnesium's unique contributions to managing hypertension.
Using measures like the Fulton Index and various cardiac dimensions, we observed improvements in right ventricular function and markers of oxidative stress. Notably, Magnesium sulfate appeared to work well with Rosuvastatin, which is known for its anti-inflammatory properties, enhancing the overall treatment effectiveness on pulmonary hypertension.
However, since Magnesium was administered in combination with these other treatments, we could not determine its isolated benefits on hypertension specifically. The study did highlight the importance of multi-pronged approaches in tackling such complex conditions, suggesting that further research might clarify Magnesium's unique contributions to managing hypertension.
Read More
9
We examined a cohort of neonates born at or above 36 weeks gestation to assess the impact of antenatal magnesium sulfate on hypoxic-ischemic encephalopathy linked to hypertensive disorders of pregnancy.
Our analysis revealed that these disorders significantly increase the risk of moderate to severe brain injury. Importantly, we observed that receiving magnesium sulfate reduced the odds of developing hypoxic-ischemic encephalopathy in affected infants.
However, it’s crucial to understand that while our study shows an association, it does not establish a cause-and-effect relationship.
Our analysis revealed that these disorders significantly increase the risk of moderate to severe brain injury. Importantly, we observed that receiving magnesium sulfate reduced the odds of developing hypoxic-ischemic encephalopathy in affected infants.
However, it’s crucial to understand that while our study shows an association, it does not establish a cause-and-effect relationship.
Read More
9
We explored the connection between dietary magnesium intake and hypertension along with other health issues in US adults. In our study, we analyzed data from over 24,000 people, taking into account various lifestyle factors.
We found that those with higher magnesium intake had significantly lower rates of hypertension, diabetes, and hyperlipidemia compared to those with the least intake. Notably, participants in the highest quintile of magnesium consumption were less likely to suffer from these conditions.
These results suggest that increasing magnesium-rich foods in our diets could help prevent these prevalent health concerns.
We found that those with higher magnesium intake had significantly lower rates of hypertension, diabetes, and hyperlipidemia compared to those with the least intake. Notably, participants in the highest quintile of magnesium consumption were less likely to suffer from these conditions.
These results suggest that increasing magnesium-rich foods in our diets could help prevent these prevalent health concerns.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.3
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced headaches
I am very satisfied with this product, and I've even ordered it for my mum as a supplement for her hypertension! Since she started, her headaches have noticeably decreased!
Read More
7.5
Heart protection
These are excellent vitamins for my mother, who suffers from hypertension. I purchased them to accompany her calcium and magnesium, aimed at protecting her heart. I completed my own course as well, ensuring we both benefit from these valuable supplements!
Read More
6
Improved mood
Magnesium is essential for converting food into energy, synthesising DNA and proteins, and conducting nerve impulses. It aids in maintaining a steady heartbeat, muscle contractions, and strong bones. A deficiency can increase the risk of cardiovascular diseases, hypertension, osteoporosis, and even type 2 diabetes. Calcium and Magnesium NOW Foods delivers 119% of the daily value of magnesium and 77% of calcium. I take 2 capsules during breakfast, along with vitamin D and krill oil. I find the taste neutral, as I drink it down with plenty of water. After two months of supplementation, my stress levels decreased and my mood has improved. Overall, I’m pleased and plan to take another course after a break!
Read More
Frequently Asked Questions
9
Reduced headaches
I am very satisfied with this product, and I've even ordered it for my mum as a supplement for her hypertension! Since she started, her headaches have noticeably decreased!
7.5
Heart protection
These are excellent vitamins for my mother, who suffers from hypertension. I purchased them to accompany her calcium and magnesium, aimed at protecting her heart. I completed my own course as well, ensuring we both benefit from these valuable supplements!
6
Improved mood
Magnesium is essential for converting food into energy, synthesising DNA and proteins, and conducting nerve impulses. It aids in maintaining a steady heartbeat, muscle contractions, and strong bones. A deficiency can increase the risk of cardiovascular diseases, hypertension, osteoporosis, and even type 2 diabetes. Calcium and Magnesium NOW Foods delivers 119% of the daily value of magnesium and 77% of calcium. I take 2 capsules during breakfast, along with vitamin D and krill oil. I find the taste neutral, as I drink it down with plenty of water. After two months of supplementation, my stress levels decreased and my mood has improved. Overall, I’m pleased and plan to take another course after a break!
7
Calcium supplementation and hypertension
We examined the role of calcium in managing hypertension, specifically looking at how it affects blood pressure levels. Our analysis included a systematic review and meta-analysis of various studies that compared calcium supplementation to control groups.
After reviewing 6,509 articles, we ultimately focused on 24 that met our criteria. The results indicated that calcium does have a noticeable impact, particularly in reducing diastolic blood pressure (DBP), which is the bottom number in a blood pressure reading. We observed a significant average drop in DBP of about 2.04 mmHg, showcasing its potential benefits for those struggling with high blood pressure.
However, we found that calcium supplementation did not significantly change systolic blood pressure (SBP) or pulse rate. This suggests that while calcium may help lower DBP, it does not appear to influence overall hypertension management as strongly as initially hypothesized.
Overall, while calcium can be a helpful addition to a hypertension management plan, it should not be seen as a standalone solution, especially since its effects on SBP and pulse rate were not statistically significant.
After reviewing 6,509 articles, we ultimately focused on 24 that met our criteria. The results indicated that calcium does have a noticeable impact, particularly in reducing diastolic blood pressure (DBP), which is the bottom number in a blood pressure reading. We observed a significant average drop in DBP of about 2.04 mmHg, showcasing its potential benefits for those struggling with high blood pressure.
However, we found that calcium supplementation did not significantly change systolic blood pressure (SBP) or pulse rate. This suggests that while calcium may help lower DBP, it does not appear to influence overall hypertension management as strongly as initially hypothesized.
Overall, while calcium can be a helpful addition to a hypertension management plan, it should not be seen as a standalone solution, especially since its effects on SBP and pulse rate were not statistically significant.
8
We explored the role of calcium in managing hypertension, particularly in relation to preeclampsia—a serious condition that affects pregnant women. The evidence suggests that calcium supplementation can be beneficial, helping to reduce the occurrence of preeclampsia.
In our review, we observed that a diet rich in calcium and other micronutrients, combined with a healthy lifestyle, might significantly lower the risks associated with hypertenion during pregnancy. While certain studies point to positive outcomes with calcium, the relationship isn't entirely straightforward, and it’s clear more research is needed to understand how effective it truly is on its own.
Overall, we found that adopting a balanced, plant-based diet and ensuring adequate calcium intake may help mitigate some risk factors of hypertension. However, the direct impact of calcium alone, without considering other lifestyle and dietary factors, still requires further investigation.
In our review, we observed that a diet rich in calcium and other micronutrients, combined with a healthy lifestyle, might significantly lower the risks associated with hypertenion during pregnancy. While certain studies point to positive outcomes with calcium, the relationship isn't entirely straightforward, and it’s clear more research is needed to understand how effective it truly is on its own.
Overall, we found that adopting a balanced, plant-based diet and ensuring adequate calcium intake may help mitigate some risk factors of hypertension. However, the direct impact of calcium alone, without considering other lifestyle and dietary factors, still requires further investigation.
7
Calcium's potential in hypertension management
We explored how calcium supplementation could affect hypertension, particularly among women with low dietary calcium intake. The idea was that increasing calcium levels might reduce issues related to elevated blood pressure, especially in the context of preventing preeclampsia—a serious pregnancy complication.
Although studies suggested that calcium could help reduce endothelium activation and hypertension, the specific impact of calcium alone on hypertension remains complex. It's important to note that despite encouraging signs, more research is needed to firmly establish the connection.
As we reviewed current findings, it became clear that while calcium supplementation carries potential benefits, its effectiveness varies depending on individual circumstances. Integrating calcium as part of a broader approach to managing blood pressure may be more beneficial than relying solely on it.
Although studies suggested that calcium could help reduce endothelium activation and hypertension, the specific impact of calcium alone on hypertension remains complex. It's important to note that despite encouraging signs, more research is needed to firmly establish the connection.
As we reviewed current findings, it became clear that while calcium supplementation carries potential benefits, its effectiveness varies depending on individual circumstances. Integrating calcium as part of a broader approach to managing blood pressure may be more beneficial than relying solely on it.
References
- Nadeem M, Javed K, Abid HMR, Hussain A, Khalid N. A Review of Dietary and Lifestyle Management of Pre-Eclampsia and Postpartum Eclampsia. Prev Nutr Food Sci. 2025;30:1. 10.3746/pnf.2025.30.1.1
- Amer SA, Abo-Elnour DE, Abbas A, Abdelrahman AS, Hamdy HM, et al. Calcium, magnesium, and vitamin D supplementations as complementary therapy for hypertensive patients: a systematic review and meta-analysis. BMC Complement Med Ther. 2025;25:89. 10.1186/s12906-025-04809-x
- Machado ML, Soares JH. Clevidipine for hypertension treatment during laparoscopic adrenalectomy for pheochromocytoma in a dog. Vet Anaesth Analg. 2025. 10.1016/j.vaa.2025.02.004
- Aldika Akbar MI, Rosaudyn R, Gumilar KE, Shanmugalingam R, Dekker G. Secondary prevention of preeclampsia. Front Cell Dev Biol. 2025;13:1520218. 10.3389/fcell.2025.1520218
- Machado-Duque M, Gaviria-Mendoza A, Valladales-Restrepo LF, Pacheco M, Franco JS, et al. Treatment Patterns of Patients With Pulmonary Hypertension: A Descriptive Study in Colombia. Clin Respir J. 2025;19:e70063. 10.1111/crj.70063
- Kang H, Lee UJ, Park BY, Kim M, Yang M. Effects of deep ocean-derived magnesium-enhanced water on metabolic diseases with microbiome changes. Diabetes Metab Syndr. 2025;19:103203. 10.1016/j.dsx.2025.103203
- Liu Y, Li W, Sun Y, Wang Z. Effects of magnesium sulfate combined with labetalol on vascular endothelial function and pregnancy outcomes in pregnant women with preeclampsia. Am J Transl Res. 2024;16:7096. 10.62347/COZZ1407
- Behers BJ, Behers BM, Stephenson-Moe CA, Vargas IA, Meng Z, et al. Magnesium and Potassium Supplementation for Systolic Blood Pressure Reduction in the General Normotensive Population: A Systematic Review and Subgroup Meta-Analysis for Optimal Dosage and Treatment Length. Nutrients. 2024;16. 10.3390/nu16213617
- Hojda SE, Chis IC, Mîrza TV, Clichici S. Monocrotaline-induced pulmonary arterial hypertension: the benefic effects of magnesium sulfate, Rosuvastatin and Sildenafil. Med Pharm Rep. 2024;97:528. 10.15386/mpr-2804
- Gong Y, Zhou C, Wan Y, Yin H. Association of magnesium deficiency, tobacco smoke exposure and hypertension in children and adolescents: evidence from the NHANES 2007-2018. BMC Pediatr. 2024;24:647. 10.1186/s12887-024-05097-z
- Dariy V, Serikov K, Kmyta O, Rybalko T, Kolesnyk O. PERSONIFICATION OF ANTIHYPERTENSIVE THERAPY IN ISCHEMIC CEREBRAL STROKE. Georgian Med News. 2024.
- Song J, Zhang Y, Lin Z, Tang J, Yang X, et al. Higher Magnesium Depletion Score Increases the Risk of All-cause and Cardiovascular Mortality in Hypertension Participants. Biol Trace Elem Res. 2025;203:1287. 10.1007/s12011-024-04254-w
- Minor KC, Liu J, Druzin ML, El-Sayed YY, Hintz SR, et al. Magnesium sulfate and risk of hypoxic-ischemic encephalopathy in a high-risk cohort. Am J Obstet Gynecol. 2024;231:647.e1. 10.1016/j.ajog.2024.04.001
- Wang Q, Si K, Xing X, Ye X, Liu Z, et al. Association between dietary magnesium intake and muscle mass among hypertensive population: evidence from the National Health and Nutrition Examination Survey. Nutr J. 2024;23:37. 10.1186/s12937-024-00940-6
- Yerubandi S, Devi Kallur S, Gala A, Chandra Ravula P, Surapaneni T, et al. Eclampsia reduction with maternal early warning trigger tool. Pregnancy Hypertens. 2024;35:6. 10.1016/j.preghy.2023.11.007
- Peng Z, Zhang J, Xiao Y, Dong W. Comparison of outcomes following intravenous magnesium compared with intravenous labetalol and oral nifedipine in 355 pregnant Han Chinese women with preeclampsia. Medicine (Baltimore). 2023;102:e35334. 10.1097/MD.0000000000035334
- Su HC, Lin CP, Ho WJ, Chou SH, Wu CT, et al. Factors affecting the intensity of chronic musculoskeletal pain in patients with cardiovascular disease and evaluation of the efficacy of magnesium emulsion cream for muscle cramps. Medicine (Baltimore). 2023;102:e35532. 10.1097/MD.0000000000035532
- Vongpatanasin W, Giacona JM, Pittman D, Murillo A, Khan G, et al. Potassium Magnesium Citrate Is Superior to Potassium Chloride in Reversing Metabolic Side Effects of Chlorthalidone. Hypertension. 2023;80:2611. 10.1161/HYPERTENSIONAHA.123.21932
- Behers BJ, Melchor J, Behers BM, Meng Z, Swanson PJ, et al. Vitamins and Minerals for Blood Pressure Reduction in the General, Normotensive Population: A Systematic Review and Meta-Analysis of Six Supplements. Nutrients. 2023;15. 10.3390/nu15194223
- Han M, Zhang Y, Fang J, Sun M, Liu Q, et al. Associations between dietary magnesium intake and hypertension, diabetes, and hyperlipidemia. Hypertens Res. 2024;47:331. 10.1038/s41440-023-01439-z
